| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bruno Legallicier, Germain Trugnan, Gillian Murphy, Brigitte Lelongt, Pierre Ronc. Expression of the type IV collagenase system during mouse kidney development and tubule segmentation. Journal of the American Society of Nephrology : JASN. vol 12. issue 11. 2002-02-15. PMID:11675412. |
type iv collagenases matrix metalloproteinase-2 (mmp2) and mmp9 and their related proteins, mt1-mmp, tissue inhibitor of metalloproteinases 1 (timp1), timp2, and timp3, are expressed during kidney morphogenesis and nephrogenesis, but the renal ontogeny of these proteins is only partially known, and their persistence in the adult remains controversial. |
2002-02-15 |
2023-08-12 |
mouse |
| Y Soini, J Satta, M Määttä, H Autio-Harmaine. Expression of MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heart. The Journal of pathology. vol 194. issue 2. 2001-06-21. PMID:11400152. |
this study was undertaken to investigate the mrna synthesis of mmp2, mmp9, membrane-type 1 (mt1)-mmp, and matrix metalloproteinase inhibitors timp1 and timp2 by in situ hybridization in a set of heart mitral and aortic valves operatively removed due to degenerative or inflammatory valvular diseases. |
2001-06-21 |
2023-08-12 |
Not clear |
| Y Soini, J Satta, M Määttä, H Autio-Harmaine. Expression of MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heart. The Journal of pathology. vol 194. issue 2. 2001-06-21. PMID:11400152. |
the results show that matrix metalloproteinases mmp2 and mmp9, and matrix metalloproteinase inhibitors timp1 and timp2 mrnas are synthesized in diseased valves and suggest that they may contribute to matrix remodelling in valvular disease. |
2001-06-21 |
2023-08-12 |
Not clear |
| W Zhao, Y O'Malley, M E Robbin. Irradiation of rat mesangial cells alters the expression of gene products associated with the development of renal fibrosis. Radiation research. vol 152. issue 2. 1999-08-26. PMID:10409325. |
to determine the ability of radiation to modulate mesangial cell expression of various molecules involved in promoting extracellular matrix (ecm) accumulation [fibronectin, plasminogen activator-inhibitor 1 (pai1), and tissue inhibitor of metalloproteinase-2 (timp2)] and degradation (tgfb, plasminogen activators u-pa or t-pa, matrix metalloproteinases mmp2 and mmp9), primary cultures of rat mesangial cells (passage number 6-11) were placed in serum-free medium 24 h prior to irradiation with single doses of 0.5-20 gy (137)cs gamma rays. |
1999-08-26 |
2023-08-12 |
rat |
| I Kazes, F Delarue, J Hagège, L Bouzhir-Sima, E Rondeau, J D Sraer, G Nguye. Soluble latent membrane-type 1 matrix metalloprotease secreted by human mesangial cells is activated by urokinase. Kidney international. vol 54. issue 6. 1999-02-11. PMID:9853262. |
matrix metalloprotease 2 (mmp2) is secreted in a latent inactive form (pro-mmp2) that is activated on the cell surface by a membrane-type 1 mmp (mt1-mmp) in the presence of the tissue inhibitor of mmp (timp2). |
1999-02-11 |
2023-08-12 |
human |
| M Ebata, Y Fukuda, I Nakano, Y Katano, N Fujimoto, T Hayakaw. Serum levels of tissue inhibitor of metalloproteinases-2 and of precursor form of matrix metalloproteinase-2 in patients with liver disease. Liver. vol 17. issue 6. 1998-03-10. PMID:9455735. |
serum levels of tissue inhibitor of metalloproteinases-2 (timp2) and of precursor form of matrix metalloproteinase-2 (prommp2) were determined in patients with chronic hepatitis and hepatocellular carcinoma by a one-step sandwich enzyme immunoassay. |
1998-03-10 |
2023-08-12 |
Not clear |
| G S Butler, M J Butler, S J Atkinson, H Will, T Tamura, S Schade van Westrum, T Crabbe, J Clements, M P d'Ortho, G Murph. The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study. The Journal of biological chemistry. vol 273. issue 2. 1998-02-09. PMID:9422744. |
we have used c-terminal domain mutants to further define the role of interactions of progelatinase a and membrane type 1 matrix metalloproteinase (mt1 mmp) in the binding of timp2 and in the cell-associated activation of progelatinase a. soluble constructs of mt1 mmp were used to demonstrate that binding with timp2 occurs primarily through n-terminal domain interactions, leaving the c-terminal domain free for interactions with progelatinase a. |
1998-02-09 |
2023-08-12 |
Not clear |
| O Musso, N Théret, J P Campion, B Turlin, S Milani, C Grappone, B Clémen. In situ detection of matrix metalloproteinase-2 (MMP2) and the metalloproteinase inhibitor TIMP2 transcripts in human primary hepatocellular carcinoma and in liver metastasis. Journal of hepatology. vol 26. issue 3. 1997-06-05. PMID:9075667. |
in situ detection of matrix metalloproteinase-2 (mmp2) and the metalloproteinase inhibitor timp2 transcripts in human primary hepatocellular carcinoma and in liver metastasis. |
1997-06-05 |
2023-08-12 |
human |
| H Kawamata, K Nakashiro, D Uchida, K Harada, H Yoshida, M Sat. Possible contribution of active MMP2 to lymph-node metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell lines. International journal of cancer. vol 70. issue 1. 1997-01-27. PMID:8985100. |
bhy cells secreted a tissue inhibitor of matrix metalloproteinase, timp2, but only a trace level of timp1. |
1997-01-27 |
2023-08-12 |
mouse |
| H Kawamata, K Kawai, S Kameyama, M D Johnson, W G Stetler-Stevenson, R Oyas. Over-expression of tissue inhibitor of matrix metalloproteinases (TIMP1 and TIMP2) suppresses extravasation of pulmonary metastasis of a rat bladder carcinoma. International journal of cancer. vol 63. issue 5. 1995-12-28. PMID:7591285. |
over-expression of tissue inhibitor of matrix metalloproteinases (timp1 and timp2) suppresses extravasation of pulmonary metastasis of a rat bladder carcinoma. |
1995-12-28 |
2023-08-12 |
mouse |
| H Kawamata, K Kawai, S Kameyama, M D Johnson, W G Stetler-Stevenson, R Oyas. Over-expression of tissue inhibitor of matrix metalloproteinases (TIMP1 and TIMP2) suppresses extravasation of pulmonary metastasis of a rat bladder carcinoma. International journal of cancer. vol 63. issue 5. 1995-12-28. PMID:7591285. |
lmc19 cells secrete pro-gelatinases a and b as well as tissue inhibitors of matrix metalloproteinase (timp1 and timp2). |
1995-12-28 |
2023-08-12 |
mouse |
| Y De Clerck, C Szpirer, M S Aly, J J Cassiman, Y Eeckhout, G Roussea. The gene for tissue inhibitor of metalloproteinases-2 is localized on human chromosome arm 17q25. Genomics. vol 14. issue 3. 1992-12-17. PMID:1427908. |
tissue inhibitor of metalloproteinases-2 (timp2) is a natural inhibitor of several proteinases that are involved in the degradation of the extracellular matrix. |
1992-12-17 |
2023-08-11 |
human |