| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Iu V Vakhitova, E I Antipina, R S Yamidanov, R Iu Khisamutdinova, F S Zarudiĭ, N Zh Baschenko, V A Dokichev, Iu V Tomilov, O M Nefedo. [Animal in vivo model of arrhythmia for genes target identification for 5-amino-exo-3-azatricyclo[5.2.1.0(2,6)]decan-4-one]. Bioorganicheskaia khimiia. vol 37. issue 6. 2012-06-07. PMID:22497081. |
comparative analysis of changes in the status of expression of genes in the heart of rats induced by p-11 against the simulated in vivo arrhythmia identified 16 genes that reproducibly alter the level of expression.these genes encode the extracellular matrix proteins (glypican 1, gpc1; tissue inhibitor of metalloproteinase 2, 3, timp2, timp 3); intracellular signaling molecules (rho gtpase activating protein 7, dlc1; protein tyrosine phosphatase 4a1, ptp4a1; phosphodiesterase 4d, pde4d; pi3-kinase regulatory subunit alpha, pik3r1; guanine nucleotide binding protein alpha 12, gna12) and protein of intermediate junctions (junction plakoglobin, jup), proteins involved in glycolysis (phosphofructokinase i, pfk1) and hemostasis (tissue plasminogen activator, plat), plasma membrane transporters (solute carrier family 16, member 1, slc16a1; atpase, na+/k+ transporting, atp1a), and ets. |
2012-06-07 |
2023-08-12 |
rat |
| Alexandre Donzé, Eric Fanchon, Lucie Martine Gattepaille, Oded Maler, Philippe Tracqu. Robustness analysis and behavior discrimination in enzymatic reaction networks. PloS one. vol 6. issue 9. 2012-04-13. PMID:21980344. |
we apply this method to a well-documented enzymatic reaction network describing collagen proteolysis by matrix metalloproteinase mmp2 and membrane type 1 metalloproteinase (mt1-mmp) in the presence of tissue inhibitor of metalloproteinase timp2. |
2012-04-13 |
2023-08-12 |
Not clear |
| Jiandong Yang, Jin Zheng, Lin Wu, Ming Shi, Hongtao Zhang, Xing Wang, Ning Xia, Desheng Wang, Xinping Liu, Libo Yao, Yan Li, Kefeng Do. NDRG2 ameliorates hepatic fibrosis by inhibiting the TGF-β1/Smad pathway and altering the MMP2/TIMP2 ratio in rats. PloS one. vol 6. issue 11. 2012-03-26. PMID:22110735. |
moreover, ndrg2 contributed to an increase in the ratio of matrix metalloproteinase 2 (mmp2) to tissue inhibitor of matrix metalloproteinase 2 (timp2), which may facilitate the degradation of the ecm. |
2012-03-26 |
2023-08-12 |
rat |
| Jon M Carthy, Zongshu Luo, Bruce M McManu. WNT3A induces a contractile and secretory phenotype in cultured vascular smooth muscle cells that is associated with increased gap junction communication. Laboratory investigation; a journal of technical methods and pathology. vol 92. issue 2. 2012-03-19. PMID:22105568. |
the wnt3a-treated smooth muscle cells displayed increased extracellular matrix synthesis, as measured by collagen i and iii mrna expression, along with increased expression of mmp2 and mmp9, but decreased timp2 levels. |
2012-03-19 |
2023-08-12 |
Not clear |
| Sherry W Yang, Diptiman Chanda, James J Cody, Angel A Rivera, Reinhard Waehler, Gene P Siegal, Joanne T Douglas, Selvarangan Ponnazhaga. Conditionally replicating adenovirus expressing TIMP2 increases survival in a mouse model of disseminated ovarian cancer. PloS one. vol 6. issue 10. 2012-02-17. PMID:22022379. |
the present study evaluated the efficacy of a novel crad (ad5/3-cxcr4-timp2) containing the cxcr4 promoter for selective viral replication in cancer cells together with timp2 as a therapeutic transgene, targeting the matrix metalloproteases (mmps) in a murine orthotopic model of disseminated ovarian cancer. |
2012-02-17 |
2023-08-12 |
mouse |
| Li Yao, Pingping Liu, Xing Lu, Fengan Li. [Expression of tissue inhibitor of metalloproteinase-2 in nasopharyngeal carcinoma]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 24. issue 18. 2011-10-04. PMID:21254651. |
to study the expression of tissue inhibitor of matrix metalloproteinase 2 (timp2)in the nasopharyngeal carcinoma and to evaluate the relationships between the expression of timp2 and biological behavior of npc. |
2011-10-04 |
2023-08-12 |
Not clear |
| Kim Hung Leung, Wai Chi Yiu, Maurice K H Yap, Po Wah Ng, Wai Yan Fung, Pak Chung Sham, Shea Ping Yi. Systematic investigation of the relationship between high myopia and polymorphisms of the MMP2, TIMP2, and TIMP3 genes by a DNA pooling approach. Investigative ophthalmology & visual science. vol 52. issue 6. 2011-08-19. PMID:21421877. |
this study examined the relationship between high myopia and three myopia candidate genes--matrix metalloproteinase 2 (mmp2) and tissue inhibitor of metalloproteinase-2 and -3 (timp2 and timp3)--involved in scleral remodeling. |
2011-08-19 |
2023-08-12 |
Not clear |
| b' Delphine Benaitreau, Esther Dos Santos, Marie-Christine Leneveu, Nadia Alfaidy, Jean-Jacques Feige, Philippe de Mazancourt, Ren\\xc3\\xa9 Pecquery, Marie-No\\xc3\\xablle Dieudonn\\xc3\\xa. Effects of adiponectin on human trophoblast invasion. The Journal of endocrinology. vol 207. issue 1. 2010-10-12. PMID:20675305.' |
these pro-invasive effects of adiponectin in human trophoblasts seem to be mediated in part via increased matrix metalloproteinases (mmp2 and mmp9) activities and via repression of timp2 mrna expression. |
2010-10-12 |
2023-08-12 |
human |
| S Padrissa-Altés, M A Zaouali, R Franco-Gou, R Bartrons, O Boillot, A Rimola, V Arroyo, J Rodés, C Peralta, J Roselló-Catafa. Matrix metalloproteinase 2 in reduced-size liver transplantation: beyond the matrix. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. vol 10. issue 5. 2010-07-21. PMID:20353474. |
in addition, we showed that tissue inhibitors of matrix metalloproteinases 2 (timp2) was also upregulated in pc and that jnk modulation also altered its levels in rolt and pc. |
2010-07-21 |
2023-08-12 |
Not clear |
| Morris Schweitzer, Benjamin Mitmaker, Daniel Obrand, Nathan Sheiner, Cherrie Abraham, Stevan Dostanic, Melissa Meilleur, Tomoko Sugahara, Lorraine E Chalifou. Atorvastatin modulates matrix metalloproteinase expression, activity, and signaling in abdominal aortic aneurysms. Vascular and endovascular surgery. vol 44. issue 2. 2010-04-01. PMID:20034937. |
matrix metalloproteinase 1, mmp2, mmp3, mmp9, tissue inhibitor of metalloproteinase (timp2), timp3, timp4, or total sma mothers against decapentaplegia (smad2) expression did not differ with treatment. |
2010-04-01 |
2023-08-12 |
human |
| Dylan N Clements, Noel Fitzpatrick, Stuart D Carter, Philip J R Da. Cartilage gene expression correlates with radiographic severity of canine elbow osteoarthritis. Veterinary journal (London, England : 1997). vol 179. issue 2. 2009-04-14. PMID:17938000. |
the levels of expression of type i collagen alpha2 chain (col1a2), type iii collagen alpha1 chain (col3a1), lumican (lum), matrix metalloproteinase-2 (mmp2), -9 (mmp9) and -13 (mmp13) genes were increased and the expression of tissue inhibitor of metalloproteinase-2 (timp2) and cathepsin d (ctsd) genes were decreased in oa cartilage relative to normal cartilage. |
2009-04-14 |
2023-08-12 |
Not clear |
| Premila Paiva, Lois A Salamonsen, Ursula Manuelpillai, Evdokia Dimitriadi. Interleukin 11 inhibits human trophoblast invasion indicating a likely role in the decidual restraint of trophoblast invasion during placentation. Biology of reproduction. vol 80. issue 2. 2009-03-27. PMID:18987331. |
interleukin 11 (100 ng/ml) had no effect on matrix metallopeptidases 2 and 9 (mmp2 and mmp9), tissue inhibitors of mmp (timp1, timp2, and timp3), plasminogen activator urokinase (plau), plasminogen activator urokinase receptor (plaur), and serpin peptidase inhibitors 1 and 2 (serpine1 and serpine2) in evt-conditioned media and/or cell lysates. |
2009-03-27 |
2023-08-12 |
human |
| Na Li, De-Zai Dai, Yin Da. CPU86017 and its isomers improve hypoxic pulmonary hypertension by attenuating increased ETA receptor expression and extracellular matrix accumulation. Naunyn-Schmiedeberg's archives of pharmacology. vol 378. issue 5. 2009-03-23. PMID:18548232. |
after 4 weeks of exposure to hypoxia, remodeling of the right ventricle and the small pulmonary arteries (<150 microm) was very pronounced, and extra-cellular matrix (ecm) had been excessively produced in association with abnormal mrna and protein expression of matrix metalloproteinase 9 (mmp9) and mrna of tissue inhibitor of matrix metalloproteinase 1 and 2 (timp1, timp2). |
2009-03-23 |
2023-08-12 |
rat |
| Olivia Fromigué, Zahia Hamidouche, Pierre J Mari. Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. The Journal of biological chemistry. vol 283. issue 45. 2008-12-23. PMID:18757369. |
the statin reduced matrix metalloproteinase (mmp) 2, 9, and 14 and timp2 expression or activity in invading cells. |
2008-12-23 |
2023-08-12 |
human |
| Henning Witt, Carola Schubert, Juliane Jaekel, Daniela Fliegner, Adam Penkalla, Klaus Tiemann, Joerg Stypmann, Stefan Roepcke, Sebastian Brokat, Shokoufeh Mahmoodzadeh, Eva Brozova, Mercy M Davidson, Patricia Ruiz Noppinger, Christian Grohé, Vera Regitz-Zagrose. Sex-specific pathways in early cardiac response to pressure overload in mice. Journal of molecular medicine (Berlin, Germany). vol 86. issue 9. 2008-11-24. PMID:18665344. |
genes encoding ribosomal proteins and genes associated with extracellular matrix remodeling exhibited relative higher expression in males (collagen 3, matrix metalloproteinase 2, timp2, and tgfbeta2, all about twofold) after tac. |
2008-11-24 |
2023-08-12 |
mouse |
| Anna M Wasilewska, Walentyna M Zoch-Zwier. Urinary levels of matrix metalloproteinases and their tissue inhibitors in nephrotic children. Pediatric nephrology (Berlin, Germany). vol 23. issue 10. 2008-11-18. PMID:18594870. |
the aim of this study was to determine the effects of cyclosporine a (cya) on urinary levels of matrix metalloproteinase 2 and 9 (mmp2, mmp9) and their tissue inhibitors 1 and 2 (timp1, timp2) in steroid-dependent nephrotic syndrome (sdns). |
2008-11-18 |
2023-08-12 |
human |
| Alka Jain, Abdullah Karadag, Larry W Fisher, Neal S Fedark. Structural requirements for bone sialoprotein binding and modulation of matrix metalloproteinase-2. Biochemistry. vol 47. issue 38. 2008-10-03. PMID:18729384. |
bone sialoprotein (bsp) has been shown to induce limited gelatinase activity in latent matrix metalloproteinase-2 (mmp-2) without removal of the propeptide and to restore enzymatic activity to mmp-2 previously inhibited by tissue inhibitor of matrix metalloproteinase-2 (timp2). |
2008-10-03 |
2023-08-12 |
human |
| Charles J Lockwood, Ceyda Oner, Yesim H Uz, Umit A Kayisli, S Joseph Huang, Lynn F Buchwalder, William Murk, Edmund F Funai, Frederick Schat. Matrix metalloproteinase 9 (MMP9) expression in preeclamptic decidua and MMP9 induction by tumor necrosis factor alpha and interleukin 1 beta in human first trimester decidual cells. Biology of reproduction. vol 78. issue 6. 2008-08-28. PMID:18276934. |
in contrast, immunostaining for mmp2 and tissue inhibitor of matrix metalloproteinases 1 and 2 (timp1 and timp2) were similar in preeclamptic and control groups. |
2008-08-28 |
2023-08-12 |
human |
| Aron Lazáry, János P Kósa, Bálint Tóbiás, Judit Lazáry, Bernadett Balla, Krisztián Bácsi, István Takács, Zsolt Nagy, Tibor Mezo, Gábor Speer, Péter Lakato. Single nucleotide polymorphisms in new candidate genes are associated with bone mineral density and fracture risk. European journal of endocrinology. vol 159. issue 2. 2008-08-19. PMID:18469019. |
we examined the effect of 24 single nucleotide polymorphisms (snps) located in five genes--alkaline phosphatase, matrix metalloproteinase-2, tissue inhibitor of metalloproteases-2 (timp2), fibroblast growth factor receptor-1 (fgfr1), and fatty acid-binding protein-3 (fabp3)--previously not associated with op. |
2008-08-19 |
2023-08-12 |
Not clear |
| M Amati, M Tomasetti, M Scartozzi, L Mariotti, M Ciuccarelli, M Valentino, M Governa, L Santarell. [Biomarkers for prevention and early diagnosis of malignant pleural mesothelioma]. Giornale italiano di medicina del lavoro ed ergonomia. vol 29. issue 3 Suppl. 2008-07-25. PMID:18409713. |
94 asbestos-exposed subjects, 22 patients with mm, and 54 healthy subjects were recruited for evaluation of the significance of 8-hydroxy-2'-deoxy-guanosine (80hdg) in white blood cells and plasma concentrations of soluble mesothelin-related peptides (smrps), angiogenic factors (pdgfbeta, hgf, bfgf, vegfbeta), and matrix proteases (mmp2, mmp9, timp1, timp2) for potential early detection of mm. |
2008-07-25 |
2023-08-12 |
human |