| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hanlet Camacho-Rodríguez, Isabel A Guillen-Pérez, Juan Roca-Campaña, Julio E Baldomero-Hernández, Ángela D Tuero-Iglesias, José A Galván-Cabrera, Maciel Rodriguez-Cordero, Daniel O Palenzuela-Gardón, Jorge Berlanga-Acosta, Lidia I Novoa-Pére. Heberprot-P's Effect on Gene Expression in Healing Diabetic Foot Ulcers. MEDICC review. vol 20. issue 3. 2019-12-06. PMID:31242156. |
results after treatment, there was a statistically significant increase in expression of genes related to cell proliferation, angiogenesis and formation of extracellular matrix (pdgfb, cdk4, p21, tp53, angpt1, col1a1, mmp2 and timp2). |
2019-12-06 |
2023-08-13 |
Not clear |
| Tácia Tavares Aquinas Liguori, Gabriel Romero Liguori, Luiz Felipe Pinho Moreira, Martin Conrad Harmse. Fibroblast growth factor-2, but not the adipose tissue-derived stromal cells secretome, inhibits TGF-β1-induced differentiation of human cardiac fibroblasts into myofibroblasts. Scientific reports. vol 8. issue 1. 2019-11-25. PMID:30413733. |
the treatment with fgf-2 increased matrix metalloproteinases gene expression (mmp1, p < 0.0001; mmp14, p = 0.0027) and decreased the expression of tissue inhibitor of metalloproteinase gene timp2 (p = 0.0023). |
2019-11-25 |
2023-08-13 |
human |
| Iwona Sidorkiewicz, Barbara Piskór, Emilia Dąbrowska, Katarzyna Guzińska-Ustymowicz, Anna Pryczynicz, Monika Zbucka-Krętowska, Sławomir Ławick. Plasma Levels and Tissue Expression of Selected Cytokines, Metalloproteinases and Tissue Inhibitors in Patients With Cervical Cancer. Anticancer research. vol 39. issue 11. 2019-11-14. PMID:31704874. |
thus, the aim of this study was to compare the concentration of plasma levels and tissue expression of macrophage colony-stimulating factor (m-csf), vascular endothelial growth factor (vegf), matrix metalloproteinases (mmp)-2 and mmp9, and their tissue inhibitors timp1 and timp2 in patients with cervical cancer, patients with high-grade cervical intraepithelial dysplasia (cin3) and patients with ectropion. |
2019-11-14 |
2023-08-13 |
Not clear |
| Wei Wang, Yifan Zhang, Mingxing Liu, Yang Wang, Tao Yang, Dongsheng Li, Feng Ding, Guang Bai, Qing L. TIMP2 is a Poor Prognostic Factor and Predicts Metastatic Biological Behavior in Gastric Cancer. Scientific reports. vol 8. issue 1. 2019-10-16. PMID:29941993. |
further go assays disclosed that the signatures related with extracellular matrix and structure, and the functions of "cell adhesion molecule binding" and "integrin binding" were the vital mechanisms of disease progression, and tissue inhibitor of metalloproteinase-2 (timp2) was the potential biomarker for prognosis. |
2019-10-16 |
2023-08-13 |
Not clear |
| Lisa Yan-Yan Xi, Shea Ping Yip, Sze Wan Shan, Jody Summers-Rada, Chea-Su Ke. Region-specific differential corneal and scleral mRNA expressions of MMP2, TIMP2, and TGFB2 in highly myopic-astigmatic chicks. Scientific reports. vol 7. issue 1. 2019-06-21. PMID:28900109. |
here we presented the changes in mrna expression levels of three genes (mmp2, timp2, and tgfb2), all known to participate in extracellular matrix organization, at five regions of the cornea and sclera in chickens developing high myopia and astigmatism induced by form deprivation. |
2019-06-21 |
2023-08-13 |
Not clear |
| Xiaoqing Yi, Jianfeng Guo, Jing Guo, Si Sun, Ping Yang, Junjie Wang, Yuan Li, Lisha Xie, Jing Cai, Zehua Wan. EZH2-mediated epigenetic silencing of TIMP2 promotes ovarian cancer migration and invasion. Scientific reports. vol 7. issue 1. 2019-06-04. PMID:28620234. |
ezh2 overexpression inhibited timp2 expression and promoted proteolytic activities of matrix metalloproteinases 2 and 9 and vice versa. |
2019-06-04 |
2023-08-13 |
Not clear |
| Zhen-Dong Zhu, Ji-Ming Ye, Xue-Mei Fu, Xue-Chang Wang, Ji-Yun Ye, Xin-Ran Wu, Peng Hua, Yu-Qiong Liao, Wei Xuan, Jin-Lan Duan, Wei-Yuan Li, Hui Fu, Zhong-Hua Xia, Xuan Zhan. DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats. International journal of molecular medicine. vol 43. issue 2. 2019-05-03. PMID:30569164. |
the functional roles of ddah2 in dcm were further determined through detection of the levels of collagen i, matrix metalloproteinase 2 (mmp2) and tissue inhibitor of metalloproteinase 2 (timp2). |
2019-05-03 |
2023-08-13 |
rat |
| Yang Wang, Qi Yang, Yanli Cheng, Meng Gao, Lei Kuang, Chun Wan. Myosin Heavy Chain 10 (MYH10) Gene Silencing Reduces Cell Migration and Invasion in the Glioma Cell Lines U251, T98G, and SHG44 by Inhibiting the Wnt/β-Catenin Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-03-04. PMID:30552850. |
western blot measured the protein expression levels, and quantitative real-time polymerase chain reaction (qrt-pcr) was used to detect the mrna expression levels, for myh10, metastasis-associated protein 1 (mta-1), matrix metalloproteinase (mmp)-1, mmp-9, tissue inhibitor of metalloproteinases 2 (timp2), collagen 1, e-cadherin, vimentin, wnt3a, β-catenin, and cyclin d1. |
2019-03-04 |
2023-08-13 |
human |
| Yunwei Ou, Qingnan Wu, Chuanyue Wu, Xuefeng Liu, Yongmei Song, Qimin Zha. Migfilin promotes migration and invasion in glioma by driving EGFR and MMP-2 signalings: A positive feedback loop regulation. Journal of genetics and genomics = Yi chuan xue bao. vol 44. issue 12. 2019-02-26. PMID:29203120. |
in this study, we found that migfilin promoted matrix metalloproteinase-2 (mmp-2) activity, and restrained the expression of tissue inhibitor of metalloproteinase 2 (timp2), which is an mmp-2 inhibitor. |
2019-02-26 |
2023-08-13 |
human |
| Wenyu Zhu, Wei Li, Qian Geng, Xiaoying Wang, Wei Sun, Hua Jiang, Xiaolin P. Silence of Stomatin-Like Protein 2 Represses Migration and Invasion Ability of Human Liver Cancer Cells via Inhibiting the Nuclear Factor Kappa B (NF-κB) Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-01-07. PMID:30359340. |
we also observed that silencing stoml2 markedly downregulated the expression levels of matrix metalloproteinase-2 (mmp-2), mmp-9, metastatic tumor antigen 1 (mta1), and nuclear factor kappa b (nf-κb), and upregulated levels of e-cadherin, tissue inhibitor of metalloproteinases 2 (timp2), and the inhibitor of kappa b (iκb). |
2019-01-07 |
2023-08-13 |
human |
| Jian Xu, Yue Du, Xiu-Jun Liu, Bing-Yan Zhu, Sheng-Hua Zhang, Liang Li, Yi Li, Xiao-Fei Wang, Chuan-Kun Shan, Rui-Qi Wang, Yong-Su Zhe. Recombinant EGFR/MMP-2 bi-targeted fusion protein markedly binding to non-small-cell lung carcinoma and exerting potent therapeutic efficacy. Pharmacological research. vol 126. 2018-06-29. PMID:28392461. |
the ec-ldp(ae)-timp2 comprises endogenous inhibitor of matrix metalloproteinase 2 (timp2), egf-derived oligopeptide (ec), lidamycin apoprotein (ldp), and the extremely potent cytotoxic enediyne (ae). |
2018-06-29 |
2023-08-13 |
mouse |
| Jeffrey Yim, Hyokeun Cho, Simon W Rabki. Gene expression and gene associations during the development of heart failure with preserved ejection fraction in the Dahl salt sensitive model of hypertension. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 40. issue 2. 2018-06-27. PMID:29140729. |
abbreviations inducible nitric oxide synthase (inos), neutrophil cytosolic factor 1 (p47phox), adrenomedullin (adm), atrial natriuretic peptide (anp), osteopontin (opn/spp1), angiotensin converting enzyme (ace), monocyte chemotactic protein 1 (mcp-1), cytochrome b-245 beta polypeptide (gp91phox), intercellular adhesion molecule 1 (icam-1), transforming growth factor beta 1 (tgf-β1), connective tissue growth factor (ctgf), endothelin-1 (et-1), cytochrome b-245, alpha polypeptide (p22phox), endothelin receptor type b (etb/ednrb), brain natriuretic peptide (bnp), endothelin receptor type a (eta/ednra), matrix metallopeptidase 13 (mmp13), type i collagen (col1a1), matrix metallopeptidase 2 (mmp2), timp metallopeptidase inhibitor 1 (timp1), type iii collagen (col3a1), interleukin 1 beta (il-1β), beta myocin heavy chain (β-mhc), endothelin converting enzyme 1 (ece1) matrix metallopeptidase 14 (mmp14), angiotensinogen (agt), angiotensin ii receptor type 1 (at1r), cytochrome c oxidase i (cox1), fms-like tyrosine kinase 1 (flt1), timp metallopeptidase inhibitor 2 (timp2), phospholamban (pln), vascular cell adhesion molecule 1 (vcam1), extracellular matrix (ecm). |
2018-06-27 |
2023-08-13 |
rat |
| Pengfei Feng, Xiaona Li, Weiyi Chen, Rui He, Xiaojun Wan. [Effects of Tumor Necrosis Factor Alpha on the Expression of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinases in Keratoconus Fibroblasts]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 33. issue 6. 2018-06-18. PMID:29714979. |
the aim of this article is to study the effect of tumor necrosis factor alpha(tnf-α)on the expression of matrix metalloproteinases(mmps)and tissue inhibitors of matrix metalloproteinases(timps)in keratoconus fibroblasts in vitro.normal cornea and keratoconus fibroblasts were extracted using enzyme digestion method and were cultured in the medium containing tnf-α(0,10 and 100ng/ml).the expression of mmps proteins in the supernatant of corneal fibroblasts and the expression of timps in the normal cornea and keratoconus fibroblasts were detected by western blot and real-time quantitative polymerase chain reaction respectively.the active form of mmp1 could be detected in the supernatant of keratoconus fibroblasts and upregulated by tnf-α.tnf-αcould increase the protein expression of mmp2,mmp3,mmp9 in the supernatant of keratoconus fibroblasts and decrease the gene expression of timp1,timp2 in keratoconus fibroblasts.the increased mmps and the decreased timps can increase the degradation of the extracellular matrix.tnf-αmay play an important role in the occurrence and development of keratoconus by regulating the expression of mmps/timps. |
2018-06-18 |
2023-08-13 |
Not clear |
| Beata Rak, Dawid Mehlich, Filip Garbicz, Zofia Domosud, Wiktor Paskal, Janina M Marczewska, Paweł K Włodarsk. Post-transcriptional Regulation of MMP16 and TIMP2 Expression Cancer genomics & proteomics. vol 14. issue 5. 2018-05-08. PMID:28871006. |
post-transcriptional regulation of mmp16 and timp2 expression the post-transcriptional regulation of matrix metalloproteinases (mmps) via micrornas (mirnas) has been recently described in numerous human malignancies. |
2018-05-08 |
2023-08-13 |
human |
| Jochen Neuhaus, Eric Schiffer, Ferdinando Mannello, Lars-Christian Horn, Roman Ganzer, Jens-Uwe Stolzenbur. Protease Expression Levels in Prostate Cancer Tissue Can Explain Prostate Cancer-Associated Seminal Biomarkers-An Explorative Concept Study. International journal of molecular sciences. vol 18. issue 5. 2018-02-12. PMID:28471417. |
we found differential gene expression of chymase (cma1), matrix metalloproteinases (mmp3, mmp7), and upregulation of mmp14 and tissue inhibitors (timp1 and timp2) in bph. |
2018-02-12 |
2023-08-13 |
Not clear |
| YanFang Zheng, Yin Zhao, QingQing Luo, XiaoXia Liu, XiaoPing Liu, Ying Hu, Li Zo. Edaravone protects against cobalt chloride-induced dysfunctions in apoptosis and invasion in trophoblast cells. Molecular reproduction and development. vol 83. issue 7. 2018-01-24. PMID:27128210. |
migration and invasion phenotypes were complemented with expression analysis of matrix metalloproteinase 2 (mmp2) and tissue inhibitor of metalloproteinase 2 (timp2) at the transcript and protein levels. |
2018-01-24 |
2023-08-13 |
Not clear |
| Guilherme Ribeiro Romualdo, Tony Fernando Grassi, Renata Leme Goto, Mariana Baptista Tablas, Lucas Tadeu Bidinotto, Ana Angélica Henrique Fernandes, Bruno Cogliati, Luís Fernando Barbisa. An integrative analysis of chemically-induced cirrhosis-associated hepatocarcinogenesis: Histological, biochemical and molecular features. Toxicology letters. vol 281. 2017-11-06. PMID:28943392. |
gene ontology and functional analysis showed the upregulation of extracellular matrix deposition genes, such as collagen type i alpha 1 and 2 (col1α1 and col1α2) and tissue inhibitor of metalloproteinase 1 and 2 genes (timp1 and timp2). |
2017-11-06 |
2023-08-13 |
human |
| Piero Pingitore, Paola Dongiovanni, Benedetta Maria Motta, Marica Meroni, Saverio Massimo Lepore, Rosellina Margherita Mancina, Serena Pelusi, Cristina Russo, Andrea Caddeo, Giorgio Rossi, Tiziana Montalcini, Arturo Pujia, Olov Wiklund, Luca Valenti, Stefano Rome. PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis. Human molecular genetics. vol 25. issue 23. 2017-07-24. PMID:27742777. |
stable overexpression of pnpla3 148i wild type, but not 148m mutant, in human hscs (lx-2 cells) induces a reduction in the secretion of matrix metallopeptidase 2 (mmp2), tissue inhibitor of metalloproteinase 1 and 2 (timp1 and timp2), which is mediated by retinoid metabolism. |
2017-07-24 |
2023-08-13 |
human |
| Hua Wang, Haiyan Zhang, Qiuyi Sun, Yun Wang, Jun Yang, Jincheng Yang, Tao Zhang, Shenqiu Luo, Liping Wang, Yu Jiang, Chun Zeng, Daozhang Cai, Xiaochun Ba. Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2. Molecular therapy : the journal of the American Society of Gene Therapy. vol 25. issue 3. 2017-06-06. PMID:28139355. |
furthermore, our results revealed mir-483-5p directly targeted to the cartilage matrix protein matrilin 3 (matn3) and tissue inhibitor of metalloproteinase 2 (timp2) to stimulate chondrocyte hypertrophy, extracellular matrix degradation, and cartilage angiogenesis, and it consequently initiated and accelerated the development of oa. |
2017-06-06 |
2023-08-13 |
mouse |
| Anja Schrade, Antti Kyrönlahti, Oyediran Akinrinade, Marjut Pihlajoki, Simon Fischer, Verena Martinez Rodriguez, Kerstin Otte, Vidya Velagapudi, Jorma Toppari, David B Wilson, Markku Heikinheim. GATA4 Regulates Blood-Testis Barrier Function and Lactate Metabolism in Mouse Sertoli Cells. Endocrinology. vol 157. issue 6. 2017-06-05. PMID:26974005. |
depletion of gata4 in tm4 cells and primary scs was associated with altered expression of genes involved in key facets of btb maintenance, including tight/adherens junction formation (tjp1, cldn12, vcl, tnc, csk) and extracellular matrix reorganization (lamc1, col4a1, col4a5, mmp10, mmp23, timp2). |
2017-06-05 |
2023-08-13 |
mouse |