| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| DongWei Liu, FengXun Liu, ZhengYong Li, ShaoKang Pan, JunWei Xie, ZiHao Zhao, ZhenJie Liu, JiaHui Zhang, ZhangSuo Li. HNRNPA1-mediated exosomal sorting of miR-483-5p out of renal tubular epithelial cells promotes the progression of diabetic nephropathy-induced renal interstitial fibrosis. Cell death & disease. vol 12. issue 3. 2021-09-14. PMID:33692334. |
our results expounded that hnrnpa1-mediated exosomal sorting transported cellular mir-483-5p out of tecs into the urine, thus lessening the restraint of cellular mir-483-5p on mapk1 and timp2 mrnas, and ultimately boosting extracellular matrix deposition and the progression of dn-induced renal interstitial fibrosis. |
2021-09-14 |
2023-08-13 |
mouse |
| Yantenew G Gete, Luke W Koblan, Xiaojing Mao, Mason Trappio, Bhushan Mahadik, John P Fisher, David R Liu, Kan Ca. Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS. Aging cell. vol 20. issue 7. 2021-08-17. PMID:34086398. |
furthermore, the expression of matrix metalloproteinase 9 (mmp-9) was reduced in hgps ipsc-ecs, while the expression of tissue inhibitor metalloproteinases 1 and 2 (timp1 and timp2) was upregulated relative to healthy controls. |
2021-08-17 |
2023-08-13 |
human |
| Shan-Shan Zhou, Zhong-Zhu Ai, Wei-Nan Li, Liang Li, Xiao-Yun Zhu, Yuan-Ming B. Shenkang VII Recipe Attenuates Unilateral Ureteral Obstruction-induced Renal Fibrosis via TGF-β/Smad, NF-κB and SHH Signaling Pathway. Current medical science. vol 40. issue 5. 2021-07-29. PMID:32980902. |
immunohistochemistry was used to detect the expression of collagen type iii (col iii), fibronectin (fn), α-smooth muscle actin (α-sma), timp metallopeptidase inhibitor 2 (timp2), matrix metallopeptidase 2 (mmp2), tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β) and monocyte chemotactic protein-1 (mcp-1). |
2021-07-29 |
2023-08-13 |
rat |
| Daniela E Barraza, Renato Zampini, Silvana A Apichela, Joel I Pacheco, Martin E Argañara. Modifications of extracellular matrix features in the left and right uterine horns during the embryo pre-implantation period in Vicugna pacos. Theriogenology. vol 157. 2021-06-21. PMID:32877844. |
subsequently, gene expression of the following components of the mmp pathway was determined: mmp-2, -3, -7, -9, and -14, mmp substrates (col1a2 and col3a1), mmp inhibitors (timp1 and timp2), lgmn, an mmp activator, and emmprin, an extracellular matrix metalloproteinase inducer. |
2021-06-21 |
2023-08-13 |
Not clear |
| Ailing Sui, Xiuping Chen, Jikui Shen, Anna M Demetriades, Yiyun Yao, Yixuan Yao, Yanji Zhu, Xi Shen, Bing Xi. Inhibiting the NLRP3 inflammasome with MCC950 ameliorates retinal neovascularization and leakage by reversing the IL-1β/IL-18 activation pattern in an oxygen-induced ischemic retinopathy mouse model. Cell death & disease. vol 11. issue 10. 2021-04-09. PMID:33093455. |
moreover, mcc950 could regulate the expression of endothelial cell- and pericyte function-associated molecules, such as vascular endothelial growth factor (vegf), vegf receptor (vegfr)1, vegfr2, matrix metalloproteinase (mmp)2, mmp9, tissue inhibitor of metalloproteinases (timp)1, timp2, platelet-derived growth factor receptor-β (pdgfr-β), platelet-derived growth factor-b (pdgf-b), and angiopoietin2 (ang2). |
2021-04-09 |
2023-08-13 |
mouse |
| Piotr Nehring, Grażyna Gromadzka, Anna Giermaziak, Miłosz Jastrzębski, Adam Przybyłkowsk. Genetic variants of tissue inhibitors of matrix metalloproteinase 1 (rs4898) and 2 (rs8179090) in diverticulosis. European journal of gastroenterology & hepatology. 2021-03-18. PMID:33731593. |
the aim of the study was to assess whether tissue inhibitors of matrix metalloproteinase (timp) 1 rs4898 and timp2 rs8179090 genetic variants are related to colonic diverticulosis. |
2021-03-18 |
2023-08-13 |
Not clear |
| Jinyan Wang, Qian Zhang, Dandan Wang, Sujin Yang, Siying Zhou, Hanzi Xu, Heda Zhang, Shanliang Zhong, Jifeng Fen. Microenvironment-induced TIMP2 loss by cancer-secreted exosomal miR-4443 promotes liver metastasis of breast cancer. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31970775. |
mir-4443 promotes the metastasis of bca cells through downregulating tissue inhibitors of metalloproteinase 2 (timp2) and upregulating matrix metalloproteinases (mmps). |
2021-03-10 |
2023-08-13 |
mouse |
| Wei Guo, Bin Zhang, Chao Sun, Hui-Quan Duan, Wei-Xiao Liu, Kun Mu, Ling Zhao, Hao-Ran Li, Zhan-Yin Dong, Qing Cu. Circular RNA derived from TIMP2 functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR‑185‑5p and matrix metalloproteinase 2. International journal of molecular medicine. vol 46. issue 2. 2021-03-08. PMID:32626912. |
circular rna derived from timp2 functions as a competitive endogenous rna and regulates intervertebral disc degeneration by targeting mir‑185‑5p and matrix metalloproteinase 2. |
2021-03-08 |
2023-08-13 |
human |
| Faramarz Yazdani, Fereshteh Shahidi, Pouran Karim. The effect of 8 weeks of high-intensity interval training and moderate-intensity continuous training on cardiac angiogenesis factor in diabetic male rats. Journal of physiology and biochemistry. vol 76. issue 2. 2021-01-29. PMID:32157499. |
western blotting was used for detection of protein expressions of vascular endothelial growth factor (vegf), transforming growth factor-beta (tgf-β), matrix metalloproteinase-2 (mmp2), and tissue inhibitor of matrix metalloproteinase-2 (timp2) in the left ventricle. |
2021-01-29 |
2023-08-13 |
rat |
| Enrico Ragni, Carlotta Perucca Orfei, Paola De Luca, Alessandra Colombini, Marco Viganò, Laura de Girolam. Secreted Factors and EV-miRNAs Orchestrate the Healing Capacity of Adipose Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis. International journal of molecular sciences. vol 21. issue 5. 2020-12-08. PMID:32111031. |
both factors (through most abundantly expressed timp1, timp2, plg and ctss) and mirnas (mir-24-3p, mir-222-3p and mir-193b-3p) suggested a strong capacity for ascs to reduce matrix degradation activities, as those activated in oa cartilage, and switch synovial macrophages, often characterized by an m1 inflammatory polarization, towards an m2 phenotype. |
2020-12-08 |
2023-08-13 |
Not clear |
| M Skorvanova, T Matakova, M Skerenova, M Sarlinova, H Drobkova, M Petras, M Janickova, M Halasa, V Repiska, E Halasov. Methylation of MMP2, TIMP2, MMP9 and TIMP1 in abdominal aortic aneurysm. Bratislavske lekarske listy. vol 121. issue 10. 2020-12-07. PMID:32955903. |
the aim of this pilot study is to explore the relationship between the methylation of matrix metalloproteinases and tissue inhibitors of the metalloproteinases genes' promoter region, and abdominal aortic aneurysm (aaa) through the detection of the methylation status of mmp2, timp2, timp1, and mmp9 genes in peripheral blood. |
2020-12-07 |
2023-08-13 |
Not clear |
| David Peeney, Yu Fan, Trinh Nguyen, Daoud Meerzaman, William G Stetler-Stevenso. Matrisome-Associated Gene Expression Patterns Correlating with TIMP2 in Cancer. Scientific reports. vol 9. issue 1. 2020-11-16. PMID:31882975. |
bioinformatic analysis of the identified gene list highlights a core of matrix and matrix-associated genes that are of interest as potential modulators of timp2 function, thus ecm structure, identifying potential tumor microenvironment biomarkers and/or therapeutic targets for further study. |
2020-11-16 |
2023-08-13 |
Not clear |
| Andrej Gorbatenko, Rolf Søkilde, Ester E Sorensen, Inga Newie, Helena Persson, Beatriz Morancho, Joaquin Arribas, Thomas Litman, Carlos Rovira, Stine Falsig Pederse. HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503. Scientific reports. vol 9. issue 1. 2020-10-14. PMID:30833639. |
p95her2 expression, or knockdown of either myb protein, elicited upregulation of tissue inhibitor of matrix metalloprotease-2 (timp2). |
2020-10-14 |
2023-08-13 |
Not clear |
| Qiongqiong Guo, Junxia Wang, Yan Ge, Deepak K Malhotra, Lance D Dworkin, Pei Wang, Rujun Gon. Brain natriuretic peptide mitigates TIMP2 induction and reinstates extracellular matrix catabolic activity American journal of translational research. vol 11. issue 2. 2020-10-01. PMID:30899395. |
brain natriuretic peptide mitigates timp2 induction and reinstates extracellular matrix catabolic activity brain natriuretic peptide (bnp) has a demonstrable anti-fibrotic effect on diverse organ systems, including the kidney. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shanlan Yin, Quanle Zhang, Yuhong Wang, Shaoru Li, Ruili H. MicroRNA-130a regulated by HPV18 E6 promotes proliferation and invasion of cervical cancer cells by targeting TIMP2. Experimental and therapeutic medicine. vol 17. issue 4. 2020-10-01. PMID:30906471. |
tissue inhibitor of metalloproteinase 2 (timp2), an antagonist of matrix metalloproteinase 2 (mmp2), was identified as a novel, direct target gene of mir-130a. |
2020-10-01 |
2023-08-13 |
human |
| Hua Zhang, Jidong Zhang, Fanrui Meng, Hanzhong Zhu, Hongyu Yan, Yunliang Guo, Shandi Zhan. MicroRNA-93 promotes the tumorigenesis of osteosarcoma by targeting TIMP2. Bioscience reports. vol 39. issue 8. 2020-09-09. PMID:31383784. |
this research was designed to verify how microrna-93 (mir-93) and tissue inhibitor of matrix metalloproteinase 2 (timp2) be involved in os development. |
2020-09-09 |
2023-08-13 |
Not clear |
| Alexander J Baker-Williams, Fiza Hashmi, Marek A Budzyński, Mark R Woodford, Stephanie Gleicher, Samu V Himanen, Alan M Makedon, Derek Friedman, Stephanie Cortes, Sara Namek, William G Stetler-Stevenson, Gennady Bratslavsky, Alaji Bah, Mehdi Mollapour, Lea Sistonen, Dimitra Bourbouli. Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis. Cell reports. vol 28. issue 7. 2020-09-04. PMID:31412254. |
co-chaperones timp2 and aha1 competitively regulate extracellular hsp90:client mmp2 activity and matrix proteolysis. |
2020-09-04 |
2023-08-13 |
Not clear |
| Mária Škereňová, Tatiana Matakova, Erika Halasova, Lucia Riskova, Michaela Skorvanova, Dušan Mistuna, Mirko Halasa, Dušan Dobrot. Common gene haplotypes of gelatinases and their tissue inhibitors in abdominal aortic aneurysm. General physiology and biophysics. vol 39. issue 1. 2020-03-09. PMID:32039823. |
gelatinases (mmp2 and mmp9) and their respective tissue inhibitors (timp1 and timp2) play a crucial role during extracellular matrix (ecm) turnover in aortic tissue. |
2020-03-09 |
2023-08-13 |
human |
| Guanghua Nie, Xiaodong Wen, Xiaojun Liang, Hongmou Zhao, Yi Li, Jun L. Additional evidence supports association of common genetic variants in MMP3 and TIMP2 with increased risk of chronic Achilles tendinopathy susceptibility. Journal of science and medicine in sport. vol 22. issue 10. 2019-12-19. PMID:31208828. |
to systematically evaluate the effects of matrix metalloproteinase-3 (mmp3) and tissue inhibitor of metalloproteinase-2 (timp2) on chronic achilles tendinopathy (at) susceptibility. |
2019-12-19 |
2023-08-13 |
Not clear |
| Jing Ni, Xijun Liu, Yiheng Yin, Peiyu Zhang, Ya-Wei Xu, Zheng Li. Exosomes Derived from TIMP2-Modified Human Umbilical Cord Mesenchymal Stem Cells Enhance the Repair Effect in Rat Model with Myocardial Infarction Possibly by the Akt/Sfrp2 Pathway. Oxidative medicine and cellular longevity. vol 2019. 2019-12-16. PMID:31182988. |
the tissue matrix metalloproteinase inhibitor 2, also known as timp2, is a member of the tissue inhibitor family of metalloproteinases. |
2019-12-16 |
2023-08-13 |
human |