| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wioletta Pietruszewska, Katarzyna Bojanowska-Poźniak, Józef Kobo. Matrix metalloproteinases MMP1, MMP2, MMP9 and their tissue inhibitors TIMP1, TIMP2, TIMP3 in head and neck cancer: an immunohistochemical study. Otolaryngologia polska = The Polish otolaryngology. vol 70. issue 3. 2017-04-10. PMID:27386931. |
matrix metalloproteinases mmp1, mmp2, mmp9 and their tissue inhibitors timp1, timp2, timp3 in head and neck cancer: an immunohistochemical study. |
2017-04-10 |
2023-08-13 |
Not clear |
| Yu-Ichiro Ohnishi, Koichi Iwatsuki, Masahiro Ishihara, Toshika Ohkawa, Manabu Kinoshita, Koei Shinzawa, Yasunori Fujimoto, Toshiki Yoshimin. Promotion of astrocytoma cell invasion by micro RNA-22 targeting of tissue inhibitor of matrix metalloproteinase-2. Journal of neurosurgery. Spine. vol 26. issue 3. 2017-03-21. PMID:27834627. |
computational in silico analysis predicted that tissue inhibitor of matrix metalloproteinase-2 (timp2) is a target gene of mir-22. |
2017-03-21 |
2023-08-13 |
mouse |
| Yun-Yan Wang, Zi-Yu Wu, Gong-Cheng Wang, Kun Liu, Xiao-Bing Niu, Shuo Gu, Jun-Song Men. LINC00312 inhibits the migration and invasion of bladder cancer cells by targeting miR-197-3p. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 11. 2017-02-17. PMID:27631965. |
western blotting was to measure matrix metalloproteinase (mmp)-2, mmp-9, and the tissue inhibitor of metalloproteinase 2 (timp2) protein levels. |
2017-02-17 |
2023-08-13 |
Not clear |
| M Knaś, K Wołosik, A Zalewska, A Mikucka-Niczyporuk, I Kasacka, M Niczyporu. The skin remodeling in type 1 diabetes and insulin resistance animal models. Physiological research. vol 64. issue 6. 2016-10-14. PMID:26047379. |
elisa kits (uscn life science, china) were used to measure content of matrix metallo-proteinase 3 (elisa kit for matrix metalloproteinase 3 - mmp3), tissue inhibitor of matrix metalloproteinase 2 (elisa kit for tissue inhibitors of metalloproteinase 2 - timp2) and content of collagen type 3 (elisa kit for collagen type iii - col3). |
2016-10-14 |
2023-08-13 |
rat |
| Frank Haubner, Dominique Muschter, Fabian Pohl, Stephan Schreml, Lukas Prantl, Holger G Gassne. A Co-Culture Model of Fibroblasts and Adipose Tissue-Derived Stem Cells Reveals New Insights into Impaired Wound Healing After Radiotherapy. International journal of molecular sciences. vol 16. issue 11. 2016-08-19. PMID:26528967. |
additionally, tissue inhibitors of matrix metalloproteinases (timp1, timp2) were determined by enzyme-linked immunosorbent assay (elisa). |
2016-08-19 |
2023-08-13 |
human |
| Jiang Wang, Ye Ren, Xin Guo, Hao Cheng, Yaping Ye, Jun Qi, Caihong Yang, Hongbo Yo. Alterations in enhancer of zeste homolog 2, matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression are associated with ex vivo and in vitro bone metastasis in renal cell carcinoma. Molecular medicine reports. vol 11. issue 5. 2016-03-04. PMID:25571919. |
the present study aimed to explore the expression levels of enhancer of zeste homolog 2 (ezh2), matrix metalloproteinase-2 (mmp2) and tissue inhibitor of metalloproteinase-2 (timp2) as determinants of rcc-associated bone metastasis. |
2016-03-04 |
2023-08-13 |
Not clear |
| Raju K Mandal, Naseem Akhter, Shafiul Haque, Aditya K Panda, Rama D Mittal, Mohammed A A Alqumbe. No correlation between TIMP2 -418 G>C polymorphism and increased risk of cancer: evidence from a meta-analysis. PloS one. vol 9. issue 8. 2015-12-18. PMID:25136829. |
tissue inhibitor of metalloproteinase (timp2) is involved in the regulation of matrix metalloproteinase 2 (mmp2) and shown to implicate in cancer development and progression. |
2015-12-18 |
2023-08-13 |
Not clear |
| Hui Pang, Bing Han, Tao Yu, Zhen Pen. The complex regulation of tanshinone IIA in rats with hypertension-induced left ventricular hypertrophy. PloS one. vol 9. issue 3. 2015-12-14. PMID:24647357. |
matrix metalloproteinase 2 (mmp2) and tissue inhibitor of matrix metalloproteinases type 2 (timp2) protein expressions in rat myocardial tissues were detected by immunohistochemistry. |
2015-12-14 |
2023-08-12 |
rat |
| Gurpreet Kaur, Neetu Singh, Poorella Lingeshwar, Hefazat H Siddiqui, Kashif Hani. Poly (ADP-ribose) polymerase-1: an emerging target in right ventricle dysfunction associated with pulmonary hypertension. Pulmonary pharmacology & therapeutics. vol 30. 2015-11-03. PMID:25481773. |
oxidative and nitosative stress, inflammation and matrix metalloproteinases (mmps)/tissue inhibitor of metalloproteinase 2 (timp2) were also assessed. |
2015-11-03 |
2023-08-13 |
rat |
| Zoë L Vincent, Murray D Mitchell, Anna P Ponnampala. Regulation of MT1-MMP/MMP-2/TIMP-2 axis in human placenta. Journal of inflammation research. vol 8. 2015-10-22. PMID:26491367. |
mt1-mmp is a powerful activator of mmp2 and this action, coupled with either no change or a decrease in timp2 concentrations, favors a gelatinolytic state leading to extracellular matrix degradation, which could predispose fetal membranes to rupture prematurely during inflammation. |
2015-10-22 |
2023-08-13 |
human |
| Y V Loskutov, P Y Kozyulina, V K Kozyreva, R J Ice, B C Jones, T J Roston, M B Smolkin, A V Ivanov, R B Wysolmerski, E N Pugachev. NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer. Oncogene. vol 34. issue 28. 2015-09-29. PMID:25241893. |
in the current study, we have found that nedd9 is required for matrix metalloproteinase 14 (mmp14) enzymatic recovery/recycling through the late endosomes to enable disengagement of tissue inhibitor of matrix metalloproteinase 2 (timp2) and tumor invasion. |
2015-09-29 |
2023-08-13 |
Not clear |
| Oz Sharabi, Jason Shirian, Moran Grossman, Mario Lebendiker, Irit Sagi, Julia Shifma. Affinity- and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPs. PloS one. vol 9. issue 4. 2015-06-11. PMID:24710006. |
here, we study evolution of an exemplary multispecific protein, a tissue inhibitor of matrix metalloproteinases 2 (timp2) that binds with comparable affinities to more than twenty-six members of the matrix metalloproteinase (mmp) and the related adams families. |
2015-06-11 |
2023-08-13 |
Not clear |
| Amit Ranjan, Rajiv D Kalraiy. Invasive potential of melanoma cells correlates with the expression of MT1-MMP and regulated by modulating its association with motility receptors via N-glycosylation on the receptors. BioMed research international. vol 2014. 2015-05-14. PMID:25180193. |
analysis of the transcripts of tissue inhibitors of matrix metalloproteinases (timps) showed that expression of both timp1 and timp2 correlates negatively with the invasive potential of cells. |
2015-05-14 |
2023-08-13 |
Not clear |
| L Z Akhmadishina, G F Korytina, O V Kochetova, E V Viktorova, T V Viktorov. [Analysis of polymorphisms of genes associated with immune response and tissue remodeling in occupational chronic bronchitis]. Genetika. vol 50. issue 11. 2015-03-24. PMID:25739290. |
the involvement of polymorphisms of genes encoding immune response-associated molecules (lta, tnfa, ilb, ilrn, il8, il10, vdbp), matrix metalloproteinases (mmp1, mmp2, mmp3, mmp9, mmp12, adam33), and tissue and serum inhibitors of proteases (timp2, timp3, serpina1, serpina3) in the predisposition to occupational chronic bronchitis was assessed by pcr-rflp analysis in groups of patients (n = 122) and healthy employees (n = 166). |
2015-03-24 |
2023-08-13 |
Not clear |
| Timothy P Yoshino, Martha Brown, Xiao-Jun Wu, Colin J Jackson, Ramon Ocadiz-Ruiz, Iain W Chalmers, Marlen Kolb, Cornelis H Hokke, Karl F Hoffman. Excreted/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression. International journal for parasitology. vol 44. issue 8. 2015-02-06. PMID:24859313. |
finally, we demonstrate that recombinant smval9 affects the expression of extracellular matrix, remodelling matrix metalloproteinase (mmp) and tissue inhibitors of metalloproteinase (timp) gene products in both biomphalaria glabrata embryonic cell (bgmmp1) and mus musculus bone marrow-derived macrophage (mmmmp2, mmmmp9, mmmmp12, mmmmp13, mmmmp14, mmmmp28, timp1 and timp2) in vitro cultures. |
2015-02-06 |
2023-08-13 |
mouse |
| Sarah L McLaughlin, Ryan J Ice, Anuradha Rajulapati, Polina Y Kozyulina, Ryan H Livengood, Varvara K Kozyreva, Yuriy V Loskutov, Mark V Culp, Scott A Weed, Alexey V Ivanov, Elena N Pugachev. NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis. Molecular cancer research : MCR. vol 12. issue 1. 2014-10-01. PMID:24202705. |
depletion of nedd9 impaired invasion of cancer cells through inactivation of membrane-bound matrix metalloproteinase mmp14 by excess timp2 on the cell surface. |
2014-10-01 |
2023-08-12 |
Not clear |
| Zhi-yong Wang, Jun Wei, Bo Yuan, Xi-Qiao Wang, Yin-kai Liu, Jiao-Yun Dong, Fei Song, Yu-zhi Jiang, Shu-liang L. The change of break modulus drives human fibroblast differentiation in 3D collagen gels. Frontiers in bioscience (Landmark edition). vol 19. 2014-09-15. PMID:24389216. |
fibroblasts cultured in denatured collagen gels showed increased expression of matrix metalloproteinase9 ( mmp-9), tissue inhibitor of metalloproteinase 2 (timp2), α-smooth muscle actin (α-sma), osteoblast cadherin, phosphorylated myosin phosphatase target subunit1 (p-mypt1), connective tissue growth factor, type i collagen, type iii collagen, α-smooth muscle actin messenger rna, rhoa, rho-associated protein kinase, and transforming growth factor β receptors 1 and 2 compared with that in cells cultured in normal collagen gel. |
2014-09-15 |
2023-08-12 |
human |
| Maria Aparecida Azevedo Koike Folgueira, Simone Maistro, Maria Lucia Hirata Katayama, Rosimeire Aparecida Roela, Fiorita Gonzales Lopes Mundim, Suely Nanogaki, Geertruida H de Bock, M Mitzi Brentan. Markers of breast cancer stromal fibroblasts in the primary tumour site associated with lymph node metastasis: a systematic review including our case series. Bioscience reports. vol 33. issue 6. 2014-08-05. PMID:24229053. |
biomarkers evaluated in these studies may be divided in two groups, according to their ontology: extracellular matrix components [mmp13 (matrix metalloproteinase 13), timp2 (tissue inhibitor of metalloproteinases-2), thbs1 (thrombospondin 1), lgals1 (lectin, galactoside-binding, soluble, 1)] and response to wounding [pdpn (podoplanin), plau (plasminogen activator, urokinase), plaur (plasminogen activator, urokinase receptor), cav1 (caveolin 1), thbs1, lgals1]. |
2014-08-05 |
2023-08-12 |
Not clear |
| Yun Wang, Hong Chen, Yonglun Fu, Ai Ai, Songguo Xue, Qifeng Lyu, Yanping Kuan. MiR-195 inhibits proliferation and growth and induces apoptosis of endometrial stromal cells by targeting FKN. International journal of clinical and experimental pathology. vol 6. issue 12. 2014-08-04. PMID:24294368. |
mir-195 could decrease the expression of survivin, matrix metalloproteinase-9 (mmp9) and up-regulate the expression of cd82, tissue inhibitor of metalloproteinase 1 (timp1) and timp2 of eutopic escs by targeting fkn. |
2014-08-04 |
2023-08-12 |
Not clear |
| A G Panayiotou, E Kamilari, M Griffin, T Tyllis, N Georgiou, D Bond, D Hoppensteadt, J Fareed, A Nicolaide. Association between serum levels of pro-metalloproteinase 1, tissue inhibitor of metalloproteinases 1 and 2 and prevalent cardiovascular disease in a population-based study. International angiology : a journal of the International Union of Angiology. vol 32. issue 6. 2014-07-01. PMID:24212294. |
the aim of the study was to test the association between circulating levels of matrix prometalloproteinase1 (pro-mmp1) and its tissue inhibitors timp1 and timp2 with prevalent cardiovascular events. |
2014-07-01 |
2023-08-12 |
Not clear |