| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Groot Kormelink, L Calus, N De Ruyck, G Holtappels, C Bachert, F A Redegeld, P Gevaer. Local free light chain expression is increased in chronic rhinosinusitis with nasal polyps. Allergy. vol 67. issue 9. 2013-01-03. PMID:22765846. |
a role for mast cells is suggested in chronic rhinosinusitis with nasal polyposis (crswnp), which is characterized by a local th2 inflammatory response. |
2013-01-03 |
2023-08-12 |
Not clear |
| Paul C Potter, Ruby Pawanka. Indications, efficacy, and safety of intranasal corticosteriods in rhinosinusitis. The World Allergy Organization journal. vol 5. issue Suppl 1. 2012-12-27. PMID:23268478. |
nasal polyposis is often associated with increased numbers of th2 lymphocytes, fibroblasts, goblet cells, mast cells, and eosinophils, with upregulation of il-13 and the release of specific ige to staphylococcal enterotoxins. |
2012-12-27 |
2023-08-12 |
human |
| L Klimek, P Högger, O Pfaa. [Mechanism of action of nasal glucocorticosteroids in the treatment of allergic rhinitis. Part 1: Pathophysiology, molecular basis]. HNO. vol 60. issue 7. 2012-12-13. PMID:22532281. |
nasal exposure to allergens leads to infiltration of inflammatory cells, such as activated eosinophils and t helper type 2 (th2) cells, into the nasal mucosa by chemoattractant factors such as cytokines including interleukin 5 (il-5), chemical mediators including cyslts and chemokines including eotaxin. |
2012-12-13 |
2023-08-12 |
Not clear |
| Guy W Scadding, Moises A Calderon, Virginia Bellido, Gitte Konsgaard Koed, Niels-Christian Nielsen, Kaare Lund, Alkis Togias, Deborah Phippard, Laurence A Turka, Trevor T Hansel, Stephen R Durham, Peter Adler Wurtze. Optimisation of grass pollen nasal allergen challenge for assessment of clinical and immunological outcomes. Journal of immunological methods. vol 384. issue 1-2. 2012-12-07. PMID:22759401. |
tryptase in local nasal secretions is a potential biomarker of the early phase response; ecp and the th2 cytokines il-5, -13 and -4 markers of late phase allergic responses. |
2012-12-07 |
2023-08-12 |
human |
| Mary S Georgy, Carol A Saltou. Chapter 3: Allergen immunotherapy: definition, indication, and reactions. Allergy and asthma proceedings. vol 33 Suppl 1. 2012-11-16. PMID:22794676. |
humoral, cellular, and tissue level changes occur with allergen immunotherapy including large increases in antiallergen igg(4) antibodies, a decrease in the postseasonal rise of antiallergen ige antibodies, reduced numbers of nasal mucosal mast cells and eosinophils, induction of treg cells, and suppression of th2 more than th1 lymphocytes. |
2012-11-16 |
2023-08-12 |
Not clear |
| Mary S Georgy, Anju T Peter. Chapter 7: Nasal polyps. Allergy and asthma proceedings. vol 33 Suppl 1. 2012-11-16. PMID:22794680. |
staphylococcal superantigens may play a role in the th2 type of chronic eosinophilic inflammation observed in nasal polyps. |
2012-11-16 |
2023-08-12 |
Not clear |
| L Derycke, N Zhang, G Holtappels, T Dutré, C Bacher. IL-17A as a regulator of neutrophil survival in nasal polyp disease of patients with and without cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. vol 11. issue 3. 2012-11-06. PMID:22178076. |
nasal polyps in adults are characterized by a chronic inflammation of the upper airways and by the preferential activation of th2 cells. |
2012-11-06 |
2023-08-12 |
Not clear |
| Teodor T Postolache, Hirsh Komarow, Leonardo H Tonell. Allergy: a risk factor for suicide? Current treatment options in neurology. vol 10. issue 5. 2012-10-02. PMID:18782509. |
our recent report of th2 (allergy-mediating) cytokine expression in the orbitofrontal cortex of suicide victims should lead to future studies to test the hypothesis that mediators of allergic inflammation in the nasal cavities may result in th2 cytokine expression in the brain, influencing affect and behavioral modulation. |
2012-10-02 |
2023-08-12 |
rat |
| Rogerio Pezato, Richard Louis Voegel. Why do we not find polyps in the lungs? Bronchial mucosa as a model in the treatment of polyposis. Medical hypotheses. vol 78. issue 4. 2012-06-28. PMID:22289339. |
nasal polyposis and asthma share basically the same inflammatory process: predominant infiltration of eosinophils, mucus cell hyperplasia, edema, thickened basal membrane, polarization for th2 cell immune response, similar pro-inflammatory mediators are increased, for example cysteinyl leukotrienes. |
2012-06-28 |
2023-08-12 |
Not clear |
| Anne Månsson Kvarnhammar, Camilla Rydberg, Malin Järnkrants, Mia Eriksson, Rolf Uddman, Mikael Benson, Lars-Olaf Cardel. Diminished levels of nasal S100A7 (psoriasin) in seasonal allergic rhinitis: an effect mediated by Th2 cytokines. Respiratory research. vol 13. 2012-06-22. PMID:22230654. |
diminished levels of nasal s100a7 (psoriasin) in seasonal allergic rhinitis: an effect mediated by th2 cytokines. |
2012-06-22 |
2023-08-12 |
Not clear |
| Y H Kim, T Y Yang, C-S Park, S-H Ahn, B K Son, J H Kim, D H Lim, T Y Jan. Anti-IL-33 antibody has a therapeutic effect in a murine model of allergic rhinitis. Allergy. vol 67. issue 2. 2012-05-07. PMID:22050307. |
interleukin (il)-33 is involved in the th2 immune response and could play an essential role in nasal allergy. |
2012-05-07 |
2023-08-12 |
Not clear |
| Yi Zheng, Changyuan Guo, Yan Zhang, Hui Qi, Qianying Sun, Enquan Xu, Yingmei Zhang, Dalong Ma, Ying Wan. Alleviation of murine allergic rhinitis by C19, a C-terminal peptide of chemokine-like factor 1 (CKLF1). International immunopharmacology. vol 11. issue 12. 2012-04-13. PMID:22001899. |
c19 was able to suppress the th2 cytokine il-4 without augmenting the th1 cytokine ifn-γ in bal and il-4(+) cells in the local nasal tissue. |
2012-04-13 |
2023-08-12 |
mouse |
| S Langier, R Landsberg, K Sade, S Kivit. Anti-IL-5 immunomodulates the effect of Staphylococcus aureus enterotoxin on T cell response in nasal polyps. Rhinology. vol 49. issue 5. 2012-03-27. PMID:22125788. |
chronic rhinosinusitis with nasal polyps (crswnp) is a t helper-2 (th2) inflammatory disease with considerable impact on the quality of life. |
2012-03-27 |
2023-08-12 |
Not clear |
| Victor J Johnson, Jeffrey S Reynolds, Wei Wang, Kara Fluharty, Berran Yuceso. Inhalation of ortho-phthalaldehyde vapor causes respiratory sensitization in mice. Journal of allergy. vol 2011. 2011-11-10. PMID:21785612. |
expression of th2 (il-4, il-5, and il-13) and anti/proinflammatory (il-10, tnfα, and il-1β) cytokine genes was upregulated in the lymph nodes and the nasal mucosa. |
2011-11-10 |
2023-08-12 |
mouse |
| Ruby Pawankar, Sachiko Mori, Chika Ozu, Satoko Kimur. Overview on the pathomechanisms of allergic rhinitis. Asia Pacific allergy. vol 1. issue 3. 2011-11-10. PMID:22053313. |
the inflammatory response in the nasal mucosa includes an immediate ige-mediated mast cell response as well as a latephase response characterized by recruitment of eosinophils, basophils, and t cells expressing th2 cytokines including interleukin (il)-4, a switch factor for ige synthesis, and il-5, an eosinophil growth factor and on-going allergic inflammation. |
2011-11-10 |
2023-08-12 |
Not clear |
| b' A Peri\\xc4\\x87, D Vojvodi\\xc4\\x87, V Radulovi\\xc4\\x87, B Vukomanovi\\xc4\\x87-\\xc4\\x90ur\\xc4\\x91evi\\xc4\\x87, O Miljanovi\\xc4\\x8. Correlation between cytokine levels in nasal fluid and eosinophil counts in nasal polyp tissue in asthmatic and non-asthmatic patients. Allergologia et immunopathologia. vol 39. issue 3. 2011-10-17. PMID:21211895.' |
so, the aim of our study was to evaluate local immune reaction by measuring crucial th1, th2 and inflammatory cytokines in nasal fluid samples of patients with nasal polyps (np), and to correlate them to clinical, radiological findings and to the degree of eosinophil infiltration of polyp tissue. |
2011-10-17 |
2023-08-12 |
Not clear |
| Ji Shen, Suling Hon. [Serum levels of IL-12, IL-4 and pathologic changes by scanning electron microscope of nasal mucous inflammation]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 24. issue 20. 2011-10-13. PMID:21171294. |
the serum levels of interleukin-4, interleukin-12 will be detected to elucidate and compare the involvement of th1 and th2 cells and the surface structures of nasal mucosa will also be observed in patients with allergic rhinitis (ar), chronic rhinosinusitis with nasal polyps (crswnp), chronic rhinosinusitis without nasal polyps (crssnp) and nasal septal deviation (nsd) to obtain the characteristics and regularity of pathological changes. |
2011-10-13 |
2023-08-12 |
Not clear |
| b' Aleksandar Peri\\xc4\\x87, Danilo Vojvodi\\xc4\\x87, Vesna Radulovi\\xc4\\x87, Biserka Vukomanovi\\xc4\\x87-Durdevi\\xc4\\x87, Aneta V Peri\\xc4\\x87, Olivera Miljanovi\\xc4\\x8. Proinflammatory cytokine levels in nasal fluid as indicators of severity of nasal polyposis. Acta clinica Croatica. vol 49. issue 4. 2011-09-15. PMID:21830450.' |
the concentrations of th2 proinflammatory cytokines il-5 and il-6 were significantly higher (p < 0.05 and p < 0.01, respectively) in patients with nasal polyposis and asthma compared with nasal polyp patients without asthma. |
2011-09-15 |
2023-08-12 |
human |
| J K Mulligan, B S Bleier, B O'Connell, R M Mulligan, C Wagner, R J Schlosse. Vitamin D3 correlates inversely with systemic dendritic cell numbers and bone erosion in chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Clinical and experimental immunology. vol 164. issue 3. 2011-07-18. PMID:21401575. |
we hypothesized that t helper type 2 (th2) disorders, chronic rhinosinusitis with nasal polyps (crswnp) and allergic fungal rhinosinusitis (afrs) would have vd(3) deficiencies, resulting in increased mature dendritic cells (dcs) and bone erosion. |
2011-07-18 |
2023-08-12 |
Not clear |
| Seung-Heon Shin, Mi-Kyung Y. Th2 responses elicited by nasal epithelial cells exposed to house dust mite extract. Clinical and experimental otorhinolaryngology. vol 2. issue 4. 2011-07-14. PMID:20072691. |
th2 responses elicited by nasal epithelial cells exposed to house dust mite extract. |
2011-07-14 |
2023-08-12 |
Not clear |