| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christina Brandenberger, Jon A Hotchkiss, Shannon M Krieger, Lynn H Pottenger, Jack R Harkem. Inhalation exposure to ethylene induces eosinophilic rhinitis and nasal epithelial remodeling in Fischer 344 rats. Chemico-biological interactions. vol 241. 2016-02-26. PMID:26367701. |
enhanced gene expression of th2 cytokines (e.g., il-5, il-13) and chitinase (ym1/2) in the nasal mucosa was much greater than that of th1 cytokines (e.g., ifnγ) after ethylene exposure. |
2016-02-26 |
2023-08-13 |
rat |
| P Campo, C Rondón, H J Gould, E Barrionuevo, P Gevaert, M Blanc. Local IgE in non-allergic rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 45. issue 5. 2016-01-06. PMID:25495772. |
local allergic rhinitis (lar) is characterized by the presence of a nasal th2 inflammatory response with local production of specific ige antibodies and a positive response to a nasal allergen provocation test (napt) without evidence of systemic atopy. |
2016-01-06 |
2023-08-13 |
human |
| b' P Panzner, I Malkusov\\xc3\\xa1, M Vachov\\xc3\\xa1, M Li\\xc5\\xa1ka, P Brodsk\\xc3\\xa1, O R\\xc5\\xaf\\xc5\\xbei\\xc4\\x8dkov\\xc3\\xa1, M Mal\\xc3\\xb. Bronchial inflammation in seasonal allergic rhinitis with or without asthma in relation to natural exposure to pollen allergens. Allergologia et immunopathologia. vol 43. issue 1. 2015-11-17. PMID:24075536.' |
nasal inflammation in allergic rhinitis enhances bronchial th2 driven inflammation and development of asthma. |
2015-11-17 |
2023-08-12 |
Not clear |
| Dong-Yeop Chang, Yeon-Hee Joo, Seong-Jae Kim, Jin Hyun Kim, Myeong Hee Jung, Dae Woo Kim, Sea-Yuong Jeon, Sang-Wook Ki. Therapeutic effects of intranasal cyclosporine for eosinophilic rhinosinusitis with nasal polyps in a mouse model. American journal of rhinology & allergy. vol 29. issue 1. 2015-10-14. PMID:25590314. |
chronic rhinosinusitis (crs) with nasal polyps (crswnp) is a principally type 2 t helper cell (th2)-mediated inflammatory disease. |
2015-10-14 |
2023-08-13 |
mouse |
| Hyun Jin Min, Hyuna Song, Su Yeon Choi, Tae Hoon Kim, Hyung-Ju Cho, Joo-Heon Yoon, Chang-Hoon Ki. Th2 cytokines differentially regulate psoriasin expression in human nasal epithelia. American journal of rhinology & allergy. vol 28. issue 6. 2015-09-30. PMID:25514480. |
th2 cytokines differentially regulate psoriasin expression in human nasal epithelia. |
2015-09-30 |
2023-08-13 |
human |
| J A Poposki, S Peterson, K Welch, R P Schleimer, K E Hulse, A T Peters, J Norton, L A Suh, R Carter, K E Harris, L C Grammer, B K Tan, R K Chandra, D B Conley, R C Kern, A Kat. Elevated presence of myeloid dendritic cells in nasal polyps of patients with chronic rhinosinusitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 45. issue 2. 2015-09-24. PMID:25469646. |
although chronic rhinosinusitis with nasal polyps (crswnp) is characterized by th2 inflammation, the mechanism underlying the onset and amplification of this inflammation has not been fully elucidated. |
2015-09-24 |
2023-08-13 |
Not clear |
| Hong Ouyang, Jie Cheng, Yajun Zheng, Jingdong D. Role of IL-31 in regulation of Th2 cytokine levels in patients with nasal polyps. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 271. issue 10. 2015-09-01. PMID:24515918. |
role of il-31 in regulation of th2 cytokine levels in patients with nasal polyps. |
2015-09-01 |
2023-08-12 |
Not clear |
| Hyun-Woo Shin, Dong-Kyu Kim, Min-Hyun Park, Kyoung Mi Eun, Mingyu Lee, Daeho So, Il Gyu Kong, Ji-Hun Mo, Min-Suk Yang, Hong Ryul Jin, Jong-Wan Park, Dae Woo Ki. IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis. The Journal of allergy and clinical immunology. vol 135. issue 6. 2015-08-12. PMID:25725991. |
chronic rhinosinusitis (crs) with nasal polyps (nps) in western populations is associated with th2 cytokine polarization. |
2015-08-12 |
2023-08-13 |
Not clear |
| Tae Young Jang, Chang-Shin Park, Kyu-Sung Kim, Min-Jeong Heo, Young Hyo Ki. Benzaldehyde suppresses murine allergic asthma and rhinitis. International immunopharmacology. vol 22. issue 2. 2015-06-09. PMID:25107441. |
the number of nose-scratching events in 10 min, levels of total and ovalbumin-specific ige in serum, differential counts of inflammatory cells in bronchoalveolar lavage (bal) fluid, titers of th2 cytokines (il-4, il-5, il-13) in bal fluid, histopathologic findings of lung and nasal tissues, and expressions of proteins involved in apoptosis (bcl-2, bax, caspase-3), inflammation (cox-2), antioxidation (extracellular sod, ho-1), and hypoxia (hif-1α, vegf) in lung tissue were evaluated. |
2015-06-09 |
2023-08-13 |
mouse |
| Bing Zhang, Tao Liu, Huarong Zho. [The promoting research of phospholipase C epsilon-1 on nasal Th2 cell polarization]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 28. issue 17. 2015-06-02. PMID:25522584. |
[the promoting research of phospholipase c epsilon-1 on nasal th2 cell polarization]. |
2015-06-02 |
2023-08-13 |
Not clear |
| Yu Zhang, Xiangdong Wang, Hong Wang, Jian Jiao, Ying Li, Erzhong Fan, Luo Zhang, Claus Bacher. TMEM16A-Mediated Mucin Secretion in IL-13-Induced Nasal Epithelial Cells From Chronic Rhinosinusitis Patients. Allergy, asthma & immunology research. vol 7. issue 4. 2015-05-04. PMID:25749771. |
chronic rhinosinusitis with nasal polyps (crswnp), a mainly th2 cytokine-mediated disease, often involves mucus secretion. |
2015-05-04 |
2023-08-13 |
human |
| Benjamin S Bleier, Angela L Nocera, Hufsa Iqbal, John D Hoang, Ulises Alvarez, Rachel E Feldman, Xue Ha. P-glycoprotein promotes epithelial T helper 2-associated cytokine secretion in chronic sinusitis with nasal polyps. International forum of allergy & rhinology. vol 4. issue 6. 2015-04-16. PMID:24599606. |
sinonasal epithelial cells are recognized as drivers of inflammation in chronic sinusitis with nasal polyps (crswnp) through secretion of t helper 2 (th2)-promoting cytokines. |
2015-04-16 |
2023-08-12 |
Not clear |
| Seok Hyun Cho, Sun Young Oh, Andrew P Lane, Joan Lee, Min-Hee Oh, Seakwoo Lee, Tao Zheng, Zhou Zh. Regulation of nasal airway homeostasis and inflammation in mice by SHP-1 and Th2/Th1 signaling pathways. PloS one. vol 9. issue 8. 2015-04-14. PMID:25090641. |
however, the role of shp-1 enzyme and its functional relationship with th2 and th1 cytokines are not known in the nasal airway. |
2015-04-14 |
2023-08-13 |
mouse |
| Michael Könnecke, Robert Böscke, Anja Waldmann, Karl-Ludwig Bruchhage, Robert Linke, Ralph Pries, Barbara Wollenber. Immune imbalance in nasal polyps of Caucasian chronic rhinosinusitis patients is associated with a downregulation of E-selectin. Journal of immunology research. vol 2014. 2015-02-23. PMID:24995349. |
chronic rhinosinusitis with nasal polyps (crswnp) in caucasians is a chronic th2 inflammatory disease of the nasal and paranasal mucosa and the recruitment of leukocytes to the site of inflammation is poorly understood. |
2015-02-23 |
2023-08-13 |
Not clear |
| Astrid Bonnegarde-Bernard, Junbae Jee, Michael J Fial, Haley Steiner, Stephanie DiBartola, Ian C Davis, Estelle Cormet-Boyaka, Daniel Tomé, Prosper N Boyak. Routes of allergic sensitization and myeloid cell IKKβ differentially regulate antibody responses and allergic airway inflammation in male and female mice. PloS one. vol 9. issue 3. 2015-01-22. PMID:24667561. |
after nasal allergen challenge, these female mice expressed higher th2 responses and associated inflammation in the lung than males. |
2015-01-22 |
2023-08-12 |
mouse |
| Yu Zhong, Yunqiu Li, Xuping Xia. [The relationship of the expression of thymic stromal lymphopoietin in nasal polyps tissues and Th2 inflammatory response]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 28. issue 11. 2015-01-08. PMID:25219211. |
[the relationship of the expression of thymic stromal lymphopoietin in nasal polyps tissues and th2 inflammatory response]. |
2015-01-08 |
2023-08-13 |
Not clear |
| Yu Zhong, Yunqiu Li, Xuping Xia. [The relationship of the expression of thymic stromal lymphopoietin in nasal polyps tissues and Th2 inflammatory response]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 28. issue 11. 2015-01-08. PMID:25219211. |
to explore the relationship of the expression of thymic stromal lymphopoietin (tslp) in nasal polyps tissues and the th2 inflammatory response. |
2015-01-08 |
2023-08-13 |
Not clear |
| Paul C Porter, Dae Jun Lim, Zahida Khan Maskatia, Garbo Mak, Chu-Lin Tsai, Martin J Citardi, Samer Fakhri, Joanne L Shaw, Annette Fothergil, Farrah Kheradmand, David B Corry, Amber Luon. Airway surface mycosis in chronic TH2-associated airway disease. The Journal of allergy and clinical immunology. vol 134. issue 2. 2014-12-05. PMID:24928648. |
environmental fungi have been linked to th2 cell-related airway inflammation and the th2-associated chronic airway diseases asthma, chronic rhinosinusitis (crs) with nasal polyps (crswnp), and allergic fungal rhinosinusitis (afrs), but whether these organisms participate directly or indirectly in disease pathology remains unknown. |
2014-12-05 |
2023-08-13 |
Not clear |
| S Baba, K Kondo, M Toma-Hirano, K Kanaya, K Suzukawa, M Ushio, M Suzukawa, K Ohta, T Yamasob. Local increase in IgE and class switch recombination to IgE in nasal polyps in chronic rhinosinusitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 44. issue 5. 2014-12-03. PMID:24931597. |
chronic rhinosinusitis with nasal polyps is generally characterized by local th2 inflammation and is categorized into two subtypes in japan: eosinophilic chronic rhinosinusitis (similar to chronic rhinosinusitis with nasal polyps in western countries) and non-eosinophilic chronic rhinosinusitis (characterized by th1-dominant inflammation). |
2014-12-03 |
2023-08-13 |
Not clear |
| T Sakurai, A Inamine, T Iinuma, U Funakoshi, S Yonekura, D Sakurai, T Hanazawa, T Nakayama, Y Ishii, Y Okamot. Activation of invariant natural killer T cells in regional lymph nodes as new antigen-specific immunotherapy via induction of interleukin-21 and interferon-γ. Clinical and experimental immunology. vol 178. issue 1. 2014-12-03. PMID:24943738. |
nasal symptoms, level of ova-specific immunoglobulin (ige), and t helper type 2 (th2) cytokine production in cervical lymph nodes (clns) were significantly ameliorated in wild-type (wt) mice treated with ova/α-galcer-bmdcs, but not in wt mice treated with ova-bmdcs. |
2014-12-03 |
2023-08-13 |
mouse |