| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Henry Yim Wu, Ruth Maron, Ann-Marcia Tukpah, Howard L Weine. Mucosal anti-CD3 monoclonal antibody attenuates collagen-induced arthritis that is associated with induction of LAP+ regulatory T cells and is enhanced by administration of an emulsome-based Th2-skewing adjuvant. Journal of immunology (Baltimore, Md. : 1950). vol 185. issue 6. 2010-11-23. PMID:20720210. |
we found, however, that coadministration of a novel emulsome adjuvant, which enhances th2 responses, resulted in the induction of lap(+) regulatory t cells and suppression of ongoing arthritis by both nasal and oral anti-cd3. |
2010-11-23 |
2023-08-12 |
Not clear |
| Jungi Choi, Zak Callaway, Hyo-Bin Kim, Takao Fujisawa, Chang-Keun Ki. The role of TNF-alpha in eosinophilic inflammation associated with RSV bronchiolitis. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. vol 21. issue 3. 2010-09-27. PMID:20088864. |
we measured the nasal lavage fluid (nlf) th2 cytokine (il-5), proinflammatory cytokine (tnf-alpha, il-8), eosinophil-active cytokine [granulocyte-macrophage colony stimulating factor (gm-csf), ifn-gamma], and eosinophil-active chemokine (eotaxin, regulated on activation normal t cell excreted and secreted) levels for both groups. |
2010-09-27 |
2023-08-12 |
Not clear |
| C A Pérez-Novo, G Holtappels, S L Vinall, L Xue, N Zhang, C Bachert, R Pettiphe. CRTH2 mediates the activation of human Th2 cells in response to PGD(2) released from IgE/anti-IgE treated nasal polyp tissue. Allergy. vol 65. issue 3. 2010-08-20. PMID:19839971. |
crth2 mediates the activation of human th2 cells in response to pgd(2) released from ige/anti-ige treated nasal polyp tissue. |
2010-08-20 |
2023-08-12 |
human |
| C A Pérez-Novo, G Holtappels, S L Vinall, L Xue, N Zhang, C Bachert, R Pettiphe. CRTH2 mediates the activation of human Th2 cells in response to PGD(2) released from IgE/anti-IgE treated nasal polyp tissue. Allergy. vol 65. issue 3. 2010-08-20. PMID:19839971. |
the objective was to determine the involvement of prostaglandin d(2) (pgd(2)) and its receptors in the chemotaxis of th2 cells, using nasal polyp tissue. |
2010-08-20 |
2023-08-12 |
human |
| Hideki Kakutani, Masuo Kondoh, Masahiro Fukasaka, Hidehiko Suzuki, Takao Hamakubo, Kiyohito Yag. Mucosal vaccination using claudin-4-targeting. Biomaterials. vol 31. issue 20. 2010-08-10. PMID:20398936. |
ova-c-cpe immunization activated both th1 and th2 responses, and nasal immunization with ova-c-cpe showed anti-tumor activity in mice inoculated with ova-expressing thymoma cells. |
2010-08-10 |
2023-08-12 |
mouse |
| Meri K Tulic, Pota Christodoulopoulos, Pierre Olivier Fiset, Patrice Vaillancourt, Francois Lavigne, Jason D Marshall, Gary Van Nest, Joseph J Eiden, Qutayba Hami. Local induction of a specific Th1 immune response by allergen linked immunostimulatory DNA in the nasal explants of ragweed-allergic subjects. Allergology international : official journal of the Japanese Society of Allergology. vol 58. issue 4. 2010-06-22. PMID:19776676. |
the objective of this study is to investigate whether iss linked to purified ragweed allergen amb-a-1 (aic) can inhibit local allergen-specific th2 and induce allergen-specific th1 responses in explanted nasal mucosa of ragweed-sensitive subjects. |
2010-06-22 |
2023-08-12 |
human |
| Manabu Nonaka, Akira Fukumoto, Nozomu Ogihara, Atsuko Sakanushi, Ruby Pawankar, Toshiaki Yag. Synergistic induction of thymic stromal lymphopoietin by tumor necrosis factor alpha and Th2 cytokine in nasal polyp fibroblasts. American journal of rhinology & allergy. vol 24. issue 1. 2010-06-11. PMID:20109311. |
synergistic induction of thymic stromal lymphopoietin by tumor necrosis factor alpha and th2 cytokine in nasal polyp fibroblasts. |
2010-06-11 |
2023-08-12 |
Not clear |
| Te-Huei Yeh, Shiann-Yann Lee, Wei-Chung Hs. Expression of SPLUNC1 protein in nasal polyp epithelial cells in air-liquid interface culture treated with IL-13. American journal of rhinology & allergy. vol 24. issue 1. 2010-06-11. PMID:20109312. |
chronic rhinosinusitis with nasal polyps (crswnps) is a disorder characterized by eosinophilic th2 inflammation and frequent microbial colonization. |
2010-06-11 |
2023-08-12 |
Not clear |
| Te-Huei Yeh, Shiann-Yann Lee, Wei-Chung Hs. Expression of SPLUNC1 protein in nasal polyp epithelial cells in air-liquid interface culture treated with IL-13. American journal of rhinology & allergy. vol 24. issue 1. 2010-06-11. PMID:20109312. |
this study investigates the splunc1 expression of nasal polyp epithelial cells in air-liquid interface (ali) culture and after treating with th2 inflammatory cytokines il-13. |
2010-06-11 |
2023-08-12 |
Not clear |
| H Kirsche, A Niederführ, T Deutschle, C Fuchs, Herbert Riechelman. Ratio of myeloid and plasmacytoid dendritic cells and TH2 skew in CRS with nasal polyps. Allergy. vol 65. issue 1. 2010-04-08. PMID:19793060. |
ratio of myeloid and plasmacytoid dendritic cells and th2 skew in crs with nasal polyps. |
2010-04-08 |
2023-08-12 |
Not clear |
| Hee Yeon Won, Hyun Jung Min, Jin Hee Ahn, Sung-Eun Yoo, Myung Ae Bae, Jeong-Ho Hong, Eun Sook Hwan. Anti-allergic function and regulatory mechanisms of KR62980 in allergen-induced airway inflammation. Biochemical pharmacology. vol 79. issue 6. 2010-03-01. PMID:19896472. |
kr62980 also decreased goblet cell hyperplasia in the airway and mucous cell metaplasia in nasal epithelium, concurrent with decreases of allergic th2 cytokines and il-17 in the draining lymph node. |
2010-03-01 |
2023-08-12 |
Not clear |
| P Van Cauwenberge, T Van Zele, C Bacher. Chronic rhinonsinusitis and nasal polyposis: the etiopathogenesis revealed? Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie. vol 70. issue 5-6. 2009-09-25. PMID:19725391. |
in caucasians, nasal polyps showed a th2 polarisation with high il-5 concentrations, while chronic rhinosinusitis without polyps was characterized by a thl polarisation with high levels of ifn-gamma. |
2009-09-25 |
2023-08-12 |
Not clear |
| P Van Cauwenberge, T Van Zele, C Bacher. Chronic rhinonsinusitis and nasal polyposis: the etiopathogenesis revealed? Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie. vol 70. issue 5-6. 2009-09-25. PMID:19725391. |
we suggest that s. aureus superantigens amplify the inflammation in about 50% of nasal polyps, resulting in a strong th2 polarisation, eosinophil activation, and an overproduction of igg4 and ige. |
2009-09-25 |
2023-08-12 |
Not clear |
| Kyu-Sup Cho, Hye-Kyung Park, Hee-Young Park, Jin Sup Jung, Seong-Gyu Jeon, Yoon-Keun Kim, Hwan Jung Ro. IFATS collection: Immunomodulatory effects of adipose tissue-derived stem cells in an allergic rhinitis mouse model. Stem cells (Dayton, Ohio). vol 27. issue 1. 2009-06-25. PMID:18832595. |
in conclusion, ascs can migrate to the nasal mucosa in the ar mouse model and inhibit eosinophilic inflammation partly via shifting to a t-helper 1 (th1) from a th2 immune response to allergens. |
2009-06-25 |
2023-08-12 |
mouse |
| G Ciprandi, I Cirillo, A Pistorio, M Di Gioacchino, D Fenogli. Ebastine increases IFN-gamma production in patients with persistent allergic rhinitis. Journal of biological regulators and homeostatic agents. vol 23. issue 1. 2009-06-25. PMID:19321044. |
nasal obstruction is a leading symptom in patients with allergic rhinitis and depends on inflammation characterized by th2 polarization. |
2009-06-25 |
2023-08-12 |
human |
| Kazuhisa Asai, Susan C Foley, Yuki Sumi, Yasuhiro Yamauchi, Naoya Takeda, Martin Desrosiers, François Lavigne, Qutayba Hami. Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy increases CD4+CD25+ T cells in the nasal mucosa of subjects with allergic rhinitis. Allergology international : official journal of the Japanese Society of Allergology. vol 57. issue 4. 2009-04-07. PMID:18797179. |
we have previously shown that short-course treatment with amb a 1-immunostimulatory phosphorothioate oligonucleotide conjugate (aic) before the ragweed season modifies the response of the nasal mucosa to allergen challenge in ragweed-sensitive patients by increasing th1 cytokines and decreasing both th2 cytokines and eosinophilia after the ragweed season. |
2009-04-07 |
2023-08-12 |
human |
| Shino Shimizu, Reiko Hattori, Yuichi Majima, Takeshi Shimiz. Th2 cytokine inhibitor suplatast tosilate inhibits antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats. The Annals of otology, rhinology, and laryngology. vol 118. issue 1. 2009-03-30. PMID:19244966. |
th2 cytokine inhibitor suplatast tosilate inhibits antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats. |
2009-03-30 |
2023-08-12 |
rat |
| Shino Shimizu, Reiko Hattori, Yuichi Majima, Takeshi Shimiz. Th2 cytokine inhibitor suplatast tosilate inhibits antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats. The Annals of otology, rhinology, and laryngology. vol 118. issue 1. 2009-03-30. PMID:19244966. |
to elucidate the functions of th2 cytokines in allergic rhinitis, we examined the in vivo effects of the th2 cytokine inhibitor suplatast tosilate on mucus hypersecretion and eosinophil infiltration in rat nasal epithelium. |
2009-03-30 |
2023-08-12 |
rat |
| Manabu Nonaka, Nozomu Ogihara, Akira Fukumoto, Atsuko Sakanushi, Ruby Pawankar, Toshiaki Yag. Toll-like receptor 2, 3, 4, 5 ligands and interleukin-4 synergistically induce TARC production in nasal polyp fibroblasts. Auris, nasus, larynx. vol 35. issue 4. 2009-01-16. PMID:18375080. |
thymus and activation-regulated chemokine (tarc) has been known to facilitate the recruitment of th2 polarized cells, resulting in high levels of th2 cytokines in the sinus mucosa as well as nasal polyps. |
2009-01-16 |
2023-08-12 |
Not clear |
| Manabu Nonaka, Nozomu Ogihara, Akira Fukumoto, Atsuko Sakanushi, Ruby Pawankar, Toshiaki Yag. Toll-like receptor 2, 3, 4, 5 ligands and interleukin-4 synergistically induce TARC production in nasal polyp fibroblasts. Auris, nasus, larynx. vol 35. issue 4. 2009-01-16. PMID:18375080. |
we investigated whether nasal polyp fibroblasts produce tarc when stimulated with the breakdown products of microorganisms (tlr ligands) and a th2 cytokine (il-4). |
2009-01-16 |
2023-08-12 |
Not clear |