| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huan Zhang, Lars Olaf Cardell, Janne Bjorkander, Mikael Benson, Hui Wan. Comprehensive profiling of peripheral immune cells and subsets in patients with intermittent allergic rhinitis compared to healthy controls and after treatment with glucocorticoids. Inflammation. vol 36. issue 4. 2014-03-21. PMID:23413042. |
local allergic inflammation in the nasal mucosa is associated with increased circulating th2 cells, eosinophils, and basophils. |
2014-03-21 |
2023-08-12 |
Not clear |
| Andrés E Ibañez, Paola Smaldini, Lorena M Coria, María V Delpino, Lucila G G Pacífico, Sergio C Oliveira, Gabriela S Risso, Karina A Pasquevich, Carlos Alberto Fossati, Guillermo H Giambartolomei, Guillermo H Docena, Juliana Cassatar. Unlipidated outer membrane protein Omp16 (U-Omp16) from Brucella spp. as nasal adjuvant induces a Th1 immune response and modulates the Th2 allergic response to cow's milk proteins. PloS one. vol 8. issue 7. 2014-02-13. PMID:23861971. |
as nasal adjuvant induces a th1 immune response and modulates the th2 allergic response to cow's milk proteins. |
2014-02-13 |
2023-08-12 |
mouse |
| S B Wang, Y Q Deng, J Ren, B K Xiao, Z Chen, Z Z Ta. Lactoferrin administration into the nostril alleviates murine allergic rhinitis and its mechanisms. Scandinavian journal of immunology. vol 78. issue 6. 2014-02-07. PMID:24111738. |
we found that the number of eosinophils and goblet cells, as well as mrna and protein expression of type 2 helper t (th2), th17 and regulatory t (treg) cells in the nasal cavity, was significantly upregulated in ar mice compared with the controls, conversely, administration of rhlf prior to or after intranasal ovalbumin challenge markedly downregulated these same parameters. |
2014-02-07 |
2023-08-12 |
mouse |
| S B Wang, Y Q Deng, J Ren, B K Xiao, Z Chen, Z Z Ta. Lactoferrin administration into the nostril alleviates murine allergic rhinitis and its mechanisms. Scandinavian journal of immunology. vol 78. issue 6. 2014-02-07. PMID:24111738. |
exogenous rhlf inhibited allergic inflammation in ar mice, most likely by promoting the endogenous lf expression and skewing t cells to a th1, but not a th2 and th17 phenotype in the nasal mucosa. |
2014-02-07 |
2023-08-12 |
mouse |
| Joanne L Shaw, Samer Fakhri, Martin J Citardi, Paul C Porter, David B Corry, Farrah Kheradmand, Yong-Jun Liu, Amber Luon. IL-33-responsive innate lymphoid cells are an important source of IL-13 in chronic rhinosinusitis with nasal polyps. American journal of respiratory and critical care medicine. vol 188. issue 4. 2014-02-04. PMID:23805875. |
chronic rhinosinusitis (crs) without nasal polyps (crssnp) and crs with nasal polyps (crswnp) are associated with th1 and th2 cytokine polarization, respectively; however, the pathophysiology of crs remains unclear. |
2014-02-04 |
2023-08-12 |
Not clear |
| Yue-Qi Sun, Meng-Xia Deng, Jia He, Qing-Xiang Zeng, Weiping Wen, David S H Wong, Hung-Fat Tse, Geng Xu, Qizhou Lian, Jianbo Shi, Qing-Ling F. Human pluripotent stem cell-derived mesenchymal stem cells prevent allergic airway inflammation in mice. Stem cells (Dayton, Ohio). vol 30. issue 12. 2013-09-06. PMID:22987325. |
in addition, treatment with ipsc-mscs or bm-mscs before the challenge phase resulted in reduced serum levels of th2 immunoglobulins (e.g., ige) and decreased levels of th2 cytokines including interleukin (il)-4, il-5, or il-13 in the bronchoalveolar and/or nasal lavage fluids. |
2013-09-06 |
2023-08-12 |
mouse |
| L Klimek, L von Bernus, O Pfaa. [Local (exclusive) IgE production in the nasal mucosa. Evidence for local allergic rhinitis]. HNO. vol 61. issue 3. 2013-08-30. PMID:23241861. |
however, there is evidence for specific th2 cytokine, tryptase, and ecp (eosinophil catonic protein) production in the nasal secretion after allergen exposure in these patients without systemic sensitization. |
2013-08-30 |
2023-08-12 |
Not clear |
| Qiang Zhang, Jia Xu, Yuru L. [Advances in cytokine immune mechanisms of allergic rhinitis]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 26. issue 23. 2013-08-15. PMID:23451486. |
the mechanism of ar is caused by the imbalance of the th1/th2, a kind of allergic inflammation who is characterized by the nasal th2 immune response dominant. |
2013-08-15 |
2023-08-12 |
Not clear |
| Ji-Hun Mo, Seung-Eun Lee, Jee Hye Wee, Ji-Eun Lee, Chae-Seo Rhee, Chul Hee Lee, Dong-Young Ki. Anti-allergic effects of So-Cheong-Ryong-Tang, a traditional Korean herbal medicine, in an allergic rhinitis mouse model. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 270. issue 3. 2013-08-09. PMID:22903755. |
scrt significantly reduced expression of the th2 cytokine, il-4; however, the expression of il-5, ifn-γ, and il-10 was unchanged in the nasal mucosa of the treatment group (by real-time rt-pcr). |
2013-08-09 |
2023-08-12 |
mouse |
| Ji-Hun Mo, Seung-Eun Lee, Jee Hye Wee, Ji-Eun Lee, Chae-Seo Rhee, Chul Hee Lee, Dong-Young Ki. Anti-allergic effects of So-Cheong-Ryong-Tang, a traditional Korean herbal medicine, in an allergic rhinitis mouse model. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 270. issue 3. 2013-08-09. PMID:22903755. |
this study shows that scrt induced anti-allergic effects by decreasing, locally and systemically, the th2 cytokine il-4, isotype switching to ige, and eosinophilic infiltration into the nasal mucosa in an allergic rhinitis mouse model. |
2013-08-09 |
2023-08-12 |
mouse |
| Joo Hyun Jung, Il Gyu Kang, Dae Young Kim, You Jin Hwang, Seon Tae Ki. The effect of Korean red ginseng on allergic inflammation in a murine model of allergic rhinitis. Journal of ginseng research. vol 37. issue 2. 2013-05-30. PMID:23717169. |
these results indicate that krg reduces the nasal allergic inflammatory reaction in an allergic murine model by reducing th2 cytokines. |
2013-05-30 |
2023-08-12 |
mouse |
| P Gevaert, K T Nouri-Aria, H Wu, C E Harper, P Takhar, D J Fear, F Acke, N De Ruyck, G Banfield, H H Kariyawasam, C Bachert, S R Durham, H J Goul. Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps. Allergy. vol 68. issue 1. 2013-05-10. PMID:23157682. |
chronic rhinosinusitis with nasal polyps (np) and allergic rhinitis (ar) is characterized by local th2 inflammation and up-regulation of ige; however, ige in np is 'polyclonal' and allergen specific, whereas ige in ar is 'oligoclonal' and allergen specific. |
2013-05-10 |
2023-08-12 |
Not clear |
| Jyoti V Thaikoottathil, Richard J Martin, Peter Y Di, Maisha Minor, Stephanie Case, Bicheng Zhang, Gongyi Zhang, Hua Huang, Hong Wei Ch. SPLUNC1 deficiency enhances airway eosinophilic inflammation in mice. American journal of respiratory cell and molecular biology. vol 47. issue 2. 2013-01-15. PMID:22499853. |
short palate, lung and nasal epithelium clone 1 (splunc1) is enriched in normal airway lining fluid, but is significantly reduced in airway epithelium exposed to a th2 cytokine milieu. |
2013-01-15 |
2023-08-12 |
mouse |
| Paul C Potter, Ruby Pawanka. Indications, efficacy, and safety of intranasal corticosteriods in rhinosinusitis. The World Allergy Organization journal. vol 5 Suppl 1. 2013-01-04. PMID:23282890. |
nasal polyposis is often associated with increased numbers of th2 lymphocytes, fibroblasts, goblet cells, mast cells, and eosinophils, with upregulation of il-13 and the release of specific ige to staphylococcal enterotoxins. |
2013-01-04 |
2023-08-12 |
human |
| T Groot Kormelink, L Calus, N De Ruyck, G Holtappels, C Bachert, F A Redegeld, P Gevaer. Local free light chain expression is increased in chronic rhinosinusitis with nasal polyps. Allergy. vol 67. issue 9. 2013-01-03. PMID:22765846. |
a role for mast cells is suggested in chronic rhinosinusitis with nasal polyposis (crswnp), which is characterized by a local th2 inflammatory response. |
2013-01-03 |
2023-08-12 |
Not clear |
| Paul C Potter, Ruby Pawanka. Indications, efficacy, and safety of intranasal corticosteriods in rhinosinusitis. The World Allergy Organization journal. vol 5. issue Suppl 1. 2012-12-27. PMID:23268478. |
nasal polyposis is often associated with increased numbers of th2 lymphocytes, fibroblasts, goblet cells, mast cells, and eosinophils, with upregulation of il-13 and the release of specific ige to staphylococcal enterotoxins. |
2012-12-27 |
2023-08-12 |
human |
| L Klimek, P Högger, O Pfaa. [Mechanism of action of nasal glucocorticosteroids in the treatment of allergic rhinitis. Part 1: Pathophysiology, molecular basis]. HNO. vol 60. issue 7. 2012-12-13. PMID:22532281. |
nasal exposure to allergens leads to infiltration of inflammatory cells, such as activated eosinophils and t helper type 2 (th2) cells, into the nasal mucosa by chemoattractant factors such as cytokines including interleukin 5 (il-5), chemical mediators including cyslts and chemokines including eotaxin. |
2012-12-13 |
2023-08-12 |
Not clear |
| Guy W Scadding, Moises A Calderon, Virginia Bellido, Gitte Konsgaard Koed, Niels-Christian Nielsen, Kaare Lund, Alkis Togias, Deborah Phippard, Laurence A Turka, Trevor T Hansel, Stephen R Durham, Peter Adler Wurtze. Optimisation of grass pollen nasal allergen challenge for assessment of clinical and immunological outcomes. Journal of immunological methods. vol 384. issue 1-2. 2012-12-07. PMID:22759401. |
tryptase in local nasal secretions is a potential biomarker of the early phase response; ecp and the th2 cytokines il-5, -13 and -4 markers of late phase allergic responses. |
2012-12-07 |
2023-08-12 |
human |
| Mary S Georgy, Carol A Saltou. Chapter 3: Allergen immunotherapy: definition, indication, and reactions. Allergy and asthma proceedings. vol 33 Suppl 1. 2012-11-16. PMID:22794676. |
humoral, cellular, and tissue level changes occur with allergen immunotherapy including large increases in antiallergen igg(4) antibodies, a decrease in the postseasonal rise of antiallergen ige antibodies, reduced numbers of nasal mucosal mast cells and eosinophils, induction of treg cells, and suppression of th2 more than th1 lymphocytes. |
2012-11-16 |
2023-08-12 |
Not clear |
| Mary S Georgy, Anju T Peter. Chapter 7: Nasal polyps. Allergy and asthma proceedings. vol 33 Suppl 1. 2012-11-16. PMID:22794680. |
staphylococcal superantigens may play a role in the th2 type of chronic eosinophilic inflammation observed in nasal polyps. |
2012-11-16 |
2023-08-12 |
Not clear |