| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gina Paris, Tatyana Pozharskaya, Tomefa Asempa, Andrew P Lan. Damage-associated molecular patterns stimulate interleukin-33 expression in nasal polyp epithelial cells. International forum of allergy & rhinology. vol 4. issue 1. 2014-10-20. PMID:24574111. |
chronic rhinosinusitis with nasal polyps (crswnp) is a disorder characterized by eosinophilic inflammation and local t-helper 2 (th2) cytokine production. |
2014-10-20 |
2023-08-12 |
Not clear |
| Gina Paris, Tatyana Pozharskaya, Tomefa Asempa, Andrew P Lan. Damage-associated molecular patterns stimulate interleukin-33 expression in nasal polyp epithelial cells. International forum of allergy & rhinology. vol 4. issue 1. 2014-10-20. PMID:24574111. |
innate lymphoid cells that elaborate th2 cytokines have recently been characterized within nasal polyps. |
2014-10-20 |
2023-08-12 |
Not clear |
| Y J Jun, S J Park, J W Hwang, T H Kim, K J Jung, J Y Jung, G H Hwang, S H Lee, S H Le. Differential expression of 11β-hydroxysteroid dehydrogenase type 1 and 2 in mild and moderate/severe persistent allergic nasal mucosa and regulation of their expression by Th2 cytokines: asthma and rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 44. issue 2. 2014-09-19. PMID:24447082. |
differential expression of 11β-hydroxysteroid dehydrogenase type 1 and 2 in mild and moderate/severe persistent allergic nasal mucosa and regulation of their expression by th2 cytokines: asthma and rhinitis. |
2014-09-19 |
2023-08-12 |
Not clear |
| Mário Henrique M Barros, Franziska Hauck, Johannes H Dreyer, Bettina Kempkes, Gerald Niedobite. Macrophage polarisation: an immunohistochemical approach for identifying M1 and M2 macrophages. PloS one. vol 8. issue 11. 2014-06-30. PMID:24260507. |
to test this hypothesis, we have studied conditions associated with th1- and th2-predominant immune responses: infectious mononucleosis and crohn's disease for th1 and allergic nasal polyps, oxyuriasis, wound healing and foreign body granulomas for predominant th2 response. |
2014-06-30 |
2023-08-12 |
Not clear |
| Rogério Pezato, Leonardo Balsalobre, Milena Lima, Thiago F P Bezerra, Richard L Voegels, Luis Carlos Gregório, Aldo Cassol Stamm, Thibaut van Zel. Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling. Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale. vol 42. 2014-06-12. PMID:23663431. |
these two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired t regulation and favoring of a th2 immune response.in patients with nasal polyposis, an exaggerated immune response to staphylococcus aureus may aggravate the airway remodeling process. |
2014-06-12 |
2023-08-12 |
Not clear |
| Daniel L Hamilo. Host-microbial interactions in patients with chronic rhinosinusitis. The Journal of allergy and clinical immunology. vol 133. issue 3. 2014-05-02. PMID:24290275. |
a downregulation of innate immunity by maladaptive th2 tissue inflammation has also been described in patients with recalcitrant nasal polyps, suggesting a link to persistent infection. |
2014-05-02 |
2023-08-12 |
Not clear |
| Huan Zhang, Lars Olaf Cardell, Janne Bjorkander, Mikael Benson, Hui Wan. Comprehensive profiling of peripheral immune cells and subsets in patients with intermittent allergic rhinitis compared to healthy controls and after treatment with glucocorticoids. Inflammation. vol 36. issue 4. 2014-03-21. PMID:23413042. |
local allergic inflammation in the nasal mucosa is associated with increased circulating th2 cells, eosinophils, and basophils. |
2014-03-21 |
2023-08-12 |
Not clear |
| Andrés E Ibañez, Paola Smaldini, Lorena M Coria, María V Delpino, Lucila G G Pacífico, Sergio C Oliveira, Gabriela S Risso, Karina A Pasquevich, Carlos Alberto Fossati, Guillermo H Giambartolomei, Guillermo H Docena, Juliana Cassatar. Unlipidated outer membrane protein Omp16 (U-Omp16) from Brucella spp. as nasal adjuvant induces a Th1 immune response and modulates the Th2 allergic response to cow's milk proteins. PloS one. vol 8. issue 7. 2014-02-13. PMID:23861971. |
as nasal adjuvant induces a th1 immune response and modulates the th2 allergic response to cow's milk proteins. |
2014-02-13 |
2023-08-12 |
mouse |
| S B Wang, Y Q Deng, J Ren, B K Xiao, Z Chen, Z Z Ta. Lactoferrin administration into the nostril alleviates murine allergic rhinitis and its mechanisms. Scandinavian journal of immunology. vol 78. issue 6. 2014-02-07. PMID:24111738. |
we found that the number of eosinophils and goblet cells, as well as mrna and protein expression of type 2 helper t (th2), th17 and regulatory t (treg) cells in the nasal cavity, was significantly upregulated in ar mice compared with the controls, conversely, administration of rhlf prior to or after intranasal ovalbumin challenge markedly downregulated these same parameters. |
2014-02-07 |
2023-08-12 |
mouse |
| S B Wang, Y Q Deng, J Ren, B K Xiao, Z Chen, Z Z Ta. Lactoferrin administration into the nostril alleviates murine allergic rhinitis and its mechanisms. Scandinavian journal of immunology. vol 78. issue 6. 2014-02-07. PMID:24111738. |
exogenous rhlf inhibited allergic inflammation in ar mice, most likely by promoting the endogenous lf expression and skewing t cells to a th1, but not a th2 and th17 phenotype in the nasal mucosa. |
2014-02-07 |
2023-08-12 |
mouse |
| Joanne L Shaw, Samer Fakhri, Martin J Citardi, Paul C Porter, David B Corry, Farrah Kheradmand, Yong-Jun Liu, Amber Luon. IL-33-responsive innate lymphoid cells are an important source of IL-13 in chronic rhinosinusitis with nasal polyps. American journal of respiratory and critical care medicine. vol 188. issue 4. 2014-02-04. PMID:23805875. |
chronic rhinosinusitis (crs) without nasal polyps (crssnp) and crs with nasal polyps (crswnp) are associated with th1 and th2 cytokine polarization, respectively; however, the pathophysiology of crs remains unclear. |
2014-02-04 |
2023-08-12 |
Not clear |
| Yue-Qi Sun, Meng-Xia Deng, Jia He, Qing-Xiang Zeng, Weiping Wen, David S H Wong, Hung-Fat Tse, Geng Xu, Qizhou Lian, Jianbo Shi, Qing-Ling F. Human pluripotent stem cell-derived mesenchymal stem cells prevent allergic airway inflammation in mice. Stem cells (Dayton, Ohio). vol 30. issue 12. 2013-09-06. PMID:22987325. |
in addition, treatment with ipsc-mscs or bm-mscs before the challenge phase resulted in reduced serum levels of th2 immunoglobulins (e.g., ige) and decreased levels of th2 cytokines including interleukin (il)-4, il-5, or il-13 in the bronchoalveolar and/or nasal lavage fluids. |
2013-09-06 |
2023-08-12 |
mouse |
| L Klimek, L von Bernus, O Pfaa. [Local (exclusive) IgE production in the nasal mucosa. Evidence for local allergic rhinitis]. HNO. vol 61. issue 3. 2013-08-30. PMID:23241861. |
however, there is evidence for specific th2 cytokine, tryptase, and ecp (eosinophil catonic protein) production in the nasal secretion after allergen exposure in these patients without systemic sensitization. |
2013-08-30 |
2023-08-12 |
Not clear |
| Qiang Zhang, Jia Xu, Yuru L. [Advances in cytokine immune mechanisms of allergic rhinitis]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 26. issue 23. 2013-08-15. PMID:23451486. |
the mechanism of ar is caused by the imbalance of the th1/th2, a kind of allergic inflammation who is characterized by the nasal th2 immune response dominant. |
2013-08-15 |
2023-08-12 |
Not clear |
| Ji-Hun Mo, Seung-Eun Lee, Jee Hye Wee, Ji-Eun Lee, Chae-Seo Rhee, Chul Hee Lee, Dong-Young Ki. Anti-allergic effects of So-Cheong-Ryong-Tang, a traditional Korean herbal medicine, in an allergic rhinitis mouse model. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 270. issue 3. 2013-08-09. PMID:22903755. |
scrt significantly reduced expression of the th2 cytokine, il-4; however, the expression of il-5, ifn-γ, and il-10 was unchanged in the nasal mucosa of the treatment group (by real-time rt-pcr). |
2013-08-09 |
2023-08-12 |
mouse |
| Ji-Hun Mo, Seung-Eun Lee, Jee Hye Wee, Ji-Eun Lee, Chae-Seo Rhee, Chul Hee Lee, Dong-Young Ki. Anti-allergic effects of So-Cheong-Ryong-Tang, a traditional Korean herbal medicine, in an allergic rhinitis mouse model. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 270. issue 3. 2013-08-09. PMID:22903755. |
this study shows that scrt induced anti-allergic effects by decreasing, locally and systemically, the th2 cytokine il-4, isotype switching to ige, and eosinophilic infiltration into the nasal mucosa in an allergic rhinitis mouse model. |
2013-08-09 |
2023-08-12 |
mouse |
| Joo Hyun Jung, Il Gyu Kang, Dae Young Kim, You Jin Hwang, Seon Tae Ki. The effect of Korean red ginseng on allergic inflammation in a murine model of allergic rhinitis. Journal of ginseng research. vol 37. issue 2. 2013-05-30. PMID:23717169. |
these results indicate that krg reduces the nasal allergic inflammatory reaction in an allergic murine model by reducing th2 cytokines. |
2013-05-30 |
2023-08-12 |
mouse |
| P Gevaert, K T Nouri-Aria, H Wu, C E Harper, P Takhar, D J Fear, F Acke, N De Ruyck, G Banfield, H H Kariyawasam, C Bachert, S R Durham, H J Goul. Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps. Allergy. vol 68. issue 1. 2013-05-10. PMID:23157682. |
chronic rhinosinusitis with nasal polyps (np) and allergic rhinitis (ar) is characterized by local th2 inflammation and up-regulation of ige; however, ige in np is 'polyclonal' and allergen specific, whereas ige in ar is 'oligoclonal' and allergen specific. |
2013-05-10 |
2023-08-12 |
Not clear |
| Jyoti V Thaikoottathil, Richard J Martin, Peter Y Di, Maisha Minor, Stephanie Case, Bicheng Zhang, Gongyi Zhang, Hua Huang, Hong Wei Ch. SPLUNC1 deficiency enhances airway eosinophilic inflammation in mice. American journal of respiratory cell and molecular biology. vol 47. issue 2. 2013-01-15. PMID:22499853. |
short palate, lung and nasal epithelium clone 1 (splunc1) is enriched in normal airway lining fluid, but is significantly reduced in airway epithelium exposed to a th2 cytokine milieu. |
2013-01-15 |
2023-08-12 |
mouse |
| Paul C Potter, Ruby Pawanka. Indications, efficacy, and safety of intranasal corticosteriods in rhinosinusitis. The World Allergy Organization journal. vol 5 Suppl 1. 2013-01-04. PMID:23282890. |
nasal polyposis is often associated with increased numbers of th2 lymphocytes, fibroblasts, goblet cells, mast cells, and eosinophils, with upregulation of il-13 and the release of specific ige to staphylococcal enterotoxins. |
2013-01-04 |
2023-08-12 |
human |