| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhao Wei Gu, Yun Xiu Wang, Zhi Wei Ca. Neutralization of interleukin-17 suppresses allergic rhinitis symptoms by downregulating Th2 and Th17 responses and upregulating the Treg response. Oncotarget. vol 8. issue 14. 2017-09-15. PMID:28423590. |
anti-il-17 abs markedly reduced the number of nasal rubbing motions and sneezes, decreased eosinophil and neutrophil infiltration, reduced th2 and th17 responses, and increased the treg response. |
2017-09-15 |
2023-08-13 |
mouse |
| Emily P S Lam, Harsha H Kariyawasam, Batika M J Rana, Stephen R Durham, Andrew N J McKenzie, Nicholas Powell, Nara Orban, Melissa Lennartz-Walker, Claire Hopkins, Sun Ying, Joanne Rimmer, Valerie J Lund, David J Cousins, Stephen J Til. IL-25/IL-33-responsive TH2 cells characterize nasal polyps with a default TH17 signature in nasal mucosa. The Journal of allergy and clinical immunology. vol 137. issue 5. 2017-06-14. PMID:26684290. |
il-25/il-33-responsive th2 cells characterize nasal polyps with a default th17 signature in nasal mucosa. |
2017-06-14 |
2023-08-13 |
Not clear |
| Emily P S Lam, Harsha H Kariyawasam, Batika M J Rana, Stephen R Durham, Andrew N J McKenzie, Nicholas Powell, Nara Orban, Melissa Lennartz-Walker, Claire Hopkins, Sun Ying, Joanne Rimmer, Valerie J Lund, David J Cousins, Stephen J Til. IL-25/IL-33-responsive TH2 cells characterize nasal polyps with a default TH17 signature in nasal mucosa. The Journal of allergy and clinical immunology. vol 137. issue 5. 2017-06-14. PMID:26684290. |
chronic rhinosinusitis with nasal polyposis (crswnp) in western countries is characterized by eosinophilia, ige production, and th2 cytokine expression. |
2017-06-14 |
2023-08-13 |
Not clear |
| Dilidaer, Yan Zheng, Zhuofu Liu, Xianting Hu, Jia Zhang, Li Hu, Miaomiao Han, Dehui Wang, Huabin L. Increased BAFF expression in nasal polyps is associated with local IgE production, Th2 response and concomitant asthma. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 274. issue 4. 2017-05-10. PMID:28035475. |
increased baff expression in nasal polyps is associated with local ige production, th2 response and concomitant asthma. |
2017-05-10 |
2023-08-13 |
human |
| Niyazi Altıntoprak, Murat Kar, Nuray Bayar Muluk, Tugba Oktemer, Kagan Ipci, Leman Birdane, Mitat Aricigil, Mehmet Senturk, Sameer Ali Bafaqeeh, Cemal Cing. Update on local allergic rhinitis. International journal of pediatric otorhinolaryngology. vol 87. 2017-04-17. PMID:27368453. |
lar is a localised nasal allergic response in the absence of systemic atopy characterised by local production of specific ige (sige) antibodies, a th2 pattern of mucosal cell infiltration during natural exposure to aeroallergens, and a positive nasal allergen provocation test response, with the release of inflammatory mediators. |
2017-04-17 |
2023-08-13 |
Not clear |
| Senthil Murugappan, Henderik W Frijlink, Nikolai Petrovsky, Wouter L J Hinrich. Enhanced pulmonary immunization with aerosolized inactivated influenza vaccine containing delta inulin adjuvant. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 66. 2017-03-13. PMID:25459531. |
however, pulmonary administration of whole inactivated influenza virus (wiv) vaccine induces a th2 dominant systemic immune response while a more balanced th1/th2 vaccine response may be preferred and only induces modest nasal immunity. |
2017-03-13 |
2023-08-13 |
Not clear |
| Shoko Akasaki, Kazufumi Matsushita, Yukinori Kato, Ayumi Fukuoka, Naruhito Iwasaki, Masakiyo Nakahira, Shigeharu Fujieda, Koubun Yasuda, Tomohiro Yoshimot. Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways. International immunology. vol 28. issue 2. 2016-12-13. PMID:26428949. |
murine allergic rhinitis and nasal th2 activation are mediated via tslp- and il-33-signaling pathways. |
2016-12-13 |
2023-08-13 |
mouse |
| Shoko Akasaki, Kazufumi Matsushita, Yukinori Kato, Ayumi Fukuoka, Naruhito Iwasaki, Masakiyo Nakahira, Shigeharu Fujieda, Koubun Yasuda, Tomohiro Yoshimot. Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways. International immunology. vol 28. issue 2. 2016-12-13. PMID:26428949. |
of note, th2 activation and nasal eosinophilia were comparable between wt and tslpr-deficient mice. |
2016-12-13 |
2023-08-13 |
mouse |
| Shoko Akasaki, Kazufumi Matsushita, Yukinori Kato, Ayumi Fukuoka, Naruhito Iwasaki, Masakiyo Nakahira, Shigeharu Fujieda, Koubun Yasuda, Tomohiro Yoshimot. Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways. International immunology. vol 28. issue 2. 2016-12-13. PMID:26428949. |
st2- and il-33-deficient mice showed defective th2 activation and nasal eosinophilia to acute, but not chronic, ragweed exposure. |
2016-12-13 |
2023-08-13 |
mouse |
| Shoko Akasaki, Kazufumi Matsushita, Yukinori Kato, Ayumi Fukuoka, Naruhito Iwasaki, Masakiyo Nakahira, Shigeharu Fujieda, Koubun Yasuda, Tomohiro Yoshimot. Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways. International immunology. vol 28. issue 2. 2016-12-13. PMID:26428949. |
tslpr and st2 double-deficient mice showed defective th2 activation and nasal eosinophilia even after chronic ragweed exposure. |
2016-12-13 |
2023-08-13 |
mouse |
| Shoko Akasaki, Kazufumi Matsushita, Yukinori Kato, Ayumi Fukuoka, Naruhito Iwasaki, Masakiyo Nakahira, Shigeharu Fujieda, Koubun Yasuda, Tomohiro Yoshimot. Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways. International immunology. vol 28. issue 2. 2016-12-13. PMID:26428949. |
the il-33/st2 pathway is central to nasal th2 activation during acute allergen exposure, but both tslpr and st2 contribute to th2 responses in chronically allergen-exposed mice. |
2016-12-13 |
2023-08-13 |
mouse |
| Benjamin S Bleier, Amy Singleton, Angela L Nocera, Armine Kocharyan, Victoria Petkova, Xue Ha. P-glycoprotein regulates Staphylococcus aureus enterotoxin B-stimulated interleukin-5 and thymic stromal lymphopoietin secretion in organotypic mucosal explants. International forum of allergy & rhinology. vol 6. issue 2. 2016-11-11. PMID:26625351. |
t-helper 2 (th2) inflammation is a hallmark of chronic rhinosinusitis with nasal polyps (crswnp) although the pathogenesis is poorly understood. |
2016-11-11 |
2023-08-13 |
Not clear |
| Mohammad Farhadi, Mitra Barati, Azardokht Tabatabaii, Mehdi Shekarabi, Samileh Noorbakhsh, Shima Javadini. Th1 and Th2 cytokine gene expression in atopic and nonatopic patients with nasal polyposis. Ear, nose, & throat journal. vol 94. issue 6. 2016-11-08. PMID:26053980. |
th1 and th2 cytokine gene expression in atopic and nonatopic patients with nasal polyposis. |
2016-11-08 |
2023-08-13 |
Not clear |
| Mohammad Farhadi, Mitra Barati, Azardokht Tabatabaii, Mehdi Shekarabi, Samileh Noorbakhsh, Shima Javadini. Th1 and Th2 cytokine gene expression in atopic and nonatopic patients with nasal polyposis. Ear, nose, & throat journal. vol 94. issue 6. 2016-11-08. PMID:26053980. |
the lymphocytes that infiltrate nasal polyps have been identified as predominantly memory t cells in an activated state, and these cells produce a mixed cytokine pattern of t1 helper (th1) and t2 helper (th2) cells. |
2016-11-08 |
2023-08-13 |
Not clear |
| Mohammad Farhadi, Mitra Barati, Azardokht Tabatabaii, Mehdi Shekarabi, Samileh Noorbakhsh, Shima Javadini. Th1 and Th2 cytokine gene expression in atopic and nonatopic patients with nasal polyposis. Ear, nose, & throat journal. vol 94. issue 6. 2016-11-08. PMID:26053980. |
our research suggests that an imbalance of th1 and th2 cells plays an important role in the pathophysiology of nasal polyps. |
2016-11-08 |
2023-08-13 |
Not clear |
| Manik Chandra Shill, Hiroyuki Mizuguchi, Sanmoy Karmakar, Takuya Kadota, Pulok K Mukherjee, Yoshiaki Kitamura, Yoshiki Kashiwada, Hisao Nemoto, Noriaki Takeda, Hiroyuki Fuku. A novel benzofuran, 4-methoxybenzofuran-5-carboxamide, from Tephrosia purpurea suppressed histamine H1 receptor gene expression through a protein kinase C-δ-dependent signaling pathway. International immunopharmacology. vol 30. 2016-09-30. PMID:26619301. |
data suggest that mbca alleviates nasal symptoms in tdi-sensitized rats through the inhibition of h1r and th2 cytokine gene expression. |
2016-09-30 |
2023-08-13 |
rat |
| Yung-An Tsou, Chia-Der Lin, Hui-Chen Chen, Hui-Ying Hsu, Lii-Tzu Wu, Chuan Chiang-Ni, Chih-Jung Chen, Tsu-Fang Wu, Min-Chuan Kao, Yu-An Chen, Ming-Te Peng, Ming-Hsui Tsai, Chuan-Mu Chen, Chih-Ho La. Interleukin-13 Inhibits Lipopolysaccharide-Induced BPIFA1 Expression in Nasal Epithelial Cells. PloS one. vol 10. issue 12. 2016-06-20. PMID:26646664. |
interleukin 13 (il-13), predominately secreted by t helper 2 (th2) cells, has been found to contribute to airway allergies and suppress bpifa1 expression in nasal epithelial cells. |
2016-06-20 |
2023-08-13 |
human |
| Rui Tada, Akira Hidaka, Naoko Iwase, Saeko Takahashi, Yuki Yamakita, Tomoko Iwata, Shoko Muto, Emi Sato, Noriko Takayama, Emi Honjo, Hiroshi Kiyono, Jun Kunisawa, Yukihiko Aramak. Intranasal Immunization with DOTAP Cationic Liposomes Combined with DC-Cholesterol Induces Potent Antigen-Specific Mucosal and Systemic Immune Responses in Mice. PloS one. vol 10. issue 10. 2016-06-02. PMID:26440657. |
intranasal vaccination with ovalbumin (ova) in combination with dotap/dc-chol liposomes induced the production of ova-specific iga in nasal tissues and increased serum igg1 levels, suggesting that the cationic dotap/dc-chol liposome leads to the induction of a th2 immune response. |
2016-06-02 |
2023-08-13 |
mouse |
| Claus Bachert, Luo Zhang, Phillippe Gevaer. Current and future treatment options for adult chronic rhinosinusitis: Focus on nasal polyposis. The Journal of allergy and clinical immunology. vol 136. issue 6. 2016-04-26. PMID:26654192. |
several clinical phenotypes often leading to uncontrolled disease, including adult nasal polyposis, aspirin-exacerbated respiratory disease, and allergic fungal rhinosinusitis, are characterized by a common endotype: a th2 bias is associated with a higher likelihood of comorbid asthma and recurrence after surgical treatment. |
2016-04-26 |
2023-08-13 |
Not clear |
| Claus Bachert, Luo Zhang, Phillippe Gevaer. Current and future treatment options for adult chronic rhinosinusitis: Focus on nasal polyposis. The Journal of allergy and clinical immunology. vol 136. issue 6. 2016-04-26. PMID:26654192. |
as a consequence, several innovative approaches targeting the th2 bias with humanized mabs have been subjected to proof-of-concept studies in patients with crs with nasal polyps with or without comorbid asthma: omalizumab, reslizumab, mepolizumab, and recently dupilumab. |
2016-04-26 |
2023-08-13 |
Not clear |