| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shoko Akasaki, Kazufumi Matsushita, Yukinori Kato, Ayumi Fukuoka, Naruhito Iwasaki, Masakiyo Nakahira, Shigeharu Fujieda, Koubun Yasuda, Tomohiro Yoshimot. Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways. International immunology. vol 28. issue 2. 2016-12-13. PMID:26428949. |
murine allergic rhinitis and nasal th2 activation are mediated via tslp- and il-33-signaling pathways. |
2016-12-13 |
2023-08-13 |
mouse |
| Shoko Akasaki, Kazufumi Matsushita, Yukinori Kato, Ayumi Fukuoka, Naruhito Iwasaki, Masakiyo Nakahira, Shigeharu Fujieda, Koubun Yasuda, Tomohiro Yoshimot. Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways. International immunology. vol 28. issue 2. 2016-12-13. PMID:26428949. |
of note, th2 activation and nasal eosinophilia were comparable between wt and tslpr-deficient mice. |
2016-12-13 |
2023-08-13 |
mouse |
| Shoko Akasaki, Kazufumi Matsushita, Yukinori Kato, Ayumi Fukuoka, Naruhito Iwasaki, Masakiyo Nakahira, Shigeharu Fujieda, Koubun Yasuda, Tomohiro Yoshimot. Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways. International immunology. vol 28. issue 2. 2016-12-13. PMID:26428949. |
st2- and il-33-deficient mice showed defective th2 activation and nasal eosinophilia to acute, but not chronic, ragweed exposure. |
2016-12-13 |
2023-08-13 |
mouse |
| Shoko Akasaki, Kazufumi Matsushita, Yukinori Kato, Ayumi Fukuoka, Naruhito Iwasaki, Masakiyo Nakahira, Shigeharu Fujieda, Koubun Yasuda, Tomohiro Yoshimot. Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways. International immunology. vol 28. issue 2. 2016-12-13. PMID:26428949. |
tslpr and st2 double-deficient mice showed defective th2 activation and nasal eosinophilia even after chronic ragweed exposure. |
2016-12-13 |
2023-08-13 |
mouse |
| Shoko Akasaki, Kazufumi Matsushita, Yukinori Kato, Ayumi Fukuoka, Naruhito Iwasaki, Masakiyo Nakahira, Shigeharu Fujieda, Koubun Yasuda, Tomohiro Yoshimot. Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways. International immunology. vol 28. issue 2. 2016-12-13. PMID:26428949. |
the il-33/st2 pathway is central to nasal th2 activation during acute allergen exposure, but both tslpr and st2 contribute to th2 responses in chronically allergen-exposed mice. |
2016-12-13 |
2023-08-13 |
mouse |
| Benjamin S Bleier, Amy Singleton, Angela L Nocera, Armine Kocharyan, Victoria Petkova, Xue Ha. P-glycoprotein regulates Staphylococcus aureus enterotoxin B-stimulated interleukin-5 and thymic stromal lymphopoietin secretion in organotypic mucosal explants. International forum of allergy & rhinology. vol 6. issue 2. 2016-11-11. PMID:26625351. |
t-helper 2 (th2) inflammation is a hallmark of chronic rhinosinusitis with nasal polyps (crswnp) although the pathogenesis is poorly understood. |
2016-11-11 |
2023-08-13 |
Not clear |
| Mohammad Farhadi, Mitra Barati, Azardokht Tabatabaii, Mehdi Shekarabi, Samileh Noorbakhsh, Shima Javadini. Th1 and Th2 cytokine gene expression in atopic and nonatopic patients with nasal polyposis. Ear, nose, & throat journal. vol 94. issue 6. 2016-11-08. PMID:26053980. |
th1 and th2 cytokine gene expression in atopic and nonatopic patients with nasal polyposis. |
2016-11-08 |
2023-08-13 |
Not clear |
| Mohammad Farhadi, Mitra Barati, Azardokht Tabatabaii, Mehdi Shekarabi, Samileh Noorbakhsh, Shima Javadini. Th1 and Th2 cytokine gene expression in atopic and nonatopic patients with nasal polyposis. Ear, nose, & throat journal. vol 94. issue 6. 2016-11-08. PMID:26053980. |
the lymphocytes that infiltrate nasal polyps have been identified as predominantly memory t cells in an activated state, and these cells produce a mixed cytokine pattern of t1 helper (th1) and t2 helper (th2) cells. |
2016-11-08 |
2023-08-13 |
Not clear |
| Mohammad Farhadi, Mitra Barati, Azardokht Tabatabaii, Mehdi Shekarabi, Samileh Noorbakhsh, Shima Javadini. Th1 and Th2 cytokine gene expression in atopic and nonatopic patients with nasal polyposis. Ear, nose, & throat journal. vol 94. issue 6. 2016-11-08. PMID:26053980. |
our research suggests that an imbalance of th1 and th2 cells plays an important role in the pathophysiology of nasal polyps. |
2016-11-08 |
2023-08-13 |
Not clear |
| Manik Chandra Shill, Hiroyuki Mizuguchi, Sanmoy Karmakar, Takuya Kadota, Pulok K Mukherjee, Yoshiaki Kitamura, Yoshiki Kashiwada, Hisao Nemoto, Noriaki Takeda, Hiroyuki Fuku. A novel benzofuran, 4-methoxybenzofuran-5-carboxamide, from Tephrosia purpurea suppressed histamine H1 receptor gene expression through a protein kinase C-δ-dependent signaling pathway. International immunopharmacology. vol 30. 2016-09-30. PMID:26619301. |
data suggest that mbca alleviates nasal symptoms in tdi-sensitized rats through the inhibition of h1r and th2 cytokine gene expression. |
2016-09-30 |
2023-08-13 |
rat |
| Yung-An Tsou, Chia-Der Lin, Hui-Chen Chen, Hui-Ying Hsu, Lii-Tzu Wu, Chuan Chiang-Ni, Chih-Jung Chen, Tsu-Fang Wu, Min-Chuan Kao, Yu-An Chen, Ming-Te Peng, Ming-Hsui Tsai, Chuan-Mu Chen, Chih-Ho La. Interleukin-13 Inhibits Lipopolysaccharide-Induced BPIFA1 Expression in Nasal Epithelial Cells. PloS one. vol 10. issue 12. 2016-06-20. PMID:26646664. |
interleukin 13 (il-13), predominately secreted by t helper 2 (th2) cells, has been found to contribute to airway allergies and suppress bpifa1 expression in nasal epithelial cells. |
2016-06-20 |
2023-08-13 |
human |
| Rui Tada, Akira Hidaka, Naoko Iwase, Saeko Takahashi, Yuki Yamakita, Tomoko Iwata, Shoko Muto, Emi Sato, Noriko Takayama, Emi Honjo, Hiroshi Kiyono, Jun Kunisawa, Yukihiko Aramak. Intranasal Immunization with DOTAP Cationic Liposomes Combined with DC-Cholesterol Induces Potent Antigen-Specific Mucosal and Systemic Immune Responses in Mice. PloS one. vol 10. issue 10. 2016-06-02. PMID:26440657. |
intranasal vaccination with ovalbumin (ova) in combination with dotap/dc-chol liposomes induced the production of ova-specific iga in nasal tissues and increased serum igg1 levels, suggesting that the cationic dotap/dc-chol liposome leads to the induction of a th2 immune response. |
2016-06-02 |
2023-08-13 |
mouse |
| Claus Bachert, Luo Zhang, Phillippe Gevaer. Current and future treatment options for adult chronic rhinosinusitis: Focus on nasal polyposis. The Journal of allergy and clinical immunology. vol 136. issue 6. 2016-04-26. PMID:26654192. |
several clinical phenotypes often leading to uncontrolled disease, including adult nasal polyposis, aspirin-exacerbated respiratory disease, and allergic fungal rhinosinusitis, are characterized by a common endotype: a th2 bias is associated with a higher likelihood of comorbid asthma and recurrence after surgical treatment. |
2016-04-26 |
2023-08-13 |
Not clear |
| Claus Bachert, Luo Zhang, Phillippe Gevaer. Current and future treatment options for adult chronic rhinosinusitis: Focus on nasal polyposis. The Journal of allergy and clinical immunology. vol 136. issue 6. 2016-04-26. PMID:26654192. |
as a consequence, several innovative approaches targeting the th2 bias with humanized mabs have been subjected to proof-of-concept studies in patients with crs with nasal polyps with or without comorbid asthma: omalizumab, reslizumab, mepolizumab, and recently dupilumab. |
2016-04-26 |
2023-08-13 |
Not clear |
| Christina Brandenberger, Jon A Hotchkiss, Shannon M Krieger, Lynn H Pottenger, Jack R Harkem. Inhalation exposure to ethylene induces eosinophilic rhinitis and nasal epithelial remodeling in Fischer 344 rats. Chemico-biological interactions. vol 241. 2016-02-26. PMID:26367701. |
enhanced gene expression of th2 cytokines (e.g., il-5, il-13) and chitinase (ym1/2) in the nasal mucosa was much greater than that of th1 cytokines (e.g., ifnγ) after ethylene exposure. |
2016-02-26 |
2023-08-13 |
rat |
| P Campo, C Rondón, H J Gould, E Barrionuevo, P Gevaert, M Blanc. Local IgE in non-allergic rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 45. issue 5. 2016-01-06. PMID:25495772. |
local allergic rhinitis (lar) is characterized by the presence of a nasal th2 inflammatory response with local production of specific ige antibodies and a positive response to a nasal allergen provocation test (napt) without evidence of systemic atopy. |
2016-01-06 |
2023-08-13 |
human |
| b' P Panzner, I Malkusov\\xc3\\xa1, M Vachov\\xc3\\xa1, M Li\\xc5\\xa1ka, P Brodsk\\xc3\\xa1, O R\\xc5\\xaf\\xc5\\xbei\\xc4\\x8dkov\\xc3\\xa1, M Mal\\xc3\\xb. Bronchial inflammation in seasonal allergic rhinitis with or without asthma in relation to natural exposure to pollen allergens. Allergologia et immunopathologia. vol 43. issue 1. 2015-11-17. PMID:24075536.' |
nasal inflammation in allergic rhinitis enhances bronchial th2 driven inflammation and development of asthma. |
2015-11-17 |
2023-08-12 |
Not clear |
| Dong-Yeop Chang, Yeon-Hee Joo, Seong-Jae Kim, Jin Hyun Kim, Myeong Hee Jung, Dae Woo Kim, Sea-Yuong Jeon, Sang-Wook Ki. Therapeutic effects of intranasal cyclosporine for eosinophilic rhinosinusitis with nasal polyps in a mouse model. American journal of rhinology & allergy. vol 29. issue 1. 2015-10-14. PMID:25590314. |
chronic rhinosinusitis (crs) with nasal polyps (crswnp) is a principally type 2 t helper cell (th2)-mediated inflammatory disease. |
2015-10-14 |
2023-08-13 |
mouse |
| Hyun Jin Min, Hyuna Song, Su Yeon Choi, Tae Hoon Kim, Hyung-Ju Cho, Joo-Heon Yoon, Chang-Hoon Ki. Th2 cytokines differentially regulate psoriasin expression in human nasal epithelia. American journal of rhinology & allergy. vol 28. issue 6. 2015-09-30. PMID:25514480. |
th2 cytokines differentially regulate psoriasin expression in human nasal epithelia. |
2015-09-30 |
2023-08-13 |
human |
| J A Poposki, S Peterson, K Welch, R P Schleimer, K E Hulse, A T Peters, J Norton, L A Suh, R Carter, K E Harris, L C Grammer, B K Tan, R K Chandra, D B Conley, R C Kern, A Kat. Elevated presence of myeloid dendritic cells in nasal polyps of patients with chronic rhinosinusitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 45. issue 2. 2015-09-24. PMID:25469646. |
although chronic rhinosinusitis with nasal polyps (crswnp) is characterized by th2 inflammation, the mechanism underlying the onset and amplification of this inflammation has not been fully elucidated. |
2015-09-24 |
2023-08-13 |
Not clear |