| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naruhito Iwasaki, Seigo Terawaki, Kouhei Shimizu, Daisuke Oikawa, Hirokazu Sakamoto, Kishiko Sunami, Fuminori Tokunag. Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 70. issue 5. 2021-11-10. PMID:33811487. |
we sought to reveal the roles of t helper 2 (th2) cell-derived histamine in nasal allergic disorders. |
2021-11-10 |
2023-08-13 |
mouse |
| Xunshuo Jiang, Taojian Huang, Hongbing Liu, Xubo Chen, Hao Zhang, Ke Liu, Jianjian Deng, Chunping Yan. Circ_0067835 regulates allergic inflammatory response in type-2 innate lymphoid cells in allergic rhinitis (AR) via miR-155/GATA3. Human cell. vol 34. issue 4. 2021-11-05. PMID:33908023. |
helper t cell 2 (th2) cytokines (il-4, il-5, il-9 and il-13) and percentage of type-2 innate lymphoid cells (ilc2s) in nasal mucosa tissues in ar mice model were evaluated needing western blot, elisa, and flow cytometry. |
2021-11-05 |
2023-08-13 |
mouse |
| Weiwei Wang, Hongwei Yu, Yongliang Pan, Shengwen Sha. Combined Treatment With H1 and H4 Receptor Antagonists Improves Th2 Inflammatory Responses in the Nasal Mucosa of Allergic Rhinitis Rats. American journal of rhinology & allergy. vol 35. issue 6. 2021-11-01. PMID:33726554. |
combined treatment with h1 and h4 receptor antagonists improves th2 inflammatory responses in the nasal mucosa of allergic rhinitis rats. |
2021-11-01 |
2023-08-13 |
rat |
| Naruhito Iwasaki, Seigo Terawaki, Kouhei Shimizu, Daisuke Oikawa, Hirokazu Sakamoto, Kishiko Sunami, Fuminori Tokunag. Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling. PloS one. vol 16. issue 3. 2021-10-15. PMID:33662037. |
collectively, these results indicate a novel histamine production mechanism by macrophages, in which th2 cells and macrophages cooperatively induce nasal allergic inflammation through histamine signaling. |
2021-10-15 |
2023-08-13 |
mouse |
| Bing Xu, Xiaozhe Liu, Shihao Ga. IL2-inducible T-cell kinase inhibitor ibrutinib reduces symptoms and Th2 differentiation in mouse allergic-rhinitis model. Drug development research. 2021-10-05. PMID:34609751. |
the symptoms of ar, serum level of immunoglobulin e, percentage of th1, th2, th17, and treg in nasal lymphoid tissues were monitored. |
2021-10-05 |
2023-08-13 |
mouse |
| Bing Xu, Xiaozhe Liu, Shihao Ga. IL2-inducible T-cell kinase inhibitor ibrutinib reduces symptoms and Th2 differentiation in mouse allergic-rhinitis model. Drug development research. 2021-10-05. PMID:34609751. |
ibrutinib treatment had no effects on the development of lymphocytes and myeloid cells, but alleviated ar symptoms and decreased th2 cell population in nasal lymphoid tissue. |
2021-10-05 |
2023-08-13 |
mouse |
| Yung Jin Jeon, Chan Hee Gil, Jina Won, Ara Jo, Hyun Jik Ki. Symbiotic microbiome Staphylococcus aureus from human nasal mucus modulates IL-33-mediated type 2 immune responses in allergic nasal mucosa. BMC microbiology. vol 20. issue 1. 2021-09-07. PMID:33028252. |
we sought to determine the distribution of nasal microbiomes in allergic nasal mucosa and elucidate the interplay between nasal microbiome staphylococcus species and th2 cytokines in allergic rhinitis (ar) models. |
2021-09-07 |
2023-08-13 |
human |
| Brennan J Blight, Amarbir S Gill, Jorgen S Sumsion, Chelsea E Pollard, Shaelene Ashby, Gretchen M Oakley, Jeremiah A Alt, Abigail Pulsiphe. Cell Adhesion Molecules are Upregulated and May Drive Inflammation in Chronic Rhinosinusitis with Nasal Polyposis. Journal of asthma and allergy. vol 14. 2021-06-05. PMID:34079296. |
chronic rhinosinusitis with nasal polyps (crswnp) is predominantly characterized by eosinophil- and t helper 2 cell (th2)-biased inflammation. |
2021-06-05 |
2023-08-13 |
Not clear |
| Xiaofeng Gu, Feng Xiao, Wenmin Lu, Ying Xu, Xia Li, Chenjie Yu, Xinyan Cu. Nanomedicine-mediated prevention of inflammatory monocytes infiltration ameliorate ovalbumin-induced allergic rhinitis in mouse model. Autoimmunity. vol 53. issue 4. 2021-06-03. PMID:32285703. |
th2 immune cells infiltration into nasal mucosa is one of the characters of allergic rhinitis (ar). |
2021-06-03 |
2023-08-13 |
mouse |
| Yuanyuan Zhang, Wei L. Effects of oral desloratadine citrate disodium combined with physiological seawater nasal irrigation on IgE levels, IL-4, IL-6, IL-13 and IFN-γ expression and treatment of intermittent allergic rhinitis. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 5. 2021-06-03. PMID:33040814. |
this experiment was performed to explore the effect of oral desloratadine citrate disodium combined with physiological seawater nasal irrigation in the treatment of intermittent allergic rhinitis and its effect on serum inflammatory factors and peripheral blood th1 and th2. |
2021-06-03 |
2023-08-13 |
Not clear |
| Júlio Cláudio Sousa, Renata Margarida Etchbehere, Eduardo Arthur Rodovalho Alves, Letícia Montes Stark, Eddie Fernando Cândido Murta, Márcia Antoniazi Micheli. Interferon-α action in cytokine profile in eosinophilic nasal polyp cultures. Brazilian journal of otorhinolaryngology. vol 87. issue 3. 2021-06-02. PMID:31870738. |
in the west, approximately 80% of chronic rhinosinusitis with nasal polyps cases are characterized by a predominantly eosinophilic cell infiltrate and a th2 cytokine pattern. |
2021-06-02 |
2023-08-13 |
Not clear |
| Gwanghui Ryu, Dae Woo Ki. Th2 inflammatory responses in the development of nasal polyps and chronic rhinosinusitis. Current opinion in allergy and clinical immunology. vol 20. issue 1. 2021-05-27. PMID:31567293. |
th2 inflammatory responses in the development of nasal polyps and chronic rhinosinusitis. |
2021-05-27 |
2023-08-13 |
Not clear |
| Gwanghui Ryu, Dae Woo Ki. Th2 inflammatory responses in the development of nasal polyps and chronic rhinosinusitis. Current opinion in allergy and clinical immunology. vol 20. issue 1. 2021-05-27. PMID:31567293. |
in this review, we summarized recently updated information in the understanding of mechanisms in the development of chronic rhinosinusitis with nasal polyp (crswnp) focusing on th2 inflammation. |
2021-05-27 |
2023-08-13 |
Not clear |
| Yaqiong Zhu, Yuehui Liu, Xinhua Zhu, Zhi Wang, Meiqun Wan. Upregulation of miR-155 regulates group 2 innate lymphoid cells by targeting c-maf in allergic rhinitis. European journal of pharmacology. vol 887. 2021-05-14. PMID:32946865. |
administration of mir-155 antagomir significantly reduced the activity of ilc2s in nasal mucosa, suppressed the production of th2 cytokines in serum and nasal mucosa, and alleviated the airway inflammation and allergic symptoms in ar mice, while mir-155 agomir increased ilc2s activity and production of th2 cytokines and induced airway inflammation and allergic symptoms in control mice. |
2021-05-14 |
2023-08-13 |
mouse |
| C Yang, N Chen, X L Tang, X H Qian, C P Ca. Immunomodulatory effects of IL-33 and IL-25 in an ovalbumin-induced allergic rhinitis mouse model. Journal of biological regulators and homeostatic agents. vol 35. issue 2. 2021-05-14. PMID:33738997. |
immunomodulatory effects were evaluated by measuring nasal rubbing, sneezing occurrence, serum ova-specific antibodies, th2 immune responses, neutrophil, eosinophil and mast cell recruitment into the nasal mucosa. |
2021-05-14 |
2023-08-13 |
mouse |
| C Yang, N Chen, X L Tang, X H Qian, C P Ca. Immunomodulatory effects of IL-33 and IL-25 in an ovalbumin-induced allergic rhinitis mouse model. Journal of biological regulators and homeostatic agents. vol 35. issue 2. 2021-05-14. PMID:33738997. |
we found that treatment with anti-il-33 ab markedly reduced nasal rubbing, sneezing events, th2 immune responses, serum ova-specific ige and igg1 levels, mucosal neutrophil, eosinophil and mast cell infiltration. |
2021-05-14 |
2023-08-13 |
mouse |
| Hao Zhang, Xinhua Zhu, Xiao Liu, Yaojie Wang, Yuehui Li. Long non-coding RNA FOXD3-AS1 regulates the expression and secretion of IL-25 in nasal epithelial cells to inhibit Th2 type immunoreaction in allergic rhinitis. Molecular and cellular biochemistry. vol 473. issue 1-2. 2021-04-28. PMID:32671514. |
long non-coding rna foxd3-as1 regulates the expression and secretion of il-25 in nasal epithelial cells to inhibit th2 type immunoreaction in allergic rhinitis. |
2021-04-28 |
2023-08-13 |
Not clear |
| G M Zhan. [Left-side endoscopic sinus surgery for Th2 type nasal polyps]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery. vol 56. issue 3. 2021-04-08. PMID:33730820. |
[left-side endoscopic sinus surgery for th2 type nasal polyps]. |
2021-04-08 |
2023-08-13 |
Not clear |
| Tim Delemarre, Natalie De Ruyck, Gabriele Holtappels, Claus Bachert, Elien Gevaer. Unravelling the expression of interleukin-9 in chronic rhinosinusitis: A possible role for Staphylococcus aureus. Clinical and translational allergy. vol 10. issue 1. 2020-12-12. PMID:33292477. |
chronic rhinosinusitis with nasal polyps (crswnp) is a th2 biased inflammation, associated with nasal colonization of staphylococcus (s.) aureus. |
2020-12-12 |
2023-08-13 |
Not clear |
| Selene K Bantz, Zhou Zhu, Tao Zhen. The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma. Journal of clinical & cellular immunology. vol 5. issue 2. 2020-10-01. PMID:25419479. |
this induces systemic th2 immunity that predisposes patients to allergic nasal responses and promotes airway hyper reactivity. |
2020-10-01 |
2023-08-13 |
Not clear |