| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naoto Uda, Sawako Ogata, Norimasa Yamasaki, Shuka Miura, Naohisa Hosomi, Akio Mori, Minoru Gotoh, Kento Miura, Osamu Kaminum. Re-evaluation of over-the-counter histamine H1-receptor antagonists based on their effects on murine models of allergen-induced nasal hyperresponsiveness. Journal of pharmacological sciences. vol 150. issue 4. 2022-11-07. PMID:36344050. |
regardless of the alleviation of stimulation-induced th2 cytokine expression by loratadine and desloratadine in vitro, allergen-induced nhr and nasal eosinophil infiltration in th2 cell-transferred mice were unaffected by loratadine in vivo. |
2022-11-07 |
2023-08-14 |
mouse |
| Takuya Hemmi, Akira Ainai, Takao Hashiguchi, Minoru Tobiume, Takayuki Kanno, Naoko Iwata-Yoshikawa, Shun Iida, Yuko Sato, Sho Miyamoto, Akira Ueno, Kaori Sano, Shinji Saito, Nozomi Shiwa-Sudo, Noriyo Nagata, Koji Tamura, Ryosuke Suzuki, Hideki Hasegawa, Tadaki Suzuk. Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathology. Vaccine. 2022-09-05. PMID:36064667. |
the nasal vaccine of this formulation induced a high number of ifn-γ-secreting cells in the draining cervical lymph nodes and a lower spike-specific igg1/igg2a ratio compared to that of subcutaneous vaccination with alum as a typical th2 adjuvant. |
2022-09-05 |
2023-08-14 |
mouse |
| Qiangyou Shi, Xueliang Shen, Chao Long, Fan Guo, Zhipeng Mi, Yongchun Li, Ruixia M. Investigation of the Immunoprotective Effect of Zinc on Ovalbumin Induced BALB/C Male Mice Based on NF-KB Signaling Pathway. Contrast media & molecular imaging. vol 2022. 2022-08-31. PMID:36043146. |
the experimental results show that zinc supplementation in allergic asthma mice with allergic rhinitis correct the immune response of th2 cells by inhibiting the nf-kb signaling pathway, reduce the infiltration of inflammatory cells into lung nasal tissue, and reduce airway co-hyperreactivity to improve the clinical symptoms of asthma and play an immune protective role. |
2022-08-31 |
2023-08-14 |
mouse |
| Yang Xie, Yuan Zhang, Tianxiao Zhu, Jingchang Ma, Chujun Duan, Lu Yang, Tingting Wang, Ran Zhuang, Ka Bian, Lianjun L. CD226 Deficiency Alleviates Murine Allergic Rhinitis by Suppressing Group 2 Innate Lymphoid Cell Responses. Mediators of inflammation. vol 2022. 2022-07-18. PMID:35846105. |
allergic rhinitis (ar) is an immunoglobulin e-mediated type 2 inflammation of the nasal mucosa that is mainly driven by type 2 helper t cells (th2) and type 2 innate lymphoid cells (ilc2s). |
2022-07-18 |
2023-08-14 |
Not clear |
| Sang-Nam Lee, Seol Ah Yoon, Ji Min Song, Hyung Chul Kim, Hyung-Ju Cho, Augustine M K Choi, Joo-Heon Yoo. Cell-Type Specific Expression of Hyaluronan Synthases HAS2 and HAS3 Promotes Goblet Cell Hyperplasia in Allergic Airway Inflammation. American journal of respiratory cell and molecular biology. 2022-06-09. PMID:35679095. |
we previously demonstrated that the intermediate progenitor cell (ipc) surface marker cd44v3 is upregulated in the basal and suprabasal layers of well-differentiated primary human nasal epithelial (hne) cells after stimulation with the th2 cytokine interleukin (il)-4, and an antibody blocking the cd44v3-ha interaction suppressed il-4-induced goblet cell hyperplasia. |
2022-06-09 |
2023-08-14 |
human |
| Jiasheng Yuan, Yuehui Liu, Juan Yu, Meina Dai, Yu Zhu, Youwei Bao, Haisen Peng, Ke Liu, Xinhua Zh. Gene knockdown of CCR3 reduces eosinophilic inflammation and the Th2 immune response by inhibiting the PI3K/AKT pathway in allergic rhinitis mice. Scientific reports. vol 12. issue 1. 2022-03-31. PMID:35354939. |
deficiency of the bone marrow ccr3 gene caused a remarkable reduction of ccr3 expression and the pi3k/akt signaling pathway activity, inhibited histopathological lesions and eosinophil infiltration of the nasal cavity, and reduced the production of th2 cytokines in serum, which led to the remission of allergic symptoms in ar mice. |
2022-03-31 |
2023-08-13 |
mouse |
| Chengcheng Liu, Wenwen Qi, Zhenxiao Teng, Runtong Xu, Yue Xi, Yiming Qin, Fenglei Xu, Lei Shi, Miaoqing Zhao, Ming Xi. NGR-modified PEG-PLGA micelles containing Shikonin enhance targeting of dendritic cells for therapy of allergic rhinitis. International immunopharmacology. vol 107. 2022-03-14. PMID:35286915. |
allergic rhinitis (ar) is a disease in the nasal mucosa related with th2 lymphocyte inflammatory action. |
2022-03-14 |
2023-08-13 |
Not clear |
| Meijia Wang, Kun Tang, Pengfei Gao, Yanjiao Lu, Shanshan Wang, Xiaojie Wu, Jianping Zhao, Jungang Xi. Club cell 10-kDa protein (CC10) as a surrogate for identifying type 2 asthma phenotypes. The Journal of asthma : official journal of the Association for the Care of Asthma. 2022-02-16. PMID:35168451. |
primarily produced by nonciliated club cells in the distal airway and in nasal epithelial cells, cc10 suppresses th2 cell differentiation and th2 cytokine production. |
2022-02-16 |
2023-08-13 |
Not clear |
| Mohamed H Shamji, Hanisah Sharif, Janice A Layhadi, Rongfei Zhu, Uday Kishore, Harald Ren. Diverse Immune Mechanisms of Allergen Immunotherapy for allergic rhinitis with and without asthma. The Journal of allergy and clinical immunology. 2022-01-30. PMID:35093483. |
this comprehensive review discusses how immune tolerance driven by scit and slit is associated with the induction of a novel regulatory subset of innate lymphoid cells, suppression of pro-inflammatory th2, th2a and t follicular helper cells, promotion of exhaustion of allergen-specific th2 cells and differential expression of nasal and systemic antibodies iga. |
2022-01-30 |
2023-08-13 |
Not clear |
| MeiNa Dai, XinHua Zhu, Juan Yu, JiaSheng Yuan, Yv Zhu, YouWei Bao, XiaoZhuang Yon. CCR3 gene knockout in bone marrow cells ameliorates combined allergic rhinitis and asthma syndrome (CARAS) by reducing airway inflammatory cell infiltration and Th2 cytokines expression in mice model. International immunopharmacology. vol 104. 2022-01-08. PMID:34998035. |
it was found that ccr3-ko significantly reduced eosinophil (eos) migration into the nasal (nalf) and bronchoalveolar (balf) cavities of mice, and decreased th2 cytokines (such as, il-4, il-5 and il-13) levels in nasal mucosa and lung tissues. |
2022-01-08 |
2023-08-13 |
mouse |
| Xiying You, Xiaopeng Sun, Junfei Kong, Jifeng Tian, Yanping Shi, Xia L. D-Pinitol Attenuated Ovalbumin-induced Allergic Rhinitis in Experimental Mice via Balancing Th1/Th2 Response. Iranian journal of allergy, asthma, and immunology. vol 20. issue 6. 2021-12-18. PMID:34920651. |
in ar-induced mice, pinitol had significant modulatory effects on representative markers of th2 (gata binding protein 3), signal transducer and activator of transcription-6, interleukins (il)-4, il-5, il-13, suppressors of cytokine signaling 1, toll-like receptor 4, and myeloid differentiation factor 88), and type 1 t helper (th1) immune responses (t-box protein expressed in t cells and interferon-gamma) as well as the histopathological aberrations induced in the nasal mucosa. |
2021-12-18 |
2023-08-13 |
mouse |
| Kon-Young Ji, Dong Ho Jung, Bo-Jeong Pyun, Yu Jin Kim, Joo Young Lee, Susanna Choi, Myung-A Jung, Kwang Hoon Song, Taesoo Ki. Angelica gigas extract ameliorates allergic rhinitis in an ovalbumin-induced mouse model by inhibiting Th2 cell activation. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 93. 2021-11-22. PMID:34634747. |
allergic rhinitis (ar) is a well-documented type 2 helper t (th2) cell-mediated allergic disease that is accompanied by symptoms such as nasal rubbing, sneezing, itching, and rhinorrhea. |
2021-11-22 |
2023-08-13 |
mouse |
| Bao Liu, Xiangming Huang, Lina Xia, Dandan Wang, Dehong Mu, Li Tia. Effects of Yupingfeng nasal drops on serum cytokines, histopathology and eosinophil cationic protein in nasal mucosa of rats with allergic rhinitis. Pakistan journal of pharmaceutical sciences. vol 34. issue 4. 2021-11-22. PMID:34799307. |
besides, histopathological features, eosinophil cationic protein (ecp) in the nasal mucosa, and expression of type 1 helper t (th1)/type 2 helper t (th2)-related cytokines in serum were analyzed. |
2021-11-22 |
2023-08-13 |
rat |
| Naruhito Iwasaki, Seigo Terawaki, Kouhei Shimizu, Daisuke Oikawa, Hirokazu Sakamoto, Kishiko Sunami, Fuminori Tokunag. Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 70. issue 5. 2021-11-10. PMID:33811487. |
th2 cell-derived histamine is involved in nasal th2 infiltration in mice. |
2021-11-10 |
2023-08-13 |
mouse |
| Naruhito Iwasaki, Seigo Terawaki, Kouhei Shimizu, Daisuke Oikawa, Hirokazu Sakamoto, Kishiko Sunami, Fuminori Tokunag. Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 70. issue 5. 2021-11-10. PMID:33811487. |
we sought to reveal the roles of t helper 2 (th2) cell-derived histamine in nasal allergic disorders. |
2021-11-10 |
2023-08-13 |
mouse |
| Xunshuo Jiang, Taojian Huang, Hongbing Liu, Xubo Chen, Hao Zhang, Ke Liu, Jianjian Deng, Chunping Yan. Circ_0067835 regulates allergic inflammatory response in type-2 innate lymphoid cells in allergic rhinitis (AR) via miR-155/GATA3. Human cell. vol 34. issue 4. 2021-11-05. PMID:33908023. |
helper t cell 2 (th2) cytokines (il-4, il-5, il-9 and il-13) and percentage of type-2 innate lymphoid cells (ilc2s) in nasal mucosa tissues in ar mice model were evaluated needing western blot, elisa, and flow cytometry. |
2021-11-05 |
2023-08-13 |
mouse |
| Weiwei Wang, Hongwei Yu, Yongliang Pan, Shengwen Sha. Combined Treatment With H1 and H4 Receptor Antagonists Improves Th2 Inflammatory Responses in the Nasal Mucosa of Allergic Rhinitis Rats. American journal of rhinology & allergy. vol 35. issue 6. 2021-11-01. PMID:33726554. |
combined treatment with h1 and h4 receptor antagonists improves th2 inflammatory responses in the nasal mucosa of allergic rhinitis rats. |
2021-11-01 |
2023-08-13 |
rat |
| Naruhito Iwasaki, Seigo Terawaki, Kouhei Shimizu, Daisuke Oikawa, Hirokazu Sakamoto, Kishiko Sunami, Fuminori Tokunag. Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling. PloS one. vol 16. issue 3. 2021-10-15. PMID:33662037. |
collectively, these results indicate a novel histamine production mechanism by macrophages, in which th2 cells and macrophages cooperatively induce nasal allergic inflammation through histamine signaling. |
2021-10-15 |
2023-08-13 |
mouse |
| Bing Xu, Xiaozhe Liu, Shihao Ga. IL2-inducible T-cell kinase inhibitor ibrutinib reduces symptoms and Th2 differentiation in mouse allergic-rhinitis model. Drug development research. 2021-10-05. PMID:34609751. |
the symptoms of ar, serum level of immunoglobulin e, percentage of th1, th2, th17, and treg in nasal lymphoid tissues were monitored. |
2021-10-05 |
2023-08-13 |
mouse |
| Bing Xu, Xiaozhe Liu, Shihao Ga. IL2-inducible T-cell kinase inhibitor ibrutinib reduces symptoms and Th2 differentiation in mouse allergic-rhinitis model. Drug development research. 2021-10-05. PMID:34609751. |
ibrutinib treatment had no effects on the development of lymphocytes and myeloid cells, but alleviated ar symptoms and decreased th2 cell population in nasal lymphoid tissue. |
2021-10-05 |
2023-08-13 |
mouse |