| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X F Sun, L J Xi. [The correlation study on pathogenesis of B cell activation factor in eosinophils and neutrophil- predominant chronic rhinosinusitis with nasal polyps]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 33. issue 2. 2019-07-22. PMID:30808151. |
the lesions of nasal polyp have different inflammatory cell infiltration and can be divided into two types in immunophenotpe: the first is characterized by th2 cell reaction and marked eosinophil infiltration,and the second is th1/th17 cell response and non-eosinophil infiltration are characteristic.np, which is mainly infiltrated by neutrophils, is more and more common in china. |
2019-07-22 |
2023-08-13 |
Not clear |
| Aideen C Allen, Mieszko M Wilk, Alicja Misiak, Lisa Borkner, Dearbhla Murphy, Kingston H G Mill. Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting T Mucosal immunology. vol 11. issue 6. 2019-04-08. PMID:30127384. |
sustained protective immunity against bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces il-17-secreting t current acellular pertussis (ap) vaccines induce strong antibody and th2 responses but fail to protect against nasal colonization and transmission of bordetella pertussis. |
2019-04-08 |
2023-08-13 |
mouse |
| Julie A Poposki, Aiko I Klingler, Bruce K Tan, Pejman Soroosh, Homayon Banie, Gavin Lewis, Kathryn E Hulse, Whitney W Stevens, Anju T Peters, Leslie C Grammer, Robert P Schleimer, Kevin C Welch, Stephanie S Smith, David B Conley, Joseph R Raviv, James G Karras, Omid Akbari, Robert C Kern, Atsushi Kat. Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps. Immunity, inflammation and disease. vol 5. issue 3. 2018-12-12. PMID:28474861. |
chronic rhinosinusitis (crs) with nasal polyps (crswnp) is characterized by type 2 inflammation with high levels of th2 cytokines. |
2018-12-12 |
2023-08-13 |
Not clear |
| Xunshuo Jiang, Xiaona Zhang, Jianguo Liu, Jiali Liu, Xinhua Zhu, Chunping Yan. Involvement of T-Helper 9 Activation in a Mouse Model of Allergic Rhinitis. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-10-24. PMID:29982264. |
th1 cells in nasal mucosa, lymph, nasal lavage, spleen, and peripheral blood were significantly reduced, while th2, th9, th17, and treg cells were significantly elevated in the ar group compared with the control group. |
2018-10-24 |
2023-08-13 |
mouse |
| Shenhong Qu, Taijie Qin, Min Li, Shaojie Zhang, Linsong Ye, Jiazhang Wei, Hua Fan, Baiwen Che. The effects of resiquimod in an ovalbumin-induced allergic rhinitis model. International immunopharmacology. vol 59. 2018-10-08. PMID:29665497. |
histological changes in the nasal mucosa were evaluated by hematoxylin and eosin (h & e) and periodic acid-schiff (pas) staining; cytokine levels in serum were measured with enzyme-linked immunosorbent assays (elisas);the mrna expression levels of ifn-γ, il-17 and foxp3 in the spleen determined by quantitative real-time rt-pcr (qrt-pcr); the proportions of th1, th2, th17, treg and tim3 + ifn-γ + th1 cells in the spleen were assessed with flow cytometry; tim1, tim3 and il-33 expression levels in the nasal mucosa were evaluated with immunofluorescence staining(if).r848 alleviated the nasal allergic symptoms; reduced eosinophil cell infiltration, goblet cell hyperplasia in the nasal mucosa; reduced il-13, il-17, il-25 and il-33 levels in serum; upregulated the relative mrna expression of ifn-γ and foxp3, and downregulated the relative mrna expression of il-17 in the spleen; decreased th2, th17 and tim3 + ifn-γ + th1 cells ratios, increased the proportion of th1 and treg cells in the spleen; suppressed tim1 and tim3,but increased il-33 expression in the nasal mucosa in ova-induced ar mice. |
2018-10-08 |
2023-08-13 |
mouse |
| L Zhang, L-L Jiang, Z-W Ca. Interleukin-33 promotes the inflammatory reaction in chronic rhinosinusitis with nasal polyps by NF-κB signaling pathway. European review for medical and pharmacological sciences. vol 21. issue 20. 2018-08-07. PMID:29131267. |
interleukin (il)-33 promotes t helper (th2) immune response and may be involved in the pathogenesis of chronic rhinosinusitis with nasal polyps (crswnp). |
2018-08-07 |
2023-08-13 |
human |
| Gargi Rai, Mohammad Ahmad Ansari, Sajad Ahmad Dar, Shyama Datt, Neelima Gupta, Sonal Sharma, Shafiul Haque, Vishnampettai Ganapathysubramanian Ramachandran, Arpeeta Mazumdar, Shivprakash Rudramurthy, Arunaloke Chakrabarti, Shukla Da. Serum Cytokine Profile in Patients with Chronic Rhinosinusitis with Nasal Polyposis Infected by Aspergillus flavus. Annals of laboratory medicine. vol 38. issue 2. 2018-07-17. PMID:29214756. |
the objective of this study was to examine the serum levels of t helper (th) cell subset th1, th2, and th17 cytokines and total ige in patients having chronic rhinosinusitis with nasal polyposis and aspergillus flavus infection. |
2018-07-17 |
2023-08-13 |
Not clear |
| Y Yuan, Q Liu, J Zhao, H Tang, J Su. SIRT1 attenuates murine allergic rhinitis by downregulated HMGB 1/TLR4 pathway. Scandinavian journal of immunology. vol 87. issue 6. 2018-07-05. PMID:29701897. |
administration of sirt1 significantly alleviated ova-induced ar symptoms with lower numbers of sneezing and nasal rubbing events, decreased levels of ova-specific ige, ltc4, ecp, pgd2, less inflammatory cells and downregulated levels of th2 type cytokines. |
2018-07-05 |
2023-08-13 |
mouse |
| Thi Tho Bui, Chun Hua Piao, Chang Ho Song, Ok Hee Cha. Skullcapflavone II attenuates ovalbumin-induced allergic rhinitis through the blocking of Th2 cytokine production and mast cell histamine release. International immunopharmacology. vol 52. 2018-06-12. PMID:28886581. |
ova-induced ar mice increased nasal symptoms, eosinophils and mast cells infiltration into nasal cavity, ova-specific ige/igg1 and histamine in serum, th2 cytokines including il-13 and gata3, and nf-κb signaling in nalf and lung homogenate. |
2018-06-12 |
2023-08-13 |
mouse |
| Thi Tho Bui, Chun Hua Piao, Chang Ho Song, Ok Hee Cha. Skullcapflavone II attenuates ovalbumin-induced allergic rhinitis through the blocking of Th2 cytokine production and mast cell histamine release. International immunopharmacology. vol 52. 2018-06-12. PMID:28886581. |
interestingly, treatment of scfii reduced the levels of ova-specific ige/igg1 and histamine in serum, of th2 cytokines and of nf-κb signaling in the nalf and the lung homogenate, and histopathological changes in the nasal tissue and the lung. |
2018-06-12 |
2023-08-13 |
mouse |
| Tianyong Hu, Xiaoqin Fan, Li Ma, Jiangqi Liu, Yunli Chang, Pingchang Yang, Shuqi Qiu, Tao Chen, Litao Yang, Zhiqiang Li. TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression. International journal of molecular medicine. vol 40. issue 5. 2018-05-30. PMID:28949386. |
the aim of the present study was to investigate the mechanisms through which the interaction between t‑cell immunoglobulin and mucin domain (tim)4 and tim1 regulates the expression of silent information regulator 1 (sirt1) in th2 cells, and the role of sirt1 in th2‑cell polarization during nasal allergic inflammation. |
2018-05-30 |
2023-08-13 |
mouse |
| Ho Chan Kim, Ji Youn Lim, Seoyeon Kim, Ji Heui Kim, Yong Ju Jan. Development of a mouse model of eosinophilic chronic rhinosinusitis with nasal polyp by nasal instillation of an Aspergillus protease and ovalbumin. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 274. issue 11. 2018-05-15. PMID:28828551. |
one subtype of chronic rhinosinusitis with nasal polyps (crswnp) is characterized by the development of a t-helper type 2 (th2) response and eosinophilic infiltration. |
2018-05-15 |
2023-08-13 |
mouse |
| Ho Chan Kim, Ji Youn Lim, Seoyeon Kim, Ji Heui Kim, Yong Ju Jan. Development of a mouse model of eosinophilic chronic rhinosinusitis with nasal polyp by nasal instillation of an Aspergillus protease and ovalbumin. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 274. issue 11. 2018-05-15. PMID:28828551. |
protein levels of th2 cytokines, inf-γ, il-17a, and chemokines in nasal lavage fluid, and total serum ige were measured by elisa. |
2018-05-15 |
2023-08-13 |
mouse |
| Taiyo Morikawa, Ayumi Fukuoka, Kazufumi Matsushita, Koubun Yasuda, Naruhito Iwasaki, Shoko Akasaki, Shigeharu Fujieda, Tomohiro Yoshimot. Activation of group 2 innate lymphoid cells exacerbates and confers corticosteroid resistance to mouse nasal type 2 inflammation. International immunology. vol 29. issue 5. 2018-05-10. PMID:28541554. |
in this study, we investigated the cooperation of th2 cells and ilc2s in a mouse model of nasal allergic disorder. |
2018-05-10 |
2023-08-13 |
mouse |
| Taiyo Morikawa, Ayumi Fukuoka, Kazufumi Matsushita, Koubun Yasuda, Naruhito Iwasaki, Shoko Akasaki, Shigeharu Fujieda, Tomohiro Yoshimot. Activation of group 2 innate lymphoid cells exacerbates and confers corticosteroid resistance to mouse nasal type 2 inflammation. International immunology. vol 29. issue 5. 2018-05-10. PMID:28541554. |
to differentially activate th2 cells and/or ilc2s in nasal mucosa, mice were intra-nasally administered ovalbumin (ova) antigen, papain, an ilc2-activator, or both for 2 weeks. |
2018-05-10 |
2023-08-13 |
mouse |
| A O Eifan, S R Durha. Pathogenesis of rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 46. issue 9. 2017-12-22. PMID:27434218. |
within hours, there is an infiltration by inflammatory cells, particularly th2 t lymphocytes, eosinophils and basophils into nasal mucosal tissue that results in the late-phase allergic response. |
2017-12-22 |
2023-08-13 |
Not clear |
| Zhao Wei Gu, Yun Xiu Wang, Zhi Wei Ca. Neutralization of interleukin-9 ameliorates symptoms of allergic rhinitis by reducing Th2, Th9, and Th17 responses and increasing the Treg response in a murine model. Oncotarget. vol 8. issue 9. 2017-10-09. PMID:28187441. |
we measured nasal rubbing motion, sneezing and eosinophils, as well as the th1 (th1 cell percentage, ifn-γ mrna/protein, t-bet mrna), th2 (th2 cell percentage, il-4 mrna/protein, gata3 mrna), th9 (th9 cell percentages il-9 mrna/protein, pu.1 and irf4 mrna), th17 (th17 cell percentage, il-17 mrna/protein, rorγt mrna), and treg (treg cell percentage, foxp3 mrna) responses in the nasal mucosa. |
2017-10-09 |
2023-08-13 |
mouse |
| Zhao Wei Gu, Yun Xiu Wang, Zhi Wei Ca. Neutralization of interleukin-9 ameliorates symptoms of allergic rhinitis by reducing Th2, Th9, and Th17 responses and increasing the Treg response in a murine model. Oncotarget. vol 8. issue 9. 2017-10-09. PMID:28187441. |
treatment with anti-il-9 abs markedly reduced nasal rubbing, sneezing, eosinophil infiltration, and th2, th9, and th17 responses, and increased the treg response. |
2017-10-09 |
2023-08-13 |
mouse |
| Mingyu Lee, Dae Woo Kim, Hyun-Woo Shi. Targeting IL-25 as a novel therapy in chronic rhinosinusitis with nasal polyps. Current opinion in allergy and clinical immunology. vol 17. issue 1. 2017-09-15. PMID:27870664. |
recent findings show that epithelial-derived cytokines, including thymic stromal lymphopoietin, il-33, and il-25, can exacerbate th2 immune responses, ultimately leading to recalcitrant chronic rhinosinusitis and nasal polyps. |
2017-09-15 |
2023-08-13 |
Not clear |
| Zhao Wei Gu, Yun Xiu Wang, Zhi Wei Ca. Neutralization of interleukin-17 suppresses allergic rhinitis symptoms by downregulating Th2 and Th17 responses and upregulating the Treg response. Oncotarget. vol 8. issue 14. 2017-09-15. PMID:28423590. |
we measured the numbers of nasal rubbing motions and sneezes, eosinophil and neutrophil levels, th1, th2, th17, and treg parameters in the nasal mucosa. |
2017-09-15 |
2023-08-13 |
mouse |