| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gargi Rai, Mohammad Ahmad Ansari, Sajad Ahmad Dar, Shyama Datt, Neelima Gupta, Sonal Sharma, Shafiul Haque, Vishnampettai Ganapathysubramanian Ramachandran, Arpeeta Mazumdar, Shivprakash Rudramurthy, Arunaloke Chakrabarti, Shukla Da. Serum Cytokine Profile in Patients with Chronic Rhinosinusitis with Nasal Polyposis Infected by Aspergillus flavus. Annals of laboratory medicine. vol 38. issue 2. 2018-07-17. PMID:29214756. |
the objective of this study was to examine the serum levels of t helper (th) cell subset th1, th2, and th17 cytokines and total ige in patients having chronic rhinosinusitis with nasal polyposis and aspergillus flavus infection. |
2018-07-17 |
2023-08-13 |
Not clear |
| Y Yuan, Q Liu, J Zhao, H Tang, J Su. SIRT1 attenuates murine allergic rhinitis by downregulated HMGB 1/TLR4 pathway. Scandinavian journal of immunology. vol 87. issue 6. 2018-07-05. PMID:29701897. |
administration of sirt1 significantly alleviated ova-induced ar symptoms with lower numbers of sneezing and nasal rubbing events, decreased levels of ova-specific ige, ltc4, ecp, pgd2, less inflammatory cells and downregulated levels of th2 type cytokines. |
2018-07-05 |
2023-08-13 |
mouse |
| Thi Tho Bui, Chun Hua Piao, Chang Ho Song, Ok Hee Cha. Skullcapflavone II attenuates ovalbumin-induced allergic rhinitis through the blocking of Th2 cytokine production and mast cell histamine release. International immunopharmacology. vol 52. 2018-06-12. PMID:28886581. |
ova-induced ar mice increased nasal symptoms, eosinophils and mast cells infiltration into nasal cavity, ova-specific ige/igg1 and histamine in serum, th2 cytokines including il-13 and gata3, and nf-κb signaling in nalf and lung homogenate. |
2018-06-12 |
2023-08-13 |
mouse |
| Thi Tho Bui, Chun Hua Piao, Chang Ho Song, Ok Hee Cha. Skullcapflavone II attenuates ovalbumin-induced allergic rhinitis through the blocking of Th2 cytokine production and mast cell histamine release. International immunopharmacology. vol 52. 2018-06-12. PMID:28886581. |
interestingly, treatment of scfii reduced the levels of ova-specific ige/igg1 and histamine in serum, of th2 cytokines and of nf-κb signaling in the nalf and the lung homogenate, and histopathological changes in the nasal tissue and the lung. |
2018-06-12 |
2023-08-13 |
mouse |
| Tianyong Hu, Xiaoqin Fan, Li Ma, Jiangqi Liu, Yunli Chang, Pingchang Yang, Shuqi Qiu, Tao Chen, Litao Yang, Zhiqiang Li. TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression. International journal of molecular medicine. vol 40. issue 5. 2018-05-30. PMID:28949386. |
the aim of the present study was to investigate the mechanisms through which the interaction between t‑cell immunoglobulin and mucin domain (tim)4 and tim1 regulates the expression of silent information regulator 1 (sirt1) in th2 cells, and the role of sirt1 in th2‑cell polarization during nasal allergic inflammation. |
2018-05-30 |
2023-08-13 |
mouse |
| Ho Chan Kim, Ji Youn Lim, Seoyeon Kim, Ji Heui Kim, Yong Ju Jan. Development of a mouse model of eosinophilic chronic rhinosinusitis with nasal polyp by nasal instillation of an Aspergillus protease and ovalbumin. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 274. issue 11. 2018-05-15. PMID:28828551. |
one subtype of chronic rhinosinusitis with nasal polyps (crswnp) is characterized by the development of a t-helper type 2 (th2) response and eosinophilic infiltration. |
2018-05-15 |
2023-08-13 |
mouse |
| Ho Chan Kim, Ji Youn Lim, Seoyeon Kim, Ji Heui Kim, Yong Ju Jan. Development of a mouse model of eosinophilic chronic rhinosinusitis with nasal polyp by nasal instillation of an Aspergillus protease and ovalbumin. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 274. issue 11. 2018-05-15. PMID:28828551. |
protein levels of th2 cytokines, inf-γ, il-17a, and chemokines in nasal lavage fluid, and total serum ige were measured by elisa. |
2018-05-15 |
2023-08-13 |
mouse |
| Taiyo Morikawa, Ayumi Fukuoka, Kazufumi Matsushita, Koubun Yasuda, Naruhito Iwasaki, Shoko Akasaki, Shigeharu Fujieda, Tomohiro Yoshimot. Activation of group 2 innate lymphoid cells exacerbates and confers corticosteroid resistance to mouse nasal type 2 inflammation. International immunology. vol 29. issue 5. 2018-05-10. PMID:28541554. |
in this study, we investigated the cooperation of th2 cells and ilc2s in a mouse model of nasal allergic disorder. |
2018-05-10 |
2023-08-13 |
mouse |
| Taiyo Morikawa, Ayumi Fukuoka, Kazufumi Matsushita, Koubun Yasuda, Naruhito Iwasaki, Shoko Akasaki, Shigeharu Fujieda, Tomohiro Yoshimot. Activation of group 2 innate lymphoid cells exacerbates and confers corticosteroid resistance to mouse nasal type 2 inflammation. International immunology. vol 29. issue 5. 2018-05-10. PMID:28541554. |
to differentially activate th2 cells and/or ilc2s in nasal mucosa, mice were intra-nasally administered ovalbumin (ova) antigen, papain, an ilc2-activator, or both for 2 weeks. |
2018-05-10 |
2023-08-13 |
mouse |
| A O Eifan, S R Durha. Pathogenesis of rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 46. issue 9. 2017-12-22. PMID:27434218. |
within hours, there is an infiltration by inflammatory cells, particularly th2 t lymphocytes, eosinophils and basophils into nasal mucosal tissue that results in the late-phase allergic response. |
2017-12-22 |
2023-08-13 |
Not clear |
| Zhao Wei Gu, Yun Xiu Wang, Zhi Wei Ca. Neutralization of interleukin-9 ameliorates symptoms of allergic rhinitis by reducing Th2, Th9, and Th17 responses and increasing the Treg response in a murine model. Oncotarget. vol 8. issue 9. 2017-10-09. PMID:28187441. |
we measured nasal rubbing motion, sneezing and eosinophils, as well as the th1 (th1 cell percentage, ifn-γ mrna/protein, t-bet mrna), th2 (th2 cell percentage, il-4 mrna/protein, gata3 mrna), th9 (th9 cell percentages il-9 mrna/protein, pu.1 and irf4 mrna), th17 (th17 cell percentage, il-17 mrna/protein, rorγt mrna), and treg (treg cell percentage, foxp3 mrna) responses in the nasal mucosa. |
2017-10-09 |
2023-08-13 |
mouse |
| Zhao Wei Gu, Yun Xiu Wang, Zhi Wei Ca. Neutralization of interleukin-9 ameliorates symptoms of allergic rhinitis by reducing Th2, Th9, and Th17 responses and increasing the Treg response in a murine model. Oncotarget. vol 8. issue 9. 2017-10-09. PMID:28187441. |
treatment with anti-il-9 abs markedly reduced nasal rubbing, sneezing, eosinophil infiltration, and th2, th9, and th17 responses, and increased the treg response. |
2017-10-09 |
2023-08-13 |
mouse |
| Mingyu Lee, Dae Woo Kim, Hyun-Woo Shi. Targeting IL-25 as a novel therapy in chronic rhinosinusitis with nasal polyps. Current opinion in allergy and clinical immunology. vol 17. issue 1. 2017-09-15. PMID:27870664. |
recent findings show that epithelial-derived cytokines, including thymic stromal lymphopoietin, il-33, and il-25, can exacerbate th2 immune responses, ultimately leading to recalcitrant chronic rhinosinusitis and nasal polyps. |
2017-09-15 |
2023-08-13 |
Not clear |
| Zhao Wei Gu, Yun Xiu Wang, Zhi Wei Ca. Neutralization of interleukin-17 suppresses allergic rhinitis symptoms by downregulating Th2 and Th17 responses and upregulating the Treg response. Oncotarget. vol 8. issue 14. 2017-09-15. PMID:28423590. |
we measured the numbers of nasal rubbing motions and sneezes, eosinophil and neutrophil levels, th1, th2, th17, and treg parameters in the nasal mucosa. |
2017-09-15 |
2023-08-13 |
mouse |
| Zhao Wei Gu, Yun Xiu Wang, Zhi Wei Ca. Neutralization of interleukin-17 suppresses allergic rhinitis symptoms by downregulating Th2 and Th17 responses and upregulating the Treg response. Oncotarget. vol 8. issue 14. 2017-09-15. PMID:28423590. |
anti-il-17 abs markedly reduced the number of nasal rubbing motions and sneezes, decreased eosinophil and neutrophil infiltration, reduced th2 and th17 responses, and increased the treg response. |
2017-09-15 |
2023-08-13 |
mouse |
| Emily P S Lam, Harsha H Kariyawasam, Batika M J Rana, Stephen R Durham, Andrew N J McKenzie, Nicholas Powell, Nara Orban, Melissa Lennartz-Walker, Claire Hopkins, Sun Ying, Joanne Rimmer, Valerie J Lund, David J Cousins, Stephen J Til. IL-25/IL-33-responsive TH2 cells characterize nasal polyps with a default TH17 signature in nasal mucosa. The Journal of allergy and clinical immunology. vol 137. issue 5. 2017-06-14. PMID:26684290. |
il-25/il-33-responsive th2 cells characterize nasal polyps with a default th17 signature in nasal mucosa. |
2017-06-14 |
2023-08-13 |
Not clear |
| Emily P S Lam, Harsha H Kariyawasam, Batika M J Rana, Stephen R Durham, Andrew N J McKenzie, Nicholas Powell, Nara Orban, Melissa Lennartz-Walker, Claire Hopkins, Sun Ying, Joanne Rimmer, Valerie J Lund, David J Cousins, Stephen J Til. IL-25/IL-33-responsive TH2 cells characterize nasal polyps with a default TH17 signature in nasal mucosa. The Journal of allergy and clinical immunology. vol 137. issue 5. 2017-06-14. PMID:26684290. |
chronic rhinosinusitis with nasal polyposis (crswnp) in western countries is characterized by eosinophilia, ige production, and th2 cytokine expression. |
2017-06-14 |
2023-08-13 |
Not clear |
| Dilidaer, Yan Zheng, Zhuofu Liu, Xianting Hu, Jia Zhang, Li Hu, Miaomiao Han, Dehui Wang, Huabin L. Increased BAFF expression in nasal polyps is associated with local IgE production, Th2 response and concomitant asthma. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 274. issue 4. 2017-05-10. PMID:28035475. |
increased baff expression in nasal polyps is associated with local ige production, th2 response and concomitant asthma. |
2017-05-10 |
2023-08-13 |
human |
| Niyazi Altıntoprak, Murat Kar, Nuray Bayar Muluk, Tugba Oktemer, Kagan Ipci, Leman Birdane, Mitat Aricigil, Mehmet Senturk, Sameer Ali Bafaqeeh, Cemal Cing. Update on local allergic rhinitis. International journal of pediatric otorhinolaryngology. vol 87. 2017-04-17. PMID:27368453. |
lar is a localised nasal allergic response in the absence of systemic atopy characterised by local production of specific ige (sige) antibodies, a th2 pattern of mucosal cell infiltration during natural exposure to aeroallergens, and a positive nasal allergen provocation test response, with the release of inflammatory mediators. |
2017-04-17 |
2023-08-13 |
Not clear |
| Senthil Murugappan, Henderik W Frijlink, Nikolai Petrovsky, Wouter L J Hinrich. Enhanced pulmonary immunization with aerosolized inactivated influenza vaccine containing delta inulin adjuvant. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 66. 2017-03-13. PMID:25459531. |
however, pulmonary administration of whole inactivated influenza virus (wiv) vaccine induces a th2 dominant systemic immune response while a more balanced th1/th2 vaccine response may be preferred and only induces modest nasal immunity. |
2017-03-13 |
2023-08-13 |
Not clear |