| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun-Xiu Wang, Zhao-Wei Gu, Li-Ying Ha. The environmental hormone nonylphenol interferes with the therapeutic effects of G protein-coupled estrogen receptor specific agonist G-1 on murine allergic rhinitis. International immunopharmacology. vol 78. 2020-07-13. PMID:31835084. |
these results indicate that g-1 attenuated the nasal symptoms, serum ova-specific ige, and th2 cell immune response, whereas it enhanced treg immune response, in mice with ar. |
2020-07-13 |
2023-08-13 |
mouse |
| Z Chen, Y Deng, F Li, B Xiao, X Zhou, Z Ta. MicroRNA-466a-3p attenuates allergic nasal inflammation in mice by targeting GATA3. Clinical and experimental immunology. vol 197. issue 3. 2020-05-06. PMID:31081939. |
allergic rhinitis is thought to be an allergic disease associated with immunoglobulin (ig)e-mediated immune response, characterized by increased t helper type 2 (th2) cytokine production, elevated eosinophil levels in the nasal mucosa and induced nasal secretions. |
2020-05-06 |
2023-08-13 |
mouse |
| Neil N Patel, Vasiliki Triantafillou, Ivy W Maina, Alan D Workman, Charles C L Tong, Edward C Kuan, Peter Papagiannopoulos, John V Bosso, Nithin D Adappa, James N Palmer, Michael A Kohanski, De'Broski R Herbert, Noam A Cohe. Fungal extracts stimulate solitary chemosensory cell expansion in noninvasive fungal rhinosinusitis. International forum of allergy & rhinology. vol 9. issue 7. 2020-04-06. PMID:30892837. |
solitary chemosensory cells (sccs) are rare epithelial cells enriched in nasal polyps and are the primary source of interleukin-25 (il-25), an innate cytokine eliciting t-helper 2 (th2) immune response. |
2020-04-06 |
2023-08-13 |
human |
| Y Zhang, L Derycke, G Holtappels, X D Wang, L Zhang, C Bachert, N Zhan. Th2 cytokines orchestrate the secretion of MUC5AC and MUC5B in IL-5-positive chronic rhinosinusitis with nasal polyps. Allergy. vol 74. issue 1. 2020-03-20. PMID:29802623. |
th2 cytokines orchestrate the secretion of muc5ac and muc5b in il-5-positive chronic rhinosinusitis with nasal polyps. |
2020-03-20 |
2023-08-13 |
Not clear |
| E Ridolo, I Martignago, S Masier. Mechanisms of allergic diseases in Otorhinolaryngology. Journal of biological regulators and homeostatic agents. vol 32. issue 1 Suppl. 1. 2019-12-09. PMID:29552867. |
such mechanism is responsible for continuing inflammation sustained by chemoattractants, cytokines and adhesion receptors that induce cellular infiltration of eosinophils, basophils, th2 lymphocytes and mast cells and is clinically mirrored by the prevalence of nasal congestion over sneezing, itching and rhinorrhea. |
2019-12-09 |
2023-08-13 |
Not clear |
| Ibon Eguíluz-Gracia, Kristiina Malmstrom, Sinan Ahmed Dheyauldeen, Jouko Lohi, Antti Sajantila, Ragnhild Aaløkken, Arvind Y M Sundaram, Gregor D Gilfillan, Mika Makela, Espen S Baekkevold, Frode L Jahnse. Monocytes accumulate in the airways of children with fatal asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 48. issue 12. 2019-11-14. PMID:30184280. |
recently, it was shown in an experimental human model of allergic rhinitis (ar) that activated monocytes rapidly accumulate in the nasal mucosa after local allergen challenge, where they promote recruitment of th2 cells and eosinophils. |
2019-11-14 |
2023-08-13 |
human |
| Xi-Hui Fan, Lei Cheng, Ai-Hui Ya. Ameliorative effect of acetylshikonin on ovalbumin (OVA)-induced allergic rhinitis in mice through the inhibition of Th2 cytokine production and mast cell histamine release. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 127. issue 10. 2019-09-17. PMID:31344274. |
acetylshikonin attenuated manifestation of nasal symptoms in sensitized mice and inhibited production of th2-related ova-specific ige, igg1, and th2 cell-produced il-4, il-5, il-13, and mast cell produced histamine; however, it had no effect on th1 cell-produced cytokines, like inf-γ. |
2019-09-17 |
2023-08-13 |
mouse |
| Lisa Giovannini-Chami, Agnès Paquet, Céline Sanfiorenzo, Nicolas Pons, Julie Cazareth, Virginie Magnone, Kévin Lebrigand, Benoit Chevalier, Ambre Vallauri, Valérie Julia, Charles-Hugo Marquette, Brice Marcet, Sylvie Leroy, Pascal Barbr. The "one airway, one disease" concept in light of Th2 inflammation. The European respiratory journal. vol 52. issue 4. 2019-08-19. PMID:30190271. |
in line with the pathophysiological continuum described between nose and bronchus in allergic respiratory diseases, we assessed whether nasal epithelium could mirror the type 2 t-helper cell (th2) status of bronchial epithelium.nasal and bronchial cells were collected by brushing from healthy controls (c, n=13), patients with allergic rhinitis and asthma (ar, n=12), and patients with isolated allergic rhinitis (r, n=14). |
2019-08-19 |
2023-08-13 |
Not clear |
| Lisa Giovannini-Chami, Agnès Paquet, Céline Sanfiorenzo, Nicolas Pons, Julie Cazareth, Virginie Magnone, Kévin Lebrigand, Benoit Chevalier, Ambre Vallauri, Valérie Julia, Charles-Hugo Marquette, Brice Marcet, Sylvie Leroy, Pascal Barbr. The "one airway, one disease" concept in light of Th2 inflammation. The European respiratory journal. vol 52. issue 4. 2019-08-19. PMID:30190271. |
the gene expression profile of nasal samples from the ar group correctly predicted the paired bronchial sample th2 status in 71% of cases. |
2019-08-19 |
2023-08-13 |
Not clear |
| Lisa Giovannini-Chami, Agnès Paquet, Céline Sanfiorenzo, Nicolas Pons, Julie Cazareth, Virginie Magnone, Kévin Lebrigand, Benoit Chevalier, Ambre Vallauri, Valérie Julia, Charles-Hugo Marquette, Brice Marcet, Sylvie Leroy, Pascal Barbr. The "one airway, one disease" concept in light of Th2 inflammation. The European respiratory journal. vol 52. issue 4. 2019-08-19. PMID:30190271. |
nevertheless, nasal cells did not appear to be a reliable surrogate for the th2 response, in particular due to a more robust influence of the ifn response in 14 out of 26 nasal samples. |
2019-08-19 |
2023-08-13 |
Not clear |
| Lisa Giovannini-Chami, Agnès Paquet, Céline Sanfiorenzo, Nicolas Pons, Julie Cazareth, Virginie Magnone, Kévin Lebrigand, Benoit Chevalier, Ambre Vallauri, Valérie Julia, Charles-Hugo Marquette, Brice Marcet, Sylvie Leroy, Pascal Barbr. The "one airway, one disease" concept in light of Th2 inflammation. The European respiratory journal. vol 52. issue 4. 2019-08-19. PMID:30190271. |
the th2 scores in the nose and bronchi correlated with mast cell count (both p<0.001) and number of sensitisations (p=0.006 and 0.002), while the th17 scores correlated with pmn count (p=0.006 and 0.003).the large variability in nasal cell composition and type of inflammation restricts its use as a surrogate for assessing bronchial th2 inflammation in ar patients. |
2019-08-19 |
2023-08-13 |
Not clear |
| Yanjing Fan, Chun Hua Piao, Eunjin Hyeon, Sun Young Jung, Ji-Eun Eom, Hee Soon Shin, Chang Ho Song, Ok Hee Cha. Gallic acid alleviates nasal inflammation via activation of Th1 and inhibition of Th2 and Th17 in a mouse model of allergic rhinitis. International immunopharmacology. vol 70. 2019-08-13. PMID:30884431. |
gallic acid alleviates nasal inflammation via activation of th1 and inhibition of th2 and th17 in a mouse model of allergic rhinitis. |
2019-08-13 |
2023-08-13 |
mouse |
| Yun-Fang An, Yong-Jin Wu, Xian-Hai Zeng, Li-Juan Song, Fei Ma, Wen-Jing Liao, Zhi-Qiang Liu, Gui Yang, Xiao-Wen Zhang, Zhi-Gang Liu, Chang-Qing Zhao, Ping-Chang Yan. B cell lymphoma-2-like protein-12 association with T-helper 2 inflammation in chronic rhinosinusitis with allergy. International forum of allergy & rhinology. vol 8. issue 11. 2019-08-05. PMID:30281927. |
t-helper 2 (th2) polarization plays a critical role in the pathogenesis of chronic rhinosinusitis (crs) with accompanying nasal allergy. |
2019-08-05 |
2023-08-13 |
Not clear |
| Y-Y Zhang, J An, K Wang, B Han, Y-F Liu, H-L Jia, Y-S Li, L Lei, N Jia, J L. Comparative studies of mucosal humoral and cellular immune responses to 2009 pandemic H1N1 influenza virus in mice. Acta virologica. vol 63. issue 2. 2019-08-01. PMID:31230449. |
compared with pr8 infection, bj501 induced a more rapid increase of virus-specific iga and igg antibodies in the nasal lavage fluid and a higher ratio of igg1/igg2a, indicating a stronger th2 response to bj501 in mucosal immunity. |
2019-08-01 |
2023-08-13 |
mouse |
| X F Sun, L J Xi. [The correlation study on pathogenesis of B cell activation factor in eosinophils and neutrophil- predominant chronic rhinosinusitis with nasal polyps]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 33. issue 2. 2019-07-22. PMID:30808151. |
the lesions of nasal polyp have different inflammatory cell infiltration and can be divided into two types in immunophenotpe: the first is characterized by th2 cell reaction and marked eosinophil infiltration,and the second is th1/th17 cell response and non-eosinophil infiltration are characteristic.np, which is mainly infiltrated by neutrophils, is more and more common in china. |
2019-07-22 |
2023-08-13 |
Not clear |
| Aideen C Allen, Mieszko M Wilk, Alicja Misiak, Lisa Borkner, Dearbhla Murphy, Kingston H G Mill. Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting T Mucosal immunology. vol 11. issue 6. 2019-04-08. PMID:30127384. |
sustained protective immunity against bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces il-17-secreting t current acellular pertussis (ap) vaccines induce strong antibody and th2 responses but fail to protect against nasal colonization and transmission of bordetella pertussis. |
2019-04-08 |
2023-08-13 |
mouse |
| Julie A Poposki, Aiko I Klingler, Bruce K Tan, Pejman Soroosh, Homayon Banie, Gavin Lewis, Kathryn E Hulse, Whitney W Stevens, Anju T Peters, Leslie C Grammer, Robert P Schleimer, Kevin C Welch, Stephanie S Smith, David B Conley, Joseph R Raviv, James G Karras, Omid Akbari, Robert C Kern, Atsushi Kat. Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps. Immunity, inflammation and disease. vol 5. issue 3. 2018-12-12. PMID:28474861. |
chronic rhinosinusitis (crs) with nasal polyps (crswnp) is characterized by type 2 inflammation with high levels of th2 cytokines. |
2018-12-12 |
2023-08-13 |
Not clear |
| Xunshuo Jiang, Xiaona Zhang, Jianguo Liu, Jiali Liu, Xinhua Zhu, Chunping Yan. Involvement of T-Helper 9 Activation in a Mouse Model of Allergic Rhinitis. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-10-24. PMID:29982264. |
th1 cells in nasal mucosa, lymph, nasal lavage, spleen, and peripheral blood were significantly reduced, while th2, th9, th17, and treg cells were significantly elevated in the ar group compared with the control group. |
2018-10-24 |
2023-08-13 |
mouse |
| Shenhong Qu, Taijie Qin, Min Li, Shaojie Zhang, Linsong Ye, Jiazhang Wei, Hua Fan, Baiwen Che. The effects of resiquimod in an ovalbumin-induced allergic rhinitis model. International immunopharmacology. vol 59. 2018-10-08. PMID:29665497. |
histological changes in the nasal mucosa were evaluated by hematoxylin and eosin (h & e) and periodic acid-schiff (pas) staining; cytokine levels in serum were measured with enzyme-linked immunosorbent assays (elisas);the mrna expression levels of ifn-γ, il-17 and foxp3 in the spleen determined by quantitative real-time rt-pcr (qrt-pcr); the proportions of th1, th2, th17, treg and tim3 + ifn-γ + th1 cells in the spleen were assessed with flow cytometry; tim1, tim3 and il-33 expression levels in the nasal mucosa were evaluated with immunofluorescence staining(if).r848 alleviated the nasal allergic symptoms; reduced eosinophil cell infiltration, goblet cell hyperplasia in the nasal mucosa; reduced il-13, il-17, il-25 and il-33 levels in serum; upregulated the relative mrna expression of ifn-γ and foxp3, and downregulated the relative mrna expression of il-17 in the spleen; decreased th2, th17 and tim3 + ifn-γ + th1 cells ratios, increased the proportion of th1 and treg cells in the spleen; suppressed tim1 and tim3,but increased il-33 expression in the nasal mucosa in ova-induced ar mice. |
2018-10-08 |
2023-08-13 |
mouse |
| L Zhang, L-L Jiang, Z-W Ca. Interleukin-33 promotes the inflammatory reaction in chronic rhinosinusitis with nasal polyps by NF-κB signaling pathway. European review for medical and pharmacological sciences. vol 21. issue 20. 2018-08-07. PMID:29131267. |
interleukin (il)-33 promotes t helper (th2) immune response and may be involved in the pathogenesis of chronic rhinosinusitis with nasal polyps (crswnp). |
2018-08-07 |
2023-08-13 |
human |