| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Ciprandi, I Cirillo, A Pistorio, M Di Gioacchino, D Fenogli. Ebastine increases IFN-gamma production in patients with persistent allergic rhinitis. Journal of biological regulators and homeostatic agents. vol 23. issue 1. 2009-06-25. PMID:19321044. |
nasal obstruction is a leading symptom in patients with allergic rhinitis and depends on inflammation characterized by th2 polarization. |
2009-06-25 |
2023-08-12 |
human |
| Kazuhisa Asai, Susan C Foley, Yuki Sumi, Yasuhiro Yamauchi, Naoya Takeda, Martin Desrosiers, François Lavigne, Qutayba Hami. Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy increases CD4+CD25+ T cells in the nasal mucosa of subjects with allergic rhinitis. Allergology international : official journal of the Japanese Society of Allergology. vol 57. issue 4. 2009-04-07. PMID:18797179. |
we have previously shown that short-course treatment with amb a 1-immunostimulatory phosphorothioate oligonucleotide conjugate (aic) before the ragweed season modifies the response of the nasal mucosa to allergen challenge in ragweed-sensitive patients by increasing th1 cytokines and decreasing both th2 cytokines and eosinophilia after the ragweed season. |
2009-04-07 |
2023-08-12 |
human |
| Shino Shimizu, Reiko Hattori, Yuichi Majima, Takeshi Shimiz. Th2 cytokine inhibitor suplatast tosilate inhibits antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats. The Annals of otology, rhinology, and laryngology. vol 118. issue 1. 2009-03-30. PMID:19244966. |
th2 cytokine inhibitor suplatast tosilate inhibits antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats. |
2009-03-30 |
2023-08-12 |
rat |
| Shino Shimizu, Reiko Hattori, Yuichi Majima, Takeshi Shimiz. Th2 cytokine inhibitor suplatast tosilate inhibits antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats. The Annals of otology, rhinology, and laryngology. vol 118. issue 1. 2009-03-30. PMID:19244966. |
to elucidate the functions of th2 cytokines in allergic rhinitis, we examined the in vivo effects of the th2 cytokine inhibitor suplatast tosilate on mucus hypersecretion and eosinophil infiltration in rat nasal epithelium. |
2009-03-30 |
2023-08-12 |
rat |
| Manabu Nonaka, Nozomu Ogihara, Akira Fukumoto, Atsuko Sakanushi, Ruby Pawankar, Toshiaki Yag. Toll-like receptor 2, 3, 4, 5 ligands and interleukin-4 synergistically induce TARC production in nasal polyp fibroblasts. Auris, nasus, larynx. vol 35. issue 4. 2009-01-16. PMID:18375080. |
thymus and activation-regulated chemokine (tarc) has been known to facilitate the recruitment of th2 polarized cells, resulting in high levels of th2 cytokines in the sinus mucosa as well as nasal polyps. |
2009-01-16 |
2023-08-12 |
Not clear |
| Manabu Nonaka, Nozomu Ogihara, Akira Fukumoto, Atsuko Sakanushi, Ruby Pawankar, Toshiaki Yag. Toll-like receptor 2, 3, 4, 5 ligands and interleukin-4 synergistically induce TARC production in nasal polyp fibroblasts. Auris, nasus, larynx. vol 35. issue 4. 2009-01-16. PMID:18375080. |
we investigated whether nasal polyp fibroblasts produce tarc when stimulated with the breakdown products of microorganisms (tlr ligands) and a th2 cytokine (il-4). |
2009-01-16 |
2023-08-12 |
Not clear |
| J L Han, R Y Ding, L Zhao, Z Ren, X J Jian. Rosiglitazone attenuates allergic inflammation and inhibits expression of galectin-3 in a mouse model of allergic rhinitis. The Journal of international medical research. vol 36. issue 4. 2008-09-18. PMID:18652780. |
rosiglitazone resulted in a statistically significant attenuation of the increased numbers of inflammatory cells and th2 cytokine levels in nasal cavity lavage fluid of ar mice. |
2008-09-18 |
2023-08-12 |
mouse |
| Toshiharu Hayashi, Keiko Hasegawa, Yuji Sasak. Systemic administration of olygodeoxynucleotides with CpG motifs at priming phase reduces local Th2 response and late allergic rhinitis in BALB/c mice. Inflammation. vol 31. issue 1. 2008-07-10. PMID:17849181. |
compared to the control group, the cpg odn-administration increased production of ova-specific th1 cytokine (interferon-gamma) and decreased productions of ovalubmin-specific th2 cytokines [interleukin (il)-5 and il-13] in nasal cavity fluids, supernatants of splenocytes and/or sera. |
2008-07-10 |
2023-08-12 |
mouse |
| Toshiharu Hayashi, Keiko Hasegawa, Yuji Sasak. Systemic administration of olygodeoxynucleotides with CpG motifs at priming phase reduces local Th2 response and late allergic rhinitis in BALB/c mice. Inflammation. vol 31. issue 1. 2008-07-10. PMID:17849181. |
the present study suggests that the systemic administration of cpg odn at the priming phase may reduce local ova-specific th2 responses, resulting in decreased nasal pathology in the late allergic eosinophilic rhinitis. |
2008-07-10 |
2023-08-12 |
mouse |
| Murugappan Ramanathan, Won-Kyung Lee, Ernst W Spannhake, Andrew P Lan. Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells. American journal of rhinology. vol 22. issue 2. 2008-07-01. PMID:18416964. |
chronic rhinosinusitis with nasal polyps (crswnps) is a disorder characterized by persistent eosinophilic th2 inflammation and frequent sinonasal microbial colonization. |
2008-07-01 |
2023-08-12 |
human |
| Xiaoying Lu, Lindsey C Pingel, Kindra K Burnell, Joseph E Cavanaugh, Kim A Brogde. Carbamoylcholine chloride induces a rapid increase in IL6 in the nasal cavity of C57BL/6 mice. Comparative medicine. vol 57. issue 4. 2007-09-25. PMID:17803048. |
in summary, carbamoylcholine chloride induces a rapid, elevated il6 response in the nasal cavity and respiratory tract of mice but does not alter the levels of other th1, th2, or proinflammatory cytokines. |
2007-09-25 |
2023-08-12 |
mouse |
| D Peeters, I R Peters, C R Helps, A Gabriel, M J Day, C Clerc. Distinct tissue cytokine and chemokine mRNA expression in canine sino-nasal aspergillosis and idiopathic lymphoplasmacytic rhinitis. Veterinary immunology and immunopathology. vol 117. issue 1-2. 2007-07-17. PMID:17336394. |
a partial th2 immune response appears to be mounted in the nasal mucosa of dogs with lpr, whereas the mucosal immune response in canine sna is of the th1 type. |
2007-07-17 |
2023-08-12 |
Not clear |
| Romy Fischer, Daniel Tomé, Jerry R McGhee, Prosper N Boyak. Th1 and Th2 cells are required for both eosinophil- and neutrophil-associated airway inflammatory responses in mice. Biochemical and biophysical research communications. vol 357. issue 1. 2007-06-12. PMID:17412309. |
antigen-specific ab responses were controlled primarily by th2 cytokines in mice sensitized by the oral route, whereas th1 cytokines appeared to play a predominant role in mice sensitized by the nasal route. |
2007-06-12 |
2023-08-12 |
mouse |
| Ashequr Rahman, Toshio Inoue, Jun Ago, Takashi Ishikawa, Chiaki Kame. Interactive effect of histamine and prostaglandin D2 on nasal allergic symptoms in rats. European journal of pharmacology. vol 554. issue 2-3. 2007-03-06. PMID:17112500. |
these results clearly indicate that prostaglandin d(2) showed a synergistic effect on sneezing and nasal rubbing induced by histamine in rats, and its effect occurred through both prostaglandin d(2) and crth2 (chemoattractant receptor-homologous molecule expressed on th2 cells) receptors. |
2007-03-06 |
2023-08-12 |
rat |
| Hiroko Saito Akei, Eric B Brandt, Anil Mishra, Richard T Strait, Fred D Finkelman, Manoj R Warrier, Gurjit K Khurana Hershey, Carine Blanchard, Marc E Rothenber. Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responses. The Journal of allergy and clinical immunology. vol 118. issue 1. 2006-08-09. PMID:16815139. |
epicutaneous aeroallergen exposure induces systemic th2 immunity that predisposes to allergic nasal responses. |
2006-08-09 |
2023-08-12 |
Not clear |
| K Yamamoto, I Kawamura, T Tominaga, T Nomura, J Ito, M Mitsuyam. Listeriolysin O derived from Listeria monocytogenes inhibits the effector phase of an experimental allergic rhinitis induced by ovalbumin in mice. Clinical and experimental immunology. vol 144. issue 3. 2006-06-29. PMID:16734617. |
taken together, these data showed that rllo suppresses the effector phase of allergic rhinitis by inhibition of th2 cell recruitment to nasal mucosa and type i allergic reaction. |
2006-06-29 |
2023-08-12 |
mouse |
| Aimen K Farraj, Jack R Harkema, Norbert E Kaminsk. Allergic rhinitis induced by intranasal sensitization and challenge with trimellitic anhydride but not with dinitrochlorobenzene or oxazolone in A/J mice. Toxicological sciences : an official journal of the Society of Toxicology. vol 79. issue 2. 2005-05-05. PMID:15056815. |
cytokine mrna levels in the nasal airway of tma treated mice also revealed an increase in the mrna levels of the th2 cytokines il-4, il-5, and il-13, but no change in the level of the th1 cytokine ifn-gamma. |
2005-05-05 |
2023-08-12 |
mouse |
| Aimen K Farraj, Jack R Harkema, Norbert E Kaminsk. Allergic rhinitis induced by intranasal sensitization and challenge with trimellitic anhydride but not with dinitrochlorobenzene or oxazolone in A/J mice. Toxicological sciences : an official journal of the Society of Toxicology. vol 79. issue 2. 2005-05-05. PMID:15056815. |
this study is the first to demonstrate that intranasal administration of a known chemical respiratory allergen is an effective method of sensitization resulting in the hallmark features of allergic rhinitis after challenge with a concomitant increase in nasal airway-derived th2 cytokine mrna, lung-derived il-5 mrna, and total serum ige. |
2005-05-05 |
2023-08-12 |
mouse |
| Bradford A Woodworth, Kusumam Joseph, Allen P Kaplan, Rodney J Schlosse. Alterations in eotaxin, monocyte chemoattractant protein-4, interleukin-5, and interleukin-13 after systemic steroid treatment for nasal polyps. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. vol 131. issue 5. 2005-01-10. PMID:15523430. |
to determine alterations in th2 chemokines eotaxin and monocyte chemoattractant protein-4 (mcp-4), and cytokines interleukin-5 (il-5) and interleukin-13 (il-13), in nasal polyps (np) after steroid treatment. |
2005-01-10 |
2023-08-12 |
Not clear |
| Lucia Pitzurra, Silvia Bellocchio, Angela Nocentini, Pierluigi Bonifazi, Raffaele Scardazza, Luigi Gallucci, Fabrizio Stracci, Costantino Simoncelli, Francesco Bistoni, Luigina Roman. Antifungal immune reactivity in nasal polyposis. Infection and immunity. vol 72. issue 12. 2004-12-30. PMID:15557653. |
the results show that th2 reactivity was a common finding for patients with nasal polyposis regardless of the presence of microbes. |
2004-12-30 |
2023-08-12 |
human |