| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J L Han, R Y Ding, L Zhao, Z Ren, X J Jian. Rosiglitazone attenuates allergic inflammation and inhibits expression of galectin-3 in a mouse model of allergic rhinitis. The Journal of international medical research. vol 36. issue 4. 2008-09-18. PMID:18652780. |
rosiglitazone resulted in a statistically significant attenuation of the increased numbers of inflammatory cells and th2 cytokine levels in nasal cavity lavage fluid of ar mice. |
2008-09-18 |
2023-08-12 |
mouse |
| Toshiharu Hayashi, Keiko Hasegawa, Yuji Sasak. Systemic administration of olygodeoxynucleotides with CpG motifs at priming phase reduces local Th2 response and late allergic rhinitis in BALB/c mice. Inflammation. vol 31. issue 1. 2008-07-10. PMID:17849181. |
compared to the control group, the cpg odn-administration increased production of ova-specific th1 cytokine (interferon-gamma) and decreased productions of ovalubmin-specific th2 cytokines [interleukin (il)-5 and il-13] in nasal cavity fluids, supernatants of splenocytes and/or sera. |
2008-07-10 |
2023-08-12 |
mouse |
| Toshiharu Hayashi, Keiko Hasegawa, Yuji Sasak. Systemic administration of olygodeoxynucleotides with CpG motifs at priming phase reduces local Th2 response and late allergic rhinitis in BALB/c mice. Inflammation. vol 31. issue 1. 2008-07-10. PMID:17849181. |
the present study suggests that the systemic administration of cpg odn at the priming phase may reduce local ova-specific th2 responses, resulting in decreased nasal pathology in the late allergic eosinophilic rhinitis. |
2008-07-10 |
2023-08-12 |
mouse |
| Murugappan Ramanathan, Won-Kyung Lee, Ernst W Spannhake, Andrew P Lan. Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells. American journal of rhinology. vol 22. issue 2. 2008-07-01. PMID:18416964. |
chronic rhinosinusitis with nasal polyps (crswnps) is a disorder characterized by persistent eosinophilic th2 inflammation and frequent sinonasal microbial colonization. |
2008-07-01 |
2023-08-12 |
human |
| Xiaoying Lu, Lindsey C Pingel, Kindra K Burnell, Joseph E Cavanaugh, Kim A Brogde. Carbamoylcholine chloride induces a rapid increase in IL6 in the nasal cavity of C57BL/6 mice. Comparative medicine. vol 57. issue 4. 2007-09-25. PMID:17803048. |
in summary, carbamoylcholine chloride induces a rapid, elevated il6 response in the nasal cavity and respiratory tract of mice but does not alter the levels of other th1, th2, or proinflammatory cytokines. |
2007-09-25 |
2023-08-12 |
mouse |
| D Peeters, I R Peters, C R Helps, A Gabriel, M J Day, C Clerc. Distinct tissue cytokine and chemokine mRNA expression in canine sino-nasal aspergillosis and idiopathic lymphoplasmacytic rhinitis. Veterinary immunology and immunopathology. vol 117. issue 1-2. 2007-07-17. PMID:17336394. |
a partial th2 immune response appears to be mounted in the nasal mucosa of dogs with lpr, whereas the mucosal immune response in canine sna is of the th1 type. |
2007-07-17 |
2023-08-12 |
Not clear |
| Romy Fischer, Daniel Tomé, Jerry R McGhee, Prosper N Boyak. Th1 and Th2 cells are required for both eosinophil- and neutrophil-associated airway inflammatory responses in mice. Biochemical and biophysical research communications. vol 357. issue 1. 2007-06-12. PMID:17412309. |
antigen-specific ab responses were controlled primarily by th2 cytokines in mice sensitized by the oral route, whereas th1 cytokines appeared to play a predominant role in mice sensitized by the nasal route. |
2007-06-12 |
2023-08-12 |
mouse |
| Ashequr Rahman, Toshio Inoue, Jun Ago, Takashi Ishikawa, Chiaki Kame. Interactive effect of histamine and prostaglandin D2 on nasal allergic symptoms in rats. European journal of pharmacology. vol 554. issue 2-3. 2007-03-06. PMID:17112500. |
these results clearly indicate that prostaglandin d(2) showed a synergistic effect on sneezing and nasal rubbing induced by histamine in rats, and its effect occurred through both prostaglandin d(2) and crth2 (chemoattractant receptor-homologous molecule expressed on th2 cells) receptors. |
2007-03-06 |
2023-08-12 |
rat |
| Hiroko Saito Akei, Eric B Brandt, Anil Mishra, Richard T Strait, Fred D Finkelman, Manoj R Warrier, Gurjit K Khurana Hershey, Carine Blanchard, Marc E Rothenber. Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responses. The Journal of allergy and clinical immunology. vol 118. issue 1. 2006-08-09. PMID:16815139. |
epicutaneous aeroallergen exposure induces systemic th2 immunity that predisposes to allergic nasal responses. |
2006-08-09 |
2023-08-12 |
Not clear |
| K Yamamoto, I Kawamura, T Tominaga, T Nomura, J Ito, M Mitsuyam. Listeriolysin O derived from Listeria monocytogenes inhibits the effector phase of an experimental allergic rhinitis induced by ovalbumin in mice. Clinical and experimental immunology. vol 144. issue 3. 2006-06-29. PMID:16734617. |
taken together, these data showed that rllo suppresses the effector phase of allergic rhinitis by inhibition of th2 cell recruitment to nasal mucosa and type i allergic reaction. |
2006-06-29 |
2023-08-12 |
mouse |
| Aimen K Farraj, Jack R Harkema, Norbert E Kaminsk. Allergic rhinitis induced by intranasal sensitization and challenge with trimellitic anhydride but not with dinitrochlorobenzene or oxazolone in A/J mice. Toxicological sciences : an official journal of the Society of Toxicology. vol 79. issue 2. 2005-05-05. PMID:15056815. |
cytokine mrna levels in the nasal airway of tma treated mice also revealed an increase in the mrna levels of the th2 cytokines il-4, il-5, and il-13, but no change in the level of the th1 cytokine ifn-gamma. |
2005-05-05 |
2023-08-12 |
mouse |
| Aimen K Farraj, Jack R Harkema, Norbert E Kaminsk. Allergic rhinitis induced by intranasal sensitization and challenge with trimellitic anhydride but not with dinitrochlorobenzene or oxazolone in A/J mice. Toxicological sciences : an official journal of the Society of Toxicology. vol 79. issue 2. 2005-05-05. PMID:15056815. |
this study is the first to demonstrate that intranasal administration of a known chemical respiratory allergen is an effective method of sensitization resulting in the hallmark features of allergic rhinitis after challenge with a concomitant increase in nasal airway-derived th2 cytokine mrna, lung-derived il-5 mrna, and total serum ige. |
2005-05-05 |
2023-08-12 |
mouse |
| Bradford A Woodworth, Kusumam Joseph, Allen P Kaplan, Rodney J Schlosse. Alterations in eotaxin, monocyte chemoattractant protein-4, interleukin-5, and interleukin-13 after systemic steroid treatment for nasal polyps. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. vol 131. issue 5. 2005-01-10. PMID:15523430. |
to determine alterations in th2 chemokines eotaxin and monocyte chemoattractant protein-4 (mcp-4), and cytokines interleukin-5 (il-5) and interleukin-13 (il-13), in nasal polyps (np) after steroid treatment. |
2005-01-10 |
2023-08-12 |
Not clear |
| Lucia Pitzurra, Silvia Bellocchio, Angela Nocentini, Pierluigi Bonifazi, Raffaele Scardazza, Luigi Gallucci, Fabrizio Stracci, Costantino Simoncelli, Francesco Bistoni, Luigina Roman. Antifungal immune reactivity in nasal polyposis. Infection and immunity. vol 72. issue 12. 2004-12-30. PMID:15557653. |
the results show that th2 reactivity was a common finding for patients with nasal polyposis regardless of the presence of microbes. |
2004-12-30 |
2023-08-12 |
human |
| M C Scavuzzo, V Rocchi, B Fattori, F Ambrogi, A Carpi, R Ruffoli, S Manganelli, F Gianness. Cytokine secretion in nasal mucus of normal subjects and patients with allergic rhinitis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 57. issue 8. 2004-06-21. PMID:14568231. |
the levels of th2 cytokines il-4, il-6, il-10 and the th1 cytokine ifn-gamma were studied in nasal mucus from 30 subjects with allergic rhinitis and 45 non-atopic healthy controls. |
2004-06-21 |
2023-08-12 |
human |
| L Nikasinovic, I Momas, J Jus. A review of experimental studies on diesel exhaust particles and nasal epithelium alterations. Journal of toxicology and environmental health. Part B, Critical reviews. vol 7. issue 2. 2004-04-15. PMID:14769545. |
dep act deeply in nasal epithelium by (1) directing cytokine gene expression toward a th2 profile, (2) enhancing local antigen-specific immunoglobulin e (ige) production, and (3) driving in vivo isotype switch to ige. |
2004-04-15 |
2023-08-12 |
human |
| Iftikhar Hussain, Jeanne Smit. Evidence for the transmissibility of atopy: hypothesis. Chest. vol 124. issue 5. 2003-12-23. PMID:14605074. |
abnormal levels of fas receptors and resistance to fas apoptosis in nasal polyp lymphocytes and abnormal th2 clones of atopy are interesting in this regard. |
2003-12-23 |
2023-08-12 |
mouse |
| D G Powe, C Jagger, A Kleinjan, A S Carney, D Jenkins, N S Jone. 'Entopy': localized mucosal allergic disease in the absence of systemic responses for atopy. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 33. issue 10. 2003-12-15. PMID:14519143. |
the th2 immune response in the nasal mucosa of subjects with allergic rhinitis is mediated by allergen-specific ige. |
2003-12-15 |
2023-08-12 |
human |
| Yoshikazu Yuki, Hiroshi Kiyon. New generation of mucosal adjuvants for the induction of protective immunity. Reviews in medical virology. vol 13. issue 5. 2003-11-21. PMID:12931340. |
when vaccine antigen is administered together with mucosal adjuvant, antigen-specific t-helper (th) 1 and th2 cells, cytotoxic t lymphocytes (ctls) and iga b cell responses are effectively induced by oral or nasal routes via the cmis. |
2003-11-21 |
2023-08-12 |
Not clear |
| Kyosuke Furukido, Sachio Takeno, Tsutomu Ueda, Katsuhiro Hirakawa, Koji Yaji. Suppression of the Th2 pathway by suplatast tosilate in patients with perennial nasal allergies. American journal of rhinology. vol 16. issue 6. 2003-04-23. PMID:12512908. |
suppression of the th2 pathway by suplatast tosilate in patients with perennial nasal allergies. |
2003-04-23 |
2023-08-12 |
human |