| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Benson, I L Strannegård, G Wennergren, O Strannegår. Low levels of interferon-gamma in nasal fluid accompany raised levels of T-helper 2 cytokines in children with ongoing allergic rhinitis. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. vol 11. issue 1. 2000-06-29. PMID:10768732. |
in the allergic children, but not in the controls, the nasal fluid levels of the th2 cytokines il-4, il-5 and il-10 increased during the season, and together with il-6, were correlated with the differential counts of eosinophils, and with the levels of ecp and ige. |
2000-06-29 |
2023-08-12 |
human |
| M Benson, I L Strannegård, G Wennergren, O Strannegår. Increase of the soluble IL-4 receptor (IL-4sR) and positive correlation between IL-4sR and IgE in nasal fluids from school children with allergic rhinitis. Allergy and asthma proceedings. vol 21. issue 2. 2000-06-21. PMID:10791109. |
we have previously found that the levels of the th2 cytokines interleukin (il)-4, il-5, il-6, and il-10 were positively correlated to eosinophils and ige in nasal fluids from 60 children with seasonal allergic rhinitis. |
2000-06-21 |
2023-08-12 |
human |
| K Matsuo, T Iwasaki, H Asanuma, T Yoshikawa, Z Chen, H Tsujimoto, T Kurata, S S Tamur. Cytokine mRNAs in the nasal-associated lymphoid tissue during influenza virus infection and nasal vaccination. Vaccine. vol 18. issue 14. 2000-03-07. PMID:10618531. |
thus, influenza virus infection and ctb*-combined nasal vaccine induced th1 dominant and th2 dominant cytokine profiles, respectively, while the similarity of mucosal iga antibody responses between infection and vaccination could be explained by the appearance of il-6 mrnas. |
2000-03-07 |
2023-08-12 |
mouse |
| G Garcia, Y Komagata, A J Slavin, R Maron, H L Weine. Suppression of collagen-induced arthritis by oral or nasal administration of type II collagen. Journal of autoimmunity. vol 13. issue 3. 2000-02-29. PMID:10550219. |
these results demonstrate the induction of antigen specific th2 and tgf-beta secreting regulatory cells following both oral and nasal treatment, which is associated with suppression of local inflammation in the joints and decreased th1 type responses in the periphery throughout the course of the illness. |
2000-02-29 |
2023-08-12 |
mouse |
| J W Simecka, R J Jackson, H Kiyono, J R McGhe. Mucosally induced immunoglobulin E-associated inflammation in the respiratory tract. Infection and immunity. vol 68. issue 2. 2000-02-10. PMID:10639432. |
thus, nasal immunization with tt plus ct likely results in the activation of th2 cells, which may contribute to serious immunopathologic reactions in the lung. |
2000-02-10 |
2023-08-12 |
mouse |
| E J Ryan, E McNeela, G A Murphy, H Stewart, D O'hagan, M Pizza, R Rappuoli, K H Mill. Mutants of Escherichia coli heat-labile toxin act as effective mucosal adjuvants for nasal delivery of an acellular pertussis vaccine: differential effects of the nontoxic AB complex and enzyme activity on Th1 and Th2 cells. Infection and immunity. vol 67. issue 12. 1999-12-20. PMID:10569737. |
mutants of escherichia coli heat-labile toxin act as effective mucosal adjuvants for nasal delivery of an acellular pertussis vaccine: differential effects of the nontoxic ab complex and enzyme activity on th1 and th2 cells. |
1999-12-20 |
2023-08-12 |
Not clear |
| Y Kurono, M Yamamoto, K Fujihashi, S Kodama, M Suzuki, G Mogi, J R McGhee, H Kiyon. Nasal immunization induces Haemophilus influenzae-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity. The Journal of infectious diseases. vol 180. issue 1. 1999-07-29. PMID:10353870. |
nasal immunization induces haemophilus influenzae-specific th1 and th2 responses with mucosal iga and systemic igg antibodies for protective immunity. |
1999-07-29 |
2023-08-12 |
mouse |
| E Csernok, A Trabandt, A Müller, G C Wang, F Moosig, J Paulsen, A Schnabel, W L Gros. Cytokine profiles in Wegener's granulomatosis: predominance of type 1 (Th1) in the granulomatous inflammation. Arthritis and rheumatism. vol 42. issue 4. 1999-04-30. PMID:10211889. |
to determine whether a specific cytokine pattern (type 1 [th1] or type 2 [th2]) predominates in wegener's granulomatosis (wg), by evaluating interferon-gamma (ifngamma) and interleukin-4 (il-4) expression in different compartments of the body (i.e., biopsied nasal mucosal tissue [nbs], bronchoalveolar lavage [bal] fluid, and peripheral blood [pb]) and comparing the findings with those in disease and healthy control subjects. |
1999-04-30 |
2023-08-12 |
human |
| M Yanagita, T Hiroi, N Kitagaki, S Hamada, H O Ito, H Shimauchi, S Murakami, H Okada, H Kiyon. Nasopharyngeal-associated lymphoreticular tissue (NALT) immunity: fimbriae-specific Th1 and Th2 cell-regulated IgA responses for the inhibition of bacterial attachment to epithelial cells and subsequent inflammatory cytokine production. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 6. 1999-04-13. PMID:10092814. |
these findings suggest that nasal vaccination is an effective immunization regimen for the induction of ag-specific th1 and th2 cell-driven iga immune responses that possess the ability to inhibit bacterial attachment to epithelial cells and subsequent inflammatory cytokine production. |
1999-04-13 |
2023-08-12 |
mouse |
| M Wang, A Saxon, D Diaz-Sanche. Early IL-4 production driving Th2 differentiation in a human in vivo allergic model is mast cell derived. Clinical immunology (Orlando, Fla.). vol 90. issue 1. 1999-03-05. PMID:9884352. |
thus we show an initial role for cells of the mast cell/basophil lineage residing in the nasal mucosa in the initial production of il-4, which frames the subsequent immune response by expanding the repertoire of th2 cytokine-producing cells in the local microvicinity. |
1999-03-05 |
2023-08-12 |
human |
| M M El-Naggar, K Ukai, K Takeuchi, Y Sakakur. Effect of allergen-specific immunotherapy on interleukin-4, interleukin-5 and interferon-gamma mRNA expression in the nasal mucosa of rats with allergic rhinitis. Scandinavian journal of immunology. vol 48. issue 6. 1999-01-22. PMID:9874497. |
we conclude that in this allergic model, the improvement of nasal responses after immunotherapy was the result of a mechanism other than decrease of t-helper 2 (th2) cytokines. |
1999-01-22 |
2023-08-12 |
rat |
| M Marinaro, P N Boyaka, R J Jackson, F D Finkelman, H Kiyono, E Jirillo, J R McGhe. Use of intranasal IL-12 to target predominantly Th1 responses to nasal and Th2 responses to oral vaccines given with cholera toxin. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 1. 1999-01-21. PMID:9886376. |
use of intranasal il-12 to target predominantly th1 responses to nasal and th2 responses to oral vaccines given with cholera toxin. |
1999-01-21 |
2023-08-12 |
mouse |
| T Hiroi, K Iwatani, H Iijima, S Kodama, M Yanagita, H Kiyon. Nasal immune system: distinctive Th0 and Th1/Th2 type environments in murine nasal-associated lymphoid tissues and nasal passage, respectively. European journal of immunology. vol 28. issue 10. 1998-12-15. PMID:9808204. |
a major aim of this study was to characterize the th1 and th2 cytokine expression of mucosal t cells residing in nasal-associated lymphoid tissue (nalt) and nasal passages (np) as iga inductive and effector sites, respectively, at the transcription and cellular levels. |
1998-12-15 |
2023-08-12 |
Not clear |
| C H Lee, C S Rhee, Y G Mi. Cytokine gene expression in nasal polyps. The Annals of otology, rhinology, and laryngology. vol 107. issue 8. 1998-09-28. PMID:9716868. |
the mrnas of il-4 and il-5 (th2 cytokines) as well as ifn-gamma (th1 cytokine) were expressed in all of the nasal polyps obtained from the 14 patients, irrespective of the presence or absence of allergy, while 2, 0, and 4 of 6 normal turbinate mucosae expressed il-4, il-5, and ifn-gamma mrnas, respectively. |
1998-09-28 |
2023-08-12 |
Not clear |
| B G Xiao, X F Bai, G X Zhang, H Lin. Suppression of acute and protracted-relapsing experimental allergic encephalomyelitis by nasal administration of low-dose IL-10 in rats. Journal of neuroimmunology. vol 84. issue 2. 1998-06-25. PMID:9628468. |
in this study we report for the first time that nasal administration of the th2 cell-related cytokine interleukin-10 (il-10), at concentrations of 1.5 microg/rat and 15 microg/rat, suppressed clinical signs of acute experimental allergic encephalomyelitis (eae) in lewis rats and prevented the development and relapse of protracted-relapsing eae (pr-eae) in da rats. |
1998-06-25 |
2023-08-12 |
rat |
| A M Casillas, A E Ne. An update on the immunopathogenesis of asthma as an inflammatory disease enhanced by environmental pollutants. Allergy and asthma proceedings. vol 18. issue 4. 1997-10-10. PMID:9270884. |
air pollution, including the contribution by diesel exhaust particle emissions, has been shown to enhance both nasal ige production and the gene expression of th2 cytokines. |
1997-10-10 |
2023-08-12 |
Not clear |
| C H Lee, C S Rhee, S H Oh, Y G Min, M S Le. Increase in expression of IL-4 and IL-5 mRNA in the nasal mucosa of patients with perennial allergic rhinitis during natural allergen exposure. The Annals of otology, rhinology, and laryngology. vol 106. issue 3. 1997-04-08. PMID:9078933. |
to understand the role of cytokines in allergic nasal disease in humans, we designed this study to investigate the expression of cytokine mrna in the nasal mucosa of 10 control subjects and 10 patients with perennial allergic rhinitis using a reverse transcription-polymerase chain reaction (rt-pcr) for il-4, il-5 (th2 cytokines), and ifn-gamma (th1 cytokine). |
1997-04-08 |
2023-08-12 |
human |
| J Tian, M A Atkinson, M Clare-Salzler, A Herschenfeld, T Forsthuber, P V Lehmann, D L Kaufma. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. The Journal of experimental medicine. vol 183. issue 4. 1996-08-05. PMID:8666914. |
nasal administration of glutamate decarboxylase (gad65) peptides induces th2 responses and prevents murine insulin-dependent diabetes. |
1996-08-05 |
2023-08-12 |
mouse |
| J Tian, M A Atkinson, M Clare-Salzler, A Herschenfeld, T Forsthuber, P V Lehmann, D L Kaufma. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. The Journal of experimental medicine. vol 183. issue 4. 1996-08-05. PMID:8666914. |
collectively, these data suggest that the nasal administration of gad65 peptides induces a th2 cell response that inhibits the spontaneous development of autoreactive th1 responses and the progression of beta cell autoimmunity in nod mice. |
1996-08-05 |
2023-08-12 |
mouse |
| M G Karlsson, A Davidsson, G Viale, D Graziani, H B Hellquis. Nasal messenger RNA expression of interleukins 2, 4, and 5 in patients with allergic rhinitis. Diagnostic molecular pathology : the American journal of surgical pathology, part B. vol 4. issue 2. 1995-11-20. PMID:7551298. |
these findings also indicate, together with earlier observations of t-cell activation, a phenotype switch toward t-helper 2 (th2) cells, and the accumulation (homing) of these t cells in the nasal mucosa, that t cells constitute the main source for il-4 in the nasal mucosa. |
1995-11-20 |
2023-08-12 |
Not clear |