| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Till, L Jopling, P Wachholz, R Robson, S Qin, D Andrew, L Wu, J van Neerven, T Williams, S Durham, I Sabro. T cell phenotypes of the normal nasal mucosa: induction of Th2 cytokines and CCR3 expression by IL-4. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 4. 2001-04-19. PMID:11160286. |
these data are consistent with the presence of a nasal mucosal microenvironment that suppresses th2 responses and may represent a protective measure against atopic allergic disease in humans and a favoring of th1 responses to infectious agents. |
2001-04-19 |
2023-08-12 |
human |
| M Okano, A R Satoskar, M Abe, D A Harn, M Okano, K Nishizaki, Y Takeda, T Yoshino, F Brombacher, A A Satoska. Interleukin-4-independent production of Th2 cytokines by nasal lymphocytes and nasal eosinophilia in murine allergic rhinitis. Allergy. vol 55. issue 8. 2001-01-25. PMID:10955698. |
interleukin-4-independent production of th2 cytokines by nasal lymphocytes and nasal eosinophilia in murine allergic rhinitis. |
2001-01-25 |
2023-08-12 |
mouse |
| E A McNeela, D O'Connor, I Jabbal-Gill, L Illum, S S Davis, M Pizza, S Peppoloni, R Rappuoli, K H Mill. A mucosal vaccine against diphtheria: formulation of cross reacting material (CRM(197)) of diphtheria toxin with chitosan enhances local and systemic antibody and Th2 responses following nasal delivery. Vaccine. vol 19. issue 9-10. 2001-01-18. PMID:11137256. |
a mucosal vaccine against diphtheria: formulation of cross reacting material (crm(197)) of diphtheria toxin with chitosan enhances local and systemic antibody and th2 responses following nasal delivery. |
2001-01-18 |
2023-08-12 |
mouse |
| F L Jahnsen, F Lund-Johansen, J F Dunne, L Farkas, R Haye, P Brandtzae. Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 7. 2000-11-03. PMID:11034417. |
plasmacytoid dendritic cells (p-dcs) matured in vitro can induce t cells to produce allergy-promoting th2 cytokines; therefore, their possible occurrence in nasal mucosa during experimentally elicited allergic rhinitis was examined. |
2000-11-03 |
2023-08-12 |
human |
| M Benson, I L Strannegård, O Strannegård, G Wennergre. Topical steroid treatment of allergic rhinitis decreases nasal fluid TH2 cytokines, eosinophils, eosinophil cationic protein, and IgE but has no significant effect on IFN-gamma, IL-1beta, TNF-alpha, or neutrophils. The Journal of allergy and clinical immunology. vol 106. issue 2. 2000-09-14. PMID:10932075. |
topical steroid treatment of allergic rhinitis decreases nasal fluid th2 cytokines, eosinophils, eosinophil cationic protein, and ige but has no significant effect on ifn-gamma, il-1beta, tnf-alpha, or neutrophils. |
2000-09-14 |
2023-08-12 |
Not clear |
| M Benson, I L Strannegård, G Wennergren, O Strannegår. Low levels of interferon-gamma in nasal fluid accompany raised levels of T-helper 2 cytokines in children with ongoing allergic rhinitis. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. vol 11. issue 1. 2000-06-29. PMID:10768732. |
the t-helper 2 (th2) cytokines interleukin-(il-) 4, il-5, il-6, il-10 and the th1 cytokine ifn-gamma and their associations with eosinophil, eosinophil cationic protein (ecp) and immunoglobulin (ig) e were studied in nasal lavage fluid from 60 school children with allergic seasonal rhinitis and 36 nonatopic healthy controls, before and during the pollen season. |
2000-06-29 |
2023-08-12 |
human |
| M Benson, I L Strannegård, G Wennergren, O Strannegår. Low levels of interferon-gamma in nasal fluid accompany raised levels of T-helper 2 cytokines in children with ongoing allergic rhinitis. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. vol 11. issue 1. 2000-06-29. PMID:10768732. |
in the allergic children, but not in the controls, the nasal fluid levels of the th2 cytokines il-4, il-5 and il-10 increased during the season, and together with il-6, were correlated with the differential counts of eosinophils, and with the levels of ecp and ige. |
2000-06-29 |
2023-08-12 |
human |
| M Benson, I L Strannegård, G Wennergren, O Strannegår. Increase of the soluble IL-4 receptor (IL-4sR) and positive correlation between IL-4sR and IgE in nasal fluids from school children with allergic rhinitis. Allergy and asthma proceedings. vol 21. issue 2. 2000-06-21. PMID:10791109. |
we have previously found that the levels of the th2 cytokines interleukin (il)-4, il-5, il-6, and il-10 were positively correlated to eosinophils and ige in nasal fluids from 60 children with seasonal allergic rhinitis. |
2000-06-21 |
2023-08-12 |
human |
| K Matsuo, T Iwasaki, H Asanuma, T Yoshikawa, Z Chen, H Tsujimoto, T Kurata, S S Tamur. Cytokine mRNAs in the nasal-associated lymphoid tissue during influenza virus infection and nasal vaccination. Vaccine. vol 18. issue 14. 2000-03-07. PMID:10618531. |
thus, influenza virus infection and ctb*-combined nasal vaccine induced th1 dominant and th2 dominant cytokine profiles, respectively, while the similarity of mucosal iga antibody responses between infection and vaccination could be explained by the appearance of il-6 mrnas. |
2000-03-07 |
2023-08-12 |
mouse |
| G Garcia, Y Komagata, A J Slavin, R Maron, H L Weine. Suppression of collagen-induced arthritis by oral or nasal administration of type II collagen. Journal of autoimmunity. vol 13. issue 3. 2000-02-29. PMID:10550219. |
these results demonstrate the induction of antigen specific th2 and tgf-beta secreting regulatory cells following both oral and nasal treatment, which is associated with suppression of local inflammation in the joints and decreased th1 type responses in the periphery throughout the course of the illness. |
2000-02-29 |
2023-08-12 |
mouse |
| J W Simecka, R J Jackson, H Kiyono, J R McGhe. Mucosally induced immunoglobulin E-associated inflammation in the respiratory tract. Infection and immunity. vol 68. issue 2. 2000-02-10. PMID:10639432. |
thus, nasal immunization with tt plus ct likely results in the activation of th2 cells, which may contribute to serious immunopathologic reactions in the lung. |
2000-02-10 |
2023-08-12 |
mouse |
| E J Ryan, E McNeela, G A Murphy, H Stewart, D O'hagan, M Pizza, R Rappuoli, K H Mill. Mutants of Escherichia coli heat-labile toxin act as effective mucosal adjuvants for nasal delivery of an acellular pertussis vaccine: differential effects of the nontoxic AB complex and enzyme activity on Th1 and Th2 cells. Infection and immunity. vol 67. issue 12. 1999-12-20. PMID:10569737. |
mutants of escherichia coli heat-labile toxin act as effective mucosal adjuvants for nasal delivery of an acellular pertussis vaccine: differential effects of the nontoxic ab complex and enzyme activity on th1 and th2 cells. |
1999-12-20 |
2023-08-12 |
Not clear |
| Y Kurono, M Yamamoto, K Fujihashi, S Kodama, M Suzuki, G Mogi, J R McGhee, H Kiyon. Nasal immunization induces Haemophilus influenzae-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity. The Journal of infectious diseases. vol 180. issue 1. 1999-07-29. PMID:10353870. |
nasal immunization induces haemophilus influenzae-specific th1 and th2 responses with mucosal iga and systemic igg antibodies for protective immunity. |
1999-07-29 |
2023-08-12 |
mouse |
| E Csernok, A Trabandt, A Müller, G C Wang, F Moosig, J Paulsen, A Schnabel, W L Gros. Cytokine profiles in Wegener's granulomatosis: predominance of type 1 (Th1) in the granulomatous inflammation. Arthritis and rheumatism. vol 42. issue 4. 1999-04-30. PMID:10211889. |
to determine whether a specific cytokine pattern (type 1 [th1] or type 2 [th2]) predominates in wegener's granulomatosis (wg), by evaluating interferon-gamma (ifngamma) and interleukin-4 (il-4) expression in different compartments of the body (i.e., biopsied nasal mucosal tissue [nbs], bronchoalveolar lavage [bal] fluid, and peripheral blood [pb]) and comparing the findings with those in disease and healthy control subjects. |
1999-04-30 |
2023-08-12 |
human |
| M Yanagita, T Hiroi, N Kitagaki, S Hamada, H O Ito, H Shimauchi, S Murakami, H Okada, H Kiyon. Nasopharyngeal-associated lymphoreticular tissue (NALT) immunity: fimbriae-specific Th1 and Th2 cell-regulated IgA responses for the inhibition of bacterial attachment to epithelial cells and subsequent inflammatory cytokine production. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 6. 1999-04-13. PMID:10092814. |
these findings suggest that nasal vaccination is an effective immunization regimen for the induction of ag-specific th1 and th2 cell-driven iga immune responses that possess the ability to inhibit bacterial attachment to epithelial cells and subsequent inflammatory cytokine production. |
1999-04-13 |
2023-08-12 |
mouse |
| M Wang, A Saxon, D Diaz-Sanche. Early IL-4 production driving Th2 differentiation in a human in vivo allergic model is mast cell derived. Clinical immunology (Orlando, Fla.). vol 90. issue 1. 1999-03-05. PMID:9884352. |
thus we show an initial role for cells of the mast cell/basophil lineage residing in the nasal mucosa in the initial production of il-4, which frames the subsequent immune response by expanding the repertoire of th2 cytokine-producing cells in the local microvicinity. |
1999-03-05 |
2023-08-12 |
human |
| M M El-Naggar, K Ukai, K Takeuchi, Y Sakakur. Effect of allergen-specific immunotherapy on interleukin-4, interleukin-5 and interferon-gamma mRNA expression in the nasal mucosa of rats with allergic rhinitis. Scandinavian journal of immunology. vol 48. issue 6. 1999-01-22. PMID:9874497. |
we conclude that in this allergic model, the improvement of nasal responses after immunotherapy was the result of a mechanism other than decrease of t-helper 2 (th2) cytokines. |
1999-01-22 |
2023-08-12 |
rat |
| M Marinaro, P N Boyaka, R J Jackson, F D Finkelman, H Kiyono, E Jirillo, J R McGhe. Use of intranasal IL-12 to target predominantly Th1 responses to nasal and Th2 responses to oral vaccines given with cholera toxin. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 1. 1999-01-21. PMID:9886376. |
use of intranasal il-12 to target predominantly th1 responses to nasal and th2 responses to oral vaccines given with cholera toxin. |
1999-01-21 |
2023-08-12 |
mouse |
| T Hiroi, K Iwatani, H Iijima, S Kodama, M Yanagita, H Kiyon. Nasal immune system: distinctive Th0 and Th1/Th2 type environments in murine nasal-associated lymphoid tissues and nasal passage, respectively. European journal of immunology. vol 28. issue 10. 1998-12-15. PMID:9808204. |
a major aim of this study was to characterize the th1 and th2 cytokine expression of mucosal t cells residing in nasal-associated lymphoid tissue (nalt) and nasal passages (np) as iga inductive and effector sites, respectively, at the transcription and cellular levels. |
1998-12-15 |
2023-08-12 |
Not clear |
| C H Lee, C S Rhee, Y G Mi. Cytokine gene expression in nasal polyps. The Annals of otology, rhinology, and laryngology. vol 107. issue 8. 1998-09-28. PMID:9716868. |
the mrnas of il-4 and il-5 (th2 cytokines) as well as ifn-gamma (th1 cytokine) were expressed in all of the nasal polyps obtained from the 14 patients, irrespective of the presence or absence of allergy, while 2, 0, and 4 of 6 normal turbinate mucosae expressed il-4, il-5, and ifn-gamma mrnas, respectively. |
1998-09-28 |
2023-08-12 |
Not clear |