| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyosuke Furukido, Sachio Takeno, Tsutomu Ueda, Katsuhiro Hirakawa, Koji Yaji. Suppression of the Th2 pathway by suplatast tosilate in patients with perennial nasal allergies. American journal of rhinology. vol 16. issue 6. 2003-04-23. PMID:12512908. |
the aim of this study was to investigate changes in the th2 pathway in human nasal mucosa after medication with ipd-1151t. |
2003-04-23 |
2023-08-12 |
human |
| Paul A Greenberge. Immunotherapy update: mechanisms of action. Allergy and asthma proceedings. vol 23. issue 6. 2003-04-10. PMID:12528601. |
there are increases in antiallergen immunoglobulin g (igg; 2- to 10-fold) and igg4 (10- to 100-fold), a gradual decline in antiallergen ige antibodies, and reduced numbers of nasal or bronchial mast cells, eosinophils, and cd4+ t-helper 2 (th2) lymphocytes. |
2003-04-10 |
2023-08-12 |
Not clear |
| Gaku Sakaue, Takachika Hiroi, Yoko Nakagawa, Kenji Someya, Kohich Iwatani, Yoshiki Sawa, Hidemi Takahashi, Mitsuo Honda, Jun Kunisawa, Hiroshi Kiyon. HIV mucosal vaccine: nasal immunization with gp160-encapsulated hemagglutinating virus of Japan-liposome induces antigen-specific CTLs and neutralizing antibody responses. Journal of immunology (Baltimore, Md. : 1950). vol 170. issue 1. 2003-03-05. PMID:12496436. |
in immunodeficient mice, nasal immunization with gp160-hvj-liposome induced ag-specific immune responses for the systemic and mucosal compartments of both th1 (ifn-gamma(-/-)) and th2 (il-4(-/-)). |
2003-03-05 |
2023-08-12 |
mouse |
| E Kanaizumi, H Shirasaki, J Sato, K Watanabe, T Him. Establishment of animal model of antigen-specific T lymphocyte recruitment into nasal mucosa. Scandinavian journal of immunology. vol 56. issue 4. 2002-11-12. PMID:12234258. |
following nasal ova challenge to do11.10 mice or to the balb/c mice into which antigen-specific th2 cells had been transferred, the number of local antigen-specific tcr-positive cells accompanying the local eosinophilia had significantly increased. |
2002-11-12 |
2023-08-12 |
mouse |
| E Kanaizumi, H Shirasaki, J Sato, K Watanabe, T Him. Establishment of animal model of antigen-specific T lymphocyte recruitment into nasal mucosa. Scandinavian journal of immunology. vol 56. issue 4. 2002-11-12. PMID:12234258. |
these observations suggest that an antigen-specific homing mechanism of th2 cells may exist in nasal mucosa. |
2002-11-12 |
2023-08-12 |
mouse |
| Petra A Wachholz, Kayhan T Nouri-Aria, Duncan R Wilson, Samantha M Walker, Adrienne Verhoef, Stephen J Till, Stephen R Durha. Grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral Th1:Th2 cytokine ratios. Immunology. vol 105. issue 1. 2002-03-04. PMID:11849315. |
grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral th1:th2 cytokine ratios. |
2002-03-04 |
2023-08-12 |
human |
| Petra A Wachholz, Kayhan T Nouri-Aria, Duncan R Wilson, Samantha M Walker, Adrienne Verhoef, Stephen J Till, Stephen R Durha. Grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral Th1:Th2 cytokine ratios. Immunology. vol 105. issue 1. 2002-03-04. PMID:11849315. |
immunotherapy may act by altering the local nasal mucosal t helper type 2 (th2) to type 1 (th1) cytokine balance either by down-regulation and/or immune deviation of t-lymphocyte responses. |
2002-03-04 |
2023-08-12 |
human |
| M Okano, M Azuma, T Yoshino, H Hattori, M Nakada, A R Satoskar, D A Harn, E Nakayama, T Akagi, K Nishizak. Differential role of CD80 and CD86 molecules in the induction and the effector phases of allergic rhinitis in mice. American journal of respiratory and critical care medicine. vol 164. issue 8 Pt 1. 2002-01-22. PMID:11704603. |
intranasal sensitization with sea in balb/c mice elicited a strong th2 response including sea-specific ige production, nasal eosinophilia, and il-4 and il-5 production by nasal lymphocytes after ag challenge. |
2002-01-22 |
2023-08-12 |
mouse |
| H P Jones, L M Hodge, K Fujihashi, H Kiyono, J R McGhee, J W Simeck. The pulmonary environment promotes Th2 cell responses after nasal-pulmonary immunization with antigen alone, but Th1 responses are induced during instances of intense immune stimulation. Journal of immunology (Baltimore, Md. : 1950). vol 167. issue 8. 2001-12-07. PMID:11591779. |
after nasal immunization with influenza ag alone, th2 cytokine mrna (il-4 and il-5) levels were increased, whereas there was no change in th1 cytokine (il-2 and ifn-gamma) mrna expression. |
2001-12-07 |
2023-08-12 |
mouse |
| T Hiroi, H Goto, K Someya, M Yanagita, M Honda, N Yamanaka, H Kiyon. HIV mucosal vaccine: nasal immunization with rBCG-V3J1 induces a long term V3J1 peptide-specific neutralizing immunity in Th1- and Th2-deficient conditions. Journal of immunology (Baltimore, Md. : 1950). vol 167. issue 10. 2001-12-07. PMID:11698461. |
nasal rbcg-v3j1 also induced high levels of prolonged hiv-specific serum igg responses in th1 (ifn-gamma(-/-))- or th2 (il-4(-/-))-immunodeficient mice. |
2001-12-07 |
2023-08-12 |
mouse |
| J Kunisawa, T Nakanishi, I Takahashi, A Okudaira, Y Tsutsumi, K Katayama, S Nakagawa, H Kiyono, T Mayum. Sendai virus fusion protein mediates simultaneous induction of MHC class I/II-dependent mucosal and systemic immune responses via the nasopharyngeal-associated lymphoreticular tissue immune system. Journal of immunology (Baltimore, Md. : 1950). vol 167. issue 3. 2001-10-25. PMID:11466359. |
according to these high delivery and adjuvant activities of fusogenic liposomes, nasal immunization with ova-encapsulated fusogenic liposomes induced high levels of ova-specific cd4(+) th1 and th2 cell responses. |
2001-10-25 |
2023-08-12 |
Not clear |
| C E Balding, A J Howie, A B Drake-Lee, C O Savag. Th2 dominance in nasal mucosa in patients with Wegener's granulomatosis. Clinical and experimental immunology. vol 125. issue 2. 2001-09-20. PMID:11529927. |
th2 dominance in nasal mucosa in patients with wegener's granulomatosis. |
2001-09-20 |
2023-08-12 |
Not clear |
| S Till, L Jopling, P Wachholz, R Robson, S Qin, D Andrew, L Wu, J van Neerven, T Williams, S Durham, I Sabro. T cell phenotypes of the normal nasal mucosa: induction of Th2 cytokines and CCR3 expression by IL-4. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 4. 2001-04-19. PMID:11160286. |
t cell phenotypes of the normal nasal mucosa: induction of th2 cytokines and ccr3 expression by il-4. |
2001-04-19 |
2023-08-12 |
human |
| S Till, L Jopling, P Wachholz, R Robson, S Qin, D Andrew, L Wu, J van Neerven, T Williams, S Durham, I Sabro. T cell phenotypes of the normal nasal mucosa: induction of Th2 cytokines and CCR3 expression by IL-4. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 4. 2001-04-19. PMID:11160286. |
this apparent suppression of th2 cytokine and ccr3 expression by nasal t cells was reversed by addition of il-4 to the culture medium. |
2001-04-19 |
2023-08-12 |
human |
| S Till, L Jopling, P Wachholz, R Robson, S Qin, D Andrew, L Wu, J van Neerven, T Williams, S Durham, I Sabro. T cell phenotypes of the normal nasal mucosa: induction of Th2 cytokines and CCR3 expression by IL-4. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 4. 2001-04-19. PMID:11160286. |
these data are consistent with the presence of a nasal mucosal microenvironment that suppresses th2 responses and may represent a protective measure against atopic allergic disease in humans and a favoring of th1 responses to infectious agents. |
2001-04-19 |
2023-08-12 |
human |
| M Okano, A R Satoskar, M Abe, D A Harn, M Okano, K Nishizaki, Y Takeda, T Yoshino, F Brombacher, A A Satoska. Interleukin-4-independent production of Th2 cytokines by nasal lymphocytes and nasal eosinophilia in murine allergic rhinitis. Allergy. vol 55. issue 8. 2001-01-25. PMID:10955698. |
interleukin-4-independent production of th2 cytokines by nasal lymphocytes and nasal eosinophilia in murine allergic rhinitis. |
2001-01-25 |
2023-08-12 |
mouse |
| E A McNeela, D O'Connor, I Jabbal-Gill, L Illum, S S Davis, M Pizza, S Peppoloni, R Rappuoli, K H Mill. A mucosal vaccine against diphtheria: formulation of cross reacting material (CRM(197)) of diphtheria toxin with chitosan enhances local and systemic antibody and Th2 responses following nasal delivery. Vaccine. vol 19. issue 9-10. 2001-01-18. PMID:11137256. |
a mucosal vaccine against diphtheria: formulation of cross reacting material (crm(197)) of diphtheria toxin with chitosan enhances local and systemic antibody and th2 responses following nasal delivery. |
2001-01-18 |
2023-08-12 |
mouse |
| F L Jahnsen, F Lund-Johansen, J F Dunne, L Farkas, R Haye, P Brandtzae. Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 7. 2000-11-03. PMID:11034417. |
plasmacytoid dendritic cells (p-dcs) matured in vitro can induce t cells to produce allergy-promoting th2 cytokines; therefore, their possible occurrence in nasal mucosa during experimentally elicited allergic rhinitis was examined. |
2000-11-03 |
2023-08-12 |
human |
| M Benson, I L Strannegård, O Strannegård, G Wennergre. Topical steroid treatment of allergic rhinitis decreases nasal fluid TH2 cytokines, eosinophils, eosinophil cationic protein, and IgE but has no significant effect on IFN-gamma, IL-1beta, TNF-alpha, or neutrophils. The Journal of allergy and clinical immunology. vol 106. issue 2. 2000-09-14. PMID:10932075. |
topical steroid treatment of allergic rhinitis decreases nasal fluid th2 cytokines, eosinophils, eosinophil cationic protein, and ige but has no significant effect on ifn-gamma, il-1beta, tnf-alpha, or neutrophils. |
2000-09-14 |
2023-08-12 |
Not clear |
| M Benson, I L Strannegård, G Wennergren, O Strannegår. Low levels of interferon-gamma in nasal fluid accompany raised levels of T-helper 2 cytokines in children with ongoing allergic rhinitis. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. vol 11. issue 1. 2000-06-29. PMID:10768732. |
the t-helper 2 (th2) cytokines interleukin-(il-) 4, il-5, il-6, il-10 and the th1 cytokine ifn-gamma and their associations with eosinophil, eosinophil cationic protein (ecp) and immunoglobulin (ig) e were studied in nasal lavage fluid from 60 school children with allergic seasonal rhinitis and 36 nonatopic healthy controls, before and during the pollen season. |
2000-06-29 |
2023-08-12 |
human |