| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M C Scavuzzo, V Rocchi, B Fattori, F Ambrogi, A Carpi, R Ruffoli, S Manganelli, F Gianness. Cytokine secretion in nasal mucus of normal subjects and patients with allergic rhinitis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 57. issue 8. 2004-06-21. PMID:14568231. |
the levels of th2 cytokines il-4, il-6, il-10 and the th1 cytokine ifn-gamma were studied in nasal mucus from 30 subjects with allergic rhinitis and 45 non-atopic healthy controls. |
2004-06-21 |
2023-08-12 |
human |
| L Nikasinovic, I Momas, J Jus. A review of experimental studies on diesel exhaust particles and nasal epithelium alterations. Journal of toxicology and environmental health. Part B, Critical reviews. vol 7. issue 2. 2004-04-15. PMID:14769545. |
dep act deeply in nasal epithelium by (1) directing cytokine gene expression toward a th2 profile, (2) enhancing local antigen-specific immunoglobulin e (ige) production, and (3) driving in vivo isotype switch to ige. |
2004-04-15 |
2023-08-12 |
human |
| Iftikhar Hussain, Jeanne Smit. Evidence for the transmissibility of atopy: hypothesis. Chest. vol 124. issue 5. 2003-12-23. PMID:14605074. |
abnormal levels of fas receptors and resistance to fas apoptosis in nasal polyp lymphocytes and abnormal th2 clones of atopy are interesting in this regard. |
2003-12-23 |
2023-08-12 |
mouse |
| D G Powe, C Jagger, A Kleinjan, A S Carney, D Jenkins, N S Jone. 'Entopy': localized mucosal allergic disease in the absence of systemic responses for atopy. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 33. issue 10. 2003-12-15. PMID:14519143. |
the th2 immune response in the nasal mucosa of subjects with allergic rhinitis is mediated by allergen-specific ige. |
2003-12-15 |
2023-08-12 |
human |
| Yoshikazu Yuki, Hiroshi Kiyon. New generation of mucosal adjuvants for the induction of protective immunity. Reviews in medical virology. vol 13. issue 5. 2003-11-21. PMID:12931340. |
when vaccine antigen is administered together with mucosal adjuvant, antigen-specific t-helper (th) 1 and th2 cells, cytotoxic t lymphocytes (ctls) and iga b cell responses are effectively induced by oral or nasal routes via the cmis. |
2003-11-21 |
2023-08-12 |
Not clear |
| Kyosuke Furukido, Sachio Takeno, Tsutomu Ueda, Katsuhiro Hirakawa, Koji Yaji. Suppression of the Th2 pathway by suplatast tosilate in patients with perennial nasal allergies. American journal of rhinology. vol 16. issue 6. 2003-04-23. PMID:12512908. |
suppression of the th2 pathway by suplatast tosilate in patients with perennial nasal allergies. |
2003-04-23 |
2023-08-12 |
human |
| Kyosuke Furukido, Sachio Takeno, Tsutomu Ueda, Katsuhiro Hirakawa, Koji Yaji. Suppression of the Th2 pathway by suplatast tosilate in patients with perennial nasal allergies. American journal of rhinology. vol 16. issue 6. 2003-04-23. PMID:12512908. |
the aim of this study was to investigate changes in the th2 pathway in human nasal mucosa after medication with ipd-1151t. |
2003-04-23 |
2023-08-12 |
human |
| Paul A Greenberge. Immunotherapy update: mechanisms of action. Allergy and asthma proceedings. vol 23. issue 6. 2003-04-10. PMID:12528601. |
there are increases in antiallergen immunoglobulin g (igg; 2- to 10-fold) and igg4 (10- to 100-fold), a gradual decline in antiallergen ige antibodies, and reduced numbers of nasal or bronchial mast cells, eosinophils, and cd4+ t-helper 2 (th2) lymphocytes. |
2003-04-10 |
2023-08-12 |
Not clear |
| Gaku Sakaue, Takachika Hiroi, Yoko Nakagawa, Kenji Someya, Kohich Iwatani, Yoshiki Sawa, Hidemi Takahashi, Mitsuo Honda, Jun Kunisawa, Hiroshi Kiyon. HIV mucosal vaccine: nasal immunization with gp160-encapsulated hemagglutinating virus of Japan-liposome induces antigen-specific CTLs and neutralizing antibody responses. Journal of immunology (Baltimore, Md. : 1950). vol 170. issue 1. 2003-03-05. PMID:12496436. |
in immunodeficient mice, nasal immunization with gp160-hvj-liposome induced ag-specific immune responses for the systemic and mucosal compartments of both th1 (ifn-gamma(-/-)) and th2 (il-4(-/-)). |
2003-03-05 |
2023-08-12 |
mouse |
| E Kanaizumi, H Shirasaki, J Sato, K Watanabe, T Him. Establishment of animal model of antigen-specific T lymphocyte recruitment into nasal mucosa. Scandinavian journal of immunology. vol 56. issue 4. 2002-11-12. PMID:12234258. |
following nasal ova challenge to do11.10 mice or to the balb/c mice into which antigen-specific th2 cells had been transferred, the number of local antigen-specific tcr-positive cells accompanying the local eosinophilia had significantly increased. |
2002-11-12 |
2023-08-12 |
mouse |
| E Kanaizumi, H Shirasaki, J Sato, K Watanabe, T Him. Establishment of animal model of antigen-specific T lymphocyte recruitment into nasal mucosa. Scandinavian journal of immunology. vol 56. issue 4. 2002-11-12. PMID:12234258. |
these observations suggest that an antigen-specific homing mechanism of th2 cells may exist in nasal mucosa. |
2002-11-12 |
2023-08-12 |
mouse |
| Petra A Wachholz, Kayhan T Nouri-Aria, Duncan R Wilson, Samantha M Walker, Adrienne Verhoef, Stephen J Till, Stephen R Durha. Grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral Th1:Th2 cytokine ratios. Immunology. vol 105. issue 1. 2002-03-04. PMID:11849315. |
grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral th1:th2 cytokine ratios. |
2002-03-04 |
2023-08-12 |
human |
| Petra A Wachholz, Kayhan T Nouri-Aria, Duncan R Wilson, Samantha M Walker, Adrienne Verhoef, Stephen J Till, Stephen R Durha. Grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral Th1:Th2 cytokine ratios. Immunology. vol 105. issue 1. 2002-03-04. PMID:11849315. |
immunotherapy may act by altering the local nasal mucosal t helper type 2 (th2) to type 1 (th1) cytokine balance either by down-regulation and/or immune deviation of t-lymphocyte responses. |
2002-03-04 |
2023-08-12 |
human |
| M Okano, M Azuma, T Yoshino, H Hattori, M Nakada, A R Satoskar, D A Harn, E Nakayama, T Akagi, K Nishizak. Differential role of CD80 and CD86 molecules in the induction and the effector phases of allergic rhinitis in mice. American journal of respiratory and critical care medicine. vol 164. issue 8 Pt 1. 2002-01-22. PMID:11704603. |
intranasal sensitization with sea in balb/c mice elicited a strong th2 response including sea-specific ige production, nasal eosinophilia, and il-4 and il-5 production by nasal lymphocytes after ag challenge. |
2002-01-22 |
2023-08-12 |
mouse |
| H P Jones, L M Hodge, K Fujihashi, H Kiyono, J R McGhee, J W Simeck. The pulmonary environment promotes Th2 cell responses after nasal-pulmonary immunization with antigen alone, but Th1 responses are induced during instances of intense immune stimulation. Journal of immunology (Baltimore, Md. : 1950). vol 167. issue 8. 2001-12-07. PMID:11591779. |
after nasal immunization with influenza ag alone, th2 cytokine mrna (il-4 and il-5) levels were increased, whereas there was no change in th1 cytokine (il-2 and ifn-gamma) mrna expression. |
2001-12-07 |
2023-08-12 |
mouse |
| T Hiroi, H Goto, K Someya, M Yanagita, M Honda, N Yamanaka, H Kiyon. HIV mucosal vaccine: nasal immunization with rBCG-V3J1 induces a long term V3J1 peptide-specific neutralizing immunity in Th1- and Th2-deficient conditions. Journal of immunology (Baltimore, Md. : 1950). vol 167. issue 10. 2001-12-07. PMID:11698461. |
nasal rbcg-v3j1 also induced high levels of prolonged hiv-specific serum igg responses in th1 (ifn-gamma(-/-))- or th2 (il-4(-/-))-immunodeficient mice. |
2001-12-07 |
2023-08-12 |
mouse |
| J Kunisawa, T Nakanishi, I Takahashi, A Okudaira, Y Tsutsumi, K Katayama, S Nakagawa, H Kiyono, T Mayum. Sendai virus fusion protein mediates simultaneous induction of MHC class I/II-dependent mucosal and systemic immune responses via the nasopharyngeal-associated lymphoreticular tissue immune system. Journal of immunology (Baltimore, Md. : 1950). vol 167. issue 3. 2001-10-25. PMID:11466359. |
according to these high delivery and adjuvant activities of fusogenic liposomes, nasal immunization with ova-encapsulated fusogenic liposomes induced high levels of ova-specific cd4(+) th1 and th2 cell responses. |
2001-10-25 |
2023-08-12 |
Not clear |
| C E Balding, A J Howie, A B Drake-Lee, C O Savag. Th2 dominance in nasal mucosa in patients with Wegener's granulomatosis. Clinical and experimental immunology. vol 125. issue 2. 2001-09-20. PMID:11529927. |
th2 dominance in nasal mucosa in patients with wegener's granulomatosis. |
2001-09-20 |
2023-08-12 |
Not clear |
| S Till, L Jopling, P Wachholz, R Robson, S Qin, D Andrew, L Wu, J van Neerven, T Williams, S Durham, I Sabro. T cell phenotypes of the normal nasal mucosa: induction of Th2 cytokines and CCR3 expression by IL-4. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 4. 2001-04-19. PMID:11160286. |
t cell phenotypes of the normal nasal mucosa: induction of th2 cytokines and ccr3 expression by il-4. |
2001-04-19 |
2023-08-12 |
human |
| S Till, L Jopling, P Wachholz, R Robson, S Qin, D Andrew, L Wu, J van Neerven, T Williams, S Durham, I Sabro. T cell phenotypes of the normal nasal mucosa: induction of Th2 cytokines and CCR3 expression by IL-4. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 4. 2001-04-19. PMID:11160286. |
this apparent suppression of th2 cytokine and ccr3 expression by nasal t cells was reversed by addition of il-4 to the culture medium. |
2001-04-19 |
2023-08-12 |
human |