| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Berger, C Bordi, H J Cüppers, P Berchtold, F A Gries, H Münterfering, R Sailer, H Zimmermann, L Orc. Functional and morphologic characterization of human insulinomas. Diabetes. vol 32. issue 10. 1983-11-23. PMID:6311653. |
based on these findings, we propose a new classification of insulinomas in two groups: group a is characterized morphologically by abundant well-granulated typical b-cells, trabecular arrangement of tumor cells, and uniform insulin immunofluorescence; functionally, these tumors are associated with a moderate elevation of proinsulin-like component and with an almost complete suppressibility of serum insulin by somatostatin and diazoxide. |
1983-11-23 |
2023-08-12 |
human |
| M Berger, C Bordi, H J Cüppers, P Berchtold, F A Gries, H Münterfering, R Sailer, H Zimmermann, L Orc. Functional and morphologic characterization of human insulinomas. Diabetes. vol 32. issue 10. 1983-11-23. PMID:6311653. |
in contrast, tumors of group b are characterized by scarce well-granulated typical b-cells, a medullary-type histologic structure, and irregular insulin immunofluorescence; functionally these tumors show elevated circulating levels of proinsulin-like component and a marked resistance of insulin secretion to somatostatin and diazoxide inhibition. |
1983-11-23 |
2023-08-12 |
human |
| K Kawa. [Regulation mechanism of insulin and glucagon secretion from the isolated, perfused canine pancreas by somatostatin]. Horumon to rinsho. Clinical endocrinology. vol 31. issue 5. 1983-10-28. PMID:6136354. |
[regulation mechanism of insulin and glucagon secretion from the isolated, perfused canine pancreas by somatostatin]. |
1983-10-28 |
2023-08-12 |
Not clear |
| G Dimitriadis, P Tessari, J Geric. Effects of a long-acting somatostatin analogue on postprandial hyperglycemia in insulin-dependent diabetes mellitus. Metabolism: clinical and experimental. vol 32. issue 10. 1983-10-28. PMID:6136893. |
to determine whether an agent such as wy-41,747, a long-acting somatostatin analogue, could be useful as an adjunct to insulin in the treatment of diabetes mellitus, postprandial plasma glucose concentrations were determined in subjects with insulin-dependent diabetes rendered euglycemic with the biostator insulin infusion device under four conditions: (1) subcutaneous minipump infusion of insulin alone (13 +/- 1 units) over 30 minutes beginning 30 minutes before ingestion of a meal using insulin doses determined by the biostator; (2) the same conditions as 1 but beginning immediately before meal ingestion; (3) the same conditions as 1 but with less insulin (7 +/- 1 units) accompanied by the analogue (0.01-0.05 mg/kg); (4) the same conditions as 2 but with the analogue and less insulin (11 +/- 1 units). |
1983-10-28 |
2023-08-12 |
human |
| G Dimitriadis, P Tessari, J Geric. Effects of a long-acting somatostatin analogue on postprandial hyperglycemia in insulin-dependent diabetes mellitus. Metabolism: clinical and experimental. vol 32. issue 10. 1983-10-28. PMID:6136893. |
administration of the somatostatin analogue increased the effectiveness of insulin in controlling postprandial hyperglycemia and permitted satisfactory postprandial glycemic control when the insulin infusion was initiated immediately before meal ingestion. |
1983-10-28 |
2023-08-12 |
human |
| G Dimitriadis, P Tessari, J Geric. Effects of a long-acting somatostatin analogue on postprandial hyperglycemia in insulin-dependent diabetes mellitus. Metabolism: clinical and experimental. vol 32. issue 10. 1983-10-28. PMID:6136893. |
these results suggest that subcutaneous administration of a long-acting somatostatin analogue such as wy-41,747 along with insulin may be clinically useful in the treatment of diabetes mellitus. |
1983-10-28 |
2023-08-12 |
human |
| C G Ostenso. Effects of the biguanide synthalin A on the pancreatic A2-cell of the guinea pig. Experimental and clinical endocrinology. vol 81. issue 3. 1983-10-28. PMID:6350026. |
the enhanced glucagon release by 5 micrograms/ml of the drug was not suppressed by high concentrations of glucose plus insulin in the medium, whereas exogenous somatostatin markedly counter-acted glucagon release evoked by synthalin a. |
1983-10-28 |
2023-08-12 |
Not clear |
| M El-Salhy, S Falkmer, K J Kramer, R D Speir. Immunohistochemical investigations of neuropeptides in the brain, corpora cardiaca, and corpora allata of an adult lepidopteran insect, Manduca sexta (L). Cell and tissue research. vol 232. issue 2. 1983-10-21. PMID:6136331. |
the neurosecretory cells found in the brain were immunoreactive with at least one of the following mammalian antisera, namely those raised against the insulin b-chain, somatostatin, glucagon c-terminal, glucagon n-terminal, pancreatic polypeptide (pp), secretin, vasoactive intestinal polypeptide (vip), glucose-dependent insulinotropic peptide (gip), gastrin c-terminus, enkephalin, alpha- and beta-endorphin, substance p, and calcitonin. |
1983-10-21 |
2023-08-12 |
Not clear |
| V N Titov, R G Kazimov, L V Kasatkina, V P Masenko, S A Beznosenk. [Relations between insulin, somatotropic hormone and somatostatin secretions in patients with ischemic heart disease]. Kardiologiia. vol 23. issue 6. 1983-10-08. PMID:6136624. |
[relations between insulin, somatotropic hormone and somatostatin secretions in patients with ischemic heart disease]. |
1983-10-08 |
2023-08-12 |
Not clear |
| V N Titov, R G Kazimov, L V Kasatkina, V P Masenko, S A Beznosenk. [Relations between insulin, somatotropic hormone and somatostatin secretions in patients with ischemic heart disease]. Kardiologiia. vol 23. issue 6. 1983-10-08. PMID:6136624. |
secretions of hormones responsible for carbohydrate metabolism, sth, insulin, s-peptide and somatostatin, were measured in coronary patients in order to investigate hormonal mechanisms involved in disordered carbohydrate metabolism. |
1983-10-08 |
2023-08-12 |
Not clear |
| S Ito, S Isemura, E Saitoh, K Sanada, T Suzuki, A Shibat. Immunohistochemical demonstration of salivary proline rich peptide P-C like immunoreactivity in human pancreatic B-cells. Acta endocrinologica. vol 103. issue 4. 1983-10-08. PMID:6351525. |
as the antisera against peptide p-c did not have any cross-reactivities to insulin, glucagon, somatostatin, pancreatic polypeptide, vip and human c-peptide, the antisera were considered to recognize specifically either peptide p-c related antigen or peptide p-c itself in human pancreatic b-cells. |
1983-10-08 |
2023-08-12 |
human |
| K Hermanse. Enkephalins and the secretion of pancreatic somatostatin and insulin in the dog: studies in vitro. Endocrinology. vol 113. issue 3. 1983-09-23. PMID:6135603. |
enkephalins and the secretion of pancreatic somatostatin and insulin in the dog: studies in vitro. |
1983-09-23 |
2023-08-12 |
dog |
| K Hermanse. Enkephalins and the secretion of pancreatic somatostatin and insulin in the dog: studies in vitro. Endocrinology. vol 113. issue 3. 1983-09-23. PMID:6135603. |
it was found that mek (1-100 nm) dose dependently inhibited somatostatin release and stimulated insulin secretion. |
1983-09-23 |
2023-08-12 |
dog |
| K Hermanse. Enkephalins and the secretion of pancreatic somatostatin and insulin in the dog: studies in vitro. Endocrinology. vol 113. issue 3. 1983-09-23. PMID:6135603. |
ten micromolar of morphine inhibited somatostatin and stimulated insulin secretion, effects being antagonized by nal (10 microm). |
1983-09-23 |
2023-08-12 |
dog |
| K Hermanse. Enkephalins and the secretion of pancreatic somatostatin and insulin in the dog: studies in vitro. Endocrinology. vol 113. issue 3. 1983-09-23. PMID:6135603. |
nal (10 microm) per se did not affect somatostatin or insulin secretion at 8.3 mm glucose. |
1983-09-23 |
2023-08-12 |
dog |
| K Hermanse. Enkephalins and the secretion of pancreatic somatostatin and insulin in the dog: studies in vitro. Endocrinology. vol 113. issue 3. 1983-09-23. PMID:6135603. |
infusions of either 1 microm phentolamine, 1 microm propranolol, or 1 microm atropine did not significantly alter the amount of somatostatin or insulin secretion during the infusion of 50 nm mek. |
1983-09-23 |
2023-08-12 |
dog |
| I C Green, D Perrin, E Penman, A Yaseen, K Ray, S L Howel. Effect of dynorphin on insulin and somatostatin secretion, calcium uptake, and c-AMP levels in isolated rat islets of Langerhans. Diabetes. vol 32. issue 8. 1983-09-20. PMID:6135634. |
effect of dynorphin on insulin and somatostatin secretion, calcium uptake, and c-amp levels in isolated rat islets of langerhans. |
1983-09-20 |
2023-08-12 |
rat |
| I C Green, D Perrin, E Penman, A Yaseen, K Ray, S L Howel. Effect of dynorphin on insulin and somatostatin secretion, calcium uptake, and c-AMP levels in isolated rat islets of Langerhans. Diabetes. vol 32. issue 8. 1983-09-20. PMID:6135634. |
dynorphin had no effect on islet somatostatin secretion, under conditions in which insulin secretion was greatly stimulated. |
1983-09-20 |
2023-08-12 |
rat |
| I C Green, D Perrin, E Penman, A Yaseen, K Ray, S L Howel. Effect of dynorphin on insulin and somatostatin secretion, calcium uptake, and c-AMP levels in isolated rat islets of Langerhans. Diabetes. vol 32. issue 8. 1983-09-20. PMID:6135634. |
glucose (20 mm) and glyceraldehyde (6 and 12 mm) significantly increased both insulin and somatostatin secretion. |
1983-09-20 |
2023-08-12 |
rat |
| I C Green, D Perrin, E Penman, A Yaseen, K Ray, S L Howel. Effect of dynorphin on insulin and somatostatin secretion, calcium uptake, and c-AMP levels in isolated rat islets of Langerhans. Diabetes. vol 32. issue 8. 1983-09-20. PMID:6135634. |
these results suggest that (1) dynorphin is a very potent stimulus for insulin secretion; (2) dynorphin does not affect somatostatin secretion in static incubations of islets, in the same way as does glucose and glyceraldehyde; (3) dynorphin's effects may involve increased calcium ion movement and can be blocked by verapamil; (4) dynorphin can also increase islet c-amp, and could thereby modulate the responsiveness of other secretagogues; (5) the actions of dynorphin on insulin secretion are not mediated by delta or mu opiate receptors in islets. |
1983-09-20 |
2023-08-12 |
rat |