| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' C G Ostenson, V Grill, A Nyl\\xc3\\xa9n, S Efendi\\xc4\\x8. Modulation by IBMX, fasting and experimental diabetes of glibenclamide-induced islet hormone release from the perfused rat pancreas. Diabete & metabolisme. vol 9. issue 1. 1983-07-15. PMID:6189748.' |
the impact of increased c-amp levels, short-term fasting as well as experimental diabetes on glibenclamide-induced secretion of somatostatin, insulin and glucagon was studied in the isolated perfused rat pancreas. |
1983-07-15 |
2023-08-12 |
rat |
| b' C G Ostenson, V Grill, A Nyl\\xc3\\xa9n, S Efendi\\xc4\\x8. Modulation by IBMX, fasting and experimental diabetes of glibenclamide-induced islet hormone release from the perfused rat pancreas. Diabete & metabolisme. vol 9. issue 1. 1983-07-15. PMID:6189748.' |
dose-response curves revealed that 1 microgram/ml of glibenclamide (in the presence of 3.3 mmol/l of glucose) induced maximal stimulation of insulin and near maximal stimulation of somatostatin release, but did not significantly affect glucagon release. |
1983-07-15 |
2023-08-12 |
rat |
| b' C G Ostenson, V Grill, A Nyl\\xc3\\xa9n, S Efendi\\xc4\\x8. Modulation by IBMX, fasting and experimental diabetes of glibenclamide-induced islet hormone release from the perfused rat pancreas. Diabete & metabolisme. vol 9. issue 1. 1983-07-15. PMID:6189748.' |
fasting the rats for 24 h significantly suppressed the insulin and glucagon responses to glibenclamide while the concomitant somatostatin response was slightly enhanced. |
1983-07-15 |
2023-08-12 |
rat |
| I B Brekke, J Alumets, F Sundle. The duct-ligated pancreas transplant and its effect on the islet cellular composition of the host pancreas. A morphometric analysis. Cell and tissue research. vol 231. issue 1. 1983-07-15. PMID:6342807. |
twenty weeks after pancreas transplantation, the volume fractions of insulin, glucagon, somatostatin and pancreatic polypeptide cells in the graft islets did not differ from those of the normal control pancreas. |
1983-07-15 |
2023-08-12 |
rat |
| D R Owens, M K Jones, A J Birtwell, I R Jones, T M Hayes, L G Hedin. The clinical pharmacology of human insulin (Novo) in normal subjects. Diabetes care. vol 6 Suppl 1. 1983-07-08. PMID:6133710. |
the plasma glucose, c-peptide, and insulin (immunoreactive) responses to human insulin and porcine insulin were identical in the studies with and without somatostatin. |
1983-07-08 |
2023-08-12 |
human |
| D R Owens, M K Jones, A J Birtwell, I R Jones, T M Hayes, L G Hedin. The clinical pharmacology of human insulin (Novo) in normal subjects. Diabetes care. vol 6 Suppl 1. 1983-07-08. PMID:6133710. |
although the incremental plasma insulin values achieved with the two insulins were similar in the two studies, the hypoglycemic effect was accentuated in the presence of somatostatin, with a delayed recovery toward normoglycemia. |
1983-07-08 |
2023-08-12 |
human |
| S Kadowaki, T Taminato, T Chiba, M Nozawa, T Fujita, A W Norma. Effect of tolbutamide on insulin, glucagon, and somatostatin release from the diabetic rat pancreas with special reference to glucose concentration. Endocrinology. vol 112. issue 6. 1983-07-08. PMID:6133743. |
effect of tolbutamide on insulin, glucagon, and somatostatin release from the diabetic rat pancreas with special reference to glucose concentration. |
1983-07-08 |
2023-08-12 |
rat |
| S Kadowaki, T Taminato, T Chiba, M Nozawa, T Fujita, A W Norma. Effect of tolbutamide on insulin, glucagon, and somatostatin release from the diabetic rat pancreas with special reference to glucose concentration. Endocrinology. vol 112. issue 6. 1983-07-08. PMID:6133743. |
the effects of tolbutamide on insulin, glucagon, and somatostatin secretion were investigated in the isolated perfused pancreas from normal and diabetic rats under low (30 mg/dl), normal (100 mg/dl), and high (300 mg/dl) glucose conditions. |
1983-07-08 |
2023-08-12 |
rat |
| S Kadowaki, T Taminato, T Chiba, M Nozawa, T Fujita, A W Norma. Effect of tolbutamide on insulin, glucagon, and somatostatin release from the diabetic rat pancreas with special reference to glucose concentration. Endocrinology. vol 112. issue 6. 1983-07-08. PMID:6133743. |
in the diabetic rat pancreas, insulin release was diminished and tolbutamide-induced somatostatin release was enhanced with increasing glucose concentrations. |
1983-07-08 |
2023-08-12 |
rat |
| F Caviezel, R Mangil. Calcitonin and insulin secretion in normal man: study with somatostatin and calcium. Acta diabetologica latina. vol 20. issue 1. 1983-07-08. PMID:6134414. |
calcitonin and insulin secretion in normal man: study with somatostatin and calcium. |
1983-07-08 |
2023-08-12 |
human |
| F Caviezel, R Mangil. Calcitonin and insulin secretion in normal man: study with somatostatin and calcium. Acta diabetologica latina. vol 20. issue 1. 1983-07-08. PMID:6134414. |
an increase in extracellular calcium concentration abolishes somatostatin-induced inhibition of insulin release from rat pancreas in vitro; since calcium fails to have a similar effect in vivo, and calcitonin (ct) is capable of inhibiting insulin release, we investigated calcium-stimulated ct secretion during somatostatin administration in normal human males. |
1983-07-08 |
2023-08-12 |
human |
| F Caviezel, R Mangil. Calcitonin and insulin secretion in normal man: study with somatostatin and calcium. Acta diabetologica latina. vol 20. issue 1. 1983-07-08. PMID:6134414. |
thus, we suggest that calcium-induced ct release in vivo may counteract the reversal effect of calcium on the suppressor activity of somatostatin on insulin secretion as shown in vitro. |
1983-07-08 |
2023-08-12 |
human |
| K E Sussman, H B Pollard, J W Leitner, R Nesher, J Adler, E Ceras. Granule fusion and fission (discharge) are biochemically dissociable events of exocytotic hormone release. Transactions of the Association of American Physicians. vol 95. 1983-07-08. PMID:6190296. |
as an index of fusion, we followed the recruitment of granule-bound somatostatin receptors to the islet surface, an event which accompanies secretion vesicle migration and insulin secretion. |
1983-07-08 |
2023-08-12 |
Not clear |
| K E Sussman, H B Pollard, J W Leitner, R Nesher, J Adler, E Ceras. Granule fusion and fission (discharge) are biochemically dissociable events of exocytotic hormone release. Transactions of the Association of American Physicians. vol 95. 1983-07-08. PMID:6190296. |
substitution of the impermeant salt sodium isethionate for nacl led to a 90% decrease in glucose-stimulated insulin release with no inhibition of somatostatin receptor recruitment. |
1983-07-08 |
2023-08-12 |
Not clear |
| K E Sussman, H B Pollard, J W Leitner, R Nesher, J Adler, E Ceras. Granule fusion and fission (discharge) are biochemically dissociable events of exocytotic hormone release. Transactions of the Association of American Physicians. vol 95. 1983-07-08. PMID:6190296. |
the phenothiazine drugs, trifluoperazine and promethazine, believed to inhibit calcium-sensitive proteins involved with stimulus-secretion coupling blocked insulin release and somatostatin receptor recruitment in parallel. |
1983-07-08 |
2023-08-12 |
Not clear |
| K E Sussman, H B Pollard, J W Leitner, R Nesher, J Adler, E Ceras. Granule fusion and fission (discharge) are biochemically dissociable events of exocytotic hormone release. Transactions of the Association of American Physicians. vol 95. 1983-07-08. PMID:6190296. |
ibmx appears to stimulate specifically granule fission since ibmx-induced insulin release occurs acutely without an increase in somatostatin receptor recruitment. |
1983-07-08 |
2023-08-12 |
Not clear |
| S Ito, S Isemura, E Saitoh, K Sanada, A Shibat. [The presence of proline-rich peptide P-C like immunoreactivity in the human pancreatic B-cells]. Nihon Naibunpi Gakkai zasshi. vol 59. issue 2. 1983-07-08. PMID:6343134. |
furthermore, observation of serial thin sections immunostained with insulin, glucagon, somatostatin, pp antisera and antisera against peptide p-c revealed that peptide p-c like immunoreactivity-containing cells were identical to insulin containing b-cells. |
1983-07-08 |
2023-08-12 |
human |
| S Ito, S Isemura, E Saitoh, K Sanada, A Shibat. [The presence of proline-rich peptide P-C like immunoreactivity in the human pancreatic B-cells]. Nihon Naibunpi Gakkai zasshi. vol 59. issue 2. 1983-07-08. PMID:6343134. |
as the antisera against peptide p-c did not have any cross-reactivity to other kinds of peptide including insulin, glucagon, somatostatin, pp, vip, human c-peptide and kallikrein, the present finding suggests that peptide p-c like immunoreactivity is present in the b-cells independently of insulin and proinsulin. |
1983-07-08 |
2023-08-12 |
human |
| P O Andersson, J Holst, J Järhul. Effects of adrenergic blockade on the release of insulin, glucagon and somatostatin from the pancreas in response to splanchnic nerve stimulation in cats. Acta physiologica Scandinavica. vol 116. issue 4. 1983-06-23. PMID:6133409. |
effects of adrenergic blockade on the release of insulin, glucagon and somatostatin from the pancreas in response to splanchnic nerve stimulation in cats. |
1983-06-23 |
2023-08-12 |
Not clear |
| P O Andersson, J Holst, J Järhul. Effects of adrenergic blockade on the release of insulin, glucagon and somatostatin from the pancreas in response to splanchnic nerve stimulation in cats. Acta physiologica Scandinavica. vol 116. issue 4. 1983-06-23. PMID:6133409. |
the effects of alpha-, beta- or alpha + beta-adrenergic blockade on arterial plasma concentrations of insulin, glucagon and somatostatin in response to splanchnic nerve stimulation were studied in anesthetized cats. |
1983-06-23 |
2023-08-12 |
Not clear |