| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Ferrannini, E J Barrett, S Bevilacqua, R A DeFronz. Effect of fatty acids on glucose production and utilization in man. The Journal of clinical investigation. vol 72. issue 5. 1983-12-17. PMID:6138367. |
in group c, plasma glucose was raised by 200 mg/100 ml above the fasting level, while insulin secretion was inhibited with somatostatin and peripheral glucagon levels were replaced with a glucagon infusion (1 ng/min x kg). |
1983-12-17 |
2023-08-12 |
human |
| V Schusdziarr. Somatostatin--physiological and pathophysiological aspects. Scandinavian journal of gastroenterology. Supplement. vol 82. 1983-12-17. PMID:6138852. |
several studies demonstrating a tight interaction between somatostatin and insulin indicate that insulin is another important factor in the regulation of basal and postprandial somatostatin release. |
1983-12-17 |
2023-08-12 |
rat |
| V Schusdziarr. Somatostatin--physiological and pathophysiological aspects. Scandinavian journal of gastroenterology. Supplement. vol 82. 1983-12-17. PMID:6138852. |
the role of somatostatin in pathophysiological states such as peptic ulceration and diabetes mellitus is not entirely clear but the present evidence indicates that alterations of tissue somatostatin content or plasma somatostatin levels are secondary to changes of other factors (increased gastric acid secretion, insulin deficiency) rather than representing the primary cause for the underlying disease. |
1983-12-17 |
2023-08-12 |
rat |
| D Grube, R Boh. The microanatomy of human islets of Langerhans, with special reference to somatostatin (D-) cells. Archivum histologicum Japonicum = Nihon soshikigaku kiroku. vol 46. issue 3. 1983-12-17. PMID:6139102. |
the arrangement of the various endocrine cells within mammalian islets of langerhans indicates that the regulation of insulin and glucagon secretion by pancreatic somatostatin may occur mainly by paracrine mechanisms. |
1983-12-17 |
2023-08-12 |
human |
| D J Fletcher, W M Grogan, E Barras, G C Wei. Hormone release by islet B cell-enriched and A and D cell-enriched populations prepared by flow cytometry. Endocrinology. vol 113. issue 5. 1983-12-17. PMID:6194980. |
relative to the original cell suspension, these preparations were enriched 3-fold in glucagon and somatostatin content and 6-fold in insulin content. |
1983-12-17 |
2023-08-12 |
Not clear |
| W K Ward, J B Halter, J D Best, J C Beard, D Port. Hyperglycemia and beta-cell adaptation during prolonged somatostatin infusion with glucagon replacement in man. Diabetes. vol 32. issue 10. 1983-11-23. PMID:6137430. |
in summary, a 46-h infusion of somatostatin with glucagon replacement in humans leads to hyperglycemia, a slightly diminished basal insulin level, markedly decreased insulin responses to glucose, and an insulin response to isoproterenol maintained at a normal level by acute and probably chronic adaptation to the hyperglycemia. |
1983-11-23 |
2023-08-12 |
Not clear |
| A Hisatomi, R H Unge. Secretin inhibits glucagon in the isolated perfused dog pancreas. Diabetes. vol 32. issue 10. 1983-11-23. PMID:6137431. |
the lowest concentration of secretin, a level which is within the physiologic range, significantly suppressed glucagon release and stimulated somatostatin release but was without significant effect on insulin release. |
1983-11-23 |
2023-08-12 |
dog |
| K Lau, J Guntupalli, B Eb. Effects of somatostatin on phosphate transport: evidence for the role of basal insulin. Kidney international. vol 24. issue 1. 1983-11-23. PMID:6137589. |
effects of somatostatin on phosphate transport: evidence for the role of basal insulin. |
1983-11-23 |
2023-08-12 |
Not clear |
| M A Maglad, I A Wasfi, S E Ada. Inhibition of glucose-induced insulin secretion by somatostatin in goats. Research in veterinary science. vol 35. issue 1. 1983-11-23. PMID:6137867. |
inhibition of glucose-induced insulin secretion by somatostatin in goats. |
1983-11-23 |
2023-08-12 |
Not clear |
| M A Maglad, I A Wasfi, S E Ada. Inhibition of glucose-induced insulin secretion by somatostatin in goats. Research in veterinary science. vol 35. issue 1. 1983-11-23. PMID:6137867. |
somatostatin inhibited glucose-induced insulin secretion in intact goats. |
1983-11-23 |
2023-08-12 |
Not clear |
| M A Maglad, I A Wasfi, S E Ada. Inhibition of glucose-induced insulin secretion by somatostatin in goats. Research in veterinary science. vol 35. issue 1. 1983-11-23. PMID:6137867. |
the inhibitory effect of somatostatin was followed by a recovery period during which high levels of insulin were attained. |
1983-11-23 |
2023-08-12 |
Not clear |
| M A Maglad, I A Wasfi, S E Ada. Inhibition of glucose-induced insulin secretion by somatostatin in goats. Research in veterinary science. vol 35. issue 1. 1983-11-23. PMID:6137867. |
these higher concentrations of insulin in the 30 to 60 minutes after somatostatin infusion, were accompanied by lowered free fatty acid and beta-hydroxybutyrate concentrations. |
1983-11-23 |
2023-08-12 |
Not clear |
| M A Maglad, I A Wasfi, S E Ada. Inhibition of glucose-induced insulin secretion by somatostatin in goats. Research in veterinary science. vol 35. issue 1. 1983-11-23. PMID:6137867. |
it is suggested that the effects of somatostatin on these metabolites is brought about by modulation of insulin secretion and not by a direct effect of somatostatin on target tissues. |
1983-11-23 |
2023-08-12 |
Not clear |
| b' R Pasquali, F Casimirri, S Venturoli, R Paradisi, L Mattioli, M Capelli, N Melchionda, G Lab\\xc3\\xb. Insulin resistance in patients with polycystic ovaries: its relationship to body weight and androgen levels. Acta endocrinologica. vol 104. issue 1. 1983-11-23. PMID:6137924.' |
using a combined infusion of somatostatin, insulin and glucose, insulin resistance was assessed in vivo in two groups of females with polycystic ovaries (pco), obese (pb-pco) and normal weight (no-pco) and in two groups of matched (for age, sex and body mass index) controls (ob and no). |
1983-11-23 |
2023-08-12 |
Not clear |
| b' A Wajngot, R Luft, S Efendi\\xc4\\x8. Oral glucose tolerance test and insulin sensitivity in low insulin responders. Acta endocrinologica. vol 104. issue 1. 1983-11-23. PMID:6137926.' |
insulin sensitivity was also measured by computer analysis of git (parameter kg) and, in a limited group of subjects, by a somatostatin infusion test. |
1983-11-23 |
2023-08-12 |
human |
| b' J Szec\\xc3\\xb3wka, D Tendler, S Efendi\\xc4\\x8. Effects of PHI on hormonal secretion from perfused rat pancreas. The American journal of physiology. vol 245. issue 4. 1983-11-23. PMID:6137956.' |
phi increased the release of insulin, glucagon, and somatostatin. |
1983-11-23 |
2023-08-12 |
rat |
| b' J Szec\\xc3\\xb3wka, D Tendler, S Efendi\\xc4\\x8. Effects of PHI on hormonal secretion from perfused rat pancreas. The American journal of physiology. vol 245. issue 4. 1983-11-23. PMID:6137956.' |
in the presence of 4.4 and 6.7 mmol/liter glucose, the same dose of this peptide stimulated insulin and somatostatin release. |
1983-11-23 |
2023-08-12 |
rat |
| b' J Szec\\xc3\\xb3wka, D Tendler, S Efendi\\xc4\\x8. Effects of PHI on hormonal secretion from perfused rat pancreas. The American journal of physiology. vol 245. issue 4. 1983-11-23. PMID:6137956.' |
when arginine was used as a secretagogue, phi (10 nmol/liter) potentiated secretion of insulin, glucagon, and somatostatin. |
1983-11-23 |
2023-08-12 |
rat |
| H L Lickley, F W Kemmer, K Doi, M Vrani. Glucagon suppression improves glucoregulation in moderate but not chronic severe diabetes. The American journal of physiology. vol 245. issue 4. 1983-11-23. PMID:6137957. |
to determine the effectiveness of glucagon suppression in improving glucose homeostasis in diabetes, tracer-determined glucose kinetics were measured during a 6-h somatostatin infusion in six alloxan-diabetic dogs (moderately severe diabetes) and five depancreatized dogs deprived of insulin treatment for 3 days (prolonged severe diabetes). |
1983-11-23 |
2023-08-12 |
Not clear |
| M Berger, C Bordi, H J Cüppers, P Berchtold, F A Gries, H Münterfering, R Sailer, H Zimmermann, L Orc. Functional and morphologic characterization of human insulinomas. Diabetes. vol 32. issue 10. 1983-11-23. PMID:6311653. |
circulating levels of insulin, proinsulin-like component, glucagon, growth hormone, and pancreatic polypeptide were measured in 12 patients with functioning insulinomas, and the suppressibility of serum insulin by somatostatin and diazoxide was assessed before surgical removal of the tumors. |
1983-11-23 |
2023-08-12 |
human |