| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mariko Nobukuni, Hideki Mochizuki, Satoshi Okada, Nobuhisa Kameyama, Anna Tanaka, Hikaru Yamamoto, Taku Amano, Takahiro Seki, Norio Saka. The C-terminal region of serotonin transporter is important for its trafficking and glycosylation. Journal of pharmacological sciences. vol 111. issue 4. 2010-02-19. PMID:19946177. |
we investigated the effects of brefeldin a and ilimaquinone, inhibitors of membrane trafficking, using serotonin transporter (sert)-expressing cos-7 cells. |
2010-02-19 |
2023-08-12 |
Not clear |
| Mariko Nobukuni, Hideki Mochizuki, Satoshi Okada, Nobuhisa Kameyama, Anna Tanaka, Hikaru Yamamoto, Taku Amano, Takahiro Seki, Norio Saka. The C-terminal region of serotonin transporter is important for its trafficking and glycosylation. Journal of pharmacological sciences. vol 111. issue 4. 2010-02-19. PMID:19946177. |
both drugs significantly inhibited the serotonin uptake activity of sert and caused sert to be retained in the endoplasmic reticulum (er), indicating that membrane trafficking is an important factor for sert functional regulation. |
2010-02-19 |
2023-08-12 |
Not clear |
| Mariko Nobukuni, Hideki Mochizuki, Satoshi Okada, Nobuhisa Kameyama, Anna Tanaka, Hikaru Yamamoto, Taku Amano, Takahiro Seki, Norio Saka. The C-terminal region of serotonin transporter is important for its trafficking and glycosylation. Journal of pharmacological sciences. vol 111. issue 4. 2010-02-19. PMID:19946177. |
in agreement with previous reports, a c-terminal-deletion mutant of sert (sertdeltact) mostly localized to the er and completely lacked serotonin uptake activity. |
2010-02-19 |
2023-08-12 |
Not clear |
| Mariko Nobukuni, Hideki Mochizuki, Satoshi Okada, Nobuhisa Kameyama, Anna Tanaka, Hikaru Yamamoto, Taku Amano, Takahiro Seki, Norio Saka. The C-terminal region of serotonin transporter is important for its trafficking and glycosylation. Journal of pharmacological sciences. vol 111. issue 4. 2010-02-19. PMID:19946177. |
to further elucidate the role of the c-terminus of sert, we investigated whether overexpression of flag-tagged sert c-terminus (flag-sert-ct) affected the serotonin uptake activity and glycosylation of sert. |
2010-02-19 |
2023-08-12 |
Not clear |
| Mariko Nobukuni, Hideki Mochizuki, Satoshi Okada, Nobuhisa Kameyama, Anna Tanaka, Hikaru Yamamoto, Taku Amano, Takahiro Seki, Norio Saka. The C-terminal region of serotonin transporter is important for its trafficking and glycosylation. Journal of pharmacological sciences. vol 111. issue 4. 2010-02-19. PMID:19946177. |
in addition, proteasome inhibitors induced apparent er stress, significantly decreased the serotonin uptake activity and mature glycosylation of sert and caused sert to be localized to the er, suggesting that sert function would be attenuated via membrane trafficking in pathological states that trigger er stress. |
2010-02-19 |
2023-08-12 |
Not clear |
| F B Lima, M L Centeno, M E Costa, A P Reddy, J L Cameron, C L Bethe. Stress sensitive female macaques have decreased fifth Ewing variant (Fev) and serotonin-related gene expression that is not reversed by citalopram. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19671441. |
fev (fifth ewing variant) ets transcription factor, tryptophan hydroxylase 2 (tph2), the serotonin reuptake transporter (sert), and the 5ht1a autoreceptor were determined at 7-8 levels of the dorsal raphe nucleus with in situ hybridization (ish) using radiolabeled- and digoxygenin-incorporated riboprobes. |
2010-02-12 |
2023-08-12 |
monkey |
| F B Lima, M L Centeno, M E Costa, A P Reddy, J L Cameron, C L Bethe. Stress sensitive female macaques have decreased fifth Ewing variant (Fev) and serotonin-related gene expression that is not reversed by citalopram. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19671441. |
these data suggest that ss monkeys have fewer serotonin (5-ht) neurons than hsr monkeys, and that they have deficient fev expression, which in turn, leads to deficient tph2, sert and 5ht1a expression. |
2010-02-12 |
2023-08-12 |
monkey |
| I-Hsun Li, Wen-Sheng Huang, Chyng-Yann Shiue, Ya-Yao Huang, Ren-Shyan Liu, San-Chong Chyueh, Shih-Hsiung Hu, Mei-Hsiu Liao, Lie-Hang Shen, Jiang-Chuan Liu, Kuo-Hsing M. Study on the neuroprotective effect of fluoxetine against MDMA-induced neurotoxicity on the serotonin transporter in rat brain using micro-PET. NeuroImage. vol 49. issue 2. 2010-02-12. PMID:19682588. |
the distribution and intensity of serotonin transporter (sert) immunostaining in the brain paralleled the pet imaging results, suggesting that a single dose of fluoxetine provides long-lasting protection against mdma-induced loss of sert and that such neuroprotection is detectable in vivo by 4-[(18)f]-adam micro-pet. |
2010-02-12 |
2023-08-12 |
rat |
| J D A Olivier, L A W Jans, A Blokland, N J Broers, J R Homberg, B A Ellenbroek, A R Cool. Serotonin transporter deficiency in rats contributes to impaired object memory. Genes, brain, and behavior. vol 8. issue 8. 2010-02-10. PMID:19740092. |
the serotonin transporter (sert) has an essential role in serotonergic neurotransmission as it determines the magnitude and duration of the serotonin signal in the synaptic cleft. |
2010-02-10 |
2023-08-12 |
human |
| J D A Olivier, L A W Jans, A Blokland, N J Broers, J R Homberg, B A Ellenbroek, A R Cool. Serotonin transporter deficiency in rats contributes to impaired object memory. Genes, brain, and behavior. vol 8. issue 8. 2010-02-10. PMID:19740092. |
in rats, sert genotype is known to affect brain serotonin levels, with sert(-/-) rats having lower intracellular basal serotonin levels than wild-type rats in several brain areas. |
2010-02-10 |
2023-08-12 |
human |
| J D A Olivier, L A W Jans, A Blokland, N J Broers, J R Homberg, B A Ellenbroek, A R Cool. Serotonin transporter deficiency in rats contributes to impaired object memory. Genes, brain, and behavior. vol 8. issue 8. 2010-02-10. PMID:19740092. |
although brain serotonin levels cannot fully explain the sert genotype effect on object memory in rats, these results do indicate that serotonin is an important player in object memory in rats, and that lower intracellular serotonin levels lead to enhanced memory loss. |
2010-02-10 |
2023-08-12 |
human |
| Jacob Andersen, Lars Olsen, Kasper B Hansen, Olivier Taboureau, Flemming S Jørgensen, Anne Marie Jørgensen, Benny Bang-Andersen, Jan Egebjerg, Kristian Strømgaard, Anders S Kristense. Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter. The Journal of biological chemistry. vol 285. issue 3. 2010-02-08. PMID:19892699. |
the serotonin transporter (sert) regulates extracellular levels of the neurotransmitter serotonin (5-hydroxytryptamine) in the brain by facilitating uptake of released 5-hydroxytryptamine into neuronal cells. |
2010-02-08 |
2023-08-12 |
human |
| Shao-Ping Zhu, Zhi-Fu Mao, Jie Huang, Jun-Yu Wan. Continuous fluoxetine administration prevents recurrence of pulmonary arterial hypertension and prolongs survival in rats. Clinical and experimental pharmacology & physiology. vol 36. issue 8. 2010-02-05. PMID:19473340. |
the serotonin transporter (sert) is strongly implicated in the pathogenesis of pulmonary arterial hypertension (pah) in patients and animal models. |
2010-02-05 |
2023-08-12 |
rat |
| Werner Zitterl, Thomas Stompe, Martin Aigner, Karin Zitterl-Eglseer, Kristina Ritter, Georg Zettinig, Kurt Hornik, Susanne Asenbaum, Walter Pirker, Kenneth Tha. Diencephalic serotonin transporter availability predicts both transporter occupancy and treatment response to sertraline in obsessive-compulsive checkers. Biological psychiatry. vol 66. issue 12. 2010-02-03. PMID:19717141. |
to our knowledge, no studies have investigated the predictive value of central serotonin transporter (sert) availability for treatment response to serotonin reuptake inhibitors (ssris) in patients with obsessive-compulsive disorder (ocd). |
2010-02-03 |
2023-08-12 |
Not clear |
| Franciszek Herold, Łukasz Izbicki, Andrzej Chodkowski, Maciej Dawidowski, Marek Król, Jerzy Kleps, Jadwiga Turło, Irena Wolska, Gabriel Nowak, Katarzyna Stachowicz, Małgorzata Dybała, Agata Siwek, Mateusz Nowak, Elzbieta Pieniazek, Małgorzata Jarończyk, Ingebrigt Sylte, Aleksander P Mazure. Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2. European journal of medicinal chemistry. vol 44. issue 11. 2010-01-28. PMID:19665823. |
in vitro binding tests were performed to determine the affinity of the compounds for the 5-ht(1a) receptor and serotonin transporter (sert) proteins in the rat brain cortex. |
2010-01-28 |
2023-08-12 |
rat |
| Franciszek Herold, Łukasz Izbicki, Andrzej Chodkowski, Maciej Dawidowski, Marek Król, Jerzy Kleps, Jadwiga Turło, Irena Wolska, Gabriel Nowak, Katarzyna Stachowicz, Małgorzata Dybała, Agata Siwek, Mateusz Nowak, Elzbieta Pieniazek, Małgorzata Jarończyk, Ingebrigt Sylte, Aleksander P Mazure. Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2. European journal of medicinal chemistry. vol 44. issue 11. 2010-01-28. PMID:19665823. |
molecular modeling techniques were used to determine the binding modes of the selected compounds at the 5-ht(1a) receptor and sert. |
2010-01-28 |
2023-08-12 |
rat |
| Franciszek Herold, Łukasz Izbicki, Andrzej Chodkowski, Maciej Dawidowski, Marek Król, Jerzy Kleps, Jadwiga Turło, Irena Wolska, Gabriel Nowak, Katarzyna Stachowicz, Małgorzata Dybała, Agata Siwek, Mateusz Nowak, Elzbieta Pieniazek, Małgorzata Jarończyk, Ingebrigt Sylte, Aleksander P Mazure. Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2. European journal of medicinal chemistry. vol 44. issue 11. 2010-01-28. PMID:19665823. |
the sar analysis showed that the presence of the 3-(4-piperidyl)-1h-indole group or its 5-methoxy derivative, as well as a para substitution with -och(3) or -f in the aryl ring of 4-aryl-5,6,7,8-tetrahydro-pyrido[1,2-c]pyrimidine, results in an increased affinity for both the 5-ht(1a) receptors and sert. |
2010-01-28 |
2023-08-12 |
rat |
| Raffaella Molteni, Francesca Calabrese, Paola F Maj, Jocelien D A Olivier, Giorgio Racagni, Bart A Ellenbroek, Marco A Riv. Altered expression and modulation of activity-regulated cytoskeletal associated protein (Arc) in serotonin transporter knockout rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 12. 2010-01-25. PMID:19576731. |
a gene variant in the human serotonin transporter (sert) can increase the vulnerability to mood disorders. |
2010-01-25 |
2023-08-12 |
human |
| David L Gray, Wenjian Xu, Brian M Campbell, Amy B Dounay, Nancy Barta, Susan Boroski, Lynne Denny, Lori Evans, Nancy Stratman, Al Prober. Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists. Bioorganic & medicinal chemistry letters. vol 19. issue 23. 2010-01-19. PMID:19854053. |
in addition, optimization of these molecules provided compounds which exhibit selectivity for nri over the dopamine (dat) and serotonin (sert) reuptake transporters. |
2010-01-19 |
2023-08-12 |
Not clear |
| Hitoshi Doihara, Katsura Nozawa, Ryosuke Kojima, Eri Kawabata-Shoda, Toshihide Yokoyama, Hiroyuki It. QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells. Molecular and cellular biochemistry. vol 331. issue 1-2. 2010-01-18. PMID:19507004. |
in this study, qgp-1 cells, a human pancreatic endocrine cell line, were found to highly express trpa1 and ec cell marker genes, such as tryptophan hydroxylase 1 (tph1), chromogranin a (cga), synaptophysin, atp-dependent vesicular monoamine transporter 1 (vmat1), metabotropic glutamate receptor 4 (mglur4), beta1-adrenergic receptor (adb1), muscarinic 4 acetylcholine receptor (acm4), substance p, serotonin transporter (sert), and guanylin. |
2010-01-18 |
2023-08-12 |
human |