| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Erritzoe, Klaus Holst, Vibe G Frokjaer, Cecilie L Licht, Jan Kalbitzer, Finn A Nielsen, Claus Svarer, Jacob Madsen, Gitte Knudse. A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 9. 2010-05-05. PMID:20203198. |
within the serotonin transmitter system, both the postsynaptically located serotonin 2a (5-ht(2a)) receptor and the presynaptic serotonin transporter (sert) are sensitive to chronic changes in cerebral 5-ht levels. |
2010-05-05 |
2023-08-12 |
human |
| David Erritzoe, Klaus Holst, Vibe G Frokjaer, Cecilie L Licht, Jan Kalbitzer, Finn A Nielsen, Claus Svarer, Jacob Madsen, Gitte Knudse. A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 9. 2010-05-05. PMID:20203198. |
additionally, experimental studies suggest that alterations in either the 5-ht(2a) receptor or sert level can affect the protein level of the counterpart. |
2010-05-05 |
2023-08-12 |
human |
| David Erritzoe, Klaus Holst, Vibe G Frokjaer, Cecilie L Licht, Jan Kalbitzer, Finn A Nielsen, Claus Svarer, Jacob Madsen, Gitte Knudse. A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 9. 2010-05-05. PMID:20203198. |
the aim of this study was to explore the covariation between cerebral 5-ht(2a) receptor and sert in vivo in the same healthy human subjects. |
2010-05-05 |
2023-08-12 |
human |
| David Erritzoe, Klaus Holst, Vibe G Frokjaer, Cecilie L Licht, Jan Kalbitzer, Finn A Nielsen, Claus Svarer, Jacob Madsen, Gitte Knudse. A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 9. 2010-05-05. PMID:20203198. |
the sert binding was imaged with [(11)c]3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (dasb) and 5-ht(2a) receptor binding with [(18)f]altanserin using positron emission tomography. |
2010-05-05 |
2023-08-12 |
human |
| David Erritzoe, Klaus Holst, Vibe G Frokjaer, Cecilie L Licht, Jan Kalbitzer, Finn A Nielsen, Claus Svarer, Jacob Madsen, Gitte Knudse. A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 9. 2010-05-05. PMID:20203198. |
an inverted u-shaped relationship between the 5-ht(2a) receptor and the sert binding was identified. |
2010-05-05 |
2023-08-12 |
human |
| David Erritzoe, Klaus Holst, Vibe G Frokjaer, Cecilie L Licht, Jan Kalbitzer, Finn A Nielsen, Claus Svarer, Jacob Madsen, Gitte Knudse. A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 9. 2010-05-05. PMID:20203198. |
the observed regional intercorrelation for both the 5-ht(2a) receptor and the sert cerebral binding suggests that, within the single individual, each marker has a set point adjusted through a common regulator. |
2010-05-05 |
2023-08-12 |
human |
| David Erritzoe, Klaus Holst, Vibe G Frokjaer, Cecilie L Licht, Jan Kalbitzer, Finn A Nielsen, Claus Svarer, Jacob Madsen, Gitte Knudse. A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 9. 2010-05-05. PMID:20203198. |
a quadratic relationship between the two markers is consistent with data from experimental studies of the effect on sert and 5-ht(2a) receptor binding of chronic changes in 5-ht levels. |
2010-05-05 |
2023-08-12 |
human |
| David Erritzoe, Klaus Holst, Vibe G Frokjaer, Cecilie L Licht, Jan Kalbitzer, Finn A Nielsen, Claus Svarer, Jacob Madsen, Gitte Knudse. A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 9. 2010-05-05. PMID:20203198. |
that is, the observed association between the 5-ht(2a) receptor and sert binding could be driven by the projection output from the raphe nuclei, but other explanations are also at hand. |
2010-05-05 |
2023-08-12 |
human |
| Julie R Field, L Keith Henry, Randy D Blakel. Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine. The Journal of biological chemistry. vol 285. issue 15. 2010-05-04. PMID:20159976. |
the plasma membrane serotonin (5-ht) transporter (sert, slc6a4) clears 5-ht after release at nerve termini and is targeted by both antidepressant medications and psychostimulants (e.g. |
2010-05-04 |
2023-08-12 |
human |
| Sandra M Wells, Mary C Buford, Virginia M Porter, Heather L Brunell, Melisa Bunderson-Schelvan, Andrew B Nevin, Fernando Cardozo-Pelaez, Andrij Holia. Role of the serotonergic system in reduced pulmonary function after exposure to methamphetamine. American journal of respiratory cell and molecular biology. vol 42. issue 5. 2010-04-30. PMID:19541843. |
pretreatment of mice with a selective 5-ht reuptake inhibitor completely ablated the ma-induced changes in pulmonary function, confirming a key role for the 5-ht transporter (serotonin transporter [sert]) and the serotonergic system in this effect. |
2010-04-30 |
2023-08-12 |
mouse |
| Sandra M Wells, Mary C Buford, Virginia M Porter, Heather L Brunell, Melisa Bunderson-Schelvan, Andrew B Nevin, Fernando Cardozo-Pelaez, Andrij Holia. Role of the serotonergic system in reduced pulmonary function after exposure to methamphetamine. American journal of respiratory cell and molecular biology. vol 42. issue 5. 2010-04-30. PMID:19541843. |
together, these data demonstrate that low-dose exposure to ma results in reduced pulmonary function mediated via sert and subsequent perturbation of 5-ht metabolism in the lung. |
2010-04-30 |
2023-08-12 |
mouse |
| Jermaine D Jones, F Scott Hall, George R Uhl, Anthony L Rile. Dopamine, norepinephrine and serotonin transporter gene deletions differentially alter cocaine-induced taste aversion. Pharmacology, biochemistry, and behavior. vol 94. issue 4. 2010-04-29. PMID:19969013. |
monoamine transporter knockout mice have been useful in the study of many different aspects of cocaine effects relevant to human drug use and addiction, yet an assessment of the effects of deletion of the genes for the dopamine, norepinephrine and serotonin transporters (dat, net, and sert, respectively) on cocaine's aversive properties has yet to be performed (uhl et al., 2002). |
2010-04-29 |
2023-08-12 |
mouse |
| Donatella Marazziti, Stefano Baroni, Irene Masala, Francesca Golia, Giorgio Consoli, Gabriele Massimetti, Michela Picchetti, Mario Catena Dell'osso, Gino Giannaccini, Laura Betti, Antonio Lucacchini, Antonio Ciapparell. Impulsivity, gender, and the platelet serotonin transporter in healthy subjects. Neuropsychiatric disease and treatment. vol 6. 2010-04-29. PMID:20169041. |
the present study explored the possible relationships between impulsivity, gender, and a peripheral serotonergic marker, the platelet serotonin (5-ht) transporter (sert), in a group of 32 healthy subjects. |
2010-04-29 |
2023-08-12 |
human |
| Sylvie Mavel, Nathalie Meheux, Denis Guilloteau, Patrick Emon. Synthesis and in vitro evaluation of fluorinated diphenyloxide derivatives and sulfur analogs as serotonin transporter ligands. Bioorganic & medicinal chemistry. vol 18. issue 1. 2010-04-27. PMID:19926484. |
as the serotonin transporter (sert) is involved in several neurodegenerative and psychiatric disorders; radiopharmaceuticals to image the sert by pet would be valuable in studying these diseases. |
2010-04-27 |
2023-08-12 |
Not clear |
| Marhaba Hojahmat, David B Horton, Seth D Norrholm, Dennis K Miller, Vladimir P Grinevich, Agripina Gabriela Deaciuc, Linda P Dwoskin, Peter A Crook. Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters. Bioorganic & medicinal chemistry. vol 18. issue 2. 2010-04-27. PMID:20036131. |
a series of carboxylic acid and sulfonic acid ester analogs 2-20 of lobeline were synthesized and evaluated for interaction with alpha4beta2 * and alpha7 * neuronal nicotinic acetylcholine receptors (nachrs), the dopamine transporter (dat), serotonin transporter (sert) and vmat2. |
2010-04-27 |
2023-08-12 |
rat |
| S J Kish, P S Fitzmaurice, L J Chang, Y Furukawa, J Ton. Low striatal serotonin transporter protein in a human polydrug MDMA (ecstasy) user: a case study. Journal of psychopharmacology (Oxford, England). vol 24. issue 2. 2010-04-26. PMID:18832433. |
evidence that the widely used methamphetamine analog mdma (3,4-methylenedioxymethamphetamine, ecstasy) might damage brain serotonin neurones in humans is derived from imaging investigations showing variably decreased binding of radioligands to the serotonin transporter (sert), a marker of serotonin neurones. |
2010-04-26 |
2023-08-12 |
human |
| S J Kish, P S Fitzmaurice, L J Chang, Y Furukawa, J Ton. Low striatal serotonin transporter protein in a human polydrug MDMA (ecstasy) user: a case study. Journal of psychopharmacology (Oxford, England). vol 24. issue 2. 2010-04-26. PMID:18832433. |
although acknowledging limitations of a case study, these findings extend imaging data based on sert binding and suggest that high-dose mdma exposure could cause loss of two key protein markers of brain serotonin neurones, a finding compatible with either physical damage to serotonin neurones or downregulation of components therein. |
2010-04-26 |
2023-08-12 |
human |
| Margaret R Maclean, Yvonne Dempsi. The serotonin hypothesis of pulmonary hypertension revisited. Advances in experimental medicine and biology. vol 661. 2010-04-26. PMID:20204739. |
both of these drugs are serotonin transporter (sert) substrates and indirect serotinergic agonists. |
2010-04-26 |
2023-08-12 |
Not clear |
| Margaret R Maclean, Yvonne Dempsi. The serotonin hypothesis of pulmonary hypertension revisited. Advances in experimental medicine and biology. vol 661. 2010-04-26. PMID:20204739. |
serotonin then acts at the 5-ht(1b) receptor and the sert to mediate constriction and proliferation of pulmonary artery smooth muscle cells. |
2010-04-26 |
2023-08-12 |
Not clear |
| Kai Yu, Chen-Li Qiu, Gui-Bo Yang, Chun-Miao Zong, Hui Xing, Yiming Shao, Qiang Wei, Chuan Qi. Alteration of serotonin transporter messenger RNA level in the peripheral blood mononuclear cells from simian/human immunodeficiency virus infected Chinese rhesus macaques (Macaca mulatta). Brain, behavior, and immunity. vol 24. issue 2. 2010-04-23. PMID:19854262. |
serotonin transporter (sert, 5-htt) is a key element in the serotonergic system which is probably involved in the psychiatric disorders commonly observed in people living with hiv/aids. |
2010-04-23 |
2023-08-12 |
monkey |