| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Morecroft, A Murray, M Nilsen, A M Gurney, M R MacLea. Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension. British journal of pharmacology. vol 157. issue 7. 2010-01-14. PMID:19508393. |
we investigated the effect of the k(v)7 channel activator, flupirtine, on pah in two independent mouse models: pah induced by hypoxia and spontaneous pah in mice over-expressing the 5-ht transporter (sert(+) mice). |
2010-01-14 |
2023-08-12 |
mouse |
| Kristofer Thorslund, Husameldin El-Nour, Klas Nordlin. The serotonin transporter protein is expressed in psoriasis, where it may play a role in regulating apoptosis. Archives of dermatological research. vol 301. issue 6. 2010-01-11. PMID:19263059. |
since the symptoms of psoriasis may be changed by treatment with selective serotonin reuptake inhibitors (ssris), the expression of serotonin (5-ht) and its transporter protein (sert) in the skin of patients with psoriasis were examined employing a biotinylated-streptavidine procedure. |
2010-01-11 |
2023-08-12 |
Not clear |
| Kristofer Thorslund, Husameldin El-Nour, Klas Nordlin. The serotonin transporter protein is expressed in psoriasis, where it may play a role in regulating apoptosis. Archives of dermatological research. vol 301. issue 6. 2010-01-11. PMID:19263059. |
in biopsies of such skin staining for 5-ht was limited to platelets; the expression of sert in the keratinocytes of involved regions was redistributed; the numbers of sert-positive dendritic or round mononuclear cells in the epidermis of involved psoriatic skin were higher than in normal healthy control skin; and the dermis of the involved skin contained higher numbers of round inflammatory cells immunostained for sert than either non-involved psoriatic skin or normal skin. |
2010-01-11 |
2023-08-12 |
Not clear |
| Dakshayani Kadiyala Babu, Alain Diaz, Thangavel Samikkannu, Kurapati V K Rao, Zainulabedin M Saiyed, Jose W Rodriguez, Madhavan P N Nai. Upregulation of serotonin transporter by alcohol in human dendritic cells: possible implication in neuroimmune deregulation. Alcoholism, clinical and experimental research. vol 33. issue 10. 2010-01-11. PMID:19572987. |
5-ht is selectively transported into neurons through the serotonin transporter (sert), which is a member of the sodium- and chloride-dependent neurotransmitter transporter (slc6) family. |
2010-01-11 |
2023-08-12 |
human |
| Dakshayani Kadiyala Babu, Alain Diaz, Thangavel Samikkannu, Kurapati V K Rao, Zainulabedin M Saiyed, Jose W Rodriguez, Madhavan P N Nai. Upregulation of serotonin transporter by alcohol in human dendritic cells: possible implication in neuroimmune deregulation. Alcoholism, clinical and experimental research. vol 33. issue 10. 2010-01-11. PMID:19572987. |
we hypothesize that alcohol can modulate sert and mao-a expression in dc, leading to reciprocal downregulation of 5-ht in extracellular medium. |
2010-01-11 |
2023-08-12 |
human |
| Krishna R Hamal, Robert F Wideman, Nicholas B Anthony, Gisela F Er. Differential expression of vasoactive mediators in microparticle-challenged lungs of chickens that differ in susceptibility to pulmonary arterial hypertension. American journal of physiology. Regulatory, integrative and comparative physiology. vol 298. issue 1. 2010-01-11. PMID:19907003. |
rt-pcr was used to examine the differences between res and sus broilers in terms of gene expression of et-1, et receptor types a and b (et(a) and et(b)), the serotonin transporter (sert), serotonin receptors (5-ht(1a), 5-ht(2a), 5-ht(1b), 5-ht(2b)), endothelial no synthase (enos), and inducible nos (inos) in the lungs of these broilers before (0 h) and after (2, 6, 12, 24, and 48 h) mp injection. |
2010-01-11 |
2023-08-12 |
Not clear |
| Alinde E Wallinga, Anna M ten Voorde, Sietse F de Boer, Jaap M Koolhaas, Bauke Buwald. MDMA-induced serotonergic neurotoxicity enhances aggressiveness in low- but not high-aggressive rats. European journal of pharmacology. vol 618. issue 1-3. 2010-01-05. PMID:19616536. |
on day 28, mdma neurotoxicity to 5-ht nerve terminals was assessed by quantification of serotonin reuptake transporter (sert) immuno-positive axons in defined brain regions. |
2010-01-05 |
2023-08-12 |
rat |
| A J Stunkard, K C Allison, J D Lundgren, J P O'Reardo. A biobehavioural model of the night eating syndrome. Obesity reviews : an official journal of the International Association for the Study of Obesity. vol 10 Suppl 2. 2010-01-05. PMID:19849804. |
this will be explored by reviewing neuroimaging of brain serotonin transporters (sert) and treatment with selective serotonin reuptake inhibitors (ssris). |
2010-01-05 |
2023-08-12 |
Not clear |
| A J Stunkard, K C Allison, J D Lundgren, J P O'Reardo. A biobehavioural model of the night eating syndrome. Obesity reviews : an official journal of the International Association for the Study of Obesity. vol 10 Suppl 2. 2010-01-05. PMID:19849804. |
this hypothesis implies that reduction of sert activity should increase postsynaptic serotonin transmission and relieve nes. |
2010-01-05 |
2023-08-12 |
Not clear |
| Luigi Michele Pavone, Anna Spina, Silviana Rea, Dionea Santoro, Vincenzo Mastellone, Pietro Lombardi, Luigi Avallon. Serotonin transporter gene deficiency is associated with sudden death of newborn mice through activation of TGF-beta1 signalling. Journal of molecular and cellular cardiology. vol 47. issue 5. 2009-12-24. PMID:19646988. |
the serotonin transporter (sert) gene has been proposed as a candidate gene responsible for the sudden infant death syndrome (sids). |
2009-12-24 |
2023-08-12 |
mouse |
| Ali Esmaili, Saad F Nazir, Alip Borthakur, Dan Yu, Jerrold R Turner, Seema Saksena, Amika Singla, Gail A Hecht, Waddah A Alrefai, Ravinder K Gil. Enteropathogenic Escherichia coli infection inhibits intestinal serotonin transporter function and expression. Gastroenterology. vol 137. issue 6. 2009-12-24. PMID:19747920. |
serotonin transporter (sert) plays a critical role in regulating serotonin (5-hydroxytryptamine [5-ht]) availability in the gut. |
2009-12-24 |
2023-08-12 |
Not clear |
| Simone Macrì, Oleg Granstrem, Maria Shumilina, Fernando João Antunes Gomes dos Santos, Alessandra Berry, Luciano Saso, Giovanni Laviol. Resilience and vulnerability are dose-dependently related to neonatal stressors in mice. Hormones and behavior. vol 56. issue 4. 2009-12-22. PMID:19632235. |
offspring attentional set-shifting abilities, central neurotrophic regulation and levels of natural auto-antibodies (na-abs) directed to serotonin (sert) and dopamine (dat) transporters were assessed in adulthood. |
2009-12-22 |
2023-08-12 |
mouse |
| Zhen Tao, Yuan-Wei Zhang, Alice Agyiri, Gary Rudnic. Ligand effects on cross-linking support a conformational mechanism for serotonin transport. The Journal of biological chemistry. vol 284. issue 49. 2009-12-22. PMID:19837674. |
serotonin transporter (sert) is responsible for the re-uptake of 5-hydroxytryptamine (5-ht) from the synaptic cleft after release from serotonergic neurons. |
2009-12-22 |
2023-08-12 |
Not clear |
| Meredith A Fox, Catherine L Jensen, Dennis L Murph. Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice. The international journal of neuropsychopharmacology. vol 12. issue 8. 2009-12-04. PMID:19275775. |
tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (sert) mice. |
2009-12-04 |
2023-08-12 |
mouse |
| Meredith A Fox, Catherine L Jensen, Dennis L Murph. Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice. The international journal of neuropsychopharmacology. vol 12. issue 8. 2009-12-04. PMID:19275775. |
we recently reported a genetic mouse model for the serotonin syndrome, as serotonin transporter (sert)-deficient mice have exaggerated serotonin syndrome behavioural responses to the maoi tranylcypromine and the serotonin precursor 5-hydroxy-l-tryptophan (5-htp). |
2009-12-04 |
2023-08-12 |
mouse |
| Meredith A Fox, Catherine L Jensen, Dennis L Murph. Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice. The international journal of neuropsychopharmacology. vol 12. issue 8. 2009-12-04. PMID:19275775. |
as numerous case reports implicate the atypical opioids tramadol and meperidine in the development of the human serotonin syndrome, we examined tramadol and meperidine as possible causative drugs in the rodent model of the serotonin syndrome in sert wild-type (+/+), heterozygous (+/-) and knockout (-/-) mice. |
2009-12-04 |
2023-08-12 |
mouse |
| Meredith A Fox, Catherine L Jensen, Dennis L Murph. Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice. The international journal of neuropsychopharmacology. vol 12. issue 8. 2009-12-04. PMID:19275775. |
comparisons were made with sert mice treated with either vehicle or morphine, an opioid not implicated in the serotonin syndrome in humans. |
2009-12-04 |
2023-08-12 |
mouse |
| Meredith A Fox, Catherine L Jensen, Dennis L Murph. Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice. The international journal of neuropsychopharmacology. vol 12. issue 8. 2009-12-04. PMID:19275775. |
here we show that tramadol and meperidine, but not morphine, induce serotonin syndrome-like behaviours in mice, and we show that this response is exaggerated in mice lacking one or two copies of sert. |
2009-12-04 |
2023-08-12 |
mouse |
| Vera Golimbet, Margarita Alfimova, Galina Korovaitseva, Lilia I Abramova, Vasily G Kale. Emotional distress in parents of psychotic patients is modified by serotonin transporter gene (5-HTTLPR)--brain-derived neurotrophic factor gene interactions. The Spanish journal of psychology. vol 12. issue 2. 2009-12-03. PMID:19899670. |
there is growing evidence that sensitivity of individuals to depressogenic effects of stressful factor is moderated by genetic variants of serotonin transporter (sert) and brain-derived neurotrophic factors (bdnf). |
2009-12-03 |
2023-08-12 |
Not clear |
| A Elizabeth Linder, Kevin M Beggs, Robert J Burnett, Stephanie W Watt. Body distribution of infused serotonin in rats. Clinical and experimental pharmacology & physiology. vol 36. issue 5-6. 2009-11-24. PMID:19207716. |
our goal was to investigate the body distribution of serotonin (5-hydroxytryptamine; 5-ht) in rats infused with 5-ht (25 microg/kg per min) for 7 days and the contribution of the 5-ht transporter (sert) for 5-ht uptake into the tissues. |
2009-11-24 |
2023-08-12 |
rat |