| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xingrong Liu, Olga Vilenski, Joyce Kwan, Subbu Apparsundaram, Robert Weiker. Unbound brain concentration determines receptor occupancy: a correlation of drug concentration and brain serotonin and dopamine reuptake transporter occupancy for eighteen compounds in rats. Drug metabolism and disposition: the biological fate of chemicals. vol 37. issue 7. 2009-09-28. PMID:19389861. |
the objective of this study was to test this hypothesis by examining the relationship between in vitro binding affinity (k(i)) and in vivo activity quantified as the drug concentration occupying 50% of the transporters (oc(50)) for 18 serotonin (sert) and dopamine transporter (dat) inhibitors. |
2009-09-28 |
2023-08-12 |
rat |
| Christian J Fehske, Kristina Leuner, Walter E Mülle. Ginkgo biloba extract (EGb761) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment. Pharmacological research. vol 60. issue 1. 2009-09-25. PMID:19427589. |
here, we confirm that the norepinephrine (net), the serotonin (sert), the dopamine (dat) uptake transporters and mao activity are inhibited by egb761 in vitro, although rather high concentrations are required for inhibition of mao-a and mao-b activity. |
2009-09-25 |
2023-08-12 |
mouse |
| Gang Zhao, Cheng Bi, Guo-Wei Qin, Li-He Gu. Caulis Sinomenii extracts activate DA/NE transporter and inhibit 5HT transporter. Experimental biology and medicine (Maywood, N.J.). vol 234. issue 8. 2009-09-10. PMID:19491370. |
we assessed whether qft would be biologically active in functionally regulating monoamine transporters using cho cells expressing dopamine transporter (dat), norepinephrine transporter (net), or serotonin transporter (sert) (i.e. |
2009-09-10 |
2023-08-12 |
Not clear |
| Ichiro Sora, Bingjin Li, Setsu Fumushima, Asami Fukui, Yosefu Arime, Yoshiyuki Kasahara, Hiroaki Tomita, Kazutaka Iked. Monoamine transporter as a target molecule for psychostimulants. International review of neurobiology. vol 85. 2009-09-10. PMID:19607959. |
the effects of map in dat or serotonin transporter (sert) single knockout (ko) mice and dat/sert double ko mice suggested that dat and sert are key molecules for hyperthermia and neuronal toxicity of map. |
2009-09-10 |
2023-08-12 |
mouse |
| Gang Zhao, Xiang-Wei Zheng, Yue Gai, Wen-Jing Chu, Guo-Wei Qin, Li-He Gu. Safflower extracts functionally regulate monoamine transporters. Journal of ethnopharmacology. vol 124. issue 1. 2009-09-09. PMID:19527825. |
our current results showed that all solvent-extracted hh fractions, in different degrees, markedly increased both dopamine uptake by chinese hamster ovary (cho) cells stably expressing dopamine transporter (dat) and norepinephrine uptake by cho cells expressing norepinephrine transporter (net), and also showed that chloroform (hc), ethyl acetate (he), and n-butyl alcohol extract strikingly depressed serotonin uptake by cho cells expressing serotonin transporter (sert); wherein, the potencies of ethanol extract, hc, he, and aqueous extract to up-regulate dopamine/norepinephrine uptake and potency of he to inhibit serotonin uptake were relatively stronger. |
2009-09-09 |
2023-08-12 |
rat |
| Neil Dawson, Linda Ferrington, Henry J Olverman, Anthony J Harmar, Paul A T Kell. Sex influences the effect of a lifelong increase in serotonin transporter function on cerebral metabolism. Journal of neuroscience research. vol 87. issue 10. 2009-08-31. PMID:19326435. |
polymorphic variation in the human serotonin transporter (sert; 5-htt) gene resulting in a lifelong increase in sert expression is associated with reduced anxiety and a reduced risk of affective disorder. |
2009-08-31 |
2023-08-12 |
mouse |
| Steven M Bromidge, Barbara Bertani, Manuela Borriello, Andrea Bozzoli, Stefania Faedo, Massimo Gianotti, Laurie J Gordon, Matthew Hill, Valeria Zucchelli, Jeannette M Watson, Laura Zonzin. 8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors--part II. Bioorganic & medicinal chemistry letters. vol 19. issue 8. 2009-08-26. PMID:19286377. |
8-[2-(4-aryl-1-piperazinyl)ethyl]-2h-1,4-benzoxazin-3(4h)-ones have been identified as highly potent 5-ht(1a/b/d) receptor antagonists with and without additional sert activity and a high degree of selectivity over herg potassium channels. |
2009-08-26 |
2023-08-12 |
Not clear |
| Sotiria Tavoulari, Lucy R Forrest, Gary Rudnic. Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 30. 2009-08-19. PMID:19641126. |
serotonin transporter (sert) is the main target for widely used antidepressant agents. |
2009-08-19 |
2023-08-12 |
Not clear |
| Stephen J Kish, Paul S Fitzmaurice, Isabelle Boileau, Gregory A Schmunk, Lee-Cyn Ang, Yoshiaki Furukawa, Li-Jan Chang, Dennis J Wickham, Allan Sherwin, Junchao Ton. Brain serotonin transporter in human methamphetamine users. Psychopharmacology. vol 202. issue 4. 2009-08-11. PMID:18841348. |
as information on the brain serotonin system in human ma users is fragmentary, our objective was to determine whether protein levels of serotonin transporter (sert), a key marker of serotonin neurones, are decreased in brain of chronic ma users. |
2009-08-11 |
2023-08-12 |
human |
| Henricus G Ruhé, Jan Booij, Johannes B Reitsma, Aart H Schen. Serotonin transporter binding with [123I]beta-CIT SPECT in major depressive disorder versus controls: effect of season and gender. European journal of nuclear medicine and molecular imaging. vol 36. issue 5. 2009-08-11. PMID:19183998. |
more specifically the serotonin transporter (sert) serves as a major target for antidepressant drugs. |
2009-08-11 |
2023-08-12 |
Not clear |
| Hsin Chun Tsai, Tzung Lieh Yeh, Ming Hong Hsieh, I Hui Lee, Kao Ching Chen, Po See Chen, Yen Kuang Yang, Wei Jen Ya. Association between serotonin transporter availability and overall rating scores of quality of life in healthy volunteers. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 4. 2009-08-10. PMID:19332100. |
the present study examined the relationship between serotonin transporter (sert) availability and life quality as measured by the world health organization quality of life brief version questionnaire (who-qol) in healthy participants in order to exclude the influence of depressive mood and disease. |
2009-08-10 |
2023-08-12 |
human |
| Jonathan G McEuen, Katharine A Semsar, Maria A Lim, Tracy L Bal. Influence of sex and corticotropin-releasing factor pathways as determinants in serotonin sensitivity. Endocrinology. vol 150. issue 8. 2009-08-05. PMID:19342454. |
mechanistically, females had decreased hippocampal 5-ht transporter (sert) levels, whereas r2ko mice showed reduced sert in the prefrontal cortex, supporting a possible intersection of sex and genotype where r2ko females would have the lowest sert to be blocked by the ssri. |
2009-08-05 |
2023-08-12 |
mouse |
| Margaret R MacLean, Yvonne Dempsi. Serotonin and pulmonary hypertension--from bench to bedside? Current opinion in pharmacology. vol 9. issue 3. 2009-08-04. PMID:19286424. |
the rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (tph1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (sert) and serotonin can induce pulmonary vasoconstriction via the 5-ht1b receptor in man. |
2009-08-04 |
2023-08-12 |
Not clear |
| Elaine L Bearer, Xiaowei Zhang, Davit Janvelyan, Benoit Boulat, Russell E Jacob. Reward circuitry is perturbed in the absence of the serotonin transporter. NeuroImage. vol 46. issue 4. 2009-07-29. PMID:19306930. |
the serotonin transporter (sert) modulates the entire serotonergic system in the brain and influences both the dopaminergic and norepinephrinergic systems. |
2009-07-29 |
2023-08-12 |
mouse |
| Elaine L Bearer, Xiaowei Zhang, Davit Janvelyan, Benoit Boulat, Russell E Jacob. Reward circuitry is perturbed in the absence of the serotonin transporter. NeuroImage. vol 46. issue 4. 2009-07-29. PMID:19306930. |
here we use high-resolution magnetic resonance imaging (mri) and spectroscopy to elucidate the effects of disruption of the serotonin transporter in an animal model system: the sert knock-out mouse. |
2009-07-29 |
2023-08-12 |
mouse |
| Thorsten Lau, Sandra Horschitz, Dusan Bartsch, Patrick Schlos. Monitoring mouse serotonin transporter internalization in stem cell-derived serotonergic neurons by confocal laser scanning microscopy. Neurochemistry international. vol 54. issue 3-4. 2009-07-28. PMID:19121357. |
this task is fulfilled by a specific serotonin transporter (sert) protein which controls the concentration of extra-cellular 5ht. |
2009-07-28 |
2023-08-12 |
mouse |
| Thorsten Lau, Sandra Horschitz, Dusan Bartsch, Patrick Schlos. Monitoring mouse serotonin transporter internalization in stem cell-derived serotonergic neurons by confocal laser scanning microscopy. Neurochemistry international. vol 54. issue 3-4. 2009-07-28. PMID:19121357. |
in addition, it has been reported that exposure to selective serotonin re-uptake inhibitors (ssris) leads to a down-regulation of sert expression in vivo and in vitro in different cellular systems. |
2009-07-28 |
2023-08-12 |
mouse |
| R Iceta, J E Mesonero, J J Aramayona, A I Alcald. Expression of 5-HT1A and 5-HT7 receptors in Caco-2 cells and their role in the regulation of serotonin transporter activity. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 60. issue 1. 2009-07-20. PMID:19439818. |
5-ht binding to receptors depends on 5-ht availability, which is, in part, modulated by the 5-ht transporter (sert) expressed in enterocytes. |
2009-07-20 |
2023-08-12 |
human |
| R Iceta, J E Mesonero, J J Aramayona, A I Alcald. Expression of 5-HT1A and 5-HT7 receptors in Caco-2 cells and their role in the regulation of serotonin transporter activity. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 60. issue 1. 2009-07-20. PMID:19439818. |
this work concerns the expression of 5-ht(1a) and 5-ht(7) receptors (5-htr(1a) and 5-htr(7)) in the human enterocyte-like caco-2 cell line and their role in sert activity modulation. |
2009-07-20 |
2023-08-12 |
human |
| R Iceta, J E Mesonero, J J Aramayona, A I Alcald. Expression of 5-HT1A and 5-HT7 receptors in Caco-2 cells and their role in the regulation of serotonin transporter activity. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 60. issue 1. 2009-07-20. PMID:19439818. |
in addition, both receptors are shown to modulate sert activity; 5-htr(1a) activation increased 5-ht uptake and 5-htr(7) activation inhibited it. |
2009-07-20 |
2023-08-12 |
human |