Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Kai Yu, Chen-Li Qiu, Gui-Bo Yang, Chun-Miao Zong, Hui Xing, Yiming Shao, Qiang Wei, Chuan Qi. Alteration of serotonin transporter messenger RNA level in the peripheral blood mononuclear cells from simian/human immunodeficiency virus infected Chinese rhesus macaques (Macaca mulatta). Brain, behavior, and immunity. vol 24. issue 2. 2010-04-23. PMID:19854262. |
these data indicated that, in addition to previously observed abnormality in serotonin metabolism, sert expression might be affected in hiv/aids, which might be associated with depression and other psychiatric disorders in hiv/aids. |
2010-04-23 |
2023-08-12 |
monkey |
A V Kalueff, J D A Olivier, L J P Nonkes, J R Homber. Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes. Neuroscience and biobehavioral reviews. vol 34. issue 3. 2010-04-07. PMID:19698744. |
the serotonin transporter knockout (sert(-/-)) mouse, generated in 1998, was followed by the sert(-/-) rat, developed in 2006. |
2010-04-07 |
2023-08-12 |
mouse |
Nuria Lauzurica, Luis García-García, Sheila Pinto, José A Fuentes, Mercedes Delgad. Changes in NPY and POMC, but not serotonin transporter, following a restricted feeding/repletion protocol in rats. Brain research. vol 1313. 2010-04-05. PMID:19968967. |
serotonin (5-ht) plays a key role in controlling food intake and feeding behaviour and drugs targeting the 5-ht transporter (sert) at the synaptic cleft have been used to treat feeding related disorders. |
2010-04-05 |
2023-08-12 |
rat |
Nicholas V Cozzi, Anupama Gopalakrishnan, Lyndsey L Anderson, Joel T Feih, Alexander T Shulgin, Paul F Daley, Arnold E Ruoh. Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 12. 2010-04-02. PMID:19756361. |
we then tested the abilities of these n,n-dialkyltryptamines to inhibit [(3)h]5-ht uptake via the plasma membrane serotonin transporter (sert) in human platelets and via the vesicle monoamine transporter (vmat2) in sf9 cells expressing the rat vmat2. |
2010-04-02 |
2023-08-12 |
human |
Nicholas V Cozzi, Anupama Gopalakrishnan, Lyndsey L Anderson, Joel T Feih, Alexander T Shulgin, Paul F Daley, Arnold E Ruoh. Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 12. 2010-04-02. PMID:19756361. |
our results show that dmt, mipt, dpt, and dipt inhibit [(3)h]5-ht transport at the sert with k ( i ) values of 4.00 +/- 0.70, 8.88 +/- 4.7, 0.594 +/- 0.12, and 2.32 +/- 0.46 microm, respectively. |
2010-04-02 |
2023-08-12 |
human |
An T Vu, Stephen T Cohn, Puwen Zhang, Callain Y Kim, Paige E Mahaney, Jenifer A Bray, Grace H Johnston, Elizabeth J Koury, Scott A Cosmi, Darlene C Deecher, Valerie A Smith, James E Harrison, Liza Leventhal, Garth T Whiteside, Jeffrey D Kennedy, Eugene J Trybulsk. 1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors. Journal of medicinal chemistry. vol 53. issue 5. 2010-04-01. PMID:20131864. |
investigation of the structure-activity relationships revealed that small alkyl substitution at the c3 position of the indoline ring enhanced selectivity for the norepinephrine transporter (net) over the serotonin transporter (sert). |
2010-04-01 |
2023-08-12 |
mouse |
Judith R Homberg, Susanne E la Fleur, Edwin Cuppe. Serotonin transporter deficiency increases abdominal fat in female, but not male rats. Obesity (Silver Spring, Md.). vol 18. issue 1. 2010-03-31. PMID:19444235. |
we found that female, but not male, depression-prone serotonin transporter knockout (sert(-/-)) rats had a strong increase (54%) in abdominal fat, whereas no increases in plasma concentrations of glucose and insulin were observed. |
2010-03-31 |
2023-08-12 |
rat |
Jocelien D A Olivier, Alexander R Cools, Peter M T Deen, Berend Olivier, Bart A Ellenbroe. Blockade of dopamine, but not noradrenaline, transporters produces hyperthermia in rats that lack serotonin transporters. European journal of pharmacology. vol 629. issue 1-3. 2010-03-30. PMID:20004658. |
the noradrenalin transporter blocker atomoxetine was more effective in reducing stress-induced hyperthermia, induced by an injection, in serotonin transporter (sert) knockout (sert(-/-)) rats compared to sert(+/+) rats. |
2010-03-30 |
2023-08-12 |
rat |
Jocelien D A Olivier, Alexander R Cools, Peter M T Deen, Berend Olivier, Bart A Ellenbroe. Blockade of dopamine, but not noradrenaline, transporters produces hyperthermia in rats that lack serotonin transporters. European journal of pharmacology. vol 629. issue 1-3. 2010-03-30. PMID:20004658. |
the lack of the serotonin transporter in sert(-/-) rats might reflect humans with a life-long disturbed serotonin system, making this rat a good model to study possible changes in dopaminergic and noradrenergic systems in psychiatric disorders. |
2010-03-30 |
2023-08-12 |
rat |
Katharina Kittler, Thorsten Lau, Patrick Schlos. Antagonists and substrates differentially regulate serotonin transporter cell surface expression in serotonergic neurons. European journal of pharmacology. vol 629. issue 1-3. 2010-03-30. PMID:20006597. |
the serotonin transporter (sert) terminates serotonergic neurotransmission by the rapid removal of serotonin (5-hydroxytryptamine, 5-ht) from the extracellular space back into serotonergic neurons. |
2010-03-30 |
2023-08-12 |
Not clear |
Katharina Kittler, Thorsten Lau, Patrick Schlos. Antagonists and substrates differentially regulate serotonin transporter cell surface expression in serotonergic neurons. European journal of pharmacology. vol 629. issue 1-3. 2010-03-30. PMID:20006597. |
sert therefore controls the concentration of extracellular 5-ht, and thus one mechanism to regulate the efficacy of serotonergic neurotransmission is via modulation of the density of sert molecules on the cell membrane. |
2010-03-30 |
2023-08-12 |
Not clear |
Katharina Kittler, Thorsten Lau, Patrick Schlos. Antagonists and substrates differentially regulate serotonin transporter cell surface expression in serotonergic neurons. European journal of pharmacology. vol 629. issue 1-3. 2010-03-30. PMID:20006597. |
we have studied the effects of prolonged exposure to various selective serotonin re-uptake inhibitors (ssris), as well as cocaine and the transport substrates 5-ht and 3,4-methylenedioxy-methamphetamine (mdma), on sert cell surface expression in cultured serotonergic neurons. |
2010-03-30 |
2023-08-12 |
Not clear |
Katharina Kittler, Thorsten Lau, Patrick Schlos. Antagonists and substrates differentially regulate serotonin transporter cell surface expression in serotonergic neurons. European journal of pharmacology. vol 629. issue 1-3. 2010-03-30. PMID:20006597. |
the substrates 5-ht and mdma also induced sert internalization, while cocaine elevated sert cell surface expression. |
2010-03-30 |
2023-08-12 |
Not clear |
Suzanne M Cloonan, John J Keating, Stephen G Butler, Andrew J S Knox, Anne M Jørgensen, Günther H Peters, Dilip Rai, Desmond Corrigan, David G Lloyd, D Clive Williams, Mary J Meega. Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. European journal of medicinal chemistry. vol 44. issue 12. 2010-03-16. PMID:19717215. |
the discovery that some serotonin reuptake transporter (sert) ligands have the potential to act as pro-apoptotic agents in the treatment of cancer adds greatly to their diverse pharmacological application. |
2010-03-16 |
2023-08-12 |
Not clear |
Synia Haub, Giridhar Kanuri, Valentina Volynets, Thomas Brune, Stephan C Bischoff, Ina Berghei. Serotonin reuptake transporter (SERT) plays a critical role in the onset of fructose-induced hepatic steatosis in mice. American journal of physiology. Gastrointestinal and liver physiology. vol 298. issue 3. 2010-03-15. PMID:19713474. |
serotonin reuptake transporter (sert) plays a critical role in the onset of fructose-induced hepatic steatosis in mice. |
2010-03-15 |
2023-08-12 |
mouse |
Synia Haub, Giridhar Kanuri, Valentina Volynets, Thomas Brune, Stephan C Bischoff, Ina Berghei. Serotonin reuptake transporter (SERT) plays a critical role in the onset of fructose-induced hepatic steatosis in mice. American journal of physiology. Gastrointestinal and liver physiology. vol 298. issue 3. 2010-03-15. PMID:19713474. |
because intestinal motility and permeability are also regulated through the bioavailability of serotonin (5-ht), we assessed markers of hepatic injury in serotonin reuptake transporter knockout (sert(-/-)) and wild-type mice chronically exposed to different monosaccharide solutions (30% glucose or fructose solution) or water for 8 wk. |
2010-03-15 |
2023-08-12 |
mouse |
Paul P Bertrand, Alma Barajas-Espinosa, Shadia Neshat, Rebecca L Bertrand, Alan E Loma. Analysis of real-time serotonin (5-HT) availability during experimental colitis in mouse. American journal of physiology. Gastrointestinal and liver physiology. vol 298. issue 3. 2010-03-15. PMID:20019165. |
peak and steady-state 5-ht concentrations were measured before and during blockade of the serotonin reuptake transporter (sert) with 1 microm fluoxetine. |
2010-03-15 |
2023-08-12 |
mouse |
Paul P Bertrand, Alma Barajas-Espinosa, Shadia Neshat, Rebecca L Bertrand, Alan E Loma. Analysis of real-time serotonin (5-HT) availability during experimental colitis in mouse. American journal of physiology. Gastrointestinal and liver physiology. vol 298. issue 3. 2010-03-15. PMID:20019165. |
these data were supported by elisa assays, which showed enhanced 5-ht release during colitis, by immunohistochemical analyses, which showed increases in ec cell numbers, and by real-time pcr, which identified a decrease in sert mrna expression in the mucosa during colitis. |
2010-03-15 |
2023-08-12 |
mouse |
Yusuke Shibui, Xi Jun He, Kazuyuki Uchida, Hiroyuki Nakayam. MPTP-induced neuroblast apoptosis in the subventricular zone is not regulated by dopamine or other monoamine transporters. Neurotoxicology. vol 30. issue 6. 2010-03-09. PMID:19616025. |
the aim of this study is to elucidate the role of dat and other monoamine transporters including vesicular monoamine transporter 2 (vmat2), the serotonin transporter (sert), and the norepinephrine transporter (net) on the neuroblast apoptosis induced by mptp administration. |
2010-03-09 |
2023-08-12 |
mouse |
Dominik K Biezonski, Jerrold S Meye. Effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin transporter and vesicular monoamine transporter 2 protein and gene expression in rats: implications for MDMA neurotoxicity. Journal of neurochemistry. vol 112. issue 4. 2010-03-08. PMID:20002520. |
experiment 1 investigated mdma-induced changes in levels of the serotonin transporter (sert) and the vesicular monoamine transporter 2 (vmat-2) in the hippocampus, a region with sparse dopaminergic innervation, after lesioning noradrenergic input with n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine (dsp-4). |
2010-03-08 |
2023-08-12 |
rat |