| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Haub, Y Ritze, I Bergheim, O Pabst, M D Gershon, S C Bischof. Enhancement of intestinal inflammation in mice lacking interleukin 10 by deletion of the serotonin reuptake transporter. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 22. issue 7. 2010-09-16. PMID:20219086. |
reuptake, mediated by a plasmalemmal transporter (sert) terminates the action of released 5-ht. |
2010-09-16 |
2023-08-12 |
mouse |
| S Haub, Y Ritze, I Bergheim, O Pabst, M D Gershon, S C Bischof. Enhancement of intestinal inflammation in mice lacking interleukin 10 by deletion of the serotonin reuptake transporter. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 22. issue 7. 2010-09-16. PMID:20219086. |
serotonin secretion and serotonin reuptake transporter (sert) expression have been reported to be decreased in tnbs-induced experimental colitis and in patients with ulcerative colitis. |
2010-09-16 |
2023-08-12 |
mouse |
| S Haub, Y Ritze, I Bergheim, O Pabst, M D Gershon, S C Bischof. Enhancement of intestinal inflammation in mice lacking interleukin 10 by deletion of the serotonin reuptake transporter. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 22. issue 7. 2010-09-16. PMID:20219086. |
the present study was designed to utilize the transgenic deletion of sert as a gain-of-function model to test the hypothesis that 5-ht is a pro-inflammatory mediator in experimental colitis. |
2010-09-16 |
2023-08-12 |
mouse |
| Peng Zhang, George Cyriac, Theresa Kopajtic, Yongfang Zhao, Jonathan A Javitch, Jonathan L Katz, Amy Hauck Newma. Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. Journal of medicinal chemistry. vol 53. issue 16. 2010-09-16. PMID:20672825. |
to further explore structure-activity relationships at the serotonin transporter (sert), a series of (+/-)-4- and 5-substituted citalopram analogues were designed, synthesized, and evaluated for binding at the sert, dopamine transporter (dat) and norepinephrine transporter (net) in native rodent tissue. |
2010-09-16 |
2023-08-12 |
Not clear |
| C Kriegebaum, L Gutknecht, A Schmitt, K-P Lesch, A Rei. [Serotonin now: Part 1. Neurobiology and developmental genetics]. Fortschritte der Neurologie-Psychiatrie. vol 78. issue 6. 2010-09-08. PMID:20340067. |
the serotonin transporter (sert), which accomplishes the re-uptake of 5-ht into the neuron following its release in the synaptic cleft, not only has an important role in the termination of serotonergic neurotransmission but is also an important drug target for antidepressant compounds. |
2010-09-08 |
2023-08-12 |
Not clear |
| Peter S Talbot, Stefan Bradley, Cyril P Clarke, Kola O Babalola, Andrew W Philipp, Gavin Brown, Adam W McMahon, Julian C Matthew. Brain serotonin transporter occupancy by oral sibutramine dosed to steady state: a PET study using (11)C-DASB in healthy humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 3. 2010-09-07. PMID:19890256. |
its effects are mostly attributable to serotonin and norepinephrine transporter (sert and net, respectively) inhibition by its potent metabolites mono-desmethylsibutramine (m1) and di-desmethylsibutramine (m2). |
2010-09-07 |
2023-08-12 |
human |
| Peter S Talbot, Stefan Bradley, Cyril P Clarke, Kola O Babalola, Andrew W Philipp, Gavin Brown, Adam W McMahon, Julian C Matthew. Brain serotonin transporter occupancy by oral sibutramine dosed to steady state: a PET study using (11)C-DASB in healthy humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 3. 2010-09-07. PMID:19890256. |
5-ht reuptake inhibition may be necessary but is not sufficient for sibutramine's efficacy in humans, supporting preclinical data suggesting that the hypophagic effect requires the co-inhibition of both sert and net. |
2010-09-07 |
2023-08-12 |
human |
| J Best, M Reed, H F Nijhou. Models of dopaminergic and serotonergic signaling. Pharmacopsychiatry. vol 43 Suppl 1. 2010-08-25. PMID:20480448. |
three results from recent in silico experiments with the dopaminergic and serotonergic synapse models are described: (1) influence of substrate inhibition on the stability of dopamine and serotonin synthesis; (2) a predicted connection between serotonin reuptake transporter (sert) density on terminals and tonic firing rates; (3) an explanation of data from autoreceptor knock-out experiments. |
2010-08-25 |
2023-08-12 |
Not clear |
| B Kivell, D Day, P Bosch, S Schenk, J Mille. MDMA causes a redistribution of serotonin transporter from the cell surface to the intracellular compartment by a mechanism independent of phospho-p38-mitogen activated protein kinase activation. Neuroscience. vol 168. issue 1. 2010-08-20. PMID:20298763. |
3,4-methylenedioxymethamphetamine (mdma) causes long-term serotonin depletion and reduced serotonin transporter (sert) function in humans and in animal models. |
2010-08-20 |
2023-08-12 |
mouse |
| Elena Marino, Bongiorno Fanny, Cristina Lorenzi, Adele Pirovano, Linda Franchini, Cristina Colombo, Placido Bramanti, Enrico Smerald. Genetic bases of comorbidity between mood disorders and migraine: possible role of serotonin transporter gene. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 31. issue 3. 2010-08-18. PMID:19936882. |
the main target of antidepressant treatments belonging to the serotonin selective reuptake inhibitors (ssri) type is the serotonin transporter (sert); a well-studied polymorphic variant, in the promoter region of the gene (sertpr), has been demonstrated to influence the availability of serotonin in the synaptic cleft. |
2010-08-18 |
2023-08-12 |
Not clear |
| Julie L Wang, Shunichi Oya, Ajit K Parhi, Brian P Lieberman, Karl Ploessl, Catherine Hou, Hank F Kun. In vivo studies of the SERT-selective [18F]FPBM and VMAT2-selective [18F]AV-133 radiotracers in a rat model of Parkinson's disease. Nuclear medicine and biology. vol 37. issue 4. 2010-08-17. PMID:20447560. |
the utility of [(18)f]fpbm [2-(2'-((dimethylamino)methyl)-4'-(3-[(18)f]-fluoropropoxy)phenylthio)benzenamine], a selective serotonin transporter (sert) tracer, and [(18)f]av-133 [(+)-2-hydroxy-3-isobutyl-9-(3-fluoropropoxy)-10-methoxy-1,2,3,4,6,7-hexahydro-11bh-benzo[a]quinolizine], a selective vesicular monoamine transporter 2 (vmat2) tracer, were tested in the 6-hydroxydopamine (6-ohda) unilateral lesioned rat model. |
2010-08-17 |
2023-08-12 |
rat |
| Nyurky Matheus, Carmen Mendoza, Ruth Iceta, José Emilio Mesonero, Ana Isabel Alcald. Melatonin inhibits serotonin transporter activity in intestinal epithelial cells. Journal of pineal research. vol 48. issue 4. 2010-08-03. PMID:20210852. |
the effects of 5-ht depend on 5-ht availability which is, in part, modulated by the serotonin transporter (sert). |
2010-08-03 |
2023-08-12 |
Not clear |
| Gino Giannaccini, Laura Betti, Lionella Palego, Lara Schmid, Laura Fabbrini, Caterina Pelosini, Claudia Gargini, Ylenia Da Valle, Mario Lanza, Alessandro Marsili, Margherita Maffei, Ferruccio Santini, Paolo Vitti, Aldo Pinchera, Antonio Lucacchin. Human serotonin transporter expression during megakaryocytic differentiation of MEG-01 cells. Neurochemical research. vol 35. issue 4. 2010-08-02. PMID:20041293. |
the serotonin (5-ht) transporter (sert) has been found altered in platelets of patients with genetically complex disorders, including mood-anxiety, pain and eating disorders. |
2010-08-02 |
2023-08-12 |
human |
| Gino Giannaccini, Laura Betti, Lionella Palego, Lara Schmid, Laura Fabbrini, Caterina Pelosini, Claudia Gargini, Ylenia Da Valle, Mario Lanza, Alessandro Marsili, Margherita Maffei, Ferruccio Santini, Paolo Vitti, Aldo Pinchera, Antonio Lucacchin. Human serotonin transporter expression during megakaryocytic differentiation of MEG-01 cells. Neurochemical research. vol 35. issue 4. 2010-08-02. PMID:20041293. |
cells were cultured for 8 days with 10(-7)m 4-beta-12-tetradecanoylphorbol-13-acetate (beta-tpa) in the presence of 10% fetal bovine serum (fbs) and sert was assessed by real time pcr, immunofluorescence microscopy, western blot and [(3)h]5-ht re-uptake. |
2010-08-02 |
2023-08-12 |
human |
| Gang Zhao, Jie Wang, Guo-Wei Qin, Li-He Gu. Cynomorium songaricum extracts functionally modulate transporters of gamma-aminobutyric acid and monoamine. Neurochemical research. vol 35. issue 4. 2010-08-02. PMID:20084455. |
here, we assessed these potential actions using chinese hamster ovary cells expressing gamma-aminobutyric acid (gaba) transporter (gat-1), dopamine transporter (dat), norepinephrine transporter (net), or serotonin transporter (sert) (i.e. |
2010-08-02 |
2023-08-12 |
Not clear |
| Susanne Nikolaus, Christina Antke, Markus Beu, Hans-Wilhelm Mülle. Cortical GABA, striatal dopamine and midbrain serotonin as the key players in compulsive and anxiety disorders--results from in vivo imaging studies. Reviews in the neurosciences. vol 21. issue 2. 2010-07-29. PMID:20614802. |
as gaba and 5-ht inhibit daergic neurotransmission, the reductions of gabaa, 5-ht1a and sert can be assumed to result in an enhanced activity of the mesolimbic daergic system. |
2010-07-29 |
2023-08-12 |
Not clear |
| Monika Wiłkość, Joanna Hauser, Marta Tomaszewska, Monika Dmitrzak-Weglarz, Maria Skibińska, Aleksandra Szczepankiewicz, Alina Borkowsk. Influence of dopaminergic and serotoninergic genes on working memory in healthy subjects. Acta neurobiologiae experimentalis. vol 70. issue 1. 2010-07-28. PMID:20407490. |
the purpose of this study was to assess the association between the polymorphisms of dopaminergic (drd1, drd3, drd4, comt) and serotoninergic (sert--serotonin transporter, 5ht2a, 5ht2c) genes' polymorphisms and performance on wcst in 200 volunteers from the polish population. |
2010-07-28 |
2023-08-12 |
human |
| Brian J Piper, Syed F Ali, Lauren G Daniels, Jerrold S Meye. Repeated intermittent methylenedioxymethamphetamine exposure protects against the behavioral and neurotoxic, but not hyperthermic, effects of an MDMA binge in adult rats. Synapse (New York, N.Y.). vol 64. issue 6. 2010-07-19. PMID:20169574. |
we have recently shown that chronic intermittent exposure of adolescent rats to 3,4-methylenedioxymethamphetamine (mdma or ecstasy) completely blocks the reduction in serotonin transporter (sert) binding and the hypoactivity seen following a subsequent mdma binge treatment. |
2010-07-19 |
2023-08-12 |
rat |
| Brian J Piper, Syed F Ali, Lauren G Daniels, Jerrold S Meye. Repeated intermittent methylenedioxymethamphetamine exposure protects against the behavioral and neurotoxic, but not hyperthermic, effects of an MDMA binge in adult rats. Synapse (New York, N.Y.). vol 64. issue 6. 2010-07-19. PMID:20169574. |
spontaneous motor activity was determined the next day, and cortical and hippocampal samples were collected at 1 week postbinge to measure serotonin (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) concentrations as well as [3h]citalopram binding to sert. |
2010-07-19 |
2023-08-12 |
rat |
| Brian J Piper, Syed F Ali, Lauren G Daniels, Jerrold S Meye. Repeated intermittent methylenedioxymethamphetamine exposure protects against the behavioral and neurotoxic, but not hyperthermic, effects of an MDMA binge in adult rats. Synapse (New York, N.Y.). vol 64. issue 6. 2010-07-19. PMID:20169574. |
mdma preexposure protected animals from the reductions in cortical 5-ht levels and sert binding produced by the high-dose binge and blocked the postbinge hypoactivity. |
2010-07-19 |
2023-08-12 |
rat |