| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masahiro Shibasaki, Mariko Inoue, Kazuhiro Kurokawa, Satoru Ogou, Seitaro Ohkum. Expression of serotonin transporter in mice with ethanol physical dependency. Journal of pharmacological sciences. vol 114. issue 2. 2011-02-24. PMID:20838024. |
in the present study, we investigated whether ethanol physical dependence causes changes of serotonin transporter (sert) expression in the brain. |
2011-02-24 |
2023-08-12 |
mouse |
| Donatella Marazziti, Giorgio Consoli, Francesca Golia, Stefano Baroni, Irene Masala, Marina Carlini, Mario Catena Dell'oss. Trazodone effects on [H]-paroxetine and alpha(2)-adrenoreceptors in platelets of patients with major depression. Neuropsychiatric disease and treatment. vol 6. 2011-02-22. PMID:20520789. |
the lack of information on its effects in vivo prompted us to evaluate alpha(2)-adrenoceptors by means of the specific binding of [(3)h]-rauwolscine, and the 5-ht transporter (sert) by means of the binding of [(3)h]-paroxetine ([(3)h]-par), in platelets of depressed patients, before and after one month of treatment with trazodone (75-300 mg/day). |
2011-02-22 |
2023-08-12 |
Not clear |
| L MacGillivray, L M Lagrou, K B Reynolds, P I Rosebush, M F Mazure. Role of serotonin transporter inhibition in the regulation of tryptophan hydroxylase in brainstem raphe nuclei: time course and regional specificity. Neuroscience. vol 171. issue 2. 2011-02-17. PMID:20868730. |
drugs that selectively inhibit the serotonin transporter (sert) are widely prescribed for treatment of depression and a range of anxiety disorders. |
2011-02-17 |
2023-08-12 |
rat |
| L MacGillivray, L M Lagrou, K B Reynolds, P I Rosebush, M F Mazure. Role of serotonin transporter inhibition in the regulation of tryptophan hydroxylase in brainstem raphe nuclei: time course and regional specificity. Neuroscience. vol 171. issue 2. 2011-02-17. PMID:20868730. |
these results indicate that sert inhibition can alter the regulation of tph, the rate limiting enzyme for serotonin biosynthesis. |
2011-02-17 |
2023-08-12 |
rat |
| L MacGillivray, L M Lagrou, K B Reynolds, P I Rosebush, M F Mazure. Role of serotonin transporter inhibition in the regulation of tryptophan hydroxylase in brainstem raphe nuclei: time course and regional specificity. Neuroscience. vol 171. issue 2. 2011-02-17. PMID:20868730. |
this persistent and regionally specific downregulation of serotonin biosynthesis may account for some of the clinical withdrawal symptoms associated with drugs that inhibit sert. |
2011-02-17 |
2023-08-12 |
rat |
| Yiyun Huang, Ming-Qiang Zheng, John M Gerde. Development of effective PET and SPECT imaging agents for the serotonin transporter: has a twenty-year journey reached its destination? Current topics in medicinal chemistry. vol 10. issue 15. 2011-02-16. PMID:20583995. |
the serotonin transporter (sert) has been implicated in a variety of neuropsychiatric disorders including depression, schizophrenia, substance abuse, alcoholism, and alzheimer's disease. |
2011-02-16 |
2023-08-12 |
Not clear |
| Andrey Kullyev, Catherine M Dempsey, Sarah Miller, Chih-Jen Kuan, Vera M Hapiak, Richard W Komuniecki, Christine T Griffin, Ji Ying Sz. A genetic survey of fluoxetine action on synaptic transmission in Caenorhabditis elegans. Genetics. vol 186. issue 3. 2011-02-15. PMID:20739712. |
fluoxetine acts primarily as an inhibitor of the serotonin reuptake transporter (sert) to block the removal of serotonin from the synaptic cleft, thereby enhancing serotonin signals. |
2011-02-15 |
2023-08-12 |
caenorhabditis_elegans |
| Andrey Kullyev, Catherine M Dempsey, Sarah Miller, Chih-Jen Kuan, Vera M Hapiak, Richard W Komuniecki, Christine T Griffin, Ji Ying Sz. A genetic survey of fluoxetine action on synaptic transmission in Caenorhabditis elegans. Genetics. vol 186. issue 3. 2011-02-15. PMID:20739712. |
we show that fluoxetine treatment and null mutation in the sole sert gene mod-5 eliminate serotonin in specific neurons. |
2011-02-15 |
2023-08-12 |
caenorhabditis_elegans |
| Kristin J Weaver, Ian A Paul, Rick C S Lin, Kimberly L Simpso. Neonatal exposure to citalopram selectively alters the expression of the serotonin transporter in the hippocampus: dose-dependent effects. Anatomical record (Hoboken, N.J. : 2007). vol 293. issue 11. 2011-02-10. PMID:20830689. |
in the present investigation, we injected rat pups with citalopram (ctm: 5 mg/kg, 10 mg/kg, and 20 mg/kg) from postnatal days 8-21, and examined serotonin transporter (sert) labeling in the hippocampus, ventrobasal thalamic complex, and caudate-putamen when the subjects reached adulthood. |
2011-02-10 |
2023-08-12 |
human |
| Pei Chun Hsieh, I Hui Lee, Tzung Lieh Yeh, Kao Chin Chen, Hui Chun Huang, Po See Chen, Yen Kuang Yang, Wei Jen Yao, Ru-Band Lu, Nan Tsing Chi. Distribution volume ratio of serotonin and dopamine transporters in euthymic patients with a history of major depression - a dual-isotope SPECT study. Psychiatry research. vol 184. issue 3. 2011-02-03. PMID:21030217. |
serotonin transporter (sert) and dopamine transporter (dat) levels differ in patients with major depression who are in a depressed state in comparison with healthy controls. |
2011-02-03 |
2023-08-12 |
human |
| R L Bertrand, S Senadheera, I Markus, L Liu, L Howitt, H Chen, T V Murphy, S L Sandow, P P Bertran. A Western diet increases serotonin availability in rat small intestine. Endocrinology. vol 152. issue 1. 2011-01-31. PMID:21068163. |
in chow-fed (cf) and western diet-fed (wd) rats electrochemical methods were used to measure compression evoked (peak) and steady state (ss) 5-ht levels with fluoxetine used to block the serotonin reuptake transporter (sert). |
2011-01-31 |
2023-08-12 |
rat |
| M A Tikhonova, E L Alperina, T G Tolstikova, D V Bazovkina, V Y Di, G V Idova, A V Kulikov, N K Popov. Effects of chronic fluoxetine treatment on catalepsy and the immune response in mice with a genetic predisposition to freezing reactions: the roles of types 1A and 2A serotonin receptors and the tph2 and SERT genes. Neuroscience and behavioral physiology. vol 40. issue 5. 2011-01-28. PMID:20464512. |
effects of chronic fluoxetine treatment on catalepsy and the immune response in mice with a genetic predisposition to freezing reactions: the roles of types 1a and 2a serotonin receptors and the tph2 and sert genes. |
2011-01-28 |
2023-08-12 |
mouse |
| Chihiro Yokoyama, Hajime Yamanaka, Kayo Onoe, Akihiro Kawasaki, Hiroko Nagata, Keiko Shirakami, Hisashi Doi, Hirotaka Ono. Mapping of serotonin transporters by positron emission tomography with [11C]DASB in conscious common marmosets: comparison with rhesus monkeys. Synapse (New York, N.Y.). vol 64. issue 8. 2011-01-26. PMID:20340166. |
to assess the brain serotonergic systems, we investigated the binding of [(11)c]-3-amino-4-(2-dimetylaminomethyl-phenylsulfanyl)-benzonitrile ([(11)c]dasb) to brain serotonin transporter (sert) in conscious common marmosets using positron emission tomography (pet), and compared with findings for rhesus monkeys. |
2011-01-26 |
2023-08-12 |
monkey |
| Elodie Trouche, Celine Mias, Marie-Helene Seguelas, Catherine Ordener, Daniel Cussac, Angelo Parin. Characterization of monoamine oxidases in mesenchymal stem cells: role in hydrogen peroxide generation and serotonin-dependent apoptosis. Stem cells and development. vol 19. issue 10. 2011-01-25. PMID:20073575. |
rt-pcr analysis and western blots showed that the serotonin transporter (sert) and the 2 mao isoenzymes, a and b, are expressed in mscs. |
2011-01-25 |
2023-08-12 |
Not clear |
| Elodie Trouche, Celine Mias, Marie-Helene Seguelas, Catherine Ordener, Daniel Cussac, Angelo Parin. Characterization of monoamine oxidases in mesenchymal stem cells: role in hydrogen peroxide generation and serotonin-dependent apoptosis. Stem cells and development. vol 19. issue 10. 2011-01-25. PMID:20073575. |
finally, exposure of the cells to serotonin promoted an increase in mscs apoptosis prevented by pargyline and the sert inhibitor imipramine. |
2011-01-25 |
2023-08-12 |
Not clear |
| Catherine E Hagan, John F Neumaier, James O Schen. Rotating disk electrode voltammetric measurements of serotonin transporter kinetics in synaptosomes. Journal of neuroscience methods. vol 193. issue 1. 2011-01-21. PMID:20713085. |
the 5-ht transporter (sert) modulates 5-ht neurotransmission strength and duration. |
2011-01-21 |
2023-08-12 |
mouse |
| Georgianna G Gould, Julie G Hensler, Teresa F Burke, Robert H Benno, Emmanuel S Onaivi, Lynette C Daw. Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior. Journal of neurochemistry. vol 116. issue 2. 2011-01-20. PMID:21070242. |
to test this, we compared 5-ht transporter (sert), 5-ht(1a) and 5-ht(2a) receptor densities among btbr and c57 strains. |
2011-01-20 |
2023-08-12 |
mouse |
| Georgianna G Gould, Julie G Hensler, Teresa F Burke, Robert H Benno, Emmanuel S Onaivi, Lynette C Daw. Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior. Journal of neurochemistry. vol 116. issue 2. 2011-01-20. PMID:21070242. |
in btbr mice, the sert blocker, fluoxetine (10 mg/kg) and the 5-ht(1a) receptor partial-agonist, buspirone (2 mg/kg) enhanced social interactions. |
2011-01-20 |
2023-08-12 |
mouse |
| Georgianna G Gould, Julie G Hensler, Teresa F Burke, Robert H Benno, Emmanuel S Onaivi, Lynette C Daw. Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior. Journal of neurochemistry. vol 116. issue 2. 2011-01-20. PMID:21070242. |
overall, altered sert and/or 5-ht(1a) functionality in hippocampus could contribute to the relatively low sociability of btbr mice. |
2011-01-20 |
2023-08-12 |
mouse |
| H N Noristani, M Olabarria, A Verkhratsky, J J Rodrígue. Serotonin fibre sprouting and increase in serotonin transporter immunoreactivity in the CA1 area of hippocampus in a triple transgenic mouse model of Alzheimer's disease. The European journal of neuroscience. vol 32. issue 1. 2011-01-13. PMID:20576032. |
here, we studied hippocampal 5-ht innervation by analysing: (i) the expression, density and distribution of 5-ht transporter (sert)-immunoreactive fibres; (ii) the specific morphological characteristics of serotonergic fibres and their relation to amyloid plaques; and (iii) the total number of 5-ht neurons within the raphe nuclei in triple transgenic mouse model of ad. |
2011-01-13 |
2023-08-12 |
mouse |