| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard B Rothman, Michael H Baumann, Bruce E Blough, Arthur E Jacobson, Kenner C Rice, John S Partill. Evidence for noncompetitive modulation of substrate-induced serotonin release. Synapse (New York, N.Y.). vol 64. issue 11. 2011-01-13. PMID:20842720. |
prior work indicated that serotonin transporter (sert) inhibitors competitively inhibit substrate-induced [(3)h]5-ht release, producing rightward shifts in the substrate-dose response curve and increasing the ec(50) value without altering the e(max). |
2011-01-13 |
2023-08-12 |
rat |
| Richard B Rothman, Michael H Baumann, Bruce E Blough, Arthur E Jacobson, Kenner C Rice, John S Partill. Evidence for noncompetitive modulation of substrate-induced serotonin release. Synapse (New York, N.Y.). vol 64. issue 11. 2011-01-13. PMID:20842720. |
to test this hypothesis, we utilized a well-characterized [(3)h]5-ht release assay that measures the ability of a sert substrate to release preloaded [(3)h]5-ht from rat brain synaptosomes. |
2011-01-13 |
2023-08-12 |
rat |
| Richard B Rothman, Michael H Baumann, Bruce E Blough, Arthur E Jacobson, Kenner C Rice, John S Partill. Evidence for noncompetitive modulation of substrate-induced serotonin release. Synapse (New York, N.Y.). vol 64. issue 11. 2011-01-13. PMID:20842720. |
dose-response curves were generated for six substrates (pal-287 [naphthylisopropylamine], (+)-fenfluramine, (+)-norfenfluramine, mcpp [meta-chlorophenylpiperazine], (±)-mdma, 5-ht) in the absence and presence of a fixed concentration of three sert inhibitors (indatraline, bw723c86, eg-1-149 [4-(2-(benzhydryloxy)ethyl)-1-(4-bromobenzyl)piperidine oxalate]). |
2011-01-13 |
2023-08-12 |
rat |
| Ali El-Kasaby, Herwig Just, Elisabeth Malle, Peggy C Stolt-Bergner, Harald H Sitte, Michael Freissmuth, Oliver Kudlace. Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter. The Journal of biological chemistry. vol 285. issue 50. 2011-01-10. PMID:20889976. |
the serotonin transporter (sert) is a member of the slc6 family of solute carriers. |
2011-01-10 |
2023-08-12 |
human |
| Ali El-Kasaby, Herwig Just, Elisabeth Malle, Peggy C Stolt-Bergner, Harald H Sitte, Michael Freissmuth, Oliver Kudlace. Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter. The Journal of biological chemistry. vol 285. issue 50. 2011-01-10. PMID:20889976. |
sert plays a crucial role in synaptic neurotransmission by retrieving released serotonin. |
2011-01-10 |
2023-08-12 |
human |
| Kang-Wei Chang, Chia-Chieh Chen, Shih-Ying Lee, Lie-Hang Shen, Hsin-Ell Wan. Development of acute and subacute toxicity with the serotonin transporter radiopharmaceutical, ADAM. Drug and chemical toxicology. vol 33. issue 4. 2011-01-07. PMID:20550426. |
(123)i-labeled adam was developed to facilitate an early diagnosis of serotonin transporter (sert) abnormalities in the brain. |
2011-01-07 |
2023-08-12 |
rat |
| Francesco Roselli, Nicola M Pisciotta, Michele Pennelli, Maria S Aniello, Angelo Gigante, Maria F De Caro, Ermanno Ferrannini, Bruno Tartaglione, Artor Niccoli-Asabella, Giovanni Defazio, Paolo Livrea, Giuseppe Rubin. Midbrain SERT in degenerative parkinsonisms: a 123I-FP-CIT SPECT study. Movement disorders : official journal of the Movement Disorder Society. vol 25. issue 12. 2010-12-28. PMID:20669272. |
we have exploited the affinity of the same radiotracer (123)i-fp-cit for the serotonin transporter to investigate sert levels in the midbrain of patients with pd, dlb, psp, and et compared to hc. |
2010-12-28 |
2023-08-12 |
Not clear |
| Morten Ziebell, Signe Holm-Hansen, Gerda Thomsen, Aase Wagner, Peter Jensen, Lars H Pinborg, Gitte Moos Knudse. Serotonin transporters in dopamine transporter imaging: a head-to-head comparison of dopamine transporter SPECT radioligands 123I-FP-CIT and 123I-PE2I. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 51. issue 12. 2010-12-22. PMID:21078806. |
current spect radioligands available for in vivo imaging of the dopamine transporter (dat) also show affinity for monoamine transporters other than dat, especially the serotonin transporter (sert). |
2010-12-22 |
2023-08-12 |
Not clear |
| Subhodeep Sarker, René Weissensteiner, Ilka Steiner, Harald H Sitte, Gerhard F Ecker, Michael Freissmuth, Sonja Suci. The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter. Molecular pharmacology. vol 78. issue 6. 2010-12-17. PMID:20829432. |
the structure of the bacterial leucine transporter from aquifex aeolicus (leut(aa)) has been used as a model for mammalian na(+)/cl(-)-dependent transporters, in particular the serotonin transporter (sert). |
2010-12-17 |
2023-08-12 |
Not clear |
| Nicole Baganz, Rebecca Horton, Kathryn Martin, Andrew Holmes, Lynette C Daw. Repeated swim impairs serotonin clearance via a corticosterone-sensitive mechanism: organic cation transporter 3, the smoking gun. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 45. 2010-12-13. PMID:21068324. |
one way could be via hpa axis-dependent impairment of serotonin transporter (sert) function, the high-affinity uptake mechanism for 5-ht. |
2010-12-13 |
2023-08-12 |
mouse |
| Charles P Mercado, Fusun Kili. Molecular mechanisms of SERT in platelets: regulation of plasma serotonin levels. Molecular interventions. vol 10. issue 4. 2010-11-30. PMID:20729489. |
molecular mechanisms of sert in platelets: regulation of plasma serotonin levels. |
2010-11-30 |
2023-08-12 |
Not clear |
| Charles P Mercado, Fusun Kili. Molecular mechanisms of SERT in platelets: regulation of plasma serotonin levels. Molecular interventions. vol 10. issue 4. 2010-11-30. PMID:20729489. |
the serotonin transporter (sert) on platelets is a primary mechanism for serotonin (5ht) uptake from the blood plasma. |
2010-11-30 |
2023-08-12 |
Not clear |
| Charles P Mercado, Fusun Kili. Molecular mechanisms of SERT in platelets: regulation of plasma serotonin levels. Molecular interventions. vol 10. issue 4. 2010-11-30. PMID:20729489. |
there is a biphasic relationship between plasma 5ht elevation, loss of surface sert, and depletion of platelet 5ht. |
2010-11-30 |
2023-08-12 |
Not clear |
| Charles P Mercado, Fusun Kili. Molecular mechanisms of SERT in platelets: regulation of plasma serotonin levels. Molecular interventions. vol 10. issue 4. 2010-11-30. PMID:20729489. |
specifically, in platelets, plasma membrane sert levels and platelet 5ht uptake initially rise as plasma 5ht levels are increased but then fall below normal as the plasma 5ht level continues to rise. |
2010-11-30 |
2023-08-12 |
Not clear |
| Charles P Mercado, Fusun Kili. Molecular mechanisms of SERT in platelets: regulation of plasma serotonin levels. Molecular interventions. vol 10. issue 4. 2010-11-30. PMID:20729489. |
therefore, we propose that elevated plasma 5ht limits its own uptake in platelets by down-regulating sert as well as modifying the characteristics of sert partners in the membrane trafficking pathway. |
2010-11-30 |
2023-08-12 |
Not clear |
| Charles P Mercado, Fusun Kili. Molecular mechanisms of SERT in platelets: regulation of plasma serotonin levels. Molecular interventions. vol 10. issue 4. 2010-11-30. PMID:20729489. |
this review will summarize current findings regarding the biochemical mechanisms by which elevated 5ht downregulates the expression of sert on the platelet membrane. |
2010-11-30 |
2023-08-12 |
Not clear |
| Anders Bue Klein, Viktorija Trajkovska, David Erritzoe, Steven Haugbol, Jacob Madsen, William Baaré, Susana Aznar, Gitte M Knudse. Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 30. issue 11. 2010-11-29. PMID:20736957. |
in this study, we investigated whether the bdnf val66met polymorphism or blood bdnf levels are associated with cerebral 5-hydroxytryptamine 2a (5-ht(2a)) receptor or serotonin transporter (sert) binding in healthy subjects. |
2010-11-29 |
2023-08-12 |
human |
| Anders Bue Klein, Viktorija Trajkovska, David Erritzoe, Steven Haugbol, Jacob Madsen, William Baaré, Susana Aznar, Gitte M Knudse. Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 30. issue 11. 2010-11-29. PMID:20736957. |
no statistically significant differences in 5-ht(2a) receptor or sert binding were found between the val/val and met carriers, nor were blood bdnf values associated with sert binding or 5-ht(2a) receptor binding. |
2010-11-29 |
2023-08-12 |
human |
| Anders Bue Klein, Viktorija Trajkovska, David Erritzoe, Steven Haugbol, Jacob Madsen, William Baaré, Susana Aznar, Gitte M Knudse. Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 30. issue 11. 2010-11-29. PMID:20736957. |
moreover, bdnf levels in blood do not correlate with either 5-ht(2a) or sert binding. |
2010-11-29 |
2023-08-12 |
human |
| Ruth Tellez, Luisa Rocha, Carlos Castillo, Alfredo Menese. Autoradiographic study of serotonin transporter during memory formation. Behavioural brain research. vol 212. issue 1. 2010-11-12. PMID:20226815. |
serotonin transporter (sert) has been associated with drugs of abuse like d-methamphetamine (meth). |
2010-11-12 |
2023-08-12 |
Not clear |