| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria J Barnes, Richard C Rogers, Montina J Van Meter, Gerlinda E Herman. Co-localization of TRHR1 and LepRb receptors on neurons in the hindbrain of the rat. Brain research. vol 1355. 2011-06-20. PMID:20691166. |
fibers in the nst and rp that possess trhr1 receptors were phenotypically identified as serotonergic [i.e., immunopositive for the serotonin transporter; sert]. |
2011-06-20 |
2023-08-12 |
rat |
| Judith R Homberg, Klaus-Peter Lesc. Looking on the bright side of serotonin transporter gene variation. Biological psychiatry. vol 69. issue 6. 2011-06-10. PMID:21047622. |
converging evidence indicates an association of the short (s), low-expressing variant of the repeat length polymorphism, serotonin transporter-linked polymorphic region (5-httlpr), in the human serotonin transporter gene (5-htt, sert, slc6a4) with anxiety-related traits and increased risk for depression in interaction with psychosocial adversity across the life span. |
2011-06-10 |
2023-08-12 |
human |
| Teodora-Adriana Perles-Barbacaru, Daniel Procissi, Andrey V Demyanenko, F Scott Hall, George R Uhl, Russell E Jacob. Quantitative pharmacologic MRI: mapping the cerebral blood volume response to cocaine in dopamine transporter knockout mice. NeuroImage. vol 55. issue 2. 2011-06-10. PMID:21185387. |
cocaine acts to block the dopamine, norepinephrine, and serotonin transporters (dat, net, and sert) that clear their respective neurotransmitters from the synapses, helping to terminate cognate neurotransmission. |
2011-06-10 |
2023-08-12 |
mouse |
| Anna Spina, Silviana Rea, Valeria De Pasquale, Vincenzo Mastellone, Luigi Avallone, Luigi Michele Pavon. Fate map of serotonin transporter-expressing cells in developing mouse thyroid. Anatomical record (Hoboken, N.J. : 2007). vol 294. issue 3. 2011-06-09. PMID:21308996. |
a cre/loxp-based fate mapping approach was used to follow the regions of the mouse thyroid labeled by the serotonin transporter sert. |
2011-06-09 |
2023-08-12 |
mouse |
| Dea Adamsen, David Meili, Nenad Blau, Beat Thöny, Vincent Ramaeker. Autism associated with low 5-hydroxyindolacetic acid in CSF and the heterozygous SLC6A4 gene Gly56Ala plus 5-HTTLPR L/L promoter variants. Molecular genetics and metabolism. vol 102. issue 3. 2011-06-06. PMID:21183371. |
the known gly56ala mutation in the serotonin transporter sert (or 5-htt), encoded by the slc6a4 gene, causes increased serotonin reuptake and has been associated with autism and rigid-compulsive behavior. |
2011-06-06 |
2023-08-12 |
Not clear |
| Dea Adamsen, David Meili, Nenad Blau, Beat Thöny, Vincent Ramaeker. Autism associated with low 5-hydroxyindolacetic acid in CSF and the heterozygous SLC6A4 gene Gly56Ala plus 5-HTTLPR L/L promoter variants. Molecular genetics and metabolism. vol 102. issue 3. 2011-06-06. PMID:21183371. |
these changes are reported to be responsible for elevated sert activity and expression, suggesting that these alterations were responsible in our patient for low serotonin turnover in the central nervous system (cns). |
2011-06-06 |
2023-08-12 |
Not clear |
| Dea Adamsen, David Meili, Nenad Blau, Beat Thöny, Vincent Ramaeker. Autism associated with low 5-hydroxyindolacetic acid in CSF and the heterozygous SLC6A4 gene Gly56Ala plus 5-HTTLPR L/L promoter variants. Molecular genetics and metabolism. vol 102. issue 3. 2011-06-06. PMID:21183371. |
we speculate that the mutated 56ala sert transporter with elevated expression and basal activity for serotonin re-uptake is accompanied with serotonin accumulation within pre-synaptic axons and their vesicles in the cns, resulting in a steady-state of lowered serotonin turnover and degradation by monoamine-oxidase (mao) enzymes in pre-synaptic or neighboring cells. |
2011-06-06 |
2023-08-12 |
Not clear |
| Xiaojun Wu, Hung Hsuchou, Abba J Kastin, Yi He, Reas S Khan, Kirsten P Stone, Michael S Cash, Weihong Pa. Interleukin-15 affects serotonin system and exerts antidepressive effects through IL15Rα receptor. Psychoneuroendocrinology. vol 36. issue 2. 2011-06-02. PMID:20724079. |
the hippocampus of the il15rα knockout mice had decreased mrna for 5-ht(1a), increased mrna for 5-ht(2c), and region-specific changes of serotonin reuptake transporter (sert) immunoreactivity. |
2011-06-02 |
2023-08-12 |
mouse |
| Xiaojun Wu, Hung Hsuchou, Abba J Kastin, Yi He, Reas S Khan, Kirsten P Stone, Michael S Cash, Weihong Pa. Interleukin-15 affects serotonin system and exerts antidepressive effects through IL15Rα receptor. Psychoneuroendocrinology. vol 36. issue 2. 2011-06-02. PMID:20724079. |
fluoxetine (the classic antidepressant prozac, which inhibits 5-ht(2c) and sert) reduced the immobility of the il15rα knockout mice in comparison with their pretreatment baseline. |
2011-06-02 |
2023-08-12 |
mouse |
| Xiaojun Wu, Hung Hsuchou, Abba J Kastin, Yi He, Reas S Khan, Kirsten P Stone, Michael S Cash, Weihong Pa. Interleukin-15 affects serotonin system and exerts antidepressive effects through IL15Rα receptor. Psychoneuroendocrinology. vol 36. issue 2. 2011-06-02. PMID:20724079. |
in ex vivo studies, il15 decreased synaptosomal uptake of 5-ht, and modulated the expression of 5-ht(2c) and sert in cultured neurons in a dose- and time-dependent manner. |
2011-06-02 |
2023-08-12 |
mouse |
| Susanna Nencetti, Maria R Mazzoni, Gabriella Ortore, Annalina Lapucci, Janette Giuntini, Elisabetta Orlandini, Irene Banti, Elisa Nuti, Antonio Lucacchini, Gino Giannaccini, Armando Rossell. Synthesis, molecular docking and binding studies of selective serotonin transporter inhibitors. European journal of medicinal chemistry. vol 46. issue 3. 2011-06-02. PMID:21272963. |
with the aim of obtaining compounds possessing high sert selectivity, in the present work we synthesized and studied the inhibition of serotonin (sert), dopamine (dat) and norepinephrine (net) transporters by docking studies and experimental binding measurements of a series of 4-(aryl)piperidin-3-one o-4-benzyl oxime hydrochlorides (1-10) of both e and z configuration. |
2011-06-02 |
2023-08-12 |
Not clear |
| Hidehito Takayama, Shigetoshi Sugi. Functional expression of milligram quantities of the synthetic human serotonin transporter gene in a tetracycline-inducible HEK293 cell line. Protein expression and purification. vol 76. issue 2. 2011-05-31. PMID:21129485. |
the serotonin transporter (sert), a member of the solute carrier 6 family, is responsible for reuptake of the monoamine neurotransmitter serotonin (5-hydroxytryptamine) from the synaptic cleft on the neural cells, and a vital target for several antidepressants. |
2011-05-31 |
2023-08-12 |
human |
| Martina Pavanetto, Alessandro Zarpellon, Christian Borgo, Arianna Donella-Deana, Renzo Dean. Regulation of serotonin transport in human platelets by tyrosine kinase Syk. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 27. issue 2. 2011-05-27. PMID:21325831. |
the circulating level of 5-ht is regulated by the membrane transporter sert present both in the presynaptic nerve terminals and blood platelets. |
2011-05-27 |
2023-08-12 |
human |
| Martina Pavanetto, Alessandro Zarpellon, Christian Borgo, Arianna Donella-Deana, Renzo Dean. Regulation of serotonin transport in human platelets by tyrosine kinase Syk. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 27. issue 2. 2011-05-27. PMID:21325831. |
it is concluded that, in addition to the phosphorylation of sert mediated by various other kinases, also that catalyzed by syk might play an important role in the 5-ht transport, likely favoring the transporter conformation exposing the neurotransmitter binding sites. |
2011-05-27 |
2023-08-12 |
human |
| Karine Madsen, David Erritzoe, Erik Lykke Mortensen, Anders Gade, Jacob Madsen, William Baaré, Gitte M Knudsen, Steen G Hasselbalc. Cognitive function is related to fronto-striatal serotonin transporter levels--a brain PET study in young healthy subjects. Psychopharmacology. vol 213. issue 2-3. 2011-05-24. PMID:20623110. |
the serotonin transporter (sert) protein is a key regulator in the serotonin system. |
2011-05-24 |
2023-08-12 |
human |
| Karine Madsen, David Erritzoe, Erik Lykke Mortensen, Anders Gade, Jacob Madsen, William Baaré, Gitte M Knudsen, Steen G Hasselbalc. Cognitive function is related to fronto-striatal serotonin transporter levels--a brain PET study in young healthy subjects. Psychopharmacology. vol 213. issue 2-3. 2011-05-24. PMID:20623110. |
we hypothesized that higher performance on tests sensitive to serotonin would be associated with higher sert levels in specific fronto-striatal brain regions. |
2011-05-24 |
2023-08-12 |
human |
| Britta Haenisch, Heinz Bönisc. Depression and antidepressants: insights from knockout of dopamine, serotonin or noradrenaline re-uptake transporters. Pharmacology & therapeutics. vol 129. issue 3. 2011-05-19. PMID:21147164. |
major targets of ads are the serotonin transporter (sert), the noradrenaline transporter (nat) and also the dopamine transporter (dat) located in the plasma membrane of corresponding neurons. |
2011-05-19 |
2023-08-12 |
mouse |
| Brent J Thompson, Tammy Jessen, L K Henry, Julie R Field, Karen L Gamble, Paul J Gresch, Ana M Carneiro, Rebecca E Horton, Peter J Chisnell, Yekaterina Belova, Douglas G McMahon, Lynette C Daws, Randy D Blakel. Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 9. 2011-05-09. PMID:21282638. |
our animals possess a modified copy of the 5-ht transporter (i.e., sert, slc6a4) that bears a single amino acid substitution, i172m, proximal to the 5-ht binding site. |
2011-05-09 |
2023-08-12 |
mouse |
| Brent J Thompson, Tammy Jessen, L K Henry, Julie R Field, Karen L Gamble, Paul J Gresch, Ana M Carneiro, Rebecca E Horton, Peter J Chisnell, Yekaterina Belova, Douglas G McMahon, Lynette C Daws, Randy D Blakel. Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 9. 2011-05-09. PMID:21282638. |
here, we demonstrate that, in m172 knock-in mice, basal sert protein levels, 5-ht transport rates, and 5-ht levels are normal. |
2011-05-09 |
2023-08-12 |
mouse |
| Brent J Thompson, Tammy Jessen, L K Henry, Julie R Field, Karen L Gamble, Paul J Gresch, Ana M Carneiro, Rebecca E Horton, Peter J Chisnell, Yekaterina Belova, Douglas G McMahon, Lynette C Daws, Randy D Blakel. Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 9. 2011-05-09. PMID:21282638. |
however, sert m172 mice display a substantial loss of sensitivity to the selective 5-ht reuptake inhibitors fluoxetine and citalopram, as well as to cocaine. |
2011-05-09 |
2023-08-12 |
mouse |