| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Berend Olivier, Johnny S W Chan, Eelke M Snoeren, Jocelien D A Olivier, Jan G Veening, Christiaan H Vinkers, Marcel D Waldinger, Ronald S Oostin. Differences in sexual behaviour in male and female rodents: role of serotonin. Current topics in behavioral neurosciences. vol 8. 2011-09-27. PMID:21374021. |
research on sexual behaviour in rats with null mutations in the serotonin transporter (sert) indicated also a differential role for 5-ht(1a) receptors in male and female sexual behaviour. |
2011-09-27 |
2023-08-12 |
rat |
| Fumihiko Toyoshima, Tadayuki Oshima, Shigemi Nakajima, Jun Sakurai, Junji Tanaka, Toshihiko Tomita, Kazutoshi Hori, Takayuki Matsumoto, Hiroto Miw. Serotonin transporter gene polymorphism may be associated with functional dyspepsia in a Japanese population. BMC medical genetics. vol 12. 2011-09-27. PMID:21714874. |
in the present study, the association between serotonin transporter (sert) gene (slc6a4) polymorphism and fd was explored. |
2011-09-27 |
2023-08-12 |
Not clear |
| Masahiro Shibasaki, Kazuhiro Kurokawa, Seitaro Ohkum. [Functional homology between alcohol dependence and mood disorder]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 46. issue 3. 2011-09-22. PMID:21861331. |
we examined functional changes in serotonin transporter (sert) and serotonin receptors (5-ht(1a) and 5-ht(2a) receptors) related with depression using alcohol physical dependent mice and found correlated changes between depression and alcohol dependence. |
2011-09-22 |
2023-08-12 |
mouse |
| Yun Wang, Dan-Dan Han, Han-Ming Wang, Ming Liu, Xin-Hua Zhang, Huai-Liang Wan. Downregulation of osteopontin is associated with fluoxetine amelioration of monocrotaline-induced pulmonary inflammation and vascular remodelling. Clinical and experimental pharmacology & physiology. vol 38. issue 6. 2011-09-20. PMID:21418086. |
at 10 mg/kg, fluoxetine significantly inhibited mct-induced increases in the expression of serotonin transporter (sert) and phosphorylated extracellular signal-regulated kinase 1/2 and downregulated the expression of opn, macrophage inflammatory protein-1β and matrix metalloproteinase 2/tissue inhibitor of metalloproteinase 2. |
2011-09-20 |
2023-08-12 |
rat |
| Rebecca Lyddon, Edwin Cuppen, Vahram Haroutunian, Larry J Siever, Stella Drachev. No link of serotonin 2C receptor editing to serotonin transporter genotype. Neuroreport. vol 21. issue 17. 2011-09-13. PMID:20948451. |
basal extracellular serotonin, which is strongly influenced by serotonin transporter (sert), was proposed as a potential trigger for this modulation; however, the data remain inconclusive. |
2011-09-13 |
2023-08-12 |
rat |
| Tamar Eshkoli, Eyal Sheiner, Zvi Ben-Zvi, Gershon Holcber. Drug transport across the placenta. Current pharmaceutical biotechnology. vol 12. issue 5. 2011-09-12. PMID:21342126. |
transporters for 5-ht (sert) and ne (net) are also expressed at the apical surface and regulate extracellular concentrations of monoamines. |
2011-09-12 |
2023-08-12 |
human |
| Aurea Elizabeth Linder, Robert Patrick Davis, Robert Burnett, Stephanie W Watt. Comparison of the function of the serotonin transporter in the vasculature of male and female rats. Clinical and experimental pharmacology & physiology. vol 38. issue 5. 2011-09-06. PMID:21371073. |
the serotonin transporter (sert) handles serotonin (5-hydroxytryptamine (5-ht)) and is blocked by the antidepressant sert inhibitors fluoxetine and fluvoxamine. |
2011-09-06 |
2023-08-12 |
rat |
| Aurea Elizabeth Linder, Robert Patrick Davis, Robert Burnett, Stephanie W Watt. Comparison of the function of the serotonin transporter in the vasculature of male and female rats. Clinical and experimental pharmacology & physiology. vol 38. issue 5. 2011-09-06. PMID:21371073. |
in in vitro experiments, sert affected the contractility of aortas from female rats, as evidenced by an eightfold increase in potency of 5-ht in fluvoxamine (1 μmol/l)-incubated wt aortas compared with control. |
2011-09-06 |
2023-08-12 |
rat |
| Aurea Elizabeth Linder, Robert Patrick Davis, Robert Burnett, Stephanie W Watt. Comparison of the function of the serotonin transporter in the vasculature of male and female rats. Clinical and experimental pharmacology & physiology. vol 38. issue 5. 2011-09-06. PMID:21371073. |
collectively, these data suggest that sert function, when challenged with 5-ht, is modestly more important in the vasculature of the female compared with male rat. |
2011-09-06 |
2023-08-12 |
rat |
| Daniel D Lam, Gina M Leinninger, Gwendolyn W Louis, Alastair S Garfield, Oliver J Marston, Rebecca L Leshan, Erica L Scheller, Lyndsay Christensen, Jose Donato, Jing Xia, Mark L Evans, Carol Elias, Jeffrey W Dalley, Denis I Burdakov, Martin G Myers, Lora K Heisle. Leptin does not directly affect CNS serotonin neurons to influence appetite. Cell metabolism. vol 13. issue 5. 2011-09-05. PMID:21531340. |
the serotonin transporter-cre allele (sert(cre)) is expressed in 5-ht (and developmentally in some non-5-ht) neurons. |
2011-09-05 |
2023-08-12 |
mouse |
| Robert Patrick Davis, A Elizabeth Linder, Stephanie W Watt. Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressure. Naunyn-Schmiedeberg's archives of pharmacology. vol 383. issue 5. 2011-09-02. PMID:21448568. |
lack of the serotonin transporter (sert) reduces the ability of 5-hydroxytryptamine to lower blood pressure. |
2011-09-02 |
2023-08-12 |
rat |
| Robert Patrick Davis, A Elizabeth Linder, Stephanie W Watt. Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressure. Naunyn-Schmiedeberg's archives of pharmacology. vol 383. issue 5. 2011-09-02. PMID:21448568. |
we tested the hypothesis that a functional serotonin transporter (sert) is critical to enabling a 5-ht-induced fall in blood pressure. |
2011-09-02 |
2023-08-12 |
rat |
| Robert Patrick Davis, A Elizabeth Linder, Stephanie W Watt. Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressure. Naunyn-Schmiedeberg's archives of pharmacology. vol 383. issue 5. 2011-09-02. PMID:21448568. |
experiments were performed in male and female rats to determine whether gender significantly affected the ability of 5-ht to lower blood pressure and to determine whether sert dependence was different in male vs. female rats. |
2011-09-02 |
2023-08-12 |
rat |
| Robert Patrick Davis, A Elizabeth Linder, Stephanie W Watt. Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressure. Naunyn-Schmiedeberg's archives of pharmacology. vol 383. issue 5. 2011-09-02. PMID:21448568. |
5-ht (25 μg/kg/min; s.c.) was infused for 7 days to male and female, sert wild-type (wt) and sert knockout (ko) rats. |
2011-09-02 |
2023-08-12 |
rat |
| Robert Patrick Davis, A Elizabeth Linder, Stephanie W Watt. Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressure. Naunyn-Schmiedeberg's archives of pharmacology. vol 383. issue 5. 2011-09-02. PMID:21448568. |
5-ht produced a significantly greater fall in map (at the nadir) in the male sert wt rat (-20 ± 1 mmhg) compared to the male sert ko rat (-10 ± 2 mmhg). |
2011-09-02 |
2023-08-12 |
rat |
| Robert Patrick Davis, A Elizabeth Linder, Stephanie W Watt. Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressure. Naunyn-Schmiedeberg's archives of pharmacology. vol 383. issue 5. 2011-09-02. PMID:21448568. |
similarly, 5-ht also produced a significantly greater fall in map (at the nadir) in the female sert wt rat (-19 ± 1 mmhg) compared to the female sert ko rat (-15 ± 0.4 mmhg). |
2011-09-02 |
2023-08-12 |
rat |
| Robert Patrick Davis, A Elizabeth Linder, Stephanie W Watt. Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressure. Naunyn-Schmiedeberg's archives of pharmacology. vol 383. issue 5. 2011-09-02. PMID:21448568. |
while the lack of a functional sert protein did not prevent a 5-ht-induced fall in blood pressure, it did reduce the ability of 5-ht to lower blood pressure in the male and female sert rat, suggesting a potentially important role for sert in producing a 5-ht-induced fall in blood pressure. |
2011-09-02 |
2023-08-12 |
rat |
| Stacey J Sukoff Rizzo, Sarah K Leonard, Adam Gilbert, Paul Dollings, Deborah L Smith, Mei-Yi Zhang, Li Di, Brian J Platt, Sarah Neal, Jason M Dwyer, Corey N Bender, Jean Zhang, Tim Lock, Dianne Kowal, Angela Kramer, Andrew Randall, Christine Huselton, Karthick Vishwanathan, Susanna Y Tse, John Butera, Robert H Ring, Sharon Rosenzweig-Lipson, Zoë A Hughes, John Dunlo. The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise? The Journal of pharmacology and experimental therapeutics. vol 338. issue 1. 2011-08-30. PMID:21508084. |
in vitro selectivity profiling of met-1 demonstrated physiologically relevant transporter binding affinity at serotonin transporter (sert), dopamine transporter (dat), and norepinephrine transporter (net) (323, 3020, and 3410 nm, respectively); whereas the parent compound amn082 had appreciable affinity at net (1385 nm). |
2011-08-30 |
2023-08-12 |
rat |
| Shiquen Zhang, Baoman Li, Ditte Lovatt, Junnan Xu, Dan Song, Steven A Goldman, Maiken Nedergaard, Leif Hertz, Liang Pen. 5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'. Neuron glia biology. vol 6. issue 2. 2011-08-29. PMID:20846463. |
in well-differentiated primary cultures of mouse astrocytes, which express no serotonin transporter (sert), the 'serotonin-specific reuptake inhibitor' (ssri) fluoxetine leads acutely to 5-ht2b receptor-mediated, transactivation-dependent phosphorylation of extracellular regulated kinases 1/2 (erk1/2) with an ec50 of ~5 μm, and chronically to erk1/2 phosphorylation-dependent upregulation of mrna and protein expression of calcium-dependent phospholipase a2 (cpla2) with ten-fold higher affinity. |
2011-08-29 |
2023-08-12 |
mouse |
| Giulia Schillani, Maria Anna Capozzo, Daniel Era, Maurizio De Vanna, Luigi Grassi, Maria Anna Conte, Tullio Girald. Pharmacogenetics of escitalopram and mental adaptation to cancer in palliative care: report of 18 cases. Tumori. vol 97. issue 3. 2011-08-25. PMID:21789016. |
ssri antidepressants are the treatment of choice; the 5-httlpr genetic polymorphism of the serotonin transporter (sert) has been shown in psychiatry to significantly determine the therapeutic response and the incidence of adverse effects. |
2011-08-25 |
2023-08-12 |
Not clear |