| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Neil Dawson, Linda Ferrington, Klaus-Peter Lesch, Paul A T Kell. Cerebral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 1. 2011-07-20. PMID:21093224. |
here we characterise the cerebral metabolic response to 5-ht(2a/c) receptor activation in two transgenic mouse models of altered sert function, sert knock-out (sert ko) and hsert over-expressing (hsert oe) mice, to test the hypothesis that genetically mediated variability in sert expression alters 5-ht(2a/c) function. |
2011-07-20 |
2023-08-12 |
mouse |
| Neil Dawson, Linda Ferrington, Klaus-Peter Lesch, Paul A T Kell. Cerebral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 1. 2011-07-20. PMID:21093224. |
we found that a constitutive increase in sert expression (hsert oe) enhanced, whereas a constitutive decrease in sert expression (sert ko) attenuated, 5-ht(2a/c) function. |
2011-07-20 |
2023-08-12 |
mouse |
| Michelle D Carter, Charisma R Shah, Christopher L Muller, Jacqueline N Crawley, Ana M D Carneiro, Jeremy Veenstra-VanderWeel. Absence of preference for social novelty and increased grooming in integrin β3 knockout mice: initial studies and future directions. Autism research : official journal of the International Society for Autism Research. vol 4. issue 1. 2011-07-20. PMID:21254450. |
recent work shows that integrin β3 interacts with the serotonin transporter (sert) in both platelets and in the midbrain. |
2011-07-20 |
2023-08-12 |
mouse |
| Christopher J Endres, Dima A Hammoud, Martin G Pompe. Reference tissue modeling with parameter coupling: application to a study of SERT binding in HIV. Physics in medicine and biology. vol 56. issue 8. 2011-07-18. PMID:21441649. |
in a study of serotonin transporter (sert) binding in hiv dementia, it was determined that applying parameter coupling to the simplified reference tissue model (srtm) reduced the variability of parameter estimates and yielded the strongest between-group significant differences in sert binding. |
2011-07-18 |
2023-08-12 |
Not clear |
| Richard B Rothman, Jean L Cadet, Christina M Dersch, Michael T McCoy, Elin Lehrmann, Kevin G Becker, Michael Bader, Natalia Alenina, Michael H Bauman. Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension. PloS one. vol 6. issue 3. 2011-07-18. PMID:21464983. |
we postulated that: 1) tph1(-/-) mice express lower levels of pulmonary 5-ht transporter (sert) when compared to wild-type controls, and 2) tph1(-/-) mice display adaptive changes in the expression of non-serotonergic pulmonary genes which are implicated in pah. |
2011-07-18 |
2023-08-12 |
mouse |
| Jeremy Veenstra-Vanderweele, Tammy N Jessen, Brent J Thompson, Michelle Carter, Harish C Prasad, Jennifer A Steiner, James S Sutcliffe, Randy D Blakel. Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse. Journal of neurodevelopmental disorders. vol 1. issue 2. 2011-07-14. PMID:19960097. |
the 5-ht transporter gene (htt, sert, slc6a4) has received considerable attention as a potential risk locus for autism-spectrum disorders, as well as disorders with overlapping symptoms, including obsessive-compulsive disorder (ocd). |
2011-07-14 |
2023-08-12 |
mouse |
| Prisila Dulcy Charles, Ganesh Ambigapathy, Pitchairaj Geraldine, Mohammad Abdulkadar Akbarsha, Koilmani Emmanuvel Raja. Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: implications in memory formation. Journal of ethnopharmacology. vol 134. issue 1. 2011-07-14. PMID:21129470. |
bacopa monniera leaf extract up-regulates tryptophan hydroxylase (tph2) and serotonin transporter (sert) expression: implications in memory formation. |
2011-07-14 |
2023-08-12 |
rat |
| Hyojin Par. Functional gastrointestinal disorders and overlap syndrome in Korea. Journal of gastroenterology and hepatology. vol 26 Suppl 3. 2011-07-13. PMID:21443700. |
recently, several genetic studies have suggested that serotonin transporter (sert) gene polymorphisms and the g-protein β3 (gnβ3) c825t gene polymorphism are associated with fd and ibs. |
2011-07-13 |
2023-08-12 |
human |
| Pei-Shen Ho, Mei-Chen Shih, Kuo-Hsing Ma, Wen-Sheng Huang, Kellen Kai-Jen Ho, Che-Hung Yen, Ru-Band Lu, San-Yuan Huan. Availability of the serotonin transporter in patients with alcohol dependence. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 12. issue 2. 2011-07-11. PMID:20642399. |
evidence has suggested that the serotonin transporter (sert) plays a role in the pathogenesis of alcohol dependence, anxiety and depression and that polymorphisms of the serotonin-transporter-linked promoter region (5-httlpr) may influence the sert. |
2011-07-11 |
2023-08-12 |
Not clear |
| Ulrike Schaz, Karl J Föhr, Stefan Liebau, Simone Fulda, Michael Koelch, Joerg M Fegert, Tobias M Boeckers, Andrea G Ludolp. Dose-dependent modulation of apoptotic processes by fluoxetine in maturing neuronal cells: an in vitro study. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 12. issue 2. 2011-07-11. PMID:20735156. |
recent studies indicate that the selective serotonin reuptake inhibitor (ssri) fluoxetine is not solely effective by the instant inhibition of the serotonin transporter (sert) but also by its influence on mitotic and/or apoptotic processes. |
2011-07-11 |
2023-08-12 |
Not clear |
| A V Kulikov, M A Tikhonova, E A Kulikova, T M Khomenko, D V Korchagina, K P Volcho, H F Salachutdinov, N K Popov. [Effect of new potential psychotropic drug, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride, on the expression of serotonin-related genes in mouse brain]. Molekuliarnaia biologiia. vol 45. issue 2. 2011-07-08. PMID:21634115. |
the expression of genes encoding 1) the key enzyme of serotonin synthesis, tryptophan hydroxylase 2 (tph2), 2) main enzyme of serotonin degradation, monoamine oxydase a (maoa), 3) 5-ht transporter (sert) and 4) 5-ht(1a) receptor was studied using quantitative rt-pcr. |
2011-07-08 |
2023-08-12 |
mouse |
| Ian D Tomlinson, Hideki Iwamoto, Randy D Blakely, Sandra J Rosentha. Biotin tethered homotryptamine derivatives: high affinity probes of the human serotonin transporter (hSERT). Bioorganic & medicinal chemistry letters. vol 21. issue 6. 2011-07-05. PMID:21334895. |
quantum dot conjugates of compounds capable of inhibiting the serotonin transporter (sert) could form the basis of fluorescent probes for live cell imaging of membrane bound sert. |
2011-07-05 |
2023-08-12 |
human |
| Bhaskar Gopishetty, Stuart Hazeldine, Soumava Santra, Mark Johnson, Gyan Modi, Solav Ali, Juan Zhen, Maarten Reith, Aloke Dutt. Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents. Journal of medicinal chemistry. vol 54. issue 8. 2011-07-04. PMID:21446715. |
the novel compounds were tested for their affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2011-07-04 |
2023-08-12 |
rat |
| Sonja Sucic, Ali El-Kasaby, Oliver Kudlacek, Subhodeep Sarker, Harald H Sitte, Philippe Marin, Michael Freissmut. The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C. The Journal of biological chemistry. vol 286. issue 18. 2011-07-01. PMID:21454670. |
the transporters for serotonin (sert), dopamine, and noradrenaline have a conserved hydrophobic core but divergent n and c termini. |
2011-07-01 |
2023-08-12 |
mouse |
| Ravinder K Gill, Arivarasu Natarajan Anbazhagan, Ali Esmaili, Anoop Kumar, Saad Nazir, Jaleh Malakooti, Waddah A Alrefai, Seema Saksen. Epidermal growth factor upregulates serotonin transporter in human intestinal epithelial cells via transcriptional mechanisms. American journal of physiology. Gastrointestinal and liver physiology. vol 300. issue 4. 2011-06-30. PMID:21273531. |
serotonin transporter (sert) regulates extracellular availability of serotonin and is a potential pharmacological target for gastrointestinal disorders. |
2011-06-30 |
2023-08-12 |
human |
| Stephen Foley, Klara Garsed, Gulzar Singh, Nathalie P Duroudier, Caroline Swan, Ian P Hall, Abed Zaitoun, Andrew Bennett, Charles Marsden, Geoffrey Holmes, Andrew Walls, Robin C Spille. Impaired uptake of serotonin by platelets from patients with irritable bowel syndrome correlates with duodenal immune activation. Gastroenterology. vol 140. issue 5. 2011-06-28. PMID:21315720. |
patients with irritable bowel syndrome with diarrhea (ibs-d) have increased mucosal serotonin (5-hydroxytryptamine [5-ht]) availability, possibly because immune activation reduces activity of the 5-ht transporter (sert). |
2011-06-28 |
2023-08-12 |
Not clear |
| Mads Breum Larsen, Mark S Sonders, Ole Valente Mortensen, Gaynor A Larson, Nancy R Zahniser, Susan G Amar. Dopamine transport by the serotonin transporter: a mechanistically distinct mode of substrate translocation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 17. 2011-06-24. PMID:21525301. |
the serotonin transporter (sert) is the principal mechanism for terminating serotonin (5-ht) signals in the nervous system and is a site of action for a variety of psychoactive drugs including antidepressants, amphetamines, and cocaine. |
2011-06-24 |
2023-08-12 |
human |
| Mads Breum Larsen, Mark S Sonders, Ole Valente Mortensen, Gaynor A Larson, Nancy R Zahniser, Susan G Amar. Dopamine transport by the serotonin transporter: a mechanistically distinct mode of substrate translocation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 17. 2011-06-24. PMID:21525301. |
da transport by hsert has a higher maximum velocity than 5-ht transport, requires significantly higher na(+) and cl(-) concentrations to sustain transport, is inhibited noncompetitively by 5-ht, and is more sensitive to sert inhibitors, including selective serotonin reuptake inhibitors. |
2011-06-24 |
2023-08-12 |
human |
| Mads Breum Larsen, Mark S Sonders, Ole Valente Mortensen, Gaynor A Larson, Nancy R Zahniser, Susan G Amar. Dopamine transport by the serotonin transporter: a mechanistically distinct mode of substrate translocation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 17. 2011-06-24. PMID:21525301. |
cotransfection of an inactive or an mts-sensitive sert with wild-type sert subunits reveals an absence of cooperative interactions between subunits during da but not 5-ht transport. |
2011-06-24 |
2023-08-12 |
human |
| Eelke Snoeren, Johnny Chan, Astrid Bovens, Edwin Cuppen, Marcel Waldinger, Berend Olivier, Ronald Oostin. Serotonin transporter null mutation and sexual behavior in female rats: 5-HT1A receptor desensitization. The journal of sexual medicine. vol 7. issue 7. 2011-06-22. PMID:20456632. |
in serotonin transporter (sert) knockout rats (-/-), basal extracellular 5-ht levels are considerably increased, indicating a serotonergic disturbance. |
2011-06-22 |
2023-08-12 |
human |