| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brent J Thompson, Tammy Jessen, L K Henry, Julie R Field, Karen L Gamble, Paul J Gresch, Ana M Carneiro, Rebecca E Horton, Peter J Chisnell, Yekaterina Belova, Douglas G McMahon, Lynette C Daws, Randy D Blakel. Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 9. 2011-05-09. PMID:21282638. |
through a series of biochemical, electrophysiological, and behavioral assays, we demonstrate the unique properties of this model and establish directly that sert is the sole protein responsible for selective 5-ht reuptake inhibitor-mediated alterations in 5-ht clearance, in 5-ht1a autoreceptor modulation of raphe neuron firing, and in behaviors used to predict the utility of antidepressants. |
2011-05-09 |
2023-08-12 |
mouse |
| Johnny S W Chan, Eelke M S Snoeren, Edwin Cuppen, Marcel D Waldinger, Berend Olivier, Ronald S Oostin. The serotonin transporter plays an important role in male sexual behavior: a study in serotonin transporter knockout rats. The journal of sexual medicine. vol 8. issue 1. 2011-05-06. PMID:20704641. |
heterozygous (+/-) serotonin transporter (sert) rats and sert knockout rats (-/-) have serotonergic disturbances with significant elevations of basal extracellular 5-ht levels. |
2011-05-06 |
2023-08-12 |
rat |
| Anja W Fjorback, Heidi K Müller, Jana Haase, Merete K Raarup, Ove Wibor. Modulation of the dopamine transporter by interaction with Secretory Carrier Membrane Protein 2. Biochemical and biophysical research communications. vol 406. issue 2. 2011-05-05. PMID:21295544. |
the monoamine transporters for dopamine (dat), norepinephrine (net) and serotonin (sert) facilitate the homeostatic balance of neurotransmitters in the synaptic cleft and thus, play a fundamental role in regulating neuronal activity. |
2011-05-05 |
2023-08-12 |
Not clear |
| Wenying Ren, Stephanie W Watts, Barry L Fanbur. Serotonin transporter interacts with the PDGFβ receptor in PDGF-BB-induced signaling and mitogenesis in pulmonary artery smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. vol 300. issue 3. 2011-05-04. PMID:21186266. |
the serotonin transporter (sert) and the platelet-derived growth factor receptor (pdgfr) have been implicated in both clinical and experimental pulmonary hypertension (ph) and the facilitation of pulmonary artery smooth muscle cell (pasmc) growth. |
2011-05-04 |
2023-08-12 |
human |
| Jennifer A Steiner, Ana Marin D Carneiro, Jane Wright, Heinrich J G Matthies, Harish C Prasad, Christian K Nicki, Wolfgang R Dostmann, Carrie C Buchanan, Jackie D Corbin, Sharron H Francis, Randy D Blakel. cGMP-dependent protein kinase Ialpha associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptake. Molecular brain. vol 2. 2011-05-02. PMID:19656393. |
the na(+)/cl(-)-dependent serotonin (5-hydroxytryptamine, 5-ht) transporter (sert) is a critical element in neuronal 5-ht signaling, being responsible for the efficient elimination of 5-ht after release. |
2011-05-02 |
2023-08-12 |
Not clear |
| Karl Strecker, Florian Wegner, Swen Hesse, Georg-Alexander Becker, Marianne Patt, Philipp M Meyer, Donald Lobsien, Johannes Schwarz, Osama Sabr. Preserved serotonin transporter binding in de novo Parkinson's disease: negative correlation with the dopamine transporter. Journal of neurology. vol 258. issue 1. 2011-04-25. PMID:20644949. |
recent imaging and neuropathological studies indicate reduced serotonin transporter (sert) in advanced parkinson's disease (pd). |
2011-04-25 |
2023-08-12 |
human |
| Nicole A Northrop, Laura P Smith, Bryan K Yamamoto, David J Eyerma. Regulation of glutamate release by α7 nicotinic receptors: differential role in methamphetamine-induced damage to dopaminergic and serotonergic terminals. The Journal of pharmacology and experimental therapeutics. vol 336. issue 3. 2011-04-21. PMID:21159748. |
in addition, the subsequent long-term decreases in markers of dopaminergic and serotonergic terminals, including da reuptake transporter (dat), serotonin reuptake transporter (sert), vesicular monoamine transporter-2, vesicular da, and vesicular 5-ht content in the rat striatum, were measured. |
2011-04-21 |
2023-08-12 |
rat |
| Nicole A Northrop, Laura P Smith, Bryan K Yamamoto, David J Eyerma. Regulation of glutamate release by α7 nicotinic receptors: differential role in methamphetamine-induced damage to dopaminergic and serotonergic terminals. The Journal of pharmacology and experimental therapeutics. vol 336. issue 3. 2011-04-21. PMID:21159748. |
in contrast, the meth-induced decreases in striatal sert immunoreactivity and vesicular 5-ht content were not affected by mla. |
2011-04-21 |
2023-08-12 |
rat |
| David B Horton, Kiran B Siripurapu, Seth D Norrholm, John P Culver, Marhaba Hojahmat, Joshua S Beckmann, Steven B Harrod, Agripina G Deaciuc, Michael T Bardo, Peter A Crooks, Linda P Dwoski. meso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release. The Journal of pharmacology and experimental therapeutics. vol 336. issue 3. 2011-04-21. PMID:21177475. |
meso-transdiene (mtd), a lobeline analog, lacks nicotinic receptor affinity, retains affinity for vesicular monoamine transporter 2 (vmat2), and, surprisingly, has enhanced affinity for dopamine (da) and serotonin transporters [da transporter (dat) and serotonin transporter (sert), respectively]. |
2011-04-21 |
2023-08-12 |
rat |
| Jennifer A Minnix, Jason D Robinson, Cho Y Lam, Brian L Carter, Jennifer E Foreman, David J Vandenbergh, Gail E Tomlinson, David W Wetter, Paul M Cinciripin. The serotonin transporter gene and startle response during nicotine deprivation. Biological psychology. vol 86. issue 1. 2011-04-20. PMID:20888887. |
affective startle probe methodology was used to examine the effects of nicotine administration and deprivation on emotional processes among individuals carrying at least one s allele versus those with the l/l genotype of the 5-hydroxytryptamine (serotonin) transporter linked polymorphic region, 5-httlpr in the promoter region of the serotonin transporter gene [solute ligand carrier family 6 member a4 (slc6a4) or sert]. |
2011-04-20 |
2023-08-12 |
human |
| Derek Angus, Matilda Bingham, Dawn Buchanan, Neil Dunbar, Linsday Gibson, Richard Goodwin, Anders Haunsø, Andrea Houghton, Margaret Huggett, Richard Morphy, Susan Napier, Olaf Nimz, Joanna Passmore, Glenn Walke. The identification, and optimisation of hERG selectivity, of a mixed NET/SERT re-uptake inhibitor for the treatment of pain. Bioorganic & medicinal chemistry letters. vol 21. issue 1. 2011-04-14. PMID:21112782. |
hit compound 1, a selective noradrenaline re-uptake transporter (net) inhibitor was optimised to build in potency at the serotonin re-uptake transporter (sert) whilst maintaining selectivity against the dopamine re-uptake transporter (dat). |
2011-04-14 |
2023-08-12 |
mouse |
| Madhusudhan Purushotham, Anjaneyulu Sheri, Duy-Phong Pham-Huu, Bertha K Madras, Aaron Janowsky, Peter C Meltze. The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes. Bioorganic & medicinal chemistry letters. vol 21. issue 1. 2011-04-14. PMID:21146984. |
cocaine, a potent stimulant of the central nervous system, owes its reinforcing and stimulant properties to its ability to inhibit monoamine uptake systems such as the dopamine transporter (dat), and the serotonin transporter (sert) located on presynaptic neurons in the striatum. |
2011-04-14 |
2023-08-12 |
Not clear |
| Ron Kupers, Vibe G Frokjaer, David Erritzoe, Arne Naert, Esben Budtz-Joergensen, Finn Aarup Nielsen, Henrik Kehlet, Gitte M Knudse. Serotonin transporter binding in the hypothalamus correlates negatively with tonic heat pain ratings in healthy subjects: a [11C]DASB PET study. NeuroImage. vol 54. issue 2. 2011-04-05. PMID:20851771. |
here we used positron emission tomography (pet) with the serotonin transporter (sert) tracer [(11)c]dasb to study the relationship between sert binding in the brain and responses to noxious heat stimulation in a group of 21 young healthy volunteers. |
2011-04-05 |
2023-08-12 |
human |
| Franciszek Herold, Andrzej Chodkowski, Łukasz Izbicki, Jadwiga Turło, Maciej Dawidowski, Jerzy Kleps, Gabriel Nowak, Katarzyna Stachowicz, Małgorzata Dybała, Agata Siwek, Aleksander P Mazurek, Andrzej Mazurek, Franciszek Plucińsk. Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT(1A) activity. part 3. European journal of medicinal chemistry. vol 46. issue 1. 2011-03-28. PMID:21093118. |
compounds 8a-8p were found to be potent ligands for both 5-ht(1a) and sert with k(i) ranging from 28,3 to 642 nm and 42,4 nm-1,8 μm, respectively. |
2011-03-28 |
2023-08-12 |
mouse |
| Sarah M Scruggs, Sirilak Disatian, E Christopher Orto. Serotonin transmembrane transporter is down-regulated in late-stage canine degenerative mitral valve disease. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology. vol 12. issue 3. 2011-03-18. PMID:21036114. |
to compare expression of the serotonin transmembrane transporter (sert) in normal, early-stage degenerative, and late-stage degenerative canine mitral valve disease. |
2011-03-18 |
2023-08-12 |
Not clear |
| Diana K Sarko, Duncan B Leitch, Isabelle Girard, Robert S Sikes, Kenneth C Catani. Organization of somatosensory cortex in the Northern grasshopper mouse (Onychomys leucogaster), a predatory rodent. The Journal of comparative neurology. vol 519. issue 1. 2011-03-14. PMID:21120928. |
these findings were then related to the distinctive chemoarchitecture of layer iv visible in flattened cortical sections of juvenile grasshopper mice labeled with the serotonin transporter (sert) antibody, revealing a striking correspondence between electrophysiological maps and cortical anatomy. |
2011-03-14 |
2023-08-12 |
mouse |
| Yuan-Wei Zhang, Gary Rudnic. Myristoylation of cGMP-dependent protein kinase dictates isoform specificity for serotonin transporter regulation. The Journal of biological chemistry. vol 286. issue 4. 2011-03-04. PMID:21097501. |
by transporting serotonin (5-ht) into neurons and other cells, serotonin transporter (sert) modulates the action of 5-ht at cell surface receptors. |
2011-03-04 |
2023-08-12 |
Not clear |
| Yuan-Wei Zhang, Gary Rudnic. Myristoylation of cGMP-dependent protein kinase dictates isoform specificity for serotonin transporter regulation. The Journal of biological chemistry. vol 286. issue 4. 2011-03-04. PMID:21097501. |
here we show that in hela cells lacking endogenous pkg, expression of pkgiα or pkgiβ was required for 8-bromoguanosine-3',5'-cyclic monophosphate (8-br-cgmp) to stimulate sert phosphorylation and 5-ht influx. |
2011-03-04 |
2023-08-12 |
Not clear |
| Chong-Bin Zhu, Kathryn M Lindler, Anthony W Owens, Lynette C Daws, Randy D Blakely, William A Hewlet. Interleukin-1 receptor activation by systemic lipopolysaccharide induces behavioral despair linked to MAPK regulation of CNS serotonin transporters. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 13. 2011-03-03. PMID:20827273. |
medications that block the neuronal 5-ht transporter (sert) are used as major pharmacological treatment for mood disorders. |
2011-03-03 |
2023-08-12 |
mouse |
| Chong-Bin Zhu, Kathryn M Lindler, Anthony W Owens, Lynette C Daws, Randy D Blakely, William A Hewlet. Interleukin-1 receptor activation by systemic lipopolysaccharide induces behavioral despair linked to MAPK regulation of CNS serotonin transporters. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 13. 2011-03-03. PMID:20827273. |
conversely, stimuli that enhance sert activity might be predicted to diminish synaptic 5-ht availability and increase the risk for 5-ht-related cns disorders. |
2011-03-03 |
2023-08-12 |
mouse |