| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jantarima Charoenphandhu, Jarinthorn Teerapornpuntakit, Amporn Nuntapornsak, Nateetip Krishnamra, Narattaphol Charoenphandh. Anxiety-like behaviors and expression of SERT and TPH in the dorsal raphé of estrogen- and fluoxetine-treated ovariectomized rats. Pharmacology, biochemistry, and behavior. vol 98. issue 4. 2011-08-24. PMID:21382399. |
furthermore, e2 and e2+flx similarly upregulated the mrna expression of serotonin reuptake transporter (sert) and tryptophan hydroxylase-2 in the dorsal raphé of ovx rats, while having no effect on sert expression in the frontal cortex, hippocampus, septum, amygdala and periaqueductal gray. |
2011-08-24 |
2023-08-12 |
rat |
| Jingying Liu, Lin Zhu, Karl Plössl, Brian P Lieberman, Hank F Kun. Synthesis and evaluation of novel N-fluoropyridyl derivatives of tropane as potential PET imaging agents for the dopamine transporter. Bioorganic & medicinal chemistry letters. vol 21. issue 10. 2011-08-23. PMID:21458259. |
a series of novel n-fluoropyridyl-containing tropane derivatives were synthesized and their binding affinities for the dopamine transporter (dat), serotonin transporter (sert) and norepinephrine (net) were determined via competitive radioligand binding assays. |
2011-08-23 |
2023-08-12 |
Not clear |
| Gholamali Jafari, Yusu Xie, Andrey Kullyev, Bin Liang, Ji Ying Sz. Regulation of extrasynaptic 5-HT by serotonin reuptake transporter function in 5-HT-absorbing neurons underscores adaptation behavior in Caenorhabditis elegans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 24. 2011-08-22. PMID:21677178. |
serotonin [5-hydroxytryptamine (5-ht)]-absorbing neurons use serotonin reuptake transporter (sert) to uptake 5-ht from extracellular space but do not synthesize it. |
2011-08-22 |
2023-08-12 |
caenorhabditis_elegans |
| Zhishan Li, Alcmène Chalazonitis, Yung-Yu Huang, J John Mann, Kara Gross Margolis, Qi Melissa Yang, Dolly O Kim, Francine Côté, Jacques Mallet, Michael D Gersho. Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 24. 2011-08-22. PMID:21677183. |
isolated enteric crest-derived cells (encdcs) expressed the serotonin reuptake transporter (sert) and 15 subtypes of 5-ht receptor. |
2011-08-22 |
2023-08-12 |
mouse |
| Kevin White, Yvonne Dempsie, Margaret Nilsen, Audrey F Wright, Lynn Loughlin, Margaret R MacLea. The serotonin transporter, gender, and 17β oestradiol in the development of pulmonary arterial hypertension. Cardiovascular research. vol 90. issue 2. 2011-08-17. PMID:21177701. |
activity of the serotonin transporter (sert) may modulate the development of pah, and mice overexpressing sert (sert+ mice) develop pah and severe hypoxia-induced pah. |
2011-08-17 |
2023-08-12 |
mouse |
| Kevin White, Lynn Loughlin, Zakia Maqbool, Margaret Nilsen, John McClure, Yvonne Dempsie, Andrew H Baker, Margaret R MacLea. Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH. Physiological genomics. vol 43. issue 8. 2011-08-12. PMID:21303932. |
female mice overexpressing the serotonin transporter (sert; sert+ mice) exhibit pah and exaggerated hypoxia-induced pah, whereas male sert+ mice remain unaffected. |
2011-08-12 |
2023-08-12 |
mouse |
| Pablo R Moya, Meredith A Fox, Catherine L Jensen, Justin L Laporte, Helen T French, Jens R Wendland, Dennis L Murph. Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice. BMC pharmacology. vol 11. 2011-08-10. PMID:21473759. |
in this study, we determined the responsiveness of 5-ht2cr in serotonin transporter (sert) knockout (-/-) mice, a model characterized by increased anxiety-like and stress-responsive behaviors. |
2011-08-10 |
2023-08-12 |
mouse |
| Vinicius Kannen, Tassiana Marini, Aline Turatti, Milene C Carvalho, Marcus L Brandão, Valquiria A P Jabor, Pierina S Bonato, Frederico R Ferreira, Dalila L Zanette, Wilson A Silva, Sérgio B Garci. Fluoxetine induces preventive and complex effects against colon cancer development in epithelial and stromal areas in rats. Toxicology letters. vol 204. issue 2-3. 2011-08-10. PMID:21554931. |
after 6 weeks of flx-treatment, our results revealed that flx and nor-fluoxetine (n-flx) are present in colon tissue, which was related to significant increase in serotonin (5-ht) levels (p<0.05) possibly through a blockade in sert mrna (serotonin reuptake transporter; p<0.05) resulting in lower 5-hydroxyindoleacetic acid (5-hiaa) levels (p<0.01) and, 5-ht2c receptor mrna expressions. |
2011-08-10 |
2023-08-12 |
rat |
| Shi-yi Song, Yan-jie Wang, De-shan Wang, Ji-yan Cha. [Effects of oculo-acupuncture therapy on colonic serotonin reuptake transporter expression in rats with irritable bowel syndrome]. Zhen ci yan jiu = Acupuncture research. vol 36. issue 2. 2011-08-04. PMID:21717776. |
to investigate the effect of oculo-acupuncture therapy (oat) on the alteration of colonic serotonin reuptake transporter (sert) expression in rats with irritable bowel syndrome (ibs) so as to explore its underlying mechanism in relieving ibs. |
2011-08-04 |
2023-08-12 |
rat |
| Ning-Ning Song, Jian-Bo Xiu, Ying Huang, Jia-Yin Chen, Lei Zhang, Lise Gutknecht, Klaus Peter Lesch, He Li, Yu-Qiang Din. Adult raphe-specific deletion of Lmx1b leads to central serotonin deficiency. PloS one. vol 6. issue 1. 2011-08-02. PMID:21246047. |
after administration of tamoxifen, the level of 5-ht in the brain of lmx1b icko mice was reduced to 60% of that in control mice, and the expression of tryptophan hydroxylase 2 (tph2), serotonin transporter (sert) and vesicular monoamine transporter 2 (vmat2) was greatly down-regulated. |
2011-08-02 |
2023-08-12 |
mouse |
| Ning-Ning Song, Jian-Bo Xiu, Ying Huang, Jia-Yin Chen, Lei Zhang, Lise Gutknecht, Klaus Peter Lesch, He Li, Yu-Qiang Din. Adult raphe-specific deletion of Lmx1b leads to central serotonin deficiency. PloS one. vol 6. issue 1. 2011-08-02. PMID:21246047. |
our results reveal that lmx1b is required for the biosynthesis of 5-ht in adult mouse brain, and it may be involved in maintaining normal functions of central 5-htergic neurons by regulating the expression of tph2, sert and vmat2. |
2011-08-02 |
2023-08-12 |
mouse |
| Benny Bang-Andersen, Thomas Ruhland, Morten Jørgensen, Garrick Smith, Kristen Frederiksen, Klaus Gjervig Jensen, Huailing Zhong, Søren Møller Nielsen, Sandra Hogg, Arne Mørk, Tine Bryan Stensbø. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. Journal of medicinal chemistry. vol 54. issue 9. 2011-08-01. PMID:21486038. |
the synthesis and structure-activity relationship of a novel series of compounds with combined effects on 5-ht(3a) and 5-ht(1a) receptors and on the serotonin (5-ht) transporter (sert) are described. |
2011-08-01 |
2023-08-12 |
human |
| Benny Bang-Andersen, Thomas Ruhland, Morten Jørgensen, Garrick Smith, Kristen Frederiksen, Klaus Gjervig Jensen, Huailing Zhong, Søren Møller Nielsen, Sandra Hogg, Arne Mørk, Tine Bryan Stensbø. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. Journal of medicinal chemistry. vol 54. issue 9. 2011-08-01. PMID:21486038. |
compound 5m (lu aa21004) was the lead compound, displaying high affinity for recombinant human 5-ht(1a) (k(i) = 15 nm), 5-ht(1b) (k(i) = 33 nm), 5-ht(3a) (k(i) = 3.7 nm), 5-ht(7) (k(i) = 19 nm), and noradrenergic β(1) (k(i) = 46 nm) receptors, and sert (k(i) = 1.6 nm). |
2011-08-01 |
2023-08-12 |
human |
| Benny Bang-Andersen, Thomas Ruhland, Morten Jørgensen, Garrick Smith, Kristen Frederiksen, Klaus Gjervig Jensen, Huailing Zhong, Søren Møller Nielsen, Sandra Hogg, Arne Mørk, Tine Bryan Stensbø. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. Journal of medicinal chemistry. vol 54. issue 9. 2011-08-01. PMID:21486038. |
compound 5m displayed antagonistic properties at 5-ht(3a) and 5-ht(7) receptors, partial agonist properties at 5-ht(1b) receptors, agonistic properties at 5-ht(1a) receptors, and potent inhibition of sert. |
2011-08-01 |
2023-08-12 |
human |
| Sara Bettè, Michela Castagna, Elena Bossi, Antonio Peres, Vellea Franca Sacch. The SLC6/NSS family members KAAT1 and CAATCH1 have weak chloride dependence. Channels (Austin, Tex.). vol 2. issue 5. 2011-07-29. PMID:19066444. |
transport by aaleut is cl⁻ independent, whereas many neurotransmitter:sodium symporters like serotonin transporter (sert), gaba transporter (gat1), dopamine transporter, and norephinephrine transporter, among others, are strongly cl⁻ dependent. |
2011-07-29 |
2023-08-12 |
Not clear |
| Robin C Spille. Targeting the 5-HT(3) receptor in the treatment of irritable bowel syndrome. Current opinion in pharmacology. vol 11. issue 1. 2011-07-25. PMID:21398180. |
several lines of evidence suggest an increase in mucosal 5-ht availability in ibs-d including a decrease in the serotonin transporter (sert) which is also seen following acute diverticulitis. |
2011-07-25 |
2023-08-12 |
Not clear |
| Dennis L Murphy, Pablo R Moy. Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional G×G and G×E differences in health and disease. Current opinion in pharmacology. vol 11. issue 1. 2011-07-25. PMID:21439906. |
recent major findings from studies of slc6a4 and its corresponding protein, the serotonin (5-ht) transporter (sert) in humans, rodents and non-human primates indicate that combinations of slc6a4 non-coding 5', 3' utrs and intronic regions plus coding variants acting together can change 5ht transport as much as 40-fold in vitro. |
2011-07-25 |
2023-08-12 |
human |
| Philippe Huot, Tom H Johnston, Katie D Lewis, James B Koprich, M Gabriela Reyes, Susan H Fox, Matthew J Piggott, Jonathan M Brotchi. Characterization of 3,4-methylenedioxymethamphetamine (MDMA) enantiomers in vitro and in the MPTP-lesioned primate: R-MDMA reduces severity of dyskinesia, whereas S-MDMA extends duration of ON-time. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 19. 2011-07-25. PMID:21562283. |
r-mdma (rectus-mdma) is relatively selective for 5-ht(2a) receptors, whereas s-mdma (sinister-mdma) inhibits both serotonin (sert) and dopamine transporters (dat; sert/dat ratio of 10 to 1). |
2011-07-25 |
2023-08-12 |
marmoset |
| Neil Dawson, Linda Ferrington, Klaus-Peter Lesch, Paul A T Kell. Cerebral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 1. 2011-07-20. PMID:21093224. |
cerebral metabolic responses to 5-ht2a/c receptor activation in mice with genetically modified serotonin transporter (sert) expression. |
2011-07-20 |
2023-08-12 |
mouse |
| Neil Dawson, Linda Ferrington, Klaus-Peter Lesch, Paul A T Kell. Cerebral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 1. 2011-07-20. PMID:21093224. |
variation in the human serotonin transporter gene (hsert; 5-htt) resulting in a life-long alteration in sert function influences anxiety and the risk of developing affective disorders. |
2011-07-20 |
2023-08-12 |
mouse |