| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J C Beucke, M Plotkin, C Winter, T Endrass, H Amthauer, G Juckel, A Kupsc. Midbrain serotonin transporters in de novo and L-DOPA-treated patients with early Parkinson's disease--a [123 I]-ADAM SPECT study. European journal of neurology. vol 18. issue 5. 2012-03-16. PMID:21143705. |
in contrast, temporal characteristics of serotonergic markers like the serotonin transporter (sert) in relation to clinical staging of pd and dopaminergic cell loss are less clear. |
2012-03-16 |
2023-08-12 |
Not clear |
| Huailing Zhong, Connie Sánchez, Marc G Caro. Consideration of allosterism and interacting proteins in the physiological functions of the serotonin transporter. Biochemical pharmacology. vol 83. issue 4. 2012-03-15. PMID:21983034. |
the serotonin transporter (sert) functions to transport serotonin (5-ht) from the extracellular space into neurons to maintain homeostatic control of 5-ht. |
2012-03-15 |
2023-08-12 |
mouse |
| Sharanappa M Bagale, Adrienne S Brown, Melissa M Carballosa Gonzalez, Alberto Vitores, Teresa L Micotto, N S Saleesh Kumar, Ian D Hentall, James N Wilso. Fluorescent reporters of monoamine transporter distribution and function. Bioorganic & medicinal chemistry letters. vol 21. issue 24. 2012-03-12. PMID:22047697. |
it was shown to act as a ligand for serotonin transporter (sert) without acute cerebral or cardiovascular toxicity or adverse effects. |
2012-03-12 |
2023-08-12 |
Not clear |
| Sharanappa M Bagale, Adrienne S Brown, Melissa M Carballosa Gonzalez, Alberto Vitores, Teresa L Micotto, N S Saleesh Kumar, Ian D Hentall, James N Wilso. Fluorescent reporters of monoamine transporter distribution and function. Bioorganic & medicinal chemistry letters. vol 21. issue 24. 2012-03-12. PMID:22047697. |
fluorescent serotonin analogs can be used for direct visualization of sert distribution and activity in live tissue. |
2012-03-12 |
2023-08-12 |
Not clear |
| Steven J O'Dell, Bryan A Galvez, Alexander J Ball, John F Marshal. Running wheel exercise ameliorates methamphetamine-induced damage to dopamine and serotonin terminals. Synapse (New York, N.Y.). vol 66. issue 1. 2012-03-07. PMID:21953518. |
also, mamph was found to reduce [(125) i]rti-55 binding to serotonin transporters (sert) in frontoparietal cortex, and this too was significantly attenuated by exercise. |
2012-03-07 |
2023-08-12 |
rat |
| Sarah Hohmann, Nina Schweinfurth, Thorsten Lau, Michael Deuschle, Florian Lederbogen, Tobias Banaschewski, Patrick Schlos. Differential expression of neuronal dopamine and serotonin transporters DAT and SERT in megakaryocytes and platelets generated from human MEG-01 megakaryoblasts. Cell and tissue research. vol 346. issue 2. 2012-03-06. PMID:22006250. |
differential expression of neuronal dopamine and serotonin transporters dat and sert in megakaryocytes and platelets generated from human meg-01 megakaryoblasts. |
2012-03-06 |
2023-08-12 |
human |
| Sarah Hohmann, Nina Schweinfurth, Thorsten Lau, Michael Deuschle, Florian Lederbogen, Tobias Banaschewski, Patrick Schlos. Differential expression of neuronal dopamine and serotonin transporters DAT and SERT in megakaryocytes and platelets generated from human MEG-01 megakaryoblasts. Cell and tissue research. vol 346. issue 2. 2012-03-06. PMID:22006250. |
in the central nervous system, serotonergic and dopaminergic signaling is terminated by the activity of specialized transporter proteins for serotonin (sert) and dopamine (dat). |
2012-03-06 |
2023-08-12 |
human |
| R Ye, R D Blakel. Natural and engineered coding variation in antidepressant-sensitive serotonin transporters. Neuroscience. vol 197. 2012-02-27. PMID:21893166. |
the presynaptic serotonin (5-ht) transporter (sert) is a key regulator of 5-ht signaling and is a major target for antidepressant medications and psychostimulants. |
2012-02-27 |
2023-08-12 |
mouse |
| R Ye, R D Blakel. Natural and engineered coding variation in antidepressant-sensitive serotonin transporters. Neuroscience. vol 197. 2012-02-27. PMID:21893166. |
in recent years, studies of natural and engineered genetic variation in sert have provided new opportunities to understand structural dimensions of drug interactions and regulation of the transporter, to explore 5-ht contributions to antidepressant action, and to assess the impact of sert-mediated 5-ht contributions to neuropsychiatric disorders. |
2012-02-27 |
2023-08-12 |
mouse |
| R Ye, R D Blakel. Natural and engineered coding variation in antidepressant-sensitive serotonin transporters. Neuroscience. vol 197. 2012-02-27. PMID:21893166. |
here we review three examples from our recent studies where genetic changes in sert, identified or engineered, have led to new models, findings, and theories that cast light on new dimensions of 5-ht action in the cns and periphery. |
2012-02-27 |
2023-08-12 |
mouse |
| Jerry C Chang, Ian D Tomlinson, Michael R Warnement, Hideki Iwamoto, Louis J DeFelice, Randy D Blakely, Sandra J Rosentha. A fluorescence displacement assay for antidepressant drug discovery based on ligand-conjugated quantum dots. Journal of the American Chemical Society. vol 133. issue 44. 2012-02-27. PMID:21970724. |
the serotonin (5-hydroxytryptamine, 5-ht) transporter (sert) protein plays a central role in terminating 5-ht neurotransmission and is the most important therapeutic target for the treatment of major depression and anxiety disorders. |
2012-02-27 |
2023-08-12 |
human |
| Jerry C Chang, Ian D Tomlinson, Michael R Warnement, Hideki Iwamoto, Louis J DeFelice, Randy D Blakely, Sandra J Rosentha. A fluorescence displacement assay for antidepressant drug discovery based on ligand-conjugated quantum dots. Journal of the American Chemical Society. vol 133. issue 44. 2012-02-27. PMID:21970724. |
our labeling approach employs a custom-made, qd-tagged indoleamine derivative ligand, idt318, that is structurally similar to 5-ht and accesses the primary binding site with enhanced human sert selectivity. |
2012-02-27 |
2023-08-12 |
human |
| Aram Rasul, Husameldin El-Nour, Randy D Blakely, Sol-Britt Lonne-Rahm, Johan Forsberg, Björn Johansson, Elvar Theodorsson, Klas Nordlin. Effect of chronic mild stress on serotonergic markers in the skin and brain of the NC/Nga atopic-like mouse strain. Archives of dermatological research. vol 303. issue 9. 2012-02-24. PMID:21400247. |
in the present study, the impact of chronic mild stress on the expression of 5-ht1a and 5-ht2a receptors and serotonin transporter protein (sert) was investigated in eczematous skin and brain of atopic-like nc/nga mice. |
2012-02-24 |
2023-08-12 |
mouse |
| Michael L Huynh, Elena Rivkin, Ryan Mui, Sabine P Corde. A tryptophan hydroxlyase 1 reporter that directs Cre recombinase extinguishable placental alkaline phosphatase expression in serotonergic (5-HT) neurons and peripheral tissues. Genesis (New York, N.Y. : 2000). vol 49. issue 11. 2012-02-24. PMID:21438125. |
while, in tph1-lox-plap mice, most plap-expressing neurons are monoaminergic, plap was expressed in only 5-10% of neurons expressing the predominant neuronal 5-ht biosynthetic enzyme tph2, serotonin transporter (sert) or aromatic amino acid decarboxylase (aadc). |
2012-02-24 |
2023-08-12 |
mouse |
| J-W Tian, W-L Jiang, Y Zhong, Q Meng, Y Gai, H-B Zhu, J Hou, Y Xing, Y-X L. Preclinical pharmacology of TP1, a novel potent triple reuptake inhibitor with antidepressant properties. Neuroscience. vol 196. 2012-02-23. PMID:21925241. |
triple reuptake inhibitors (tris) that block the dopamine transporter (dat), norepinephrine transporter (net), and serotonin transporter (sert) are being developed as a new class of antidepressant that may have better efficacy and fewer side effects compared with traditional antidepressants. |
2012-02-23 |
2023-08-12 |
human |
| Martin Parent, Marie-Josée Wallman, Dave Gagnon, André Paren. Serotonin innervation of basal ganglia in monkeys and humans. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21664455. |
we have visualized the 5-ht neuronal system in squirrel monkey (saimiri sciureus) and human postmortem materials with antibodies directed against either 5-ht, 5-ht transporter (sert) or 5-ht synthesizing enzyme tryptophan hydroxylase (tph). |
2012-02-22 |
2023-08-12 |
human |
| Cynthia L Bethea, Fernanda B Lima, Maria L Centeno, Karin V Weissheimer, Olga Senashova, Arubala P Reddy, Judy L Camero. Effects of citalopram on serotonin and CRF systems in the midbrain of primates with differences in stress sensitivity. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21683135. |
examination of the serotonin system revealed that ss monkeys had significantly lower fev (fifth ewing variant, rodent pet1), tph2 (tryptophan hydroxylase 2), 5ht1a autoreceptor and sert (serotonin reuptake transporter) expression in the dorsal raphe than sr monkeys. |
2012-02-22 |
2023-08-12 |
monkey |
| Balasubramaniam Annamalai, Padmanabhan Mannangatti, Obulakshmi Arapulisamy, Toni S Shippenberg, Lankupalle D Jayanthi, Sammanda Ramamoorth. Tyrosine phosphorylation of the human serotonin transporter: a role in the transporter stability and function. Molecular pharmacology. vol 81. issue 1. 2012-02-07. PMID:21992875. |
the serotonin (5-ht) transporter (sert) regulates serotoninergic neurotransmission by clearing 5-ht released into the synaptic space. |
2012-02-07 |
2023-08-12 |
human |
| Balasubramaniam Annamalai, Padmanabhan Mannangatti, Obulakshmi Arapulisamy, Toni S Shippenberg, Lankupalle D Jayanthi, Sammanda Ramamoorth. Tyrosine phosphorylation of the human serotonin transporter: a role in the transporter stability and function. Molecular pharmacology. vol 81. issue 1. 2012-02-07. PMID:21992875. |
here, we tested the hypothesis that tyrosine-phosphorylation of sert regulates 5-ht transport. |
2012-02-07 |
2023-08-12 |
human |
| Balasubramaniam Annamalai, Padmanabhan Mannangatti, Obulakshmi Arapulisamy, Toni S Shippenberg, Lankupalle D Jayanthi, Sammanda Ramamoorth. Tyrosine phosphorylation of the human serotonin transporter: a role in the transporter stability and function. Molecular pharmacology. vol 81. issue 1. 2012-02-07. PMID:21992875. |
compared with wt-sert, sert tyrosine mutants y47f and y142f exhibited reduced 5-ht transport despite their higher total and cell surface expression levels. |
2012-02-07 |
2023-08-12 |
human |