| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Małgorzata Jarończyk, Karol Wołosewicz, Mari Gabrielsen, Gabriel Nowak, Irina Kufareva, Aleksander P Mazurek, Aina W Ravna, Ruben Abagyan, Andrzej J Bojarski, Ingebrigt Sylte, Zdzisław Chilmonczy. Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors. European journal of medicinal chemistry. vol 49. 2012-06-12. PMID:22309909. |
it is well known that 6-nitroquipazine exhibits about 150-fold higher affinity for the serotonin transporter (sert) than quipazine and recently we showed quipazine buspirone analogues with high to moderate sert affinity. |
2012-06-12 |
2023-08-12 |
human |
| Gabriele Jedlitschky, Andreas Greinacher, Heyo K Kroeme. Transporters in human platelets: physiologic function and impact for pharmacotherapy. Blood. vol 119. issue 15. 2012-06-12. PMID:22337717. |
the serotonin transporter (sert, slc6a4) in the platelet plasma membrane represents a well-characterized example of the slc family. |
2012-06-12 |
2023-08-12 |
human |
| Simon Vermeire, Kurt Audenaert, Rudy De Meester, Eva Vandermeulen, Tim Waelbers, Bart De Spiegeleer, Jos Eersels, André Dobbeleir, Kathelijne Pereman. Serotonin 2A receptor, serotonin transporter and dopamine transporter alterations in dogs with compulsive behaviour as a promising model for human obsessive-compulsive disorder. Psychiatry research. vol 201. issue 1. 2012-06-11. PMID:22285716. |
single photon emission computed tomography was used with (123)i-r91150 and (123)i-fp-cit, in combination with (99m)tc-ecd brain perfusion co-registration, to measure the serotonin (5-ht) 2a receptor, dopamine transporter (dat) and serotonin transporter (sert) availability. |
2012-06-11 |
2023-08-12 |
human |
| Floris Klumpers, Ivo Heitland, Ronald S Oosting, J Leon Kenemans, Johanna M P Baa. Genetic variation in serotonin transporter function affects human fear expression indexed by fear-potentiated startle. Biological psychology. vol 89. issue 2. 2012-06-04. PMID:22061270. |
the serotonin transporter (sert) plays a crucial role in anxiety. |
2012-06-04 |
2023-08-12 |
human |
| Melissa A Papesh, Laura M Hurle. Plasticity of serotonergic innervation of the inferior colliculus in mice following acoustic trauma. Hearing research. vol 283. issue 1-2. 2012-06-04. PMID:22101024. |
following a minimum recovery period of three weeks, serotonergic fibers were visualized via histochemical techniques targeting the serotonin reuptake transporter (sert) and quantified using stereologic probes. |
2012-06-04 |
2023-08-12 |
mouse |
| F S Hall, J M Schwarzbaum, M T G Perona, J S Templin, M G Caron, K-P Lesch, D L Murphy, G R Uh. A greater role for the norepinephrine transporter than the serotonin transporter in murine nociception. Neuroscience. vol 175. 2012-06-01. PMID:21129446. |
norepinephrine and serotonin involvement in nociceptive functions is supported by observations of analgesic effects of norepinephrine transporter (net) and serotonin transporter (sert) inhibitors such as amitriptyline. |
2012-06-01 |
2023-08-12 |
mouse |
| F S Hall, J M Schwarzbaum, M T G Perona, J S Templin, M G Caron, K-P Lesch, D L Murphy, G R Uh. A greater role for the norepinephrine transporter than the serotonin transporter in murine nociception. Neuroscience. vol 175. 2012-06-01. PMID:21129446. |
nonetheless, the necessary exclusion of these subjects because of profound baseline hypoalgesia strongly supports the role of norepinephrine and net in basal nociceptive behavior while indicating a much smaller role for serotonin and sert. |
2012-06-01 |
2023-08-12 |
mouse |
| Catherine E Hagan, James O Schenk, John F Neumaie. The contribution of low-affinity transport mechanisms to serotonin clearance in synaptosomes. Synapse (New York, N.Y.). vol 65. issue 10. 2012-05-30. PMID:21437992. |
although many studies assert that the serotonin (5-ht) transporter (sert) is the predominant mechanism controlling extracellular 5-ht concentrations, accumulating evidence suggests that low affinity, high capacity transport mechanisms may contribute more to 5-ht clearance than previously thought. |
2012-05-30 |
2023-08-12 |
mouse |
| Catherine E Hagan, James O Schenk, John F Neumaie. The contribution of low-affinity transport mechanisms to serotonin clearance in synaptosomes. Synapse (New York, N.Y.). vol 65. issue 10. 2012-05-30. PMID:21437992. |
the goal of this study was to quantify the contributions of sert relative to other mechanisms in clearing extracellular 5-ht concentrations ranging from 50 nm to 1 μm in synaptosomes prepared from wild-type and sert knockout mice using rotating disk electrode voltammetry. |
2012-05-30 |
2023-08-12 |
mouse |
| Catherine E Hagan, James O Schenk, John F Neumaie. The contribution of low-affinity transport mechanisms to serotonin clearance in synaptosomes. Synapse (New York, N.Y.). vol 65. issue 10. 2012-05-30. PMID:21437992. |
sert inhibitors combined with decynium-22 (d-22), a blocker of several low-affinity transporters, blocked all uptake of 5-ht into synaptosomes. |
2012-05-30 |
2023-08-12 |
mouse |
| Catherine E Hagan, James O Schenk, John F Neumaie. The contribution of low-affinity transport mechanisms to serotonin clearance in synaptosomes. Synapse (New York, N.Y.). vol 65. issue 10. 2012-05-30. PMID:21437992. |
we found that sert is responsible for the majority of synaptosomal uptake only at relatively low 5-ht concentrations, but comprises a diminishing proportion of 5-ht clearance when extracellular 5-ht increases above 100 nm. |
2012-05-30 |
2023-08-12 |
mouse |
| Catherine E Hagan, James O Schenk, John F Neumaie. The contribution of low-affinity transport mechanisms to serotonin clearance in synaptosomes. Synapse (New York, N.Y.). vol 65. issue 10. 2012-05-30. PMID:21437992. |
these are surprising results, in light of the prevailing view that sert is the primary uptake mechanism for extracellular 5-ht at physiological concentrations. |
2012-05-30 |
2023-08-12 |
mouse |
| Mari Gabrielsen, Rafał Kurczab, Aina W Ravna, Irina Kufareva, Ruben Abagyan, Zdzisław Chilmonczyk, Andrzej J Bojarski, Ingebrigt Sylt. Molecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol. European journal of medicinal chemistry. vol 47. issue 1. 2012-05-29. PMID:22071255. |
the two main groups of antidepressant drugs, the tricyclic antidepressants (tcas) and the selective serotonin reuptake inhibitors (ssris), as well as several other compounds, act by inhibiting the serotonin transporter (sert). |
2012-05-29 |
2023-08-12 |
Not clear |
| A C Meyer, D B Horton, N M Neugebauer, T E Wooters, J R Nickell, L P Dwoskin, M T Bard. Tetrabenazine inhibition of monoamine uptake and methamphetamine behavioral effects: locomotor activity, drug discrimination and self-administration. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21669212. |
effects of tbz on function of the dopamine transporter (dat) and serotonin transporter (sert) in striatal and hippocampal synaptosomes, respectively, and on vmat2 function in isolated striatal synaptic vesicles were determined. |
2012-05-25 |
2023-08-12 |
rat |
| Marios Politis, Clare Loane, Kit Wu, David J Brooks, Paola Piccin. Serotonergic mediated body mass index changes in Parkinson's disease. Neurobiology of disease. vol 43. issue 3. 2012-05-21. PMID:21624463. |
the serotonergic (5-ht) system has been proposed to regulate appetite and the 5-ht transporter (sert) is a key modulator of 5-ht metabolism. |
2012-05-21 |
2023-08-12 |
Not clear |
| Marios Politis, Clare Loane, Kit Wu, David J Brooks, Paola Piccin. Serotonergic mediated body mass index changes in Parkinson's disease. Neurobiology of disease. vol 43. issue 3. 2012-05-21. PMID:21624463. |
our findings suggest that abnormal bmi changes over a 12-month period are linked with relatively raised sert availability in pd on an overall background of decreased 5-ht function. |
2012-05-21 |
2023-08-12 |
Not clear |
| Jeremy Veenstra-VanderWeele, Christopher L Muller, Hideki Iwamoto, Jennifer E Sauer, W Anthony Owens, Charisma R Shah, Jordan Cohen, Padmanabhan Mannangatti, Tammy Jessen, Brent J Thompson, Ran Ye, Travis M Kerr, Ana M Carneiro, Jacqueline N Crawley, Elaine Sanders-Bush, Douglas G McMahon, Sammanda Ramamoorthy, Lynette C Daws, James S Sutcliffe, Randy D Blakel. Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 14. 2012-05-21. PMID:22431635. |
the 5-ht transporter (sert) gene (slc6a4) has been associated with whole blood 5-ht levels and asd susceptibility. |
2012-05-21 |
2023-08-12 |
mouse |
| Jeremy Veenstra-VanderWeele, Christopher L Muller, Hideki Iwamoto, Jennifer E Sauer, W Anthony Owens, Charisma R Shah, Jordan Cohen, Padmanabhan Mannangatti, Tammy Jessen, Brent J Thompson, Ran Ye, Travis M Kerr, Ana M Carneiro, Jacqueline N Crawley, Elaine Sanders-Bush, Douglas G McMahon, Sammanda Ramamoorthy, Lynette C Daws, James S Sutcliffe, Randy D Blakel. Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 14. 2012-05-21. PMID:22431635. |
here we establish that transgenic mice expressing the most common of these variants, sert ala56, exhibit elevated, p38 mapk-dependent transporter phosphorylation, enhanced 5-ht clearance rates and hyperserotonemia. |
2012-05-21 |
2023-08-12 |
mouse |
| Akihiro Mouri, Aya Sasaki, Ken Watanabe, Chiharu Sogawa, Shigeo Kitayama, Takayoshi Mamiya, Yoshiaki Miyamoto, Kiyofumi Yamada, Yukihiro Noda, Toshitaka Nabeshim. MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 13. 2012-05-18. PMID:22457503. |
here, we clarified a novel role of mage-d1 in emotional functions, namely its modulation of ubiquitylation to the serotonin transporter (sert). |
2012-05-18 |
2023-08-12 |
mouse |
| Akihiro Mouri, Aya Sasaki, Ken Watanabe, Chiharu Sogawa, Shigeo Kitayama, Takayoshi Mamiya, Yoshiaki Miyamoto, Kiyofumi Yamada, Yukihiro Noda, Toshitaka Nabeshim. MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 13. 2012-05-18. PMID:22457503. |
mage-d1 overexpression in cells resulted in a decrease in serotonin uptake activity and the protein level of sert but an increase in ubiquitylated sert. |
2012-05-18 |
2023-08-12 |
mouse |