| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniela Zuccarello, Marco Ghezzi, Manuel Pengo, Monica Forzan, Anna Chiara Frigo, Alberto Ferlin, Carlo Forest. No difference in 5-HTTLPR and Stin2 polymorphisms frequency between premature ejaculation patients and controls. The journal of sexual medicine. vol 9. issue 6. 2012-10-10. PMID:22489680. |
recently, genetic polymorphisms located on slc6a4 gene codifying for 5-ht transporter (5-htt or serotonin transporter [sert]), the major regulator of serotonergic neurotransmission, have been linked with the pathogenesis of pe and associated with the clinical response to therapy with contrasting results. |
2012-10-10 |
2023-08-12 |
Not clear |
| Joel G Anderson, Paula T Cooney, Keith M Erikso. Inhibition of DAT function attenuates manganese accumulation in the globus pallidus. Environmental toxicology and pharmacology. vol 23. issue 2. 2012-10-02. PMID:17387379. |
our primary goal of this study was to examine the potential roles of the monoamine transporters, dopamine transporter (dat), serotonin transporter (sert) and norepinephrine transporter (net), in neuronal mn transport. |
2012-10-02 |
2023-08-12 |
rat |
| Mari Gabrielsen, Ingebrigt Sylte, Svein G Dahl, Aina W Ravn. A short update on the structure of drug binding sites on neurotransmitter transporters. BMC research notes. vol 4. 2012-10-02. PMID:22192271. |
the dopamine (dat), noradrenalin (net) and serotonin (sert) transporters are molecular targets for different classes of psychotropic drugs. |
2012-10-02 |
2023-08-12 |
Not clear |
| E J Burnett, A T Davenport, K A Grant, D P Friedma. The effects of chronic ethanol self-administration on hippocampal serotonin transporter density in monkeys. Frontiers in psychiatry. vol 3. 2012-10-02. PMID:22557982. |
research has focused primarily on the serotonin transporter (sert) due in part to its role in regulating extracellular levels of serotonin. |
2012-10-02 |
2023-08-12 |
human |
| Xue Y Zhu, Jagan R Etukala, Suresh V K Eyunni, Vincent Setola, Bryan L Roth, Seth Y Ablordeppe. Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants. European journal of medicinal chemistry. vol 53. 2012-09-25. PMID:22520153. |
benzothiazoles as probes for the 5ht1a receptor and the serotonin transporter (sert): a search for new dual-acting agents as potential antidepressants. |
2012-09-25 |
2023-08-12 |
Not clear |
| Xue Y Zhu, Jagan R Etukala, Suresh V K Eyunni, Vincent Setola, Bryan L Roth, Seth Y Ablordeppe. Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants. European journal of medicinal chemistry. vol 53. 2012-09-25. PMID:22520153. |
the synthesis and evaluation of several benzothiazole-based compounds are described in an attempt to identify novel dual-acting 5ht(1a) receptor and sert inhibitors as new antidepressants. |
2012-09-25 |
2023-08-12 |
Not clear |
| Xue Y Zhu, Jagan R Etukala, Suresh V K Eyunni, Vincent Setola, Bryan L Roth, Seth Y Ablordeppe. Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants. European journal of medicinal chemistry. vol 53. 2012-09-25. PMID:22520153. |
compounds 20 and 23 show moderate binding affinity at the 5ht(1a) receptor and the sert site and thus, have the potential to be further explored as dual-acting agents. |
2012-09-25 |
2023-08-12 |
Not clear |
| Xue Y Zhu, Jagan R Etukala, Suresh V K Eyunni, Vincent Setola, Bryan L Roth, Seth Y Ablordeppe. Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants. European journal of medicinal chemistry. vol 53. 2012-09-25. PMID:22520153. |
in addition, compound 20 binds with low affinity to the dopamine transporter (dat), the norepinephrine transporter (net) and 5ht(2c) receptor, which are desirable properties as selectivity for sert (and not dat or net) is associated with an absence of cardiovascular side effects. |
2012-09-25 |
2023-08-12 |
Not clear |
| Way K W Lau, Moira M W Chan-Yeung, Benjamin H K Yip, Amy H K Cheung, Mary S M Ip, Judith C W Ma. The role of circulating serotonin in the development of chronic obstructive pulmonary disease. PloS one. vol 7. issue 2. 2012-09-24. PMID:22319639. |
the serotonin transporter (sert) gene polymorphism has been reported to be associated with copd, and the degree of cigarette smoking has been shown to be a significant mediator in this relationship. |
2012-09-24 |
2023-08-12 |
Not clear |
| Y M Wang, Y Chang, Y Y Chang, J Cheng, J Li, T Wang, Q Y Zhang, D C Liang, B Sun, B M Wan. Serotonin transporter gene promoter region polymorphisms and serotonin transporter expression in the colonic mucosa of irritable bowel syndrome patients. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 24. issue 6. 2012-09-21. PMID:22435794. |
the role of serotonin transporter (sert) gene polymorphism in irritable bowel syndrome (ibs) has been demonstrated. |
2012-09-21 |
2023-08-12 |
Not clear |
| Jens Benninghoff, Amelie van der Ven, Robert J Schloesser, Rainald Moessner, Hans Jürgen Möller, Dan Rujesc. The complex role of the serotonin transporter in adult neurogenesis and neuroplasticity. A critical review. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 13. issue 4. 2012-09-17. PMID:22409535. |
studies on the serotonin transporter (sert) with regard to neurogenesis and neuroplastic effects on the adult brain are scarce. |
2012-09-17 |
2023-08-12 |
Not clear |
| Jens Benninghoff, Amelie van der Ven, Robert J Schloesser, Rainald Moessner, Hans Jürgen Möller, Dan Rujesc. The complex role of the serotonin transporter in adult neurogenesis and neuroplasticity. A critical review. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 13. issue 4. 2012-09-17. PMID:22409535. |
this is intriguing since neurogenesis is believed to play a decisive role in modulating the effect of selective serotonin reuptake inhibitors (ssri), which are targeting sert. |
2012-09-17 |
2023-08-12 |
Not clear |
| Karin E Koopman, Susanne E la Fleur, Eric Fliers, Mireille J Serlie, Jan Booi. Assessing the optimal time point for the measurement of extrastriatal serotonin transporter binding with 123I-FP-CIT SPECT in healthy, male subjects. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 53. issue 7. 2012-09-13. PMID:22627000. |
however, recent studies suggest that this tracer may be used also to assess binding to monoamine transporters in the midbrain or diencephalon, which may reflect predominantly serotonin transporter (sert) binding. |
2012-09-13 |
2023-08-12 |
human |
| Andrew B Newberg, Jay D Amsterdam, Nancy Wintering, Justine Shult. Low brain serotonin transporter binding in major depressive disorder. Psychiatry research. vol 202. issue 2. 2012-09-13. PMID:22698760. |
we examined midbrain, medial temporal lobe, and basal ganglia serotonin transporter (sert) distribution volume ratio (dvr) values in subjects with major depressive disorder versus healthy volunteers using a selective sert radioligand and single photon emission computed tomography (spect). |
2012-09-13 |
2023-08-12 |
human |
| Margaret M Heitkemper, Ruth Kohen, Sang-Eun Jun, Monica E Jarret. Genetics and gastrointestinal symptoms. Annual review of nursing research. vol 29. 2012-09-11. PMID:22891508. |
four genes coding for proteins involved in neurotransmission (i.e., the serotonin reuptake transporter [sert], tryptophan hydroxylase [tph], alpha2-adrenergic receptor [alpha2-adr], catechol-o-methyl transferase [comt]) and their potential relevance to gi symptoms and ibs will be reviewed. |
2012-09-11 |
2023-08-12 |
Not clear |
| Anne Saulin, Markus Savli, Rupert Lanzenberge. Serotonin and molecular neuroimaging in humans using PET. Amino acids. vol 42. issue 6. 2012-09-10. PMID:21947614. |
this review aims at illustrating the distribution and summarizing the main functions of the serotonin (5-hydroxytryptamin, 5-ht) receptors as well as the serotonin transporter (sert, 5-htt), the vesicular monoamine transporter 2, monoamine oxidase type a and 5-ht synthesis in the human brain. |
2012-09-10 |
2023-08-12 |
human |
| Christoffer Bundgaard, Christina Sveigaard, Lise T Brennum, Tine B Stensbø. Associating in vitro target binding and in vivo CNS occupancy of serotonin reuptake inhibitors in rats: the role of free drug concentrations. Xenobiotica; the fate of foreign compounds in biological systems. vol 42. issue 3. 2012-09-10. PMID:22017605. |
the present study aimed at investigating the theory that free (unbound) active site concentrations are the best predictors of target binding of compounds blocking the serotonin transporter (sert) in the central nervous system (cns). |
2012-09-10 |
2023-08-12 |
rat |
| Christoffer Bundgaard, Christina Sveigaard, Lise T Brennum, Tine B Stensbø. Associating in vitro target binding and in vivo CNS occupancy of serotonin reuptake inhibitors in rats: the role of free drug concentrations. Xenobiotica; the fate of foreign compounds in biological systems. vol 42. issue 3. 2012-09-10. PMID:22017605. |
these data emphasize the use and impact of applying free fraction data in assessment of pharmacological in vitro-in vivo correlations and demonstrates its use to validate in vivo sert occupancy as pharmacodynamic marker for serotonin reuptake inhibitors in rats. |
2012-09-10 |
2023-08-12 |
rat |
| Jerry C Chang, Ian D Tomlinson, Michael R Warnement, Alessandro Ustione, Ana M D Carneiro, David W Piston, Randy D Blakely, Sandra J Rosentha. Single molecule analysis of serotonin transporter regulation using antagonist-conjugated quantum dots reveals restricted, p38 MAPK-dependent mobilization underlying uptake activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 26. 2012-09-10. PMID:22745492. |
the presynaptic serotonin (5-ht) transporter (sert) is targeted by widely prescribed antidepressant medications. |
2012-09-10 |
2023-08-12 |
Not clear |
| Mark D Underwood, Suham A Kassir, Mihran J Bakalian, Hanga Galfalvy, J John Mann, Victoria Arang. Neuron density and serotonin receptor binding in prefrontal cortex in suicide. The international journal of neuropsychopharmacology. vol 15. issue 4. 2012-09-05. PMID:21733245. |
therefore, we measured neuron density and serotonin transporter (sert), 5-ht1a and 5-ht2a binding in matched suicides and controls. |
2012-09-05 |
2023-08-12 |
Not clear |