| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Riccio, M Jacobshagen, B Golding, L Vutskits, D Jabaudon, J P Hornung, A G Daye. Excess of serotonin affects neocortical pyramidal neuron migration. Translational psychiatry. vol 1. 2013-04-04. PMID:22833193. |
the serotonin transporter (sert) is a key molecule involved in the homeostasis of extracellular levels of serotonin and is regulated developmentally. |
2013-04-04 |
2023-08-12 |
mouse |
| O Riccio, M Jacobshagen, B Golding, L Vutskits, D Jabaudon, J P Hornung, A G Daye. Excess of serotonin affects neocortical pyramidal neuron migration. Translational psychiatry. vol 1. 2013-04-04. PMID:22833193. |
genetic deletion of sert in rodents increases extracellular levels of serotonin and affects cellular processes involved in neocortical circuit assembly such as barrel cortex wiring and cortical interneuron migration. |
2013-04-04 |
2023-08-12 |
mouse |
| J M Launay, S Mouillet-Richard, A Baudry, M Pietri, O Kellerman. Raphe-mediated signals control the hippocampal response to SRI antidepressants via miR-16. Translational psychiatry. vol 1. 2013-04-04. PMID:22833211. |
fluoxetine, acting on serotonergic raphe neurons, decreases the amount of mir-16 in the hippocampus, which in turn increases the levels of the serotonin transporter (sert), the target of sri, and that of bcl-2 and the number of cells positive for doublecortin, a marker of neuronal maturation. |
2013-04-04 |
2023-08-12 |
mouse |
| Philippe Huot, Tom H Johnston, Michael N Gandy, M Gabriela Reyes, Susan H Fox, Matthew J Piggott, Jonathan M Brotchi. The monoamine re-uptake inhibitor UWA-101 improves motor fluctuations in the MPTP-lesioned common marmoset. PloS one. vol 7. issue 9. 2013-03-28. PMID:23029119. |
we recently described the discovery of uwa-101, a dual serotonin (sert) and dopamine (dat) transporter inhibitor, which increases the duration of "good quality" on-time provided by l-dopa in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-lesioned primate. |
2013-03-28 |
2023-08-12 |
marmoset |
| Julie A Wixey, Hanna E Reinebrant, Kathryn M Bulle. Evidence that the serotonin transporter does not shift into the cytosol of remaining neurons after neonatal brain injury. Neuroscience research. vol 73. issue 3. 2013-03-26. PMID:22525280. |
the regulation of brain 5-ht is dependent on the serotonin transporter (sert) localised at the neuronal pre-synaptic cell membrane. |
2013-03-26 |
2023-08-12 |
rat |
| Julie A Wixey, Hanna E Reinebrant, Kathryn M Bulle. Evidence that the serotonin transporter does not shift into the cytosol of remaining neurons after neonatal brain injury. Neuroscience research. vol 73. issue 3. 2013-03-26. PMID:22525280. |
however sert can also traffic away from the cell membrane into the cytosol and, after injury, may contribute to the cell's inability to maintain 5-ht levels. |
2013-03-26 |
2023-08-12 |
rat |
| Julie A Wixey, Hanna E Reinebrant, Kathryn M Bulle. Evidence that the serotonin transporter does not shift into the cytosol of remaining neurons after neonatal brain injury. Neuroscience research. vol 73. issue 3. 2013-03-26. PMID:22525280. |
we conclude that neuronal sert is the primary regulator of synaptic 5-ht availability in the intact and p3 hi-injured neonatal brain. |
2013-03-26 |
2023-08-12 |
rat |
| Julie A Wixey, Hanna E Reinebrant, Kathryn M Bulle. Evidence that the serotonin transporter does not shift into the cytosol of remaining neurons after neonatal brain injury. Neuroscience research. vol 73. issue 3. 2013-03-26. PMID:22525280. |
furthermore, since concomitant reductions in 5-ht, sert and serotonergic neurons occur after neonatal hi, it is plausible that the decrease in brain 5-ht is a consequence of sert being lost as neurons degenerate as opposed to remaining neurons internalising sert or clearance by glial cells. |
2013-03-26 |
2023-08-12 |
rat |
| Liang Peng, Jingyang Huan. Astrocytic 5-HT(2B) receptor as in vitro and in vivo target of SSRIs. Recent patents on CNS drug discovery. vol 7. issue 3. 2013-03-22. PMID:22963281. |
since astrocytes in the mature brain and in our cultures do not express sert, both acute and chronic effects in cultured astrocytes must be directly mediated by 5-ht(2b) receptor activation. |
2013-03-22 |
2023-08-12 |
mouse |
| Saskia J Rietjens, Laura Hondebrink, Remco H S Westerink, Jan Meulenbel. Pharmacokinetics and pharmacodynamics of 3,4-methylenedioxymethamphetamine (MDMA): interindividual differences due to polymorphisms and drug-drug interactions. Critical reviews in toxicology. vol 42. issue 10. 2013-03-20. PMID:23030234. |
blood pressure, heart rate, body temperature) can be reduced, possibly due to a pharmacodynamic interaction at the serotonin reuptake transporter (sert). |
2013-03-20 |
2023-08-12 |
Not clear |
| Cecilia Ratner, Anders Ettrup, Marco Bueter, Mette E Haahr, Valérie Compan, Carel W le Roux, Barry Levin, Henrik H Hansen, Gitte M Knudse. Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass. Obesity (Silver Spring, Md.). vol 20. issue 10. 2013-03-19. PMID:22450706. |
using receptor autoradiography, brain regional-densities of the serotonin transporter (sert) and the 5-ht(2a) and 5-ht(4) receptors were measured in (i) selectively bred polygenic diet-induced obese (pgdio) rats, (ii) outbred dio rats, and (iii) roux-en-y gastric bypass (rygb)-operated rats. |
2013-03-19 |
2023-08-12 |
rat |
| Cecilia Ratner, Anders Ettrup, Marco Bueter, Mette E Haahr, Valérie Compan, Carel W le Roux, Barry Levin, Henrik H Hansen, Gitte M Knudse. Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass. Obesity (Silver Spring, Md.). vol 20. issue 10. 2013-03-19. PMID:22450706. |
pgdio rats had higher 5-ht(4) and 5-ht(2a) receptor binding and lower sert binding when compared to polygenic diet-resistant (pgdr) rats. |
2013-03-19 |
2023-08-12 |
rat |
| Y S Singh, S C Altieri, T L Gilman, H M Michael, I D Tomlinson, S J Rosenthal, G M Swain, M A Murphey-Corb, R E Ferrell, A M Andrew. Differential serotonin transport is linked to the rh5-HTTLPR in peripheral blood cells. Translational psychiatry. vol 2. 2013-03-04. PMID:22832814. |
the human serotonin transporter (sert) gene possesses a 43-base pair (bp) insertion-deletion promoter polymorphism, the h5-httlpr. |
2013-03-04 |
2023-08-12 |
human |
| Y S Singh, S C Altieri, T L Gilman, H M Michael, I D Tomlinson, S J Rosenthal, G M Swain, M A Murphey-Corb, R E Ferrell, A M Andrew. Differential serotonin transport is linked to the rh5-HTTLPR in peripheral blood cells. Translational psychiatry. vol 2. 2013-03-04. PMID:22832814. |
reductions in serotonin uptake rates, cell surface sert binding, and 5-hydroxyindoleacetic acid/serotonin ratios, but not sert mrna levels, were associated with the rh5-httlpr short allele. |
2013-03-04 |
2023-08-12 |
human |
| D E Payer, E L Nurmi, S A Wilson, J T McCracken, E D Londo. Effects of methamphetamine abuse and serotonin transporter gene variants on aggression and emotion-processing neurocircuitry. Translational psychiatry. vol 2. 2013-03-04. PMID:22832817. |
as variability in the serotonin transporter (sert) gene can influence aggression, this study assessed possible contributions of this gene to ma-related aggression. |
2013-03-04 |
2023-08-12 |
human |
| Víctor Pérez, Juan Carlos Pascual, Joaquim Soler, Thais Tiana, Anna Cortés, Montserrat Baiget, Ana Martín-Blanco, Enrique Alvare. [Pyschotherapygenetics. Do genes influence psychotherapy adherence?]. Revista de psiquiatria y salud mental. vol 3. issue 2. 2013-03-01. PMID:23445932. |
the aim was to examine the association between polymorphisms of the serotonin transporter gene (sert) and the dopamine 4-receptor gene (drd4) with adherence to psychotherapy. |
2013-03-01 |
2023-08-12 |
Not clear |
| Lena Sørensen, Jacob Andersen, Mette Thomsen, Stinna M R Hansen, Xiaobei Zhao, Albin Sandelin, Kristian Strømgaard, Anders S Kristense. Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket. The Journal of biological chemistry. vol 287. issue 52. 2013-02-26. PMID:23086945. |
the serotonin transporter (sert) and the norepinephrine transporter (net) are sodium-dependent neurotransmitter transporters responsible for reuptake of released serotonin and norepinephrine, respectively, into nerve terminals in the brain. |
2013-02-26 |
2023-08-12 |
human |
| Catherine E Hagan, Ross A McDevitt, Yusha Liu, Amy R Furay, John F Neumaie. 5-HT(1B) autoreceptor regulation of serotonin transporter activity in synaptosomes. Synapse (New York, N.Y.). vol 66. issue 12. 2013-02-21. PMID:22961814. |
serotonin-1b (5-ht(1b) ) autoreceptors are located in serotonin (5-ht) terminals, along with serotonin transporters (sert), and play a critical role in autoregulation of serotonergic neurotransmission and are implicated in disorders of serotonergic function, particularly emotional regulation. |
2013-02-21 |
2023-08-12 |
mouse |
| Catherine E Hagan, Ross A McDevitt, Yusha Liu, Amy R Furay, John F Neumaie. 5-HT(1B) autoreceptor regulation of serotonin transporter activity in synaptosomes. Synapse (New York, N.Y.). vol 66. issue 12. 2013-02-21. PMID:22961814. |
sert modulates serotonergic neurotransmission by high-affinity reuptake of 5-ht. |
2013-02-21 |
2023-08-12 |
mouse |
| Catherine E Hagan, Ross A McDevitt, Yusha Liu, Amy R Furay, John F Neumaie. 5-HT(1B) autoreceptor regulation of serotonin transporter activity in synaptosomes. Synapse (New York, N.Y.). vol 66. issue 12. 2013-02-21. PMID:22961814. |
several neurotransmitter receptors are known to regulate sert k(m) and v(max) , and previous work suggests that 5-ht(1b) autoreceptors may regulate 5-ht reuptake, in addition to modulating 5-ht release and synthesis. |
2013-02-21 |
2023-08-12 |
mouse |