| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael H Baumann, John S Partilla, Kurt R Lehne. Psychoactive "bath salts": not so soothing. European journal of pharmacology. vol 698. issue 1-3. 2013-06-10. PMID:23178799. |
similar to other psychomotor stimulants, synthetic cathinones target plasma membrane transporters for dopamine (i.e., dat), norepinephrine (i.e., net) and serotonin (i.e, sert). |
2013-06-10 |
2023-08-12 |
rat |
| Peng Zhang, Trine Nygaard Jørgensen, Claus J Loland, Amy Hauck Newma. A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter. Bioorganic & medicinal chemistry letters. vol 23. issue 1. 2013-05-28. PMID:23168018. |
a novel fluorescent ligand was synthesized as a high-affinity, high specificity probe for visualizing the serotonin transporter (sert). |
2013-05-28 |
2023-08-12 |
Not clear |
| Peng Zhang, Trine Nygaard Jørgensen, Claus J Loland, Amy Hauck Newma. A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter. Bioorganic & medicinal chemistry letters. vol 23. issue 1. 2013-05-28. PMID:23168018. |
the resulting rhodamine-labeled ligand 8 inhibited [(3)h]5-ht uptake in cos-7 cells (k(i)=225 nm) with similar potency to the tropane-based jhc 1-064 (1), but with higher specificity towards the sert relative to the transporters for dopamine and norepinephrine. |
2013-05-28 |
2023-08-12 |
Not clear |
| Nobuo Tsuruoka, Yoshinori Beppu, Hirofumi Koda, Nobutaka Doe, Hiroshi Watanabe, Keiichi Ab. A DKP cyclo(L-Phe-L-Phe) found in chicken essence is a dual inhibitor of the serotonin transporter and acetylcholinesterase. PloS one. vol 7. issue 11. 2013-05-22. PMID:23209830. |
we found that a chicken essence beverage, which is popular among southeast asians as a traditional remedy and a rich source of dkps, inhibited the serotonin transporter (sert) and suppressed serotonin uptake from rat brain synaptosomes, which prompted us to isolate and identify the active substance(s). |
2013-05-22 |
2023-08-12 |
mouse |
| Junlin Zhang, Katie A Dennis, Ryan D Darling, Loai Alzghoul, Ian A Paul, Kimberly L Simpson, Rick C S Li. Neonatal citalopram exposure decreases serotonergic fiber density in the olfactory bulb of male but not female adult rats. Frontiers in cellular neuroscience. vol 7. 2013-05-16. PMID:23675318. |
recent studies have demonstrated altered raphe-derived 5ht transporter (sert) immunoreactive axonal expression in several cortical target sites after brief perinatal exposure to selective 5ht reuptake inhibitors such as citalopram (ctm). |
2013-05-16 |
2023-08-12 |
rat |
| Louise M Paterson, Birgitte R Kornum, David J Nutt, Victor W Pike, Gitte M Knudse. 5-HT radioligands for human brain imaging with PET and SPECT. Medicinal research reviews. vol 33. issue 1. 2013-05-14. PMID:21674551. |
this review provides the history and current status of radioligands used for positron emission tomography (pet) and single photon emission computerized tomography (spect) imaging of human brain serotonin (5-ht) receptors, the 5-ht transporter (sert), and 5-ht synthesis rate. |
2013-05-14 |
2023-08-12 |
human |
| Louise M Paterson, Birgitte R Kornum, David J Nutt, Victor W Pike, Gitte M Knudse. 5-HT radioligands for human brain imaging with PET and SPECT. Medicinal research reviews. vol 33. issue 1. 2013-05-14. PMID:21674551. |
currently available radioligands for in vivo brain imaging of the 5-ht system in humans include antagonists for the 5-ht(1a), 5-ht(1b), 5-ht(2a), and 5-ht(4) receptors, and for sert. |
2013-05-14 |
2023-08-12 |
human |
| Anke J Borgers, Anneke Alkemade, Elsmarieke M Van de Giessen, Madeleine L Drent, Jan Booij, Peter H Bisschop, Eric Flier. Imaging of serotonin transporters with [123I]FP-CIT SPECT in the human hypothalamus. EJNMMI research. vol 3. issue 1. 2013-05-09. PMID:23618227. |
in the present study, we aimed to develop a method to visualize serotonin transporters (sert) in the hypothalamus. |
2013-05-09 |
2023-08-12 |
human |
| Soumava Santra, Sanjib Gogoi, Bhaskar Gopishetty, Tamara Antonio, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Structural exploration of (3S,6S)-6-benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine analogues: identification of potent triple monoamine reuptake inhibitors as potential antidepressants. ChemMedChem. vol 7. issue 12. 2013-04-29. PMID:23060293. |
the new compounds were tested for their affinities for the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net) in rat brain by measuring their capacity to inhibit the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2013-04-29 |
2023-08-12 |
rat |
| Sonja Sucic, Florian Koban, Ali El-Kasaby, Oliver Kudlacek, Thomas Stockner, Harald H Sitte, Michael Freissmut. Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C. The Journal of biological chemistry. vol 288. issue 8. 2013-04-25. PMID:23288844. |
the serotonin transporter (sert) maintains serotonergic neurotransmission via rapid reuptake of serotonin from the synaptic cleft. |
2013-04-25 |
2023-08-12 |
Not clear |
| Rupert Lanzenberger, Georg S Kranz, Daniela Haeusler, Elena Akimova, Markus Savli, Andreas Hahn, Markus Mitterhauser, Christoph Spindelegger, Cecile Philippe, Martin Fink, Wolfgang Wadsak, Georgios Karanikas, Siegfried Kaspe. Prediction of SSRI treatment response in major depression based on serotonin transporter interplay between median raphe nucleus and projection areas. NeuroImage. vol 63. issue 2. 2013-04-18. PMID:22828162. |
recent mathematical models suggest restored serotonergic burst-firing to underlie the antidepressant effect of selective serotonin reuptake inhibitors (ssri), resulting from down-regulated serotonin transporters (sert) in terminal regions. |
2013-04-18 |
2023-08-12 |
Not clear |
| Abigail G Schindler, Daniel I Messinger, Jeffrey S Smith, Haripriya Shankar, Richard M Gustin, Selena S Schattauer, Julia C Lemos, Nicholas W Chavkin, Catherine E Hagan, John F Neumaier, Charles Chavki. Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 49. 2013-04-11. PMID:23223282. |
activation of the dynorphin/κ-opioid receptor (kor) system by repeated stress exposure or agonist treatment produces place aversion, social avoidance, and reinstatement of extinguished cocaine place preference behaviors by stimulation of p38α mapk, which subsequently causes the translocation of the serotonin transporter (sert, slc6a4) to the synaptic terminals of serotonergic neurons. |
2013-04-11 |
2023-08-12 |
mouse |
| Harun N Noristani, Alexei Verkhratsky, José J Rodrígue. High tryptophan diet reduces CA1 intraneuronal β-amyloid in the triple transgenic mouse model of Alzheimer's disease. Aging cell. vol 11. issue 5. 2013-04-10. PMID:22702392. |
here, we analysed the effect of chronic (1 month) food diets containing low (ltrp), normal (ntrp) and high tryptophan (htrp), 0.04, 0.20 and 0.40 g/100 g, respectively, on ca1 serotonin transporter (sert) fibre density, intraneuronal aβ deposition and total number of serotonergic (5-ht) neurons in an ad triple transgenic (3xtg-ad) mouse model. |
2013-04-10 |
2023-08-12 |
mouse |
| Harun N Noristani, Alexei Verkhratsky, José J Rodrígue. High tryptophan diet reduces CA1 intraneuronal β-amyloid in the triple transgenic mouse model of Alzheimer's disease. Aging cell. vol 11. issue 5. 2013-04-10. PMID:22702392. |
transgenic animals showed increased sert fibre density in ca1 s.mol compared to diet-matched non-tg irrespective of dietary tryptophan content (104% for ltrp, 74% for ntrp and 35% for htrp); no differences were observed in the total number of 5-ht neurons neither in the dorsal nor in the median raphe nuclei. |
2013-04-10 |
2023-08-12 |
mouse |
| Ravinder K Gill, Anoop Kumar, Pooja Malhotra, Daniel Maher, Varsha Singh, Pradeep K Dudeja, Waddah Alrefai, Seema Saksen. Regulation of intestinal serotonin transporter expression via epigenetic mechanisms: role of HDAC2. American journal of physiology. Cell physiology. vol 304. issue 4. 2013-04-08. PMID:23195070. |
the serotonin (5-ht) transporter (sert) facilitates clearance of extracellular 5-ht by its uptake and internalization. |
2013-04-08 |
2023-08-12 |
mouse |
| Ravinder K Gill, Anoop Kumar, Pooja Malhotra, Daniel Maher, Varsha Singh, Pradeep K Dudeja, Waddah Alrefai, Seema Saksen. Regulation of intestinal serotonin transporter expression via epigenetic mechanisms: role of HDAC2. American journal of physiology. Cell physiology. vol 304. issue 4. 2013-04-08. PMID:23195070. |
decreased expression of sert and consequent high 5-ht levels have been implicated in various diarrheal disorders. |
2013-04-08 |
2023-08-12 |
mouse |
| Ravinder K Gill, Anoop Kumar, Pooja Malhotra, Daniel Maher, Varsha Singh, Pradeep K Dudeja, Waddah Alrefai, Seema Saksen. Regulation of intestinal serotonin transporter expression via epigenetic mechanisms: role of HDAC2. American journal of physiology. Cell physiology. vol 304. issue 4. 2013-04-08. PMID:23195070. |
thus, appropriate regulation of sert is critical for maintenance of 5-ht homeostasis in health and disease. |
2013-04-08 |
2023-08-12 |
mouse |
| Clelia Dallanoce, Mara Canovi, Carlo Matera, Tiziana Mennini, Marco De Amici, Marco Gobbi, Carlo De Michel. A novel spirocyclic tropanyl-Δ²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake. Bioorganic & medicinal chemistry. vol 20. issue 21. 2013-04-05. PMID:23022052. |
their interaction with the dopamine and serotonin transporters (dat and sert, respectively) was evaluated through binding experiments. |
2013-04-05 |
2023-08-12 |
rat |
| Clelia Dallanoce, Mara Canovi, Carlo Matera, Tiziana Mennini, Marco De Amici, Marco Gobbi, Carlo De Michel. A novel spirocyclic tropanyl-Δ²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake. Bioorganic & medicinal chemistry. vol 20. issue 21. 2013-04-05. PMID:23022052. |
unexpectedly, one of the tertiary amines under investigation, that is 3'-methoxy-8-methyl-spiro{8-azabicyclo[3.2.1]octane-3,5'(4'h)-isoxazole 7a, was able to enhance at a concentration of 10 μm both [(3)h]citalopram and [(3)h]paroxetine binding to sert in rat brain homogenate (up to 25%, due to an increase of b(max)) and [(3)h]serotonin uptake (up to 30%) in cortical synaptosomes. |
2013-04-05 |
2023-08-12 |
rat |
| R Avula, A Rand, J L Black, D J O'Kan. Simultaneous genotyping of multiple polymorphisms in human serotonin transporter gene and detection of novel allelic variants. Translational psychiatry. vol 1. 2013-04-04. PMID:22832606. |
the serotonin transporter, called slc6a4, sert or 5-htt, modulates neurotransmission by removal of serotonin from the synapse of serotonergic neurons, facilitating serotonin reuptake into the presynaptic terminus. |
2013-04-04 |
2023-08-12 |
human |