| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Donatella Marazziti, Paola Landi, Stefano Baroni, Federica Vanelli, Natalia Bartolommei, Michela Picchetti, Liliana Dell'Oss. The role of platelet/lymphocyte serotonin transporter in depression and beyond. Current drug targets. vol 14. issue 5. 2013-10-29. PMID:23514378. |
this paper aims to review briefly the literature on the 5-ht hypothesis of depression with a major focus on the possible role of sert in this disorder, while highlighting how recent data are more oriented on dimensional rather than nosological involvement of this structure in different conditions spanning from normality to pathology. |
2013-10-29 |
2023-08-12 |
Not clear |
| Stephen M Stahl, Clara Lee-Zimmerman, Sylvia Cartwright, Debbi Ann Morrissett. Serotonergic drugs for depression and beyond. Current drug targets. vol 14. issue 5. 2013-10-29. PMID:23531115. |
the current generation of antidepressant drugs acts predominantly by targeting the serotonin transporter (sert). |
2013-10-29 |
2023-08-12 |
Not clear |
| Stephen M Stahl, Clara Lee-Zimmerman, Sylvia Cartwright, Debbi Ann Morrissett. Serotonergic drugs for depression and beyond. Current drug targets. vol 14. issue 5. 2013-10-29. PMID:23531115. |
the original trend to do this selectively (e.g., with ssris or selective serotonin reuptake inhibitors) has given way to combining various additional pharmacologic mechanisms with sert inhibition, including dual actions by single drugs (e.g., snris or serotonin norepinephrine reuptake inhibitors), or by augmenting ssris with a second drug of a different mechanism (e.g., bupropion with dopamine and norepinephrine reuptake inhibition; trazodone with 5ht2a antagonism; mirtazapine with 5ht2a/5ht2c/5ht3/alpha2 antagonism; buspirone or some atypical antipsychotics with 5ht1a partial agonism; other atypical antipsychotics with 5ht2c/5ht7 antagonism and other mechanisms). |
2013-10-29 |
2023-08-12 |
Not clear |
| Naozumi Araragi, Klaus-Peter Lesc. Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models. Current drug targets. vol 14. issue 5. 2013-10-29. PMID:23547810. |
over the last decade, research on mice with a targeted inactivation of the 5-ht transporter (5-htt, sert, slc6a4) has considerably advanced our knowledge about functions that the 5-htt plays in the context of emotion related to depression. |
2013-10-29 |
2023-08-12 |
mouse |
| Richard J Karpowicz, Matthew Dunn, David Sulzer, Dalibor Same. APP+, a fluorescent analogue of the neurotoxin MPP+, is a marker of catecholamine neurons in brain tissue, but not a fluorescent false neurotransmitter. ACS chemical neuroscience. vol 4. issue 5. 2013-10-22. PMID:23647019. |
app+ is a substrate for the dopamine transporter (dat), norepinephrine transporter (net), and serotonin transporter (sert), and as such represented a candidate for the development of new ffn probes. |
2013-10-22 |
2023-08-12 |
mouse |
| Florian Buchmayer, Klaus Schicker, Thomas Steinkellner, Petra Geier, Gerald Stübiger, Peter J Hamilton, Andreas Jurik, Thomas Stockner, Jae-Won Yang, Therese Montgomery, Marion Holy, Tina Hofmaier, Oliver Kudlacek, Heinrich J G Matthies, Gerhard F Ecker, Valery Bochkov, Aurelio Galli, Stefan Boehm, Harald H Sitt. Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 28. 2013-10-18. PMID:23798435. |
channel properties are also attributed to serotonin transporters (serts); however, sert regulation by pip2 has not been reported. |
2013-10-18 |
2023-08-12 |
human |
| YoneJung Yoon, Morgan C McKenna, David A Rollins, Minseok Song, Tal Nuriel, Steven S Gross, Guoqiang Xu, Charles E Glat. Anxiety-associated alternative polyadenylation of the serotonin transporter mRNA confers translational regulation by hnRNPK. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 28. 2013-10-18. PMID:23798440. |
the serotonin transporter (sert) is a major regulator of serotonergic neurotransmission and anxiety-related behaviors. |
2013-10-18 |
2023-08-12 |
mouse |
| Marilia Barros, Emma L Dempster, Nicholas Illott, Soha Chabrawi, Rafael S Maior, Carlos Tomaz, Maria A De Souza Silva, Joseph P Huston, Jonathan Mill, Christian P Mülle. Decreased methylation of the NK3 receptor coding gene (TACR3) after cocaine-induced place preference in marmoset monkeys. Addiction biology. vol 18. issue 3. 2013-10-17. PMID:22070124. |
here we measured dna methylation at promoter cpg sites of the dopamine transporter (dat1) and serotonin transporter (sert) and neurokinin3-receptor (nk3-r)-receptor (tacr3) coding genes in marmoset monkeys after repeated cocaine injections in a conditioned place preference paradigm. |
2013-10-17 |
2023-08-12 |
monkey |
| Andrew E Arrant, Hikma Jemal, Cynthia M Kuh. Adolescent male rats are less sensitive than adults to the anxiogenic and serotonin-releasing effects of fenfluramine. Neuropharmacology. vol 65. 2013-10-17. PMID:23103347. |
serotonin transporter (sert) immunoreactivity and sert radioligand binding were comparable between age groups in all three brain regions. |
2013-10-17 |
2023-08-12 |
rat |
| Robert A Comley, Cristian A Salinas, Mark Slifstein, Marcella Petrone, Carmine Marzano, Idriss Bennacef, Paul Shotbolt, Jasper Van der Aart, Marta Neve, Laura Iavarone, Roberto Gomeni, Marc Laruelle, Frank A Gray, Roger N Gunn, Eugenii A Rabine. Monoamine transporter occupancy of a novel triple reuptake inhibitor in baboons and humans using positron emission tomography. The Journal of pharmacology and experimental therapeutics. vol 346. issue 2. 2013-09-25. PMID:23685546. |
studies were performed in baboons (papio anubis) to determine the relationship between plasma concentration and occupancy of brain serotonin reuptake transporter (sert), dopamine reuptake transporter (dat), and norepinephrine uptake transporter (net) using the radioligands [(11)c]dasb [(n,n-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine], [(11)c]pe2i [n-(3-iodoprop-2e-enyl)-2β-carbomethoxy-3β-(4-methylphenyl)nortropane], and [(11)c]2-[(2-methoxyphenoxy)phenylmethyl]morpholine (also known as [(11)c]mrb) and in humans using [(11)c]dasb and [(11)c]pe2i. |
2013-09-25 |
2023-08-12 |
Not clear |
| Stephanie B Linley, Walter B Hoover, Robert P Verte. Pattern of distribution of serotonergic fibers to the orbitomedial and insular cortex in the rat. Journal of chemical neuroanatomy. vol 48-49. 2013-09-12. PMID:23337940. |
in addition, no reports have described the distribution of 5-ht fibers to pfc in rats using antisera to the serotonin transporter (sert). |
2013-09-12 |
2023-08-12 |
rat |
| Stephanie B Linley, Walter B Hoover, Robert P Verte. Pattern of distribution of serotonergic fibers to the orbitomedial and insular cortex in the rat. Journal of chemical neuroanatomy. vol 48-49. 2013-09-12. PMID:23337940. |
using immunostaining for sert, we examined the pattern of distribution of 5-ht fibers to the medial, orbital and insular cortices in the rat. |
2013-09-12 |
2023-08-12 |
rat |
| Sandra Malynn, Antonio Campos-Torres, Paul Moynagh, Jana Haas. The pro-inflammatory cytokine TNF-α regulates the activity and expression of the serotonin transporter (SERT) in astrocytes. Neurochemical research. vol 38. issue 4. 2013-09-12. PMID:23338678. |
the pro-inflammatory cytokine tnf-α regulates the activity and expression of the serotonin transporter (sert) in astrocytes. |
2013-09-12 |
2023-08-12 |
human |
| Sandra Malynn, Antonio Campos-Torres, Paul Moynagh, Jana Haas. The pro-inflammatory cytokine TNF-α regulates the activity and expression of the serotonin transporter (SERT) in astrocytes. Neurochemical research. vol 38. issue 4. 2013-09-12. PMID:23338678. |
pro-inflammatory cytokines have been implicated in the precipitation of depression and related disorders, and the antidepressant sensitive serotonin transporter (sert) may be a major target for immune regulation in these disorders. |
2013-09-12 |
2023-08-12 |
human |
| Sandra Malynn, Antonio Campos-Torres, Paul Moynagh, Jana Haas. The pro-inflammatory cytokine TNF-α regulates the activity and expression of the serotonin transporter (SERT) in astrocytes. Neurochemical research. vol 38. issue 4. 2013-09-12. PMID:23338678. |
further analysis in primary astrocytes revealed that tnf-α enhanced the transport capacity (vmax) of sert-specific 5-ht uptake, suggesting enhanced transporter expression, consistent with our observation of an increase in sert mrna levels. |
2013-09-12 |
2023-08-12 |
human |
| Nicholas V Cozzi, Simon D Brandt, Paul F Daley, John S Partilla, Richard B Rothman, Andreas Tulzer, Harald H Sitte, Michael H Bauman. Pharmacological examination of trifluoromethyl ring-substituted methcathinone analogs. European journal of pharmacology. vol 699. issue 1-3. 2013-09-02. PMID:23178523. |
at the serotonin transporter (sert), 3-tfmap and 4-tfmap were 10-fold more potent than methcathinone as uptake inhibitors and as releasing agents, but 2-tfmap was both a weak uptake inhibitor and releaser. |
2013-09-02 |
2023-08-12 |
rat |
| Rebecca E Horton, Deana M Apple, W Anthony Owens, Nicole L Baganz, Sonia Cano, Nathan C Mitchell, Melissa Vitela, Georgianna G Gould, Wouter Koek, Lynette C Daw. Decynium-22 enhances SSRI-induced antidepressant-like effects in mice: uncovering novel targets to treat depression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 25. 2013-08-30. PMID:23785165. |
the most commonly prescribed antidepressant drugs are the selective serotonin (5-ht) reuptake inhibitors (ssris), which act by blocking the high-affinity 5-ht transporter (sert). |
2013-08-30 |
2023-08-12 |
mouse |
| Rebecca E Horton, Deana M Apple, W Anthony Owens, Nicole L Baganz, Sonia Cano, Nathan C Mitchell, Melissa Vitela, Georgianna G Gould, Wouter Koek, Lynette C Daw. Decynium-22 enhances SSRI-induced antidepressant-like effects in mice: uncovering novel targets to treat depression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 25. 2013-08-30. PMID:23785165. |
decynium-22 (d-22) is a blocker of these transporters, and using this compound we uncovered a significant role for octs in 5-ht uptake in mice genetically modified to have reduced or no sert expression (baganz et al., 2008). |
2013-08-30 |
2023-08-12 |
mouse |
| S Yubero-Lahoz, P Robledo, M Farré, R de laTorr. Platelet SERT as a peripheral biomarker of serotonergic neurotransmission in the central nervous system. Current medicinal chemistry. vol 20. issue 11. 2013-08-28. PMID:23409709. |
the serotonin (5-hydroxytryptamine; 5-ht) transporter(sert) in the brain clears 5-ht from extracellular spaces, modulating the strength and duration of serotonergic signaling.outside the central nervous system, it is also present in platelets, where it takes up 5-ht from plasma, keeping levels very low (i.e., ~1 nm). |
2013-08-28 |
2023-08-12 |
human |
| Eva Latorre, Carmen Mendoza, Nyurky Matheus, Marta Castro, Laura Grasa, José E Mesonero, Ana I Alcald. IL-10 modulates serotonin transporter activity and molecular expression in intestinal epithelial cells. Cytokine. vol 61. issue 3. 2013-08-27. PMID:23410504. |
the serotonin transporter (sert) determines the final serotonin availability and has been described as altered in inflammatory bowel diseases. |
2013-08-27 |
2023-08-12 |
Not clear |