| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bryan K Sander. Flowers for Algernon: steroid dysgenesis, epigenetics and brain disorders. Pharmacological reports : PR. vol 64. issue 6. 2013-07-16. PMID:23406739. |
while research efforts have demonstrated that transgenic mice expressing the most common of multiple gain-of-function 5-ht reuptake transporter (sert) coding variants, sert ala56, previously identified in children with asd, exhibit autistic-like behaviors, elevated p38 mapk-dependent transporter phosphorylation, enhanced 5-ht clearance rates and hyperserotonemia, a few studies provide some evidence that 5-ht may alter gonadal steroidogenesis. |
2013-07-16 |
2023-08-12 |
mouse |
| A Ferrés-Coy, F Pilar-Cuellar, R Vidal, V Paz, M Masana, R Cortés, M C Carmona, L Campa, A Pazos, A Montefeltro, E M Valdizán, F Artigas, A Bortolozz. RNAi-mediated serotonin transporter suppression rapidly increases serotonergic neurotransmission and hippocampal neurogenesis. Translational psychiatry. vol 3. 2013-07-04. PMID:23321808. |
current antidepressants, which inhibit the serotonin transporter (sert), display limited efficacy and slow onset of action. |
2013-07-04 |
2023-08-12 |
mouse |
| A Ferrés-Coy, F Pilar-Cuellar, R Vidal, V Paz, M Masana, R Cortés, M C Carmona, L Campa, A Pazos, A Montefeltro, E M Valdizán, F Artigas, A Bortolozz. RNAi-mediated serotonin transporter suppression rapidly increases serotonergic neurotransmission and hippocampal neurogenesis. Translational psychiatry. vol 3. 2013-07-04. PMID:23321808. |
the use of sirna-targeting genes in serotonin neurons (sert, 5-ht(1a)-autoreceptor) may be a novel therapeutic strategy to develop fast-acting antidepressants. |
2013-07-04 |
2023-08-12 |
mouse |
| Lynette C Daws, Wouter Koek, Nathan C Mitchel. Revisiting serotonin reuptake inhibitors and the therapeutic potential of "uptake-2" in psychiatric disorders. ACS chemical neuroscience. vol 4. issue 1. 2013-07-02. PMID:23336039. |
the most commonly prescribed class of antidepressants, the selective serotonin reuptake inhibitors (ssris), are thought to act by increasing extracellular serotonin in brain by blocking its uptake via the high-affinity serotonin transporter (sert). |
2013-07-02 |
2023-08-12 |
Not clear |
| William B Siesser, Benjamin D Sachs, Amy J Ramsey, Tatyana D Sotnikova, Jean-Martin Beaulieu, Xiaodong Zhang, Marc G Caron, Raul R Gainetdino. Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice. ACS chemical neuroscience. vol 4. issue 1. 2013-07-02. PMID:23336047. |
selective serotonin reuptake inhibitors (ssris) are a major class of antidepressants that act by blocking inward transport of serotonin (5-ht) into presynaptic neurons mediated by the serotonin transporter (sert). |
2013-07-02 |
2023-08-12 |
mouse |
| Brendan S Beikmann, Ian D Tomlinson, Sandra J Rosenthal, Anne Milasincic Andrew. Serotonin uptake is largely mediated by platelets versus lymphocytes in peripheral blood cells. ACS chemical neuroscience. vol 4. issue 1. 2013-07-02. PMID:23336055. |
the serotonin transporter (sert), a primary target for many antidepressants, is expressed in the brain and also in peripheral blood cells. |
2013-07-02 |
2023-08-12 |
human |
| Brendan S Beikmann, Ian D Tomlinson, Sandra J Rosenthal, Anne Milasincic Andrew. Serotonin uptake is largely mediated by platelets versus lymphocytes in peripheral blood cells. ACS chemical neuroscience. vol 4. issue 1. 2013-07-02. PMID:23336055. |
lack of measurable sert function in lymphocytes was corroborated by chronoamperometry using serotonin as a substrate. |
2013-07-02 |
2023-08-12 |
human |
| Lei Xu, Hua Tian, Wei Wang, Shaoguo R. Effects of monocrotophos pesticide on serotonin metabolism during early development in the sea urchin, Hemicentrotus pulcherrimus. Environmental toxicology and pharmacology. vol 34. issue 2. 2013-06-25. PMID:22824501. |
fertilized embryos of sea urchin were incubated with 40% mcp pesticide at nominal concentrations of 0.01, 0.10 and 1.00mg/l, and the effects on tryptophan hydroxylase of hemicentrotus pulcherrimus (hptph), serotonin reuptake transporter (sert), monoamine oxidase (mao), and serotonin levels were investigated. |
2013-06-25 |
2023-08-12 |
Not clear |
| Lei Xu, Hua Tian, Wei Wang, Shaoguo R. Effects of monocrotophos pesticide on serotonin metabolism during early development in the sea urchin, Hemicentrotus pulcherrimus. Environmental toxicology and pharmacology. vol 34. issue 2. 2013-06-25. PMID:22824501. |
when serotonin should be quickly metabolized at 36-hpf stage, hptph and sert expression was decreased and mao activity was induced by mcp pesticide, leading to the impairment of serotonergic synaptic activity. |
2013-06-25 |
2023-08-12 |
Not clear |
| Lei Xu, Hua Tian, Wei Wang, Shaoguo R. Effects of monocrotophos pesticide on serotonin metabolism during early development in the sea urchin, Hemicentrotus pulcherrimus. Environmental toxicology and pharmacology. vol 34. issue 2. 2013-06-25. PMID:22824501. |
but when serotonin should be metabolized at low levels during the other six stages, mcp pesticide induced hptph and sert expression, resulting in the improvement of serotonergic synaptic activity. |
2013-06-25 |
2023-08-12 |
Not clear |
| Pinguan Zheng, Brian P Lieberman, Karl Ploessl, Laetitia Lemoine, Sara Miller, Hank F Kun. A new single-photon emission computed tomography (SPECT) imaging agent for serotonin transporters: [(125)I]Flip-IDAM, (2-((2-((dimethylamino)methyl)-4-iodophenyl)thio)phenyl)methanol. Bioorganic & medicinal chemistry letters. vol 23. issue 3. 2013-06-25. PMID:23265880. |
new ligands for in vivo brain imaging of serotonin transporter (sert) with single photon emission tomography (spect) were prepared and evaluated. |
2013-06-25 |
2023-08-12 |
human |
| Wen-Sheng Huang, San-Yuan Huang, Pei-Shen Ho, Kuo-Hsing Ma, Ya-Yao Huang, Chin-Bin Yeh, Ren-Syuan Liu, Cheng-Yi Cheng, Chyng-Yann Shiu. PET imaging of the brain serotonin transporters (SERT) with N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) in humans: a preliminary study. European journal of nuclear medicine and molecular imaging. vol 40. issue 1. 2013-06-21. PMID:23053324. |
pet imaging of the brain serotonin transporters (sert) with n,n-dimethyl-2-(2-amino-4-[18f]fluorophenylthio)benzylamine (4-[18f]-adam) in humans: a preliminary study. |
2013-06-21 |
2023-08-12 |
Not clear |
| Hikaru Yammamoto, Shigeru Tanaka, Anna Tanaka, Izumi Hide, Takahiro Seki, Norio Saka. Long-term exposure of RN46A cells expressing serotonin transporter (SERT) to a cAMP analog up-regulates SERT activity and is accompanied by neural differentiation of the cells. Journal of pharmacological sciences. vol 121. issue 1. 2013-06-21. PMID:23269237. |
long-term exposure of rn46a cells expressing serotonin transporter (sert) to a camp analog up-regulates sert activity and is accompanied by neural differentiation of the cells. |
2013-06-21 |
2023-08-12 |
rat |
| Hikaru Yammamoto, Shigeru Tanaka, Anna Tanaka, Izumi Hide, Takahiro Seki, Norio Saka. Long-term exposure of RN46A cells expressing serotonin transporter (SERT) to a cAMP analog up-regulates SERT activity and is accompanied by neural differentiation of the cells. Journal of pharmacological sciences. vol 121. issue 1. 2013-06-21. PMID:23269237. |
to examine the functional regulation of serotonin transporter (sert) by camp, we examined whether sert uptake activity was affected by dibutyryl camp (dbcamp), a camp analog, in sert-transfected rn46a cells derived from embryonic rat raphe neurons. |
2013-06-21 |
2023-08-12 |
rat |
| Hikaru Yammamoto, Shigeru Tanaka, Anna Tanaka, Izumi Hide, Takahiro Seki, Norio Saka. Long-term exposure of RN46A cells expressing serotonin transporter (SERT) to a cAMP analog up-regulates SERT activity and is accompanied by neural differentiation of the cells. Journal of pharmacological sciences. vol 121. issue 1. 2013-06-21. PMID:23269237. |
in addition, a selective pka activator, but not a selective epac activator, increased the serotonin uptake activity of sert, suggesting that this regulation was mainly mediated via pka. |
2013-06-21 |
2023-08-12 |
rat |
| Francesc Artiga. Serotonin receptors involved in antidepressant effects. Pharmacology & therapeutics. vol 137. issue 1. 2013-06-20. PMID:23022360. |
presynaptic 5-ht(1a) and 5-ht(1b) autoreceptors play a major detrimental role in antidepressant treatments, as their activation by the excess of the active (extracellular) 5-ht fraction produced by serotonin transporter (sert) blockade reduces presynaptic serotonergic function. |
2013-06-20 |
2023-08-12 |
Not clear |
| Francesc Artiga. Serotonin receptors involved in antidepressant effects. Pharmacology & therapeutics. vol 137. issue 1. 2013-06-20. PMID:23022360. |
however, 5-ht(3) receptor blockade augments the 5-ht increase evoked by sert inhibition, and 5-ht(4) receptor activation may have antidepressant effects on its own. |
2013-06-20 |
2023-08-12 |
Not clear |
| Francesc Artiga. Serotonin receptors involved in antidepressant effects. Pharmacology & therapeutics. vol 137. issue 1. 2013-06-20. PMID:23022360. |
finally, blockade of 5-ht(6) and 5-ht(7) receptors appears also to augment the antidepressant effects of sert inhibition. |
2013-06-20 |
2023-08-12 |
Not clear |
| Stéphanie Miceli, Moritz Negwer, Fenneke van Eijs, Carla Kalkhoven, Ilja van Lierop, Judith Homberg, Dirk Schuber. High serotonin levels during brain development alter the structural input-output connectivity of neural networks in the rat somatosensory layer IV. Frontiers in cellular neuroscience. vol 7. 2013-06-14. PMID:23761736. |
down-regulation of the serotonin transporter (sert) and the consequent impaired reuptake of 5-ht at the synapse, results in a reduced terminal branching of developing tc afferents within the primary somatosensory cortex (s1). |
2013-06-14 |
2023-08-12 |
rat |
| Stéphanie Miceli, Moritz Negwer, Fenneke van Eijs, Carla Kalkhoven, Ilja van Lierop, Judith Homberg, Dirk Schuber. High serotonin levels during brain development alter the structural input-output connectivity of neural networks in the rat somatosensory layer IV. Frontiers in cellular neuroscience. vol 7. 2013-06-14. PMID:23761736. |
here, using juvenile sert knockout (sert(-/-)) rats we investigated, in vitro, the effect of increased 5-ht levels on the structural organization of (i) the tc projections of the ventroposteromedial thalamic nucleus toward s1, (ii) the general barrel-field pattern, and (iii) the electrophysiological and morphological properties of the excitatory cell population in layer iv of s1 [spiny stellate (spst) and pyramidal cells]. |
2013-06-14 |
2023-08-12 |
rat |