| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Czopek, Marcin Kołaczkowski, Adam Bucki, Hanna Byrtus, Maciej Pawłowski, Agata Siwek, Andrzej J Bojarski, Marek Bednarski, Dagmara Wróbel, Anna Wesołowsk. Novel mannich bases, 5-arylimidazolidine-2,4-dione derivatives with dual 5-HT(1A) receptor and serotonin transporter affinity. Archiv der Pharmazie. vol 346. issue 2. 2013-12-09. PMID:23288448. |
investigated compounds were tested for 5-ht(1a) , 5-ht(2a) , α(1) and sert affinity. |
2013-12-09 |
2023-08-12 |
mouse |
| Anna Czopek, Marcin Kołaczkowski, Adam Bucki, Hanna Byrtus, Maciej Pawłowski, Agata Siwek, Andrzej J Bojarski, Marek Bednarski, Dagmara Wróbel, Anna Wesołowsk. Novel mannich bases, 5-arylimidazolidine-2,4-dione derivatives with dual 5-HT(1A) receptor and serotonin transporter affinity. Archiv der Pharmazie. vol 346. issue 2. 2013-12-09. PMID:23288448. |
two selected compounds (5, 9) were characterized in functional experiments and possessed a pharmacological profile which may enhance sert blocking efficacy - 5-ht(1a) partial agonism and 5-ht(2a) antagonism in one molecule. |
2013-12-09 |
2023-08-12 |
mouse |
| Ruth Kohen, Mon T Myaing, Julie Richards, Chuan Zhou, Elizabeth A McCauley, Wayne Katon, Laura P Richardso. Depression persistence and serotonin transporter genotype in adolescents under usual care conditions. Journal of child and adolescent psychopharmacology. vol 23. issue 4. 2013-12-09. PMID:23647137. |
polymorphisms of the serotonin transporter (sert) gene have been shown to influence the risk for depression. |
2013-12-09 |
2023-08-12 |
Not clear |
| Lara Eid, Marie-France Champigny, André Parent, Martin Paren. Quantitative and ultrastructural study of serotonin innervation of the globus pallidus in squirrel monkeys. The European journal of neuroscience. vol 37. issue 10. 2013-12-05. PMID:23432025. |
the present immunohistochemical study was aimed at characterizing the serotonin (5-ht) innervation of the internal (gpi) and external (gpe) pallidal segments in the squirrel monkey (saimiri sciureus) with an antibody against the 5-ht transporter (sert). |
2013-12-05 |
2023-08-12 |
monkey |
| Martyna Z Wróbel, Andrzej Chodkowski, Franciszek Herold, Anna Gomółka, Jerzy Kleps, Aleksander P Mazurek, Franciszek Pluciński, Andrzej Mazurek, Gabriel Nowak, Agata Siwek, Katarzyna Stachowicz, Anna Sławińska, Małgorzata Wolak, Bernadeta Szewczyk, Grzegorz Satała, Andrzej J Bojarski, Jadwiga Turł. Synthesis and biological evaluation of novel pyrrolidine-2,5-dione derivatives as potential antidepressant agents. Part 1. European journal of medicinal chemistry. vol 63. 2013-11-27. PMID:23524160. |
all tested compounds proved to be potent 5-ht1a receptor and serotonin transporter protein (sert) ligands. |
2013-11-27 |
2023-08-12 |
Not clear |
| Cecilia Mattsson, Peder Svensson, Henning Boettcher, Clas Sonesso. Structure-activity relationship of 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole analogues as 5-HT(6) receptor agonists. European journal of medicinal chemistry. vol 63. 2013-11-27. PMID:23542166. |
a few compounds within the 2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1h-indoles were also screened for off-targets and generally they displayed low affinity for other 5-ht subtypes and serotonin transporter protein (sert). |
2013-11-27 |
2023-08-12 |
Not clear |
| Clara Naimi-Akbar, Markus Ritter, Sasika Demel, Husameldin El-Nour, Mari-Anne Hedblad, Efrain C Azmitia, Klas Nordlin. Different serotonergic expression in nevomelanocytic tumors. Cancers. vol 2. issue 2. 2013-11-27. PMID:24281111. |
for this purpose, paraffin-embedded biopsies of superficial spreading malignant melanoma (ssm), dysplastic compound nevi (dn) and benign compound nevi (bcn) were characterized with regard to their expression of 5-ht, the 5-ht1a and 5-ht2a receptors, and the serotonin transporter protein (sert), by immunohistochemical analysis. |
2013-11-27 |
2023-08-12 |
Not clear |
| Hsiao-Hsien Kang, Chih-Hung Wang, Hsin-Chien Chen, I-Hsun Li, Cheng-Yi Cheng, Ren-Shyan Liu, Wen-Sheng Huang, Chyng-Yann Shiue, Kuo-Hsing M. Investigating the effects of noise-induced hearing loss on serotonin transporters in rat brain using 4-[18F]-ADAM/small animal PET. NeuroImage. vol 75. 2013-11-26. PMID:22766166. |
the serotonin transporter (sert) is an important marker of the status of serotonergic neurons. |
2013-11-26 |
2023-08-12 |
rat |
| Hsiao-Hsien Kang, Chih-Hung Wang, Hsin-Chien Chen, I-Hsun Li, Cheng-Yi Cheng, Ren-Shyan Liu, Wen-Sheng Huang, Chyng-Yann Shiue, Kuo-Hsing M. Investigating the effects of noise-induced hearing loss on serotonin transporters in rat brain using 4-[18F]-ADAM/small animal PET. NeuroImage. vol 75. 2013-11-26. PMID:22766166. |
the main function of sert is to regulate the serotonin concentration in the synapse. |
2013-11-26 |
2023-08-12 |
rat |
| Mathieu Seimandi, Pascal Seyer, C Sehwan Park, Franck Vandermoere, Benjamin Chanrion, Joël Bockaert, Isabelle M Mansuy, Philippe Mari. Calcineurin interacts with the serotonin transporter C-terminus to modulate its plasma membrane expression and serotonin uptake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 41. 2013-11-26. PMID:24107951. |
homeostasis of serotonergic transmission critically depends on the rate of serotonin reuptake via its plasma membrane transporter (sert). |
2013-11-26 |
2023-08-12 |
mouse |
| Mathieu Seimandi, Pascal Seyer, C Sehwan Park, Franck Vandermoere, Benjamin Chanrion, Joël Bockaert, Isabelle M Mansuy, Philippe Mari. Calcineurin interacts with the serotonin transporter C-terminus to modulate its plasma membrane expression and serotonin uptake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 41. 2013-11-26. PMID:24107951. |
coexpression of constitutively active can with sert increases sert cell surface expression and 5-ht uptake in hek-293 cells. |
2013-11-26 |
2023-08-12 |
mouse |
| Mathieu Seimandi, Pascal Seyer, C Sehwan Park, Franck Vandermoere, Benjamin Chanrion, Joël Bockaert, Isabelle M Mansuy, Philippe Mari. Calcineurin interacts with the serotonin transporter C-terminus to modulate its plasma membrane expression and serotonin uptake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 41. 2013-11-26. PMID:24107951. |
it also prevents the reduction of 5-ht uptake induced by an acute treatment of cells with the protein kinase c activator β-pma and concomitantly decreases pma-elicited sert phosphorylation. |
2013-11-26 |
2023-08-12 |
mouse |
| Linnea Karlsson, Lauri Tuominen, Antti Huotarinen, Sami Leppämäki, Elina Sihvola, Semi Helin, Maria Sipilä, Pekka Tani, Jussi Hirvonen, Jarmo Hietala, Hasse Karlsso. Serotonin transporter in attention-deficit hyperactivity disorder--preliminary results from a positron emission tomography study. Psychiatry research. vol 212. issue 2. 2013-11-19. PMID:23566552. |
the serotonin transporter (sert) in attention-deficit hyperactivity disorder (adhd) patients has not been explored by earlier positron emission tomography (pet) studies. |
2013-11-19 |
2023-08-12 |
Not clear |
| Nicholas G Campbell, Chong-Bin Zhu, Kathryn M Lindler, Brian L Yaspan, Emily Kistner-Griffin, William A Hewlett, Christopher G Tate, Randy D Blakely, James S Sutcliff. Rare coding variants of the adenosine A3 receptor are increased in autism: on the trail of the serotonin transporter regulome. Molecular autism. vol 4. issue 1. 2013-11-15. PMID:23953133. |
altered serotonin (5-ht) signaling has been implicated in asd, and we and others have discovered multiple, rare, asd-associated variants in the 5-ht transporter (sert) gene leading to elevated 5-ht re-uptake and perturbed regulation. |
2013-11-15 |
2023-08-12 |
Not clear |
| Travis M Kerr, Christopher L Muller, Mahfuzur Miah, Christopher S Jetter, Rita Pfeiffer, Charisma Shah, Nicole Baganz, George M Anderson, Jacqueline N Crawley, James S Sutcliffe, Randy D Blakely, Jeremy Veenstra-Vanderweel. Genetic background modulates phenotypes of serotonin transporter Ala56 knock-in mice. Molecular autism. vol 4. issue 1. 2013-11-15. PMID:24083388. |
previously, we identified multiple, rare serotonin (5-ht) transporter (sert) variants in children with autism spectrum disorder (asd). |
2013-11-15 |
2023-08-12 |
mouse |
| Roselyn Rose'meye. A review of the serotonin transporter and prenatal cortisol in the development of autism spectrum disorders. Molecular autism. vol 4. issue 1. 2013-11-15. PMID:24103554. |
this review seeks to provide an understanding of the biochemistry and physiological actions of serotonin and its termination of action through the serotonin reuptake transporter (sert). |
2013-11-15 |
2023-08-12 |
Not clear |
| Yuan-Hwa Chou, Chih-Ken Chen, Shyh-Jen Wang, Shih-Jen Tsai, Jiing-Feng Lirng, Ying-Jay Liou, Chun-Lung Lin, Kai-Chun Yang, Ming-Wei Lin, Whai-Chin Lo, Mei-Hsiu Liao, Chia-Chieh Che. Association of brain serotonin transporter availability and brain-derived neurotrophic factor in models of serotonin transporter genotypes in healthy subjects. Journal of clinical psychopharmacology. vol 33. issue 3. 2013-11-07. PMID:23609403. |
the s-allele of functional polymorphisms of the serotonin transporter (sert) gene has been demonstrated to have lower transcriptional activity compared with the l-allele, which shows low expression of sert in the brain. |
2013-11-07 |
2023-08-12 |
human |
| Nathan C Mitchell, Georgianna G Gould, Corey M Smolik, Wouter Koek, Lynette C Daw. Antidepressant-like drug effects in juvenile and adolescent mice in the tail suspension test: Relationship with hippocampal serotonin and norepinephrine transporter expression and function. Frontiers in pharmacology. vol 4. 2013-11-05. PMID:24191152. |
the smaller antidepressant response of juveniles was not related to either maximal binding (b max) or affinity (k d) for [(3)h]citalopram binding to the serotonin transporter (sert) in hippocampus, which did not vary significantly among ages. |
2013-11-05 |
2023-08-12 |
mouse |
| Darrick T Balu, Jill R Turner, Bethany R Brookshire, Tiffany E Hill-Smith, Julie A Blendy, Irwin Luck. Brain monoamines and antidepressant-like responses in MRL/MpJ versus C57BL/6J mice. Neuropharmacology. vol 67. 2013-11-04. PMID:23220293. |
in addition, the expression of 5-ht(1a) mrna was lower in the hippocampus, 5-ht(1b) mrna was higher in the hippocampus and brainstem and sert mrna was higher in the brain stem of mrl/mpj mice. |
2013-11-04 |
2023-08-12 |
mouse |
| Pablo R Moya, Jens R Wendland, Jennifer Salemme, Ruby L Fried, Dennis L Murph. miR-15a and miR-16 regulate serotonin transporter expression in human placental and rat brain raphe cells. The international journal of neuropsychopharmacology. vol 16. issue 3. 2013-10-31. PMID:22564678. |
the serotonin transporter (sert) is a key regulatory molecule in serotonergic transmission implicated in numerous biological processes relevant to human disorders. |
2013-10-31 |
2023-08-12 |
mouse |