| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Catherine E Hagan, Ross A McDevitt, Yusha Liu, Amy R Furay, John F Neumaie. 5-HT(1B) autoreceptor regulation of serotonin transporter activity in synaptosomes. Synapse (New York, N.Y.). vol 66. issue 12. 2013-02-21. PMID:22961814. |
the selective 5-ht(1b) antagonist sb224289 decreased sert activity in synaptosomes prepared from wild-type but not 5-ht(1b) knockout mice, whereas sert uptake was enhanced after pretreatment with the selective 5-ht(1b) agonist cp94253. |
2013-02-21 |
2023-08-12 |
mouse |
| Catherine E Hagan, Ross A McDevitt, Yusha Liu, Amy R Furay, John F Neumaie. 5-HT(1B) autoreceptor regulation of serotonin transporter activity in synaptosomes. Synapse (New York, N.Y.). vol 66. issue 12. 2013-02-21. PMID:22961814. |
furthermore, sert activity varies as a function of 5-ht(1b) receptor expression-specifically, genetic deletion of 5-ht(1b) decreased sert function, while viral-mediated overexpression of 5-ht(1b) autoreceptors in rat raphe neurons increased sert activity in rat hippocampal synaptosomes. |
2013-02-21 |
2023-08-12 |
mouse |
| Catherine E Hagan, Ross A McDevitt, Yusha Liu, Amy R Furay, John F Neumaie. 5-HT(1B) autoreceptor regulation of serotonin transporter activity in synaptosomes. Synapse (New York, N.Y.). vol 66. issue 12. 2013-02-21. PMID:22961814. |
considered collectively, these results provide evidence that 5-ht(1b) autoreceptors regulate sert activity. |
2013-02-21 |
2023-08-12 |
mouse |
| Catherine E Hagan, Ross A McDevitt, Yusha Liu, Amy R Furay, John F Neumaie. 5-HT(1B) autoreceptor regulation of serotonin transporter activity in synaptosomes. Synapse (New York, N.Y.). vol 66. issue 12. 2013-02-21. PMID:22961814. |
because sert clearance rate varies as a function of 5-ht(1b) autoreceptor expression levels and is modulated by both activation and inhibition of 5-ht(1b) autoreceptors, this dynamic interaction may be an important mechanism of serotonin autoregulation with therapeutic implications. |
2013-02-21 |
2023-08-12 |
mouse |
| Elisabetta Tronci, Eunju Shin, Anders Björklund, Manolo Cart. Amphetamine-induced rotation and L-DOPA-induced dyskinesia in the rat 6-OHDA model: a correlation study. Neuroscience research. vol 73. issue 2. 2013-02-19. PMID:22450171. |
moreover, sert expression levels suggest that reduced striatal and pallidal serotonin innervation might have contributed to the lower dyskinesia levels observed in a subset of amphetamine-responsive rats. |
2013-02-19 |
2023-08-12 |
rat |
| Per Plenge, Lei Shi, Thijs Beuming, Jerez Te, Amy Hauck Newman, Harel Weinstein, Ulrik Gether, Claus J Lolan. Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter. The Journal of biological chemistry. vol 287. issue 47. 2013-02-19. PMID:23007398. |
the serotonin transporter (sert) controls synaptic serotonin levels and is the primary target for antidepressants, including selective serotonin reuptake inhibitors (e.g. |
2013-02-19 |
2023-08-12 |
Not clear |
| Rachel W S Li, Cui Yang, Y W Kwan, S W Chan, Simon M Y Lee, George P H Leun. Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells. Frontiers in pharmacology. vol 4. 2013-02-15. PMID:23407616. |
the specific serotonin re-uptake transporter (sert) inhibitor citalopram, the specific norepinephrine transporter (net) inhibitor desipramine, and the dopamine transporter (dat) inhibitor gbr12935 inhibited 5-ht uptake in hbvsmcs with ic(50) values of 97.03 ± 40.10, 10.49 ± 5.98, and 2.80 ± 1.04 μm, respectively. |
2013-02-15 |
2023-08-12 |
human |
| Jia Zhang, Yan Fan, Ying Li, Hobart Zhu, Liang Wang, Meng-Yang Zh. Chronic social defeat up-regulates expression of the serotonin transporter in rat dorsal raphe nucleus and projection regions in a glucocorticoid-dependent manner. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:23061525. |
protein levels of the serotonin transporter (sert) in the dorsal raphe nucleus (drn), hippocampus, frontal cortex, and amygdala were examined by western blotting or immunofluorescence staining. |
2013-02-14 |
2023-08-12 |
rat |
| Jia Zhang, Yan Fan, Ying Li, Hobart Zhu, Liang Wang, Meng-Yang Zh. Chronic social defeat up-regulates expression of the serotonin transporter in rat dorsal raphe nucleus and projection regions in a glucocorticoid-dependent manner. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:23061525. |
furthermore, both csd- and cort-induced up-regulation of sert protein levels in the drn and three brain regions were attenuated by simultaneous treatment with fluoxetine, an antidepressant that specifically inhibits serotonin reuptake. |
2013-02-14 |
2023-08-12 |
rat |
| Prasanna Tamarapu Parthasarathy, Lakshmi Galam, Bao Huynh, Asfiya Yunus, Toaa Abuelenen, Annie Castillo, Gurukumar Kollongod Ramanathan, Ruan Cox, Narasaiah Kolliput. MicroRNA 16 modulates epithelial sodium channel in human alveolar epithelial cells. Biochemical and biophysical research communications. vol 426. issue 2. 2013-01-31. PMID:22940131. |
recent studies suggest that microrna-16 (mir-16) targets serotonin transporter (sert) involved in the serotonin (5-ht) transmitter system. |
2013-01-31 |
2023-08-12 |
mouse |
| Prasanna Tamarapu Parthasarathy, Lakshmi Galam, Bao Huynh, Asfiya Yunus, Toaa Abuelenen, Annie Castillo, Gurukumar Kollongod Ramanathan, Ruan Cox, Narasaiah Kolliput. MicroRNA 16 modulates epithelial sodium channel in human alveolar epithelial cells. Biochemical and biophysical research communications. vol 426. issue 2. 2013-01-31. PMID:22940131. |
in the present study, the expression patterns of mir-16, sert, enac and serotonin were investigated in mice exposed to room air and hyperoxia. |
2013-01-31 |
2023-08-12 |
mouse |
| Valeria Paola Carlini, María Belén Poretti, Mathias Rask-Andersen, Rohit A Chavan, Marina F Ponzio, Rahul S Sawant, Susana Rubiales de Barioglio, Helgi B Schiöth, Marta Fiol de Cune. Differential effects of fluoxetine and venlafaxine on memory recognition: possible mechanisms of action. Progress in neuro-psychopharmacology & biological psychiatry. vol 38. issue 2. 2013-01-21. PMID:22449479. |
considering that the changes in gene expression involved in the action of antidepressant drugs on memory have not been identified, in this study we investigated the impact of chronic treatment with a ssri (fluoxetine) and a snri (venlafaxine) on the mrna expression of genes related to memory cascade in the mouse hippocampus, namely, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa), nitric oxide synthase 1 (nos1), neurotrophic tyrosine kinase receptor type 2 (trkb), mitogen-activated protein kinases (mapk/erk) and serotonin transporter (sert). |
2013-01-21 |
2023-08-12 |
mouse |
| Shih-Hsien Lin, Kao Chin Chen, Sheng-Yu Lee, Wei Jen Yao, Nan-Tsing Chiu, I Hui Lee, Po See Chen, Tzung Lieh Yeh, Mei-Hsiu Liao, Ru-Band Lu, Yen Kuang Yan. The association between availability of serotonin transporters and time to relapse in heroin users: a two-isotope SPECT small sample pilot study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 22. issue 9. 2013-01-17. PMID:22335891. |
in this two-isotope spect small sample (n=9) pilot study, the relationship between the availability of serotonin transporter (sert) and dopamine transporter (dat) and the relapse of heroin users was investigated. |
2013-01-17 |
2023-08-12 |
Not clear |
| Hsiang-Yi Tsai, I Hui Lee, Tzung Lieh Yeh, Wei Jen Yao, Kao Chin Chen, Po See Chen, Nan-Tsing Chiu, Ru-Band Lu, Yen Kuang Yan. Association between the dexamethasone suppression test and serotonin transporter availability in healthy volunteer: a SPECT with [(123)I] ADAM study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 22. issue 9. 2013-01-17. PMID:22356823. |
the aim of this study was to explore the neuroendocrine relationships between the dexamethasone suppression test (dst) and serotonin transporter (sert) availability in healthy volunteers. |
2013-01-17 |
2023-08-12 |
human |
| M L J Schouw, S Gevers, M W A Caan, C B L M Majoie, J Booij, A J Nederveen, L Renema. Mapping serotonergic dysfunction in MDMA (ecstasy) users using pharmacological MRI. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 22. issue 8. 2013-01-16. PMID:22209360. |
single photon emission computed tomography (spect) imaging was used to assess the availability of 5-ht transporters (sert). |
2013-01-16 |
2023-08-12 |
human |
| Donatella Marazziti, Stefano Baroni, Gino Giannaccini, Laura Betti, Gabriele Massimetti, Claudia Carmassi, Mario Catena-Dell'Oss. A link between oxytocin and serotonin in humans: supporting evidence from peripheral markers. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 22. issue 8. 2013-01-16. PMID:22297159. |
interestingly, immunocytochemical and double-immunofluorescent techniques revealed a high degree of overlap between 5-ht transporter (sert)-labeled fibers and ot-containing cells in the paraventricular and supraoptic nuclei of primate hypothalamus. |
2013-01-16 |
2023-08-12 |
human |
| Donatella Marazziti, Stefano Baroni, Gino Giannaccini, Laura Betti, Gabriele Massimetti, Claudia Carmassi, Mario Catena-Dell'Oss. A link between oxytocin and serotonin in humans: supporting evidence from peripheral markers. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 22. issue 8. 2013-01-16. PMID:22297159. |
these findings suggest that the influence of 5-ht on ot system might be mediated by sert. |
2013-01-16 |
2023-08-12 |
human |
| Philip R Buskohl, Michelle J Sun, Michelle L Sun, Robert P Thompson, Jonathan T Butche. Serotonin potentiates transforming growth factor-beta3 induced biomechanical remodeling in avian embryonic atrioventricular valves. PloS one. vol 7. issue 8. 2013-01-10. PMID:22880017. |
blockade of the 5ht2b receptor, but not 5-ht2a receptor or serotonin transporter (sert), resulted in complete cessation of tgfβ3 induced mechanical strengthening. |
2013-01-10 |
2023-08-12 |
Not clear |
| Albert Wong, Yuan-Wei Zhang, Grace R Jeschke, Benjamin E Turk, Gary Rudnic. Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase. The Journal of biological chemistry. vol 287. issue 43. 2012-12-28. PMID:22942288. |
the serotonin transporter (sert) is responsible for reuptake of serotonin (5-hydroxytryptamine) after its exocytotic release from neurons. |
2012-12-28 |
2023-08-12 |
Not clear |
| Denis A Nikishin, Stanislav V Kremnyov, Victoria V Konduktorova, Yuri B Shmukle. Expression of serotonergic system components during early Xenopus embryogenesis. The International journal of developmental biology. vol 56. issue 5. 2012-12-14. PMID:22811272. |
transcripts encoding the serotonin receptors htr2c and htr7, as well as the vesicular monoamine transporter vmat2, the serotonin transporter (sert) and the serotonin synthesis enzymes tryptophan hydroxylase (tph2) and aromatic amino acid decarboxylase (aaad) were found to be expressed during the cleavage division stages, whereas the degradation enzyme monoamine oxidase a (maoa) was absent. |
2012-12-14 |
2023-08-12 |
xenopus_laevis |