| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Swen Hesse, Peter Brust, Peter Mäding, Georg-Alexander Becker, Marianne Patt, Anita Seese, Dietlind Sorger, Jörg Zessin, Philipp M Meyer, Donald Lobsien, Sven Laudi, Bernd Habermann, Frank Füchtner, Julia Luthardt, Anke Bresch, Jörg Steinbach, Osama Sabr. Imaging of the brain serotonin transporters (SERT) with 18F-labelled fluoromethyl-McN5652 and PET in humans. European journal of nuclear medicine and molecular imaging. vol 39. issue 6. 2012-09-05. PMID:22349718. |
imaging of the brain serotonin transporters (sert) with 18f-labelled fluoromethyl-mcn5652 and pet in humans. |
2012-09-05 |
2023-08-12 |
Not clear |
| Sunil Kumar, Prabhat Ranjan, Balraj Mittal, Uday C Ghosha. Serotonin transporter gene (SLC6A4) polymorphism in patients with irritable bowel syndrome and healthy controls. Journal of gastrointestinal and liver diseases : JGLD. vol 21. issue 1. 2012-08-17. PMID:22457857. |
polymorphisms in serotonin re-uptake transporter (sert or slc6a4) gene may play role in disturbance in gut function in irritable bowel syndrome (ibs). |
2012-08-17 |
2023-08-12 |
Not clear |
| Simon Bulling, Klaus Schicker, Yuan-Wei Zhang, Thomas Steinkellner, Thomas Stockner, Christian W Gruber, Stefan Boehm, Michael Freissmuth, Gary Rudnick, Harald H Sitte, Walter Sandtne. The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters. The Journal of biological chemistry. vol 287. issue 22. 2012-08-15. PMID:22451652. |
ibogaine, a hallucinogenic alkaloid proposed as a treatment for opiate withdrawal, has been shown to inhibit serotonin transporter (sert) noncompetitively, in contrast to all other known inhibitors, which are competitive with substrate. |
2012-08-15 |
2023-08-12 |
Not clear |
| Simon Bulling, Klaus Schicker, Yuan-Wei Zhang, Thomas Steinkellner, Thomas Stockner, Christian W Gruber, Stefan Boehm, Michael Freissmuth, Gary Rudnick, Harald H Sitte, Walter Sandtne. The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters. The Journal of biological chemistry. vol 287. issue 22. 2012-08-15. PMID:22451652. |
because of the structural similarity between ibogaine and serotonin, it had been suggested that ibogaine binds to the substrate site of sert. |
2012-08-15 |
2023-08-12 |
Not clear |
| Nina Bl Urban, Ragy R Girgis, Peter S Talbot, Lawrence S Kegeles, X Xu, W Gordon Frankle, Carl L Hart, Mark Slifstein, Anissa Abi-Dargham, Marc Laruell. Sustained recreational use of ecstasy is associated with altered pre and postsynaptic markers of serotonin transmission in neocortical areas: a PET study with [¹¹C]DASB and [¹¹C]MDL 100907. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 6. 2012-08-14. PMID:22353758. |
the aim of this study was to investigate both presynaptic (5-ht transporter, sert) and postsynaptic (5-ht(2a) receptor) markers of 5-ht transmission in recently abstinent chronic mdma users compared with matched healthy controls. |
2012-08-14 |
2023-08-12 |
Not clear |
| Nina Bl Urban, Ragy R Girgis, Peter S Talbot, Lawrence S Kegeles, X Xu, W Gordon Frankle, Carl L Hart, Mark Slifstein, Anissa Abi-Dargham, Marc Laruell. Sustained recreational use of ecstasy is associated with altered pre and postsynaptic markers of serotonin transmission in neocortical areas: a PET study with [¹¹C]DASB and [¹¹C]MDL 100907. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 6. 2012-08-14. PMID:22353758. |
we hypothesized that mdma use is associated with lower sert density and concomitant upregulation of 5-ht(2a) receptors. |
2012-08-14 |
2023-08-12 |
Not clear |
| Nina Bl Urban, Ragy R Girgis, Peter S Talbot, Lawrence S Kegeles, X Xu, W Gordon Frankle, Carl L Hart, Mark Slifstein, Anissa Abi-Dargham, Marc Laruell. Sustained recreational use of ecstasy is associated with altered pre and postsynaptic markers of serotonin transmission in neocortical areas: a PET study with [¹¹C]DASB and [¹¹C]MDL 100907. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 6. 2012-08-14. PMID:22353758. |
positron emission tomography studies using the sert ligand [¹¹c]dasb and the 5-ht(2a) receptor ligand [¹¹c]mdl 100907 were evaluated in 13 current and recently detoxified mdma users and 13 matched healthy controls. |
2012-08-14 |
2023-08-12 |
Not clear |
| Nina Bl Urban, Ragy R Girgis, Peter S Talbot, Lawrence S Kegeles, X Xu, W Gordon Frankle, Carl L Hart, Mark Slifstein, Anissa Abi-Dargham, Marc Laruell. Sustained recreational use of ecstasy is associated with altered pre and postsynaptic markers of serotonin transmission in neocortical areas: a PET study with [¹¹C]DASB and [¹¹C]MDL 100907. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 6. 2012-08-14. PMID:22353758. |
sert and 5-ht(2a) receptor availability (binding potential, bp(nd)) were analyzed with a two-tissue compartment model with arterial input function. |
2012-08-14 |
2023-08-12 |
Not clear |
| Nina Bl Urban, Ragy R Girgis, Peter S Talbot, Lawrence S Kegeles, X Xu, W Gordon Frankle, Carl L Hart, Mark Slifstein, Anissa Abi-Dargham, Marc Laruell. Sustained recreational use of ecstasy is associated with altered pre and postsynaptic markers of serotonin transmission in neocortical areas: a PET study with [¹¹C]DASB and [¹¹C]MDL 100907. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 6. 2012-08-14. PMID:22353758. |
current recreational mdma use was significantly associated with lower sert bp(nd) and higher 5-ht(2a) receptor bp(nd) in cortical, but not subcortical regions. |
2012-08-14 |
2023-08-12 |
Not clear |
| Nina Bl Urban, Ragy R Girgis, Peter S Talbot, Lawrence S Kegeles, X Xu, W Gordon Frankle, Carl L Hart, Mark Slifstein, Anissa Abi-Dargham, Marc Laruell. Sustained recreational use of ecstasy is associated with altered pre and postsynaptic markers of serotonin transmission in neocortical areas: a PET study with [¹¹C]DASB and [¹¹C]MDL 100907. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 6. 2012-08-14. PMID:22353758. |
decreased sert bp(nd) was regionally associated with upregulated 5-ht(2a) receptor bp(nd). |
2012-08-14 |
2023-08-12 |
Not clear |
| Mari Gabrielsen, Aina Westrheim Ravna, Kurt Kristiansen, Ingebrigt Sylt. Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations. Journal of molecular modeling. vol 18. issue 3. 2012-08-07. PMID:21670993. |
the serotonin (5-ht) transporter (sert) plays an important role in the termination of 5-ht-mediated neurotransmission by transporting 5-ht away from the synaptic cleft and into the presynaptic neuron. |
2012-08-07 |
2023-08-12 |
Not clear |
| Mari Gabrielsen, Aina Westrheim Ravna, Kurt Kristiansen, Ingebrigt Sylt. Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations. Journal of molecular modeling. vol 18. issue 3. 2012-08-07. PMID:21670993. |
in addition, sert is the main target for antidepressant drugs, including the selective serotonin reuptake inhibitors (ssris). |
2012-08-07 |
2023-08-12 |
Not clear |
| Mari Gabrielsen, Aina Westrheim Ravna, Kurt Kristiansen, Ingebrigt Sylt. Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations. Journal of molecular modeling. vol 18. issue 3. 2012-08-07. PMID:21670993. |
our results show that 5-ht in the sert-5-ht(b) complex induced larger conformational changes in the cytoplasmic parts of the transmembrane helices of sert than any of the other ligands. |
2012-08-07 |
2023-08-12 |
Not clear |
| Endrit Ziu, Charles P Mercado, Yicong Li, Preeti Singh, Billow A Ahmed, Samuel Freyaldenhoven, Shelly Lensing, Jerry Ware, Fusun Kili. Down-regulation of the serotonin transporter in hyperreactive platelets counteracts the pro-thrombotic effect of serotonin. Journal of molecular and cellular cardiology. vol 52. issue 5. 2012-08-07. PMID:22366712. |
5-ht-infused mice were treated with paroxetine (prx) to block 5-ht uptake via the serotonin transporter (sert). |
2012-08-07 |
2023-08-12 |
mouse |
| Endrit Ziu, Charles P Mercado, Yicong Li, Preeti Singh, Billow A Ahmed, Samuel Freyaldenhoven, Shelly Lensing, Jerry Ware, Fusun Kili. Down-regulation of the serotonin transporter in hyperreactive platelets counteracts the pro-thrombotic effect of serotonin. Journal of molecular and cellular cardiology. vol 52. issue 5. 2012-08-07. PMID:22366712. |
although a down-regulation of the serotonin transporter (sert) on the platelet surface may counteract the pro-thrombotic influence of elevated plasma [5ht], this compensatory mechanism may fail to prevent the increased thrombotic risk caused by elevated plasma [5-ht]. |
2012-08-07 |
2023-08-12 |
mouse |
| Murat Oz, Dmytro Isaev, Dietrich E Lorke, Muhammed Hasan, Georg Petroianu, Toni S Shippenber. Methylene blue inhibits function of the 5-HT transporter. British journal of pharmacology. vol 166. issue 1. 2012-08-06. PMID:21542830. |
given the role of the 5-ht transporter (sert) in the regulation of extracellular 5-ht concentrations, the present study aimed to characterize the effect of mb on sert. |
2012-08-06 |
2023-08-12 |
Not clear |
| Xiaoning Chen, Kara J Margolis, Michael D Gershon, Gary J Schwartz, Ji Y Sz. Reduced serotonin reuptake transporter (SERT) function causes insulin resistance and hepatic steatosis independent of food intake. PloS one. vol 7. issue 3. 2012-08-02. PMID:22412882. |
reduced serotonin reuptake transporter (sert) function causes insulin resistance and hepatic steatosis independent of food intake. |
2012-08-02 |
2023-08-12 |
mouse |
| Xiaoning Chen, Kara J Margolis, Michael D Gershon, Gary J Schwartz, Ji Y Sz. Reduced serotonin reuptake transporter (SERT) function causes insulin resistance and hepatic steatosis independent of food intake. PloS one. vol 7. issue 3. 2012-08-02. PMID:22412882. |
serotonin reuptake transporter (sert) is a key regulator of serotonin neurotransmission and a major target of antidepressants. |
2012-08-02 |
2023-08-12 |
mouse |
| Xiaoning Chen, Kara J Margolis, Michael D Gershon, Gary J Schwartz, Ji Y Sz. Reduced serotonin reuptake transporter (SERT) function causes insulin resistance and hepatic steatosis independent of food intake. PloS one. vol 7. issue 3. 2012-08-02. PMID:22412882. |
antidepressants, such as selectively serotonin reuptake inhibitors (ssris), that block sert function are known to affect food intake and body weight. |
2012-08-02 |
2023-08-12 |
mouse |
| Erica Y Shen, Syed F Ali, Jerrold S Meye. Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats. Neuropharmacology. vol 61. issue 8. 2012-08-01. PMID:21763331. |
therefore, the present study was conducted to investigate the effects of chronic adolescent administration of both thc and mdma on behavior and on regional serotonin transporter (sert) binding and serotonin (5-ht) concentrations as indices of serotonergic system integrity. |
2012-08-01 |
2023-08-12 |
rat |