| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erica Y Shen, Syed F Ali, Jerrold S Meye. Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats. Neuropharmacology. vol 61. issue 8. 2012-08-01. PMID:21763331. |
thc additionally attenuated mdma -induced decreases in 5-ht levels and in sert binding in the frontal cortex, parietal cortex, and striatum, but not in the hippocampus. |
2012-08-01 |
2023-08-12 |
rat |
| Michael W McLane, Una McCann, George Ricaurt. Identifying the serotonin transporter signal in Western blot studies of the neurotoxic potential of MDMA and related drugs. Synapse (New York, N.Y.). vol 65. issue 12. 2012-07-30. PMID:21633976. |
a number of published studies have questioned the serotonin neurotoxic potential of 3,4-methylenedioxymethamphetamine (mdma, "ecstasy") and related drugs (fenfluramine, p-chloroamphetamine) based upon results from western blot studies using a custom synthesized serotonin transporter (sert) antibody that found no reduction in the abundance of a 50kda protein after substituted amphetamine treatment. |
2012-07-30 |
2023-08-12 |
rat |
| C P Li, C Ling, P Biancani, J Beha. Effect of progesterone on colonic motility and fecal output in mice with diarrhea. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 24. issue 4. 2012-07-30. PMID:22284724. |
over expression of progesterone (p4) receptors in epithelial and muscle cells of the colon may reconcile this contradiction because p4 decreases sert and increases 5-ht levels, but their effects are rendered ineffective because of the impaired muscle contraction. |
2012-07-30 |
2023-08-12 |
mouse |
| Carmela M Reichel, Lauren A Ramsey, Marek Schwendt, Jacqueline F McGinty, Ronald E Se. Methamphetamine-induced changes in the object recognition memory circuit. Neuropharmacology. vol 62. issue 2. 2012-07-27. PMID:22115899. |
subsequently, transporters for serotonin (sert) and norepinephrine (net) were quantified using western blot in tissue obtained from the hippocampus, perirhinal cortex, and prefrontal cortex. |
2012-07-27 |
2023-08-12 |
human |
| Samuel Freyaldenhoven, Yicong Li, Arif M Kocabas, Enrit Ziu, Serra Ucer, Raman Ramanagoudr-Bhojappa, Grover P Miller, Fusun Kili. The role of ERp44 in maturation of serotonin transporter protein. The Journal of biological chemistry. vol 287. issue 21. 2012-07-23. PMID:22451649. |
in heterologous and endogenous expression systems, we studied the role of erp44 and its complex partner endoplasmic reticulum (er) oxidase 1-α (ero1-lα) in mechanisms regulating disulfide bond formation for serotonin transporter (sert), an oligomeric glycoprotein. |
2012-07-23 |
2023-08-12 |
Not clear |
| Samuel Freyaldenhoven, Yicong Li, Arif M Kocabas, Enrit Ziu, Serra Ucer, Raman Ramanagoudr-Bhojappa, Grover P Miller, Fusun Kili. The role of ERp44 in maturation of serotonin transporter protein. The Journal of biological chemistry. vol 287. issue 21. 2012-07-23. PMID:22451649. |
those efforts resulted in increased sert localization to the plasma membrane but decreased serotonin (5-ht) uptake rates, indicating the importance of the erp44 retention mechanism in the proper maturation of sert proteins. |
2012-07-23 |
2023-08-12 |
Not clear |
| Gianluigi Guidotti, Francesca Calabrese, Francesca Auletta, Jocelien Olivier, Giorgio Racagni, Judith Homberg, Marco A Riv. Developmental influence of the serotonin transporter on the expression of npas4 and GABAergic markers: modulation by antidepressant treatment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 3. 2012-07-19. PMID:22012473. |
genetic deletion of the serotonin transporter (sert) in rodents leads to an anxious and depressive phenotype, and is associated with reduced neuronal plasticity as indicated by decreased brain-derived neurotrophic factor (bdnf) expression levels. |
2012-07-19 |
2023-08-12 |
rat |
| Lindsey MacGillivray, Katelyn B Reynolds, Patricia I Rosebush, Michael F Mazure. The comparative effects of environmental enrichment with exercise and serotonin transporter blockade on serotonergic neurons in the dorsal raphe nucleus. Synapse (New York, N.Y.). vol 66. issue 5. 2012-07-09. PMID:22121041. |
we have previously reported that inhibition of the serotonin transporter (sert) by selective serotonin reuptake inhibitor (ssri) fluoxetine significantly reduces the number of tryptophan hydroxylase (tph)-positive cells in the dorsal raphe nucleus (drn). |
2012-07-09 |
2023-08-12 |
rat |
| Theodore W Valenti, Georgianna G Gould, Jason P Berninger, Kristin A Connors, N Bradley Keele, Krista N Prosser, Bryan W Brook. Human therapeutic plasma levels of the selective serotonin reuptake inhibitor (SSRI) sertraline decrease serotonin reuptake transporter binding and shelter-seeking behavior in adult male fathead minnows. Environmental science & technology. vol 46. issue 4. 2012-07-09. PMID:22296170. |
binding activity of the serotonin reuptake transporter (sert), previously demonstrated in mammals and fish models to respond to sertraline exposure, was selected as an endpoint associated with therapeutic activity. |
2012-07-09 |
2023-08-12 |
human |
| Ruth Tellez, Leticia Gómez-Víquez, Alfredo Menese. GABA, glutamate, dopamine and serotonin transporters expression on memory formation and amnesia. Neurobiology of learning and memory. vol 97. issue 2. 2012-07-05. PMID:22183017. |
notwithstanding several neurotransmission systems are frequently related to memory formation, amnesia and/or therapeutic targets for memory alterations, the role of transporters γ-aminobutyric acid (gaba, gat1), glutamate (neuronal glutamate transporter excitatory amino acid carrier; eacc1), dopamine (dat) and serotonin (sert) is poorly understood. |
2012-07-05 |
2023-08-12 |
rat |
| Yu-An Chen, Wen-Sheng Huang, Yaoh-Shiang Lin, Cheng-Yi Cheng, Ren-Shyan Liu, Shyh-Jen Wang, I-Hsun Li, San-Yuan Huang, Chyng-Yann Shiue, Cheng-Yu Chen, Kuo-Hsing M. Characterization of 4-[18F]-ADAM as an imaging agent for SERT in non-human primate brain using PET: a dynamic study. Nuclear medicine and biology. vol 39. issue 2. 2012-06-29. PMID:22136885. |
serotonin transporter (sert) has been associated with many psychiatric diseases. |
2012-06-29 |
2023-08-12 |
Not clear |
| Angèle P M Kerckhoffs, José J M ter Linde, Louis M A Akkermans, Melvin Samso. SERT and TPH-1 mRNA expression are reduced in irritable bowel syndrome patients regardless of visceral sensitivity state in large intestine. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 9. 2012-06-25. PMID:22323131. |
gene transcripts of protease-activated receptor (par)-2, trypsinogen iv, tryptophan hydroxylase (tph)-1, and serotonin reuptake transporter (sert) were quantified using real-time polymerase chain reaction. |
2012-06-25 |
2023-08-12 |
Not clear |
| Adolfo Baloira, Marta Núñez, José Cifrian, Carlos Vilariño, María Ojeda, Diana Valverd. Polymorphisms in the serotonin transporter protein (SERT) gene in patients with pulmonary arterial hypertension. Archivos de bronconeumologia. vol 48. issue 3. 2012-06-19. PMID:22177971. |
polymorphisms in the serotonin transporter protein (sert) gene in patients with pulmonary arterial hypertension. |
2012-06-19 |
2023-08-12 |
Not clear |
| Adolfo Baloira, Marta Núñez, José Cifrian, Carlos Vilariño, María Ojeda, Diana Valverd. Polymorphisms in the serotonin transporter protein (SERT) gene in patients with pulmonary arterial hypertension. Archivos de bronconeumologia. vol 48. issue 3. 2012-06-19. PMID:22177971. |
its functions are mediated in part by the serotonin transporter protein (sert) whose gene can have two allelic forms, both long (l) and short (s). |
2012-06-19 |
2023-08-12 |
Not clear |
| D Lanoix, J St-Pierre, A A Lacasse, M Viau, J Lafond, C Vaillancour. Stability of reference proteins in human placenta: general protein stains are the benchmark. Placenta. vol 33. issue 3. 2012-06-19. PMID:22244735. |
the effect of different normalization strategies was determined by normalizing serotonin transporter (sert) expression against the different reference protein markers. |
2012-06-19 |
2023-08-12 |
human |
| Noah B Gross, Patrick C Duncker, John F Marshal. Striatal dopamine D1 and D2 receptors: widespread influences on methamphetamine-induced dopamine and serotonin neurotoxicity. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584865. |
in animals, binge mamph dosing regimens deplete markers for monoamine nerve terminals, for example, dopamine and serotonin transporters (dat and sert), in striatum and cerebral cortex. |
2012-06-18 |
2023-08-12 |
Not clear |
| L MacGillivray, K B Reynolds, M Sickand, P I Rosebush, M F Mazure. Inhibition of the serotonin transporter induces microglial activation and downregulation of dopaminergic neurons in the substantia nigra. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584867. |
drugs that selectively inhibit the serotonin transporter (sert) are widely used in the treatment of depression and anxiety disorders. |
2012-06-18 |
2023-08-12 |
rat |
| Catherine Bédard, Marie-Josée Wallman, Emmanuelle Pourcher, Peter V Gould, André Parent, Martin Paren. Serotonin and dopamine striatal innervation in Parkinson's disease and Huntington's chorea. Parkinsonism & related disorders. vol 17. issue 8. 2012-06-18. PMID:21664855. |
antibodies against tyrosine hydroxylase (th) and 5-ht transporter (sert) were used as markers of da and 5-ht axonal profiles, respectively. |
2012-06-18 |
2023-08-12 |
Not clear |
| Petroula Proitsi, Michelle K Lupton, Suzanne J Reeves, Gillian Hamilton, Nicola Archer, Belinda M Martin, Conrad Iyegbe, Paul Hollingworth, Brian Lawlor, Michael Gill, Carol Brayne, David C Rubinsztein, Michael J Owen, Julie Williams, Simon Lovestone, John F Powel. Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:20685009. |
significant associations were observed between the serotonin transporter gene (sert) polymorphism stin2 and "psychosis"; the dopamine transporter gene (dat) 3' variable number tandem repeats (vntr) and "agitation"; and the dopamine receptor 4 (drd4) vntr and "moods" factors. |
2012-06-15 |
2023-08-12 |
Not clear |
| Róbert Kiss, Márk Sándor, Anikó Gere, Eva Schmidt, György T Balogh, Béla Kiss, László Molnár, Christian Lemmen, György M Keser. Discovery of novel histamine H4 and serotonin transporter ligands using the topological feature tree descriptor. Journal of chemical information and modeling. vol 52. issue 1. 2012-06-14. PMID:22168379. |
in this study, we tested the screening efficiency of ftrees by both retrospective and prospective screens using known histamine h4 antagonists and serotonin transporter (sert) inhibitors as query molecules. |
2012-06-14 |
2023-08-12 |
Not clear |