| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming Hui Chou, Kao Chin Chen, Tzung Lieh Yeh, I Hui Lee, Wei Jen Yao, Po See Chen, Kang-Wei Chang, Mei-Hsiu Liao, Yen Kuang Yan. Association between somatization subscale score and serotonin transporter availability in healthy volunteers--a single photon emission computed tomography study with [¹²³I] ADAM. Psychopharmacology. vol 219. issue 4. 2012-05-16. PMID:21845388. |
this study aims to examine the correlation between somatization subscale score and serotonin transporter (sert) availability in healthy volunteers. |
2012-05-16 |
2023-08-12 |
human |
| Linda Wildling, Christian Rankl, Thomas Haselgrübler, Hermann J Gruber, Marion Holy, Amy Hauck Newman, Mu-Fa Zou, Rong Zhu, Michael Freissmuth, Harald H Sitte, Peter Hinterdorfe. Probing binding pocket of serotonin transporter by single molecular force spectroscopy on living cells. The Journal of biological chemistry. vol 287. issue 1. 2012-05-08. PMID:22033932. |
the serotonin transporter (sert) terminates neurotransmission by removing serotonin from the synaptic cleft. |
2012-05-08 |
2023-08-12 |
Not clear |
| Zeng-Liang Jin, Nana Gao, Dan Zhou, Mu-Gen Chi, Xue-Mei Yang, Jiang-Ping X. The extracts of Fructus Akebiae, a preparation containing 90% of the active ingredient hederagenin: serotonin, norepinephrine and dopamine reuptake inhibitor. Pharmacology, biochemistry, and behavior. vol 100. issue 3. 2012-05-04. PMID:22005599. |
in rat brain membrane preparations and hek293 cells transfected with human serotonin transporter (sert), ne transporter (net) and da transporter (dat), we found that fae displayed marked affinity to rat and cloned human monoamine transporters in ex vivo and in vitro experiments, using competitive radio ligand binding assay. |
2012-05-04 |
2023-08-12 |
human |
| A Mørk, A Pehrson, L T Brennum, S Møller Nielsen, H Zhong, A B Lassen, S Miller, L Westrich, N J Boyle, C Sánchez, C W Fischer, N Liebenberg, G Wegener, C Bundgaard, S Hogg, B Bang-Andersen, T Bryan Stensbø. Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder. The Journal of pharmacology and experimental therapeutics. vol 340. issue 3. 2012-05-04. PMID:22171087. |
1-[2-(2,4-dimethylphenyl-sulfanyl)-phenyl]-piperazine (lu aa21004) is a human (h) serotonin (5-ht)(3a) receptor antagonist (k(i) = 3.7 nm), h5-ht(7) receptor antagonist (k(i) = 19 nm), h5-ht(1b) receptor partial agonist (k(i) = 33 nm), h5-ht(1a) receptor agonist (k(i) = 15 nm), and a human 5-ht transporter (sert) inhibitor (k(i) = 1.6 nm) (j med chem 54:3206-3221, 2011). |
2012-05-04 |
2023-08-12 |
human |
| David L Bourdet, Pamela R Tsuruda, Glenmar P Obedencio, Jacqueline A M Smit. Prediction of human serotonin and norepinephrine transporter occupancy of duloxetine by pharmacokinetic/pharmacodynamic modeling in the rat. The Journal of pharmacology and experimental therapeutics. vol 341. issue 1. 2012-05-04. PMID:22235148. |
the current studies evaluate the ability of a rodent pharmacokinetic/pharmacodynamic (pk/pd) modeling approach to translate ex vivo occupancy determined in rats to that observed after positron emission tomography (pet) imaging in humans for the dual serotonin transporter (sert) and norepinephrine transporter (net) inhibitor duloxetine. |
2012-05-04 |
2023-08-12 |
human |
| Samanta Yubero-Lahoz, Mario A Ayestas, Bruce E Blough, John S Partilla, Richard B Rothman, Rafael de la Torre, Michael H Bauman. Effects of MDMA and related analogs on plasma 5-HT: relevance to 5-HT transporters in blood and brain. European journal of pharmacology. vol 674. issue 2-3. 2012-05-03. PMID:22079770. |
5-ht transporter (sert) proteins are also expressed in non-neural tissues (e.g., blood), and evidence suggests that mdma targets platelet sert to increase plasma 5-ht. |
2012-05-03 |
2023-08-12 |
rat |
| Samanta Yubero-Lahoz, Mario A Ayestas, Bruce E Blough, John S Partilla, Richard B Rothman, Rafael de la Torre, Michael H Bauman. Effects of MDMA and related analogs on plasma 5-HT: relevance to 5-HT transporters in blood and brain. European journal of pharmacology. vol 674. issue 2-3. 2012-05-03. PMID:22079770. |
second, to determine whether effects of mdma on plasma 5-ht might be used as an index of central sert activity, we carried out in vivo microdialysis in blood and brain after intravenous mdma administration. |
2012-05-03 |
2023-08-12 |
rat |
| Samanta Yubero-Lahoz, Mario A Ayestas, Bruce E Blough, John S Partilla, Richard B Rothman, Rafael de la Torre, Michael H Bauman. Effects of MDMA and related analogs on plasma 5-HT: relevance to 5-HT transporters in blood and brain. European journal of pharmacology. vol 674. issue 2-3. 2012-05-03. PMID:22079770. |
the ability of mdma and related analogs to elevate plasma 5-ht is correlated with their potency as sert substrates in rat brain synaptosomes. |
2012-05-03 |
2023-08-12 |
rat |
| Samanta Yubero-Lahoz, Mario A Ayestas, Bruce E Blough, John S Partilla, Richard B Rothman, Rafael de la Torre, Michael H Bauman. Effects of MDMA and related analogs on plasma 5-HT: relevance to 5-HT transporters in blood and brain. European journal of pharmacology. vol 674. issue 2-3. 2012-05-03. PMID:22079770. |
collectively, our findings indicate that mdma and its metabolites increase plasma 5-ht by a sert-dependent mechanism, and suggest the possibility that measures of evoked 5-ht release in blood may reflect central sert activity. |
2012-05-03 |
2023-08-12 |
rat |
| Tania Rivera-Baltanas, Jose M Olivares, Maria Calado-Otero, Lisa E Kalynchuk, Jose R Martinez-Villamarin, Hector J Carunch. Serotonin transporter clustering in blood lymphocytes as a putative biomarker of therapeutic efficacy in major depressive disorder. Journal of affective disorders. vol 137. issue 1-3. 2012-04-27. PMID:22257570. |
serotonin transporter (sert) binding is decreased in lymphocytes of depression patients and this decrease is partially reversed by antidepressant medication. |
2012-04-27 |
2023-08-12 |
Not clear |
| Janina Witowska-Jarosz, Małgorzata Jarończyk, Aleksander P Mazurek, Ingebrigt Sylte, Andrzej J Bojarski, Zdzisław Chilmonczyk, Maciej Jaros. Mass-spectrometric studies of new 6-nitroquipazines-serotonin transporter inhibitors. Analytical and bioanalytical chemistry. vol 402. issue 1. 2012-04-19. PMID:21960253. |
the compounds exhibit high affinity for the serotonin transporter (sert) and belong to a new class of sert inhibitors. |
2012-04-19 |
2023-08-12 |
Not clear |
| Robert W Gould, H Donald Gage, Matthew L Banks, Brandi L Blaylock, Paul W Czoty, Michael A Nade. Differential effects of cocaine and MDMA self-administration on cortical serotonin transporter availability in monkeys. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21521647. |
we previously reported that, compared to drug-naïve rhesus monkeys, self-administration of cocaine but not mdma was associated with increased serotonin transporter (sert) availability in two mesolimbic regions, the caudate nucleus and putamen, as measured by positron emission tomography (pet) using the sert-specific ligand [(11)c]-3-amino-4(2-dimethylamino-methyl-phenylsulfanyl)-benzonitrile ([(11)c]dasb). |
2012-04-17 |
2023-08-12 |
human |
| Ashley N Hutchinson, Jie V Deng, Dipendra K Aryal, William C Wetsel, Anne E Wes. Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 2. 2012-04-17. PMID:21956448. |
selective blockade of the da transporter (dat) or the 5-ht transporter (sert), but not the ne transporter (net), was sufficient to induce pmecp2 in the cns. |
2012-04-17 |
2023-08-12 |
mouse |
| N Pavese, B S Simpson, V Metta, A Ramlackhansingh, K Ray Chaudhuri, D J Brook. [¹⁸F]FDOPA uptake in the raphe nuclei complex reflects serotonin transporter availability. A combined [¹⁸F]FDOPA and [¹¹C]DASB PET study in Parkinson's disease. NeuroImage. vol 59. issue 2. 2012-04-17. PMID:21963917. |
eighteen patients with pd were investigated with both [(18)f]fdopa and [(11)c]dasb pet, the latter being a marker of serotonin transport (sert) availability. |
2012-04-17 |
2023-08-12 |
Not clear |
| Speranta Avram, Catalin Buiu, Daniel M Duda-Seiman, Corina Duda-Seiman, Dan Mihailesc. 3D-QSAR design of new escitalopram derivatives for the treatment of major depressive disorders. Scientia pharmaceutica. vol 78. issue 2. 2012-04-09. PMID:21179345. |
having studied five qsar models predicting the biological activities of 18 antidepressants, already approved for clinical treatment, in interaction with the serotonin transporter (sert), we attempted to establish the membrane ionsâ contributions (sodium, potassium, chlorine and calcium) supplied by donor/acceptor hydrogen bond character and electrostatic field to the antidepressant activity. |
2012-04-09 |
2023-08-12 |
human |
| Jacobus J Dudok, Alexander J A Groffen, Ruud F T Toonen, Matthijs Verhag. Deletion of Munc18-1 in 5-HT neurons results in rapid degeneration of the 5-HT system and early postnatal lethality. PloS one. vol 6. issue 11. 2012-04-09. PMID:22140524. |
to specifically ablate the 5-ht system we generated mutant mice carrying a floxed munc18-1 gene and cre recombinase driven by the 5-ht-specific serotonin reuptake transporter (sert) promoter. |
2012-04-09 |
2023-08-12 |
mouse |
| Cynthia M Nijenhuis, Peter G J ter Horst, Lolkje T W de Jong-van den Berg, Bob Wilffer. Disturbed development of the enteric nervous system after in utero exposure of selective serotonin re-uptake inhibitors and tricyclic antidepressants. Part 1: Literature review. British journal of clinical pharmacology. vol 73. issue 1. 2012-03-30. PMID:21815911. |
blockage of the serotonin re-uptake transporter (sert) during foetal development could influence migration, differentiation and survival of cells. |
2012-03-30 |
2023-08-12 |
Not clear |
| Raghuvir S Pissurlenkar, Ashish Dhir, Satinder V Kessar, Shrinivas K Kulkarni, Evans C Coutinh. An activity model for novel antidepressants that interact with the serotonin transporter (SERT). Central nervous system agents in medicinal chemistry. vol 11. issue 3. 2012-03-29. PMID:21919867. |
an activity model for novel antidepressants that interact with the serotonin transporter (sert). |
2012-03-29 |
2023-08-12 |
mouse |
| Raghuvir S Pissurlenkar, Ashish Dhir, Satinder V Kessar, Shrinivas K Kulkarni, Evans C Coutinh. An activity model for novel antidepressants that interact with the serotonin transporter (SERT). Central nervous system agents in medicinal chemistry. vol 11. issue 3. 2012-03-29. PMID:21919867. |
in the present study, the binding of these new nmes to the serotonin transporter protein (sert) has been modeled and their activity correlated with the behavioral pattern observed in the mouse forced swim test (fst) model. |
2012-03-29 |
2023-08-12 |
mouse |
| Shaine A Cararas, Sari Izenwasser, Dean Wade, Amy Housman, Abha Verma, Stacey A Lomenzo, Mark L Trudel. Further structure-activity relationship studies on 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives at monoamine transporters. Bioorganic & medicinal chemistry. vol 19. issue 24. 2012-03-19. PMID:22055716. |
the synthesis and structure-activity relationships of 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives were investigated at the dopamine transporter (dat), the serotonin transporter (sert) and norepinephrine transporter (net). |
2012-03-19 |
2023-08-12 |
Not clear |