| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laurent Descarries, Mustaph Ria. Effects of the antidepressant fluoxetine on the subcellular localization of 5-HT1A receptors and SERT. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1601. 2012-12-06. PMID:22826342. |
serotonin (5-ht) 5-ht(1a) autoreceptors (5-ht(1a)autor) and the plasmalemmal 5-ht transporter (sert) are key elements in the regulation of central 5-ht function and its responsiveness to antidepressant drugs. |
2012-12-06 |
2023-08-12 |
rat |
| Laurent Descarries, Mustaph Ria. Effects of the antidepressant fluoxetine on the subcellular localization of 5-HT1A receptors and SERT. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1601. 2012-12-06. PMID:22826342. |
in contrast, the sert internalizes in both the cell bodies and axon terminals of 5-ht neurons after chronic but not acute fluoxetine treatment. |
2012-12-06 |
2023-08-12 |
rat |
| Ruth Tellez, Leticia Gómez-Viquez, Gustavo Liy-Salmeron, Alfredo Menese. GABA, glutamate, dopamine and serotonin transporters expression on forgetting. Neurobiology of learning and memory. vol 98. issue 1. 2012-12-03. PMID:22633984. |
notwithstanding several neurotransmission systems are frequently related to memory formation; forgetting process and neurotransmission systems or their transporters; the role of γ-aminobutyric acid (gat1), glutamate (eacc1), dopamine (dat) and serotonin (sert) is poorly understood. |
2012-12-03 |
2023-08-12 |
rat |
| Ruth Tellez, Leticia Gómez-Viquez, Gustavo Liy-Salmeron, Alfredo Menese. GABA, glutamate, dopamine and serotonin transporters expression on forgetting. Neurobiology of learning and memory. vol 98. issue 1. 2012-12-03. PMID:22633984. |
hence, in this paper western-blot analysis was used to evaluate expression of gat1, eaac1, dat and sert during forgetting in trained and untrained rats treated with the selective serotonin transporter inhibitor fluoxetine, the amnesic drug d-methamphetamine (meth) and fluoxetine plus meth. |
2012-12-03 |
2023-08-12 |
rat |
| Andreas Husch, Gabrielle N Van Patten, Diana N Hong, Moira M Scaperotti, Nathan Cramer, Ronald M Harris-Warric. Spinal cord injury induces serotonin supersensitivity without increasing intrinsic excitability of mouse V2a interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 38. 2012-12-03. PMID:22993431. |
immunocytochemical analysis showed that sci caused a coordinated loss of serotonergic fibers and the 5-ht transporter (sert). |
2012-12-03 |
2023-08-12 |
mouse |
| Andreas Husch, Gabrielle N Van Patten, Diana N Hong, Moira M Scaperotti, Nathan Cramer, Ronald M Harris-Warric. Spinal cord injury induces serotonin supersensitivity without increasing intrinsic excitability of mouse V2a interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 38. 2012-12-03. PMID:22993431. |
blocking the sert with citalopram in intact mice did not increase 5-ht sensitivity to the level seen after sci. |
2012-12-03 |
2023-08-12 |
mouse |
| Martina M Hughes, Angela Carballedo, Declan M McLoughlin, Francesco Amico, Andrew Harkin, Thomas Frodl, Thomas J Conno. Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation. Brain, behavior, and immunity. vol 26. issue 6. 2012-11-20. PMID:22683764. |
studies also indicate that inflammatory cytokines upregulate the serotonin transporter (sert), representing another mechanism by which inflammation could influence serotonin availability. |
2012-11-20 |
2023-08-12 |
Not clear |
| Stephen J Kohut, Kathleen L Decicco-Skinner, Shirin Johari, Zachary E Hurwitz, Michael H Baumann, Anthony L Rile. Differential modulation of cocaine's discriminative cue by repeated and variable stress exposure: relation to monoamine transporter levels. Neuropharmacology. vol 63. issue 2. 2012-11-19. PMID:22516586. |
dopamine (dat), serotonin (sert) and norepinephrine (net) transporter levels in mesocorticolimbic areas were also measured using western blotting after stress exposure to determine if the relative ratio of these proteins may explain differences in behavior. |
2012-11-19 |
2023-08-12 |
rat |
| Alexandre Bonnin, Le Zhang, Randy D Blakely, Pat Levit. The SSRI citalopram affects fetal thalamic axon responsiveness to netrin-1 in vitro independently of SERT antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 8. 2012-11-13. PMID:22414815. |
embryonic thalamic axons transiently express the 5-ht transporter (sert; slc6a4) and accumulate 5-ht, suggesting that the sert activity of these axons may regulate 5-ht-modulated guidance cues. |
2012-11-13 |
2023-08-12 |
mouse |
| Alexandre Bonnin, Le Zhang, Randy D Blakely, Pat Levit. The SSRI citalopram affects fetal thalamic axon responsiveness to netrin-1 in vitro independently of SERT antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 8. 2012-11-13. PMID:22414815. |
we tested whether pharmacologically blocking sert using selective 5-ht reuptake inhibitors (ssris) would impact the action of 5-ht on thalamic axon responses to netrin-1 in vitro. |
2012-11-13 |
2023-08-12 |
mouse |
| A Bortolozzi, A Castañé, J Semakova, N Santana, G Alvarado, R Cortés, A Ferrés-Coy, G Fernández, M C Carmona, M Toth, J C Perales, A Montefeltro, F Artiga. Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects. Molecular psychiatry. vol 17. issue 6. 2012-11-07. PMID:21808255. |
we developed a conjugated sirna (c-1a-sirna) by covalently binding sirna targeting 5-ht(1a) receptor mrna with the ssri sertraline in order to concentrate it in serotonin axons, rich in serotonin transporter (sert) sites. |
2012-11-07 |
2023-08-12 |
mouse |
| Andrew C Parrot. MDMA and 5-HT neurotoxicity: the empirical evidence for its adverse effects in humans - no need for translation. British journal of pharmacology. vol 166. issue 5. 2012-10-30. PMID:22404300. |
reduced levels of the 5-ht transporter (sert) have been found by research groups worldwide using a variety of assessment measures. |
2012-10-30 |
2023-08-12 |
human |
| Susanne Nikolaus, Hubertus Hautzel, Alexander Heinzel, Hans-Wilhelm Mülle. Key players in major and bipolar depression--a retrospective analysis of in vivo imaging studies. Behavioural brain research. vol 232. issue 2. 2012-10-22. PMID:22483788. |
in acute mdd, findings revealed significant increases of prefrontal and frontal da synthesis, decreases of thalamic and midbrain sert, increases of insular sert, decreases of midbrain 5-ht(1a) receptors and decreases of prefrontal, frontal, occipital and cingulate 5-ht(2a) receptors, whereas, in remission, decreases of striatal d₂ receptors, midbrain sert, frontal, parietal, temporal, occipital and cingulate 5-ht(1a) receptors and parietal 5-ht(2a) receptors were observed. |
2012-10-22 |
2023-08-12 |
Not clear |
| Carmen Mendoza, Nyurky Matheus, Eva Latorre, Marta Castro, José Emilio Mesonero, Ana Isabel Alcald. Toll-like receptor 3 activation affects serotonin transporter activity and expression in human enterocyte-like Caco-2 cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 30. issue 1. 2012-10-22. PMID:22759966. |
the present study analyzes the effect of tlr3 activation on serotonin transporter (sert) activity in caco-2 cells. |
2012-10-22 |
2023-08-12 |
human |
| Carmen Mendoza, Nyurky Matheus, Eva Latorre, Marta Castro, José Emilio Mesonero, Ana Isabel Alcald. Toll-like receptor 3 activation affects serotonin transporter activity and expression in human enterocyte-like Caco-2 cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 30. issue 1. 2012-10-22. PMID:22759966. |
treatment with poly(i:c), dsrna synthetic analogue and tlr3 ligand, was assayed and sert activity determined by 5-ht uptake and transepithelial flux. |
2012-10-22 |
2023-08-12 |
human |
| Carmen Mendoza, Nyurky Matheus, Eva Latorre, Marta Castro, José Emilio Mesonero, Ana Isabel Alcald. Toll-like receptor 3 activation affects serotonin transporter activity and expression in human enterocyte-like Caco-2 cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 30. issue 1. 2012-10-22. PMID:22759966. |
our results demonstrate that tlr3 inhibits sert activity, which may increase 5-ht extracellular levels and contribute to the inflammatory response; however, 5-ht treatment did not affect tlr3 expression. |
2012-10-22 |
2023-08-12 |
human |
| Mark J Airhart, Deborah H Lee, Tracy D Wilson, Barney E Miller, Merry N Miller, Richard G Skalko, Paul J Monac. Adverse effects of serotonin depletion in developing zebrafish. Neurotoxicology and teratology. vol 34. issue 1. 2012-10-15. PMID:21893190. |
reverse transcriptase polymerase chain reaction (rt-pcr) was performed to determine the relative levels of the serotonin 1a receptor (5ht(1a)) transcript and the serotonin transporter (sert) transcript in the brain and spinal cord of control and treated embryos. |
2012-10-15 |
2023-08-12 |
zebrafish |
| Mark J Airhart, Deborah H Lee, Tracy D Wilson, Barney E Miller, Merry N Miller, Richard G Skalko, Paul J Monac. Adverse effects of serotonin depletion in developing zebrafish. Neurotoxicology and teratology. vol 34. issue 1. 2012-10-15. PMID:21893190. |
five days subsequent to pcpa rescue, 5ht(1a) transcript concentrations remained decreased in brain while sert transcript levels were elevated in both regions. |
2012-10-15 |
2023-08-12 |
zebrafish |
| R L Bertrand, S Senadheera, A Tanoto, K L Tan, L Howitt, H Chen, T V Murphy, S L Sandow, L Liu, P P Bertran. Serotonin availability in rat colon is reduced during a Western diet model of obesity. American journal of physiology. Gastrointestinal and liver physiology. vol 303. issue 3. 2012-10-11. PMID:22595993. |
fluoxetine was used to block the 5-ht reuptake transporter (sert), and the levels of mrna for tryptophan hydroxylase 1 and sert were determined by quantitative pcr, and sert protein was determined by western blot. |
2012-10-11 |
2023-08-12 |
rat |
| R L Bertrand, S Senadheera, A Tanoto, K L Tan, L Howitt, H Chen, T V Murphy, S L Sandow, L Liu, P P Bertran. Serotonin availability in rat colon is reduced during a Western diet model of obesity. American journal of physiology. Gastrointestinal and liver physiology. vol 303. issue 3. 2012-10-11. PMID:22595993. |
sert-dependent uptake of 5-ht was unchanged, which was supported by a lack of change in sert protein levels. |
2012-10-11 |
2023-08-12 |
rat |