| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dianca R Graham, Anita Sidh. Mice expressing the A53T mutant form of human alpha-synuclein exhibit hyperactivity and reduced anxiety-like behavior. Journal of neuroscience research. vol 88. issue 8. 2010-07-12. PMID:20077428. |
in this study, we examined the effect of the ha53t mutation during development by analyzing the protein expression of norepinephrine (net), serotonin (sert), and dopamine (dat) transporters in addition to assessing locomotor and anxiety-like behavior. |
2010-07-12 |
2023-08-12 |
mouse |
| Donatella Marazziti, Giorgio Consoli, Irene Masala, Mario Catena Dell'Osso, Stefano Baron. Latest advancements on serotonin and dopamine transporters in lymphocytes. Mini reviews in medicinal chemistry. vol 10. issue 1. 2010-07-12. PMID:20105129. |
different data show that circulating lymphocytes possess functional serotonin and dopamine transporters (sert and dat, respectively). |
2010-07-12 |
2023-08-12 |
Not clear |
| Meredith A Fox, Alison R Stein, Helen T French, Dennis L Murph. Functional interactions between 5-HT2A and presynaptic 5-HT1A receptor-based responses in mice genetically deficient in the serotonin 5-HT transporter (SERT). British journal of pharmacology. vol 159. issue 4. 2010-07-09. PMID:20128812. |
functional interactions between 5-ht2a and presynaptic 5-ht1a receptor-based responses in mice genetically deficient in the serotonin 5-ht transporter (sert). |
2010-07-09 |
2023-08-12 |
mouse |
| Meredith A Fox, Alison R Stein, Helen T French, Dennis L Murph. Functional interactions between 5-HT2A and presynaptic 5-HT1A receptor-based responses in mice genetically deficient in the serotonin 5-HT transporter (SERT). British journal of pharmacology. vol 159. issue 4. 2010-07-09. PMID:20128812. |
despite decreased presynaptic 5-ht(1a) and altered 5-ht(2a) receptor function in genetically-deficient serotonin (5-ht) transporter (sert) mice, the 5-ht(1a) receptor antagonist n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinylcyclohexanecarboxamide maleate salt (way 100635) still induced head twitches in these mice, a well-established 5-ht(2a) receptor-mediated response. |
2010-07-09 |
2023-08-12 |
mouse |
| Leonora Franke, Marco Schmidtmann, Andrea Riedl, Anne Riedl, Ivo van der Voort, Ralf Uebelhack, Hubert Mönnike. Serotonin transporter activity and serotonin concentration in platelets of patients with irritable bowel syndrome: effect of gender. Journal of gastroenterology. vol 45. issue 4. 2010-07-02. PMID:19997855. |
in the past decade, a strong argument has been built for the role of serotonin (5ht) and the serotonin transporter (sert) in irritable bowel syndrome (ibs). |
2010-07-02 |
2023-08-12 |
Not clear |
| Katherine M Serafine, Anthony L Rile. Preexposure to cocaine attenuates aversions induced by both cocaine and fluoxetine: Implications for the basis of cocaine-induced conditioned taste aversions. Pharmacology, biochemistry, and behavior. vol 95. issue 2. 2010-07-01. PMID:20122955. |
to address the role of serotonin (5-ht) in cocaine-induced aversions, the present experiments used the cross-drug preexposure design in which the effects of exposure to fluoxetine, a selective 5-ht reuptake inhibitor (ssri) with 5-ht transporter (sert) inhibitory properties, were examined on aversions induced by cocaine (a nonselective monoamine transport inhibitor) and the effects of cocaine preexposure were examined on fluoxetine-induced aversions. |
2010-07-01 |
2023-08-12 |
rat |
| Martin Parent, Marie-Josée Wallman, Laurent Descarrie. Distribution and ultrastructural features of the serotonin innervation in rat and squirrel monkey subthalamic nucleus. The European journal of neuroscience. vol 31. issue 7. 2010-07-01. PMID:20345924. |
the main purpose of this light and electron microscopic immunocytochemical study was to characterize and compare the serotonin (5-ht) innervation of the subthalamic nucleus (stn) in rats and squirrel monkeys (saimiri sciureus) following labeling with an antibody against the 5-ht transporter (sert). |
2010-07-01 |
2023-08-12 |
rat |
| Qi Zhu, Jing Wang, Hua-mei La. [Effect of changji'an on visceral hypersensitivity in rats with irritable bowel syndrome and its mechanism]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 28. issue 9. 2010-06-15. PMID:19065896. |
to explore the mechanism and efficiency of changji'an (cja) in treating irritable bowel syndrome through studying the relationship between serotonin transporter (sert) and visceral hypersensitivity in rats. |
2010-06-15 |
2023-08-12 |
rat |
| Hanna E Reinebrant, Julie A Wixey, Glenda C Gobe, Paul B Colditz, Kathryn M Bulle. Differential effects of neonatal hypoxic-ischemic brain injury on brainstem serotonergic raphe nuclei. Brain research. vol 1322. 2010-06-15. PMID:20122905. |
we also discovered that p3 hi significantly reduces brainstem sert protein expression; the key regulator of 5-ht in the cns. |
2010-06-15 |
2023-08-12 |
rat |
| Narihiro Toda, Tsugio Kaneko, Hiroshi Koge. Development of an efficient therapeutic agent for Alzheimer's disease: design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter. Chemical & pharmaceutical bulletin. vol 58. issue 3. 2010-06-15. PMID:20190429. |
since patients of alzheimer's disease often exhibit depression as well as memory impairment, dual inhibitors of ache and serotonin transporter (sert) would be a better therapeutic method. |
2010-06-15 |
2023-08-12 |
mouse |
| Melissa I Torres-Altoro, Charles P Kuntz, David E Nichols, Eric L Barke. Structural analysis of the extracellular entrance to the serotonin transporter permeation pathway. The Journal of biological chemistry. vol 285. issue 20. 2010-06-14. PMID:20304925. |
we have developed a homology model for the serotonin transporter (sert) based on the crystal structure of the leucine transporter (leut(aa)) from aquifex aeolicus. |
2010-06-14 |
2023-08-12 |
Not clear |
| Carolina Chavez, Marianne Hollaus, Elizabeth Scarr, Geoff Pavey, Andrea Gogos, Maarten van den Buus. The effect of estrogen on dopamine and serotonin receptor and transporter levels in the brain: an autoradiography study. Brain research. vol 1321. 2010-06-09. PMID:20079719. |
the aim of the present study was to elucidate the effect of estrogen on dopaminergic and serotonergic regulation of prepulse inhibition (ppi) by measuring its effects on the density of dopamine transporters (dat), dopamine d(1) and d(2) receptors, serotonin transporters (sert), serotonin-1a (5-ht(1a)) and 5-ht(2a) receptors using radioligand binding autoradiography. |
2010-06-09 |
2023-08-12 |
rat |
| Carolina Chavez, Marianne Hollaus, Elizabeth Scarr, Geoff Pavey, Andrea Gogos, Maarten van den Buus. The effect of estrogen on dopamine and serotonin receptor and transporter levels in the brain: an autoradiography study. Brain research. vol 1321. 2010-06-09. PMID:20079719. |
there were no differences between the groups with respect to the densities of dopamine d(1) receptors, sert, 5-ht(1a) receptors or 5-ht(2a) receptors. |
2010-06-09 |
2023-08-12 |
rat |
| Raffaella Molteni, Annamaria Cattaneo, Francesca Calabrese, Flavia Macchi, Jocelien D A Olivier, Giorgio Racagni, Bart A Ellenbroek, Massimo Gennarelli, Marco A Riv. Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans. Neurobiology of disease. vol 37. issue 3. 2010-06-08. PMID:20034565. |
in order to identify the molecular mechanisms that may contribute to the enhanced susceptibility to depression under serotonin transporter (sert) dysfunction, we analyzed the expression of brain-derived neurotrophic factor (bdnf), a key player in neuronal plasticity, which is implicated in the etiology and treatment of depression. |
2010-06-08 |
2023-08-12 |
human |
| Judith Homberg, Isaäc J Nijman, Sylvia Kuijpers, Edwin Cuppe. Identification of genetic modifiers of behavioral phenotypes in serotonin transporter knockout rats. BMC genetics. vol 11. 2010-06-08. PMID:20459657. |
to gain insight into serotonin transporter (sert)-specific genetic modifiers, we studied an intercross between the wistar sert-/- rat and the behaviorally and genetically divergent brown norway rat, and performed a qtl analysis. |
2010-06-08 |
2023-08-12 |
human |
| Francesca Calabrese, Raffaella Molteni, Annamaria Cattaneo, Flavia Macchi, Giorgio Racagni, Massimo Gennarelli, Bart A Ellenbroek, Marco A Riv. Long-Term duloxetine treatment normalizes altered brain-derived neurotrophic factor expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms. Molecular pharmacology. vol 77. issue 5. 2010-05-28. PMID:20159945. |
major vulnerability genes for mood disorders are also related to the serotonergic system: one of these genes encodes for the serotonin transporter (sert), which represent a major target for the action of antidepressant drugs. |
2010-05-28 |
2023-08-12 |
rat |
| Sonja Sucic, Stefan Dallinger, Barbara Zdrazil, René Weissensteiner, Trine N Jørgensen, Marion Holy, Oliver Kudlacek, Stefan Seidel, Joo Hwan Cha, Ulrik Gether, Amy H Newman, Gerhard F Ecker, Michael Freissmuth, Harald H Sitt. The N terminus of monoamine transporters is a lever required for the action of amphetamines. The Journal of biological chemistry. vol 285. issue 14. 2010-05-14. PMID:20118234. |
the serotonin transporter (sert) terminates neurotransmission by removing serotonin from the synaptic cleft. |
2010-05-14 |
2023-08-12 |
Not clear |
| Carmen Mendoza, Nyurky Matheus, Ruth Iceta, Jose E Mesonero, Ana I Alcald. Lipopolysaccharide induces alteration of serotonin transporter in human intestinal epithelial cells. Innate immunity. vol 15. issue 4. 2010-05-13. PMID:19587001. |
intestinal serotoninergic activity and serotonin transporter (sert) function have been shown to be altered in intestinal inflammatory diseases. |
2010-05-13 |
2023-08-12 |
human |
| Carmen Mendoza, Nyurky Matheus, Ruth Iceta, Jose E Mesonero, Ana I Alcald. Lipopolysaccharide induces alteration of serotonin transporter in human intestinal epithelial cells. Innate immunity. vol 15. issue 4. 2010-05-13. PMID:19587001. |
activity of 5-ht depends on its extracellular availability, partly modulated by sert that transports 5-ht into the cell. |
2010-05-13 |
2023-08-12 |
human |
| Qiuli Liu, Margaret T T Wong-Rile. Postnatal changes in tryptophan hydroxylase and serotonin transporter immunoreactivity in multiple brainstem nuclei of the rat: implications for a sensitive period. The Journal of comparative neurology. vol 518. issue 7. 2010-05-05. PMID:20127812. |
because an abnormal serotonergic system has recently been implicated in sids, we conducted a large-scale investigation of the 5-ht-synthesizing enzyme tryptophan hydroxylase (tph) and serotonin transporter (sert) with semiquantitative immunohistochemistry in multiple brainstem nuclei of normal rats aged p2-21. |
2010-05-05 |
2023-08-12 |
rat |