| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ellen Scotton, Pedro Lenz Casa, Fernanda Pessi de Abreu, Scheila de Avila E Silva, Renata Luiza Boff Wilges, Marcos Vinicius Rossetto, Luiza Paul Géa, Adriane Ribeiro Rosa, Rafael Colomb. Differentially regulated targets in the fast-acting antidepressant effect of (R)-ketamine: A systems biology approach. Pharmacology, biochemistry, and behavior. 2023-02-02. PMID:36731751. |
differential regulation of transforming growth factor beta 1 (tgf-β1) receptors-mitogen-activated protein kinases (mapk's), receptor activator of nuclear factor-kappa beta ligand (rankl), and serotonin transporter (sert) seems to be particularly involved in (r)-ketamine antidepressant effects. |
2023-02-02 |
2023-08-14 |
Not clear |
| R Janet, N Costes, I Mérida, E Derrington, J C Drehe. Relationships between serotonin availability and frontolimbic response to fearful and threatening faces. Scientific reports. vol 13. issue 1. 2023-01-27. PMID:36707612. |
using a multimodal neuroimaging approach with a simultaneous pet-3t fmri scanner, we simultaneously acquired bold signal while participants viewed emotional faces depicting fear and anger, while also measuring serotonin transporter (sert) levels, regulating serotonin functions. |
2023-01-27 |
2023-08-14 |
human |
| Michael R Chojnacki, Eric B Thorndike, John S Partilla, Kenner C Rice, Charles W Schindler, Michael H Bauman. The Journal of pharmacology and experimental therapeutics. 2023-01-20. PMID:36669877. |
synaptosomes were prepared from rat caudate for dopamine transporter (dat) assays, or from whole brain minus caudate and cerebellum for norepinephrine transporter (net) and serotonin transporter (sert) assays. |
2023-01-20 |
2023-08-14 |
rat |
| Shreyas Bhat, Ali El-Kasaby, Ameya Kasture, Danila Boytsov, Julian B Reichelt, Thomas Hummel, Sonja Sucic, Christian Pifl, Michael Freissmuth, Walter Sandtne. A mechanism of uncompetitive inhibition of the serotonin transporter. eLife. vol 12. 2023-01-17. PMID:36648438. |
during its eponymous action - i.e., the retrieval of serotonin from the extracellular space - sert undergoes a conformational cycle. |
2023-01-17 |
2023-08-14 |
Not clear |
| Shreyas Bhat, Ali El-Kasaby, Ameya Kasture, Danila Boytsov, Julian B Reichelt, Thomas Hummel, Sonja Sucic, Christian Pifl, Michael Freissmuth, Walter Sandtne. A mechanism of uncompetitive inhibition of the serotonin transporter. eLife. vol 12. 2023-01-17. PMID:36648438. |
here, we explored the action of n-formyl-1,3-bis (3,4-methylenedioxyphenyl)-prop-2-yl-amine (ecsi#6) on sert: inhibition of serotonin uptake by ecsi#6 was enhanced with increasing serotonin concentration. |
2023-01-17 |
2023-08-14 |
Not clear |
| Bin Wang, Lu Cui, Qingqing Song, Moyan Liu, Jiao Kou, Shiqiang Sun, Hui Chen, Yahui Shi, Zhenlong Wu, Zhaolai Da. Excessive dietary L-tryptophan regulated amino acids metabolism and serotonin signaling in the colon of weaning piglets with acetate-induced gut inflammation. Amino acids. 2023-01-17. PMID:36648538. |
trp restored (p < 0.05) acetate-induced increase in concentrations of free aspartate, glutamate/glutamine, glycine, 5-ht, and 3-methylindole in the colon, downregulation of zonula occludens-1 and 5-ht reuptake transporter (sert) expression and upregulation of il-1β, il-8, tlr4, and 5-ht receptor 2a (htr2a) expression, and the increase in ratios of p-stat3/ stat3 and p-p65/p65 in the colon. |
2023-01-17 |
2023-08-14 |
Not clear |
| Zhi-Zheng Wang, Chao Yi, Jun-Jie Huang, Teng-Fei Xu, Kang-Zhi Chen, Zu-Sheng Wang, Ya-Ping Xue, Jie-Lian Lu, Biao Nie, Ying-Jun Zhang, Chuan-Fei Jin, Ge-Fei Ha. Deciphering Nonbioavailable Substructures Improves the Bioavailability of Antidepressants by Serotonin Transporter. Journal of medicinal chemistry. 2023-01-04. PMID:36598095. |
serotonin transporter (sert) inhibitors are first-line drugs for major depression disorder, and improving their bioavailability may be able to decrease side-effects by reducing daily dose. |
2023-01-04 |
2023-08-14 |
Not clear |
| Estibaliz Castillero, Emmett Fitzpatrick, Samuel J Keeney, Alex M D'Angelo, Benjamin B Pressly, Michael T Simpson, Mangesh Kurade, W Clinton Erwin, Vivian Moreno, Chiara Camillo, Halley J Shukla, Vaishali V Inamdar, Arbi Aghali, Juan B Grau, Elisa Salvati, Itzhak Nissim, Lubica Rauova, Mark A Oyama, Stanley J Stachelek, Chase Brown, Abba M Krieger, Robert J Levy, Giovanni Ferrar. Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation. Science translational medicine. vol 15. issue 677. 2023-01-04. PMID:36599005. |
here, we show that a decrease in the activity of the serotonin transporter (sert) accelerates mv remodeling and progression to mr. |
2023-01-04 |
2023-08-14 |
Not clear |
| Samantha González Delgado, Idalia Garza-Veloz, Fabiola Trejo-Vazquez, Margarita L Martinez-Fierr. Interplay between Serotonin, Immune Response, and Intestinal Dysbiosis in Inflammatory Bowel Disease. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555276. |
furthermore, serotonin transporter (sert) coded by solute carrier family 6 member 4 ( |
2022-12-23 |
2023-08-14 |
Not clear |
| Gustavo Henrique Marques Sousa, Renan Augusto Gomes, Eliseu Ortega de Oliveira, Gustavo Henrique Goulart Trossin. Machine learning methods applied for the prediction of biological activities of triple reuptake inhibitors. Journal of biomolecular structure & dynamics. 2022-12-22. PMID:36546689. |
thus, major efforts have been made to develop drugs that inhibit serotonin (sert), norepinephrine (net) and dopamine (dat) transporters and increase the availability of these monoamines. |
2022-12-22 |
2023-08-14 |
Not clear |
| Yuki Numagami, Fumi Hoshino, Chiaki Murakami, Masayuki Ebina, Fumio Sakan. Distinct regions of Praja-1 E3 ubiquitin-protein ligase selectively bind to docosahexaenoic acid-containing phosphatidic acid and diacylglycerol kinase δ. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2022-12-17. PMID:36528254. |
1-stearoyl-2-docosahexaenoyl (18:0/22:6)-phosphatidic acid (pa) interacts with and activates praja-1 e3 ubiquitin-protein ligase (full length: 615 aa) to ubiquitinate and degrade the serotonin transporter (sert). |
2022-12-17 |
2023-08-14 |
Not clear |
| Natalie Lipari, Ashley Centner, John Glinski, Sophie Cohen, Fredric P Manfredsson, Christopher Bisho. Characterizing the relationship between L-DOPA-induced-dyskinesia and psychosis-like behaviors in a bilateral rat model of Parkinson's disease. Neurobiology of disease. 2022-12-16. PMID:36526089. |
in experiment 2, vilazodone (vzd), a serotonin transporter (sert) blocker and 1a receptor (5-ht |
2022-12-16 |
2023-08-14 |
rat |
| David Matuskey, Jean-Dominique Gallezot, Nabeel Nabulsi, Shannan Henry, Kristen Torres, Mark Dias, Gustavo A Angarita, Yiyun Huang, Susan E Shoaf, Richard E Carson, Shailly Mehrotr. Neurotransmitter transporter occupancy following administration of centanafadine sustained-release tablets: A phase 1 study in healthy male adults. Journal of psychopharmacology (Oxford, England). 2022-12-14. PMID:36515395. |
centanafadine is an inhibitor of reuptake transporters for norepinephrine (net), dopamine (dat) and serotonin (sert). |
2022-12-14 |
2023-08-14 |
Not clear |
| Nina M Alyoshina, Maria D Tkachenko, Lyudmila A Malchenko, Yuri B Shmukler, Denis A Nikishi. Uptake and Metabolization of Serotonin by Granulosa Cells Form a Functional Barrier in the Mouse Ovary. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499156. |
5-ht accumulates in the mammalian ovary with the involvement of membrane serotonin transporter sert and is functionally active in the oocytes of growing follicles, but shows almost no activity in follicular cells. |
2022-12-11 |
2023-08-14 |
mouse |
| Nina M Alyoshina, Maria D Tkachenko, Lyudmila A Malchenko, Yuri B Shmukler, Denis A Nikishi. Uptake and Metabolization of Serotonin by Granulosa Cells Form a Functional Barrier in the Mouse Ovary. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499156. |
this confirms that the activity of sert and mao in the granulosa cells surrounding the oocytes impedes the accumulation of serotonin in the oocytes and forms a functional barrier to serotonin. |
2022-12-11 |
2023-08-14 |
mouse |
| Elizabeth M Knapp, Andrea Kaiser, Rebecca C Arnold, Maureen M Sampson, Manuela Ruppert, Li Xu, Matthew I Anderson, Shivan L Bonanno, Henrike Scholz, Jeffrey M Donlea, David E Krant. Mutation of the Drosophila melanogaster serotonin transporter dSERT impacts sleep, courtship, and feeding behaviors. PLoS genetics. vol 18. issue 11. 2022-11-21. PMID:36409783. |
the serotonin transporter (sert) regulates extracellular serotonin levels and is the target of most current drugs used to treat depression. |
2022-11-21 |
2023-08-14 |
drosophila_melanogaster |
| George M Anderson, Isabella Bruno-Pacell. Systematic review of studies using platelet serotonin content to assess bioeffect of serotonin reuptake inhibitors at the serotonin transporter. Psychopharmacology. 2022-11-18. PMID:36399187. |
assessment of the bioeffect of serotonin reuptake inhibitors (sris, including both selective serotonin reuptake inhibitors (ssris) and serotonin-norepinephrine reuptake inhibitors (snris)) at the serotonin transporter (sert) in patients and healthy controls can have important theoretical and clinical implications. |
2022-11-18 |
2023-08-14 |
Not clear |
| Robert D Levitan, Maria Sqapi, Martin Post, Julia A Knight, Stephen J Lye, Stephen G Matthew. Increasing maternal age predicts placental protein expression critical for fetal serotonin metabolism: Potential implications for neurodevelopmental research. Placenta. vol 130. 2022-11-07. PMID:36343528. |
while identifying covariates for a study of placental protein expression, we found a significant negative correlation between maternal age and the expression of monoamine oxidase a (maoa), and a significant positive correlation between maternal age and the expression of the serotonin transporter sert. |
2022-11-07 |
2023-08-14 |
Not clear |
| Robert D Levitan, Maria Sqapi, Martin Post, Julia A Knight, Stephen J Lye, Stephen G Matthew. Increasing maternal age predicts placental protein expression critical for fetal serotonin metabolism: Potential implications for neurodevelopmental research. Placenta. vol 130. 2022-11-07. PMID:36343528. |
maoa and sert play key roles in placental serotonin metabolism relevant to fetal neurodevelopment. |
2022-11-07 |
2023-08-14 |
Not clear |
| Paul W Andrews, Catherine Bosyj, Luke Brenton, Laura Green, Paul J Gasser, Christopher A Lowry, Virginia M Picke. All the brain's a stage for serotonin: the forgotten story of serotonin diffusion across cell membranes. Proceedings. Biological sciences. vol 289. issue 1986. 2022-11-02. PMID:36321487. |
the actions of serotonin are terminated by active transport of serotonin back into the releasing neuron, which is mediated by the serotonin reuptake transporter (sert). |
2022-11-02 |
2023-08-14 |
Not clear |