| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T L Steininger, B H Wainer, R D Blakely, D B Ry. Serotonergic dorsal raphe nucleus projections to the cholinergic and noncholinergic neurons of the pedunculopontine tegmental region: a light and electron microscopic anterograde tracing and immunohistochemical study. The Journal of comparative neurology. vol 382. issue 3. 1997-07-30. PMID:9183696. |
in a separate set of experiments, we utilized immunohistochemistry for the serotonin transporter (sert), combined with chat immunohistochemistry at the light and electron microscopic levels, to determine whether ppt neurons receive serotonergic innervation. |
1997-07-30 |
2023-08-12 |
Not clear |
| A Galli, C I Petersen, M deBlaquiere, R D Blakely, L J DeFelic. Drosophila serotonin transporters have voltage-dependent uptake coupled to a serotonin-gated ion channel. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 10. 1997-06-02. PMID:9133366. |
these data support a model in which 500 sert cycles occur for each 5ht-induced channel opening or a model in which 500 5ht molecules and 10,000 electronic charges pass through a common pore. |
1997-06-02 |
2023-08-12 |
xenopus_laevis |
| A S Chang, S M Chang, D M Starnes, S Schroeter, A L Bauman, R D Blakel. Cloning and expression of the mouse serotonin transporter. Brain research. Molecular brain research. vol 43. issue 1-2. 1997-05-29. PMID:9037532. |
a mouse brain cdna encoding the high-affinity serotonin transporter (sert) has been identified and characterized. |
1997-05-29 |
2023-08-12 |
mouse |
| S Apparsundaram, K R Moore, M D Malone, H C Hartzell, R D Blakel. Molecular cloning and characterization of an L-epinephrine transporter from sympathetic ganglia of the bullfrog, Rana catesbiana. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 8. 1997-04-28. PMID:9092590. |
inferred fet protein sequence bears 75, 66, and 48% amino acid identity with human net, dat, and the 5-hydroxytryptamine transporter (sert), respectively. |
1997-04-28 |
2023-08-12 |
human |
| D Matecka, D Lewis, R B Rothman, C M Dersch, F H Wojnicki, J R Glowa, A C DeVries, A Pert, K C Ric. Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors. Journal of medicinal chemistry. vol 40. issue 5. 1997-04-17. PMID:9057857. |
analogs 5-16, in which the benzene ring in the phenylpropyl side chain of the gbr molecule had been replaced with a thiophene, furan, or pyridine ring, exhibited high affinity and selectivity for the dat vs serotonin transporter (sert) and stimulated locomotor activity in rats in a manner similar to the parent compound 2. |
1997-04-17 |
2023-08-12 |
rat |
| M M Stephan, M A Chen, K M Penado, G Rudnic. An extracellular loop region of the serotonin transporter may be involved in the translocation mechanism. Biochemistry. vol 36. issue 6. 1997-03-17. PMID:9063880. |
the serotonin transporter (sert) is a member of a highly homologous family of proteins responsible for the reuptake of biogenic amines from the synaptic cleft. |
1997-03-17 |
2023-08-12 |
Not clear |
| M M Stephan, M A Chen, K M Penado, G Rudnic. An extracellular loop region of the serotonin transporter may be involved in the translocation mechanism. Biochemistry. vol 36. issue 6. 1997-03-17. PMID:9063880. |
this chimera transports serotonin very slowly compared to wild type sert. |
1997-03-17 |
2023-08-12 |
Not clear |
| J G Chen, S Liu-Chen, G Rudnic. External cysteine residues in the serotonin transporter. Biochemistry. vol 36. issue 6. 1997-03-17. PMID:9063896. |
hydropathy analysis predicts three cysteines (c109, c200, and c209) in extracellular loops of the rat serotonin transporter (sert). |
1997-03-17 |
2023-08-12 |
rat |
| A K Dutta, L L Coffey, M E Reit. Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]- 1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity. Journal of medicinal chemistry. vol 40. issue 1. 1997-03-04. PMID:9016326. |
several analogs of the potent and selective dopamine transporter (dat) ligand 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine, 1a, were prepared and biologically evaluated at the dopamine and serotonin transporter (sert) sites. |
1997-03-04 |
2023-08-12 |
Not clear |
| Y Qian, A Galli, S Ramamoorthy, S Risso, L J DeFelice, R D Blakel. Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 1. 1997-02-04. PMID:8987735. |
to explore protein kinase c-mediated sert regulation, we generated a stable human sert (hsert)-expressing cell line (293-hsert) and evaluated modulation of 5-ht activity via studies of 5-ht flux, hsert-mediated currents under voltage clamp, and surface distribution of sert protein. |
1997-02-04 |
2023-08-12 |
human |
| H Tamir, S C Hsiung, K P Liu, R D Blakely, A F Russo, M S Clark, E A Nunez, M D Gersho. Expression and development of a functional plasmalemmal 5-hydroxytryptamine transporter by thyroid follicular cells. Endocrinology. vol 137. issue 10. 1996-12-18. PMID:8828510. |
a 5-ht transporter (sert) in the plasma membrane of serotonergic neurons inactivates neuronal 5-ht. |
1996-12-18 |
2023-08-12 |
mouse |
| E L Barker, R D Blakel. Identification of a single amino acid, phenylalanine 586, that is responsible for high affinity interactions of tricyclic antidepressants with the human serotonin transporter. Molecular pharmacology. vol 50. issue 4. 1996-11-25. PMID:8863842. |
interactions with other sert antagonists, including paroxetine and cocaine, as well as the sert substrates 5-hydroxytryptamine and d-amphetamine were unaffected by interconversion of this residue. |
1996-11-25 |
2023-08-12 |
human |
| H H Gu, J Ahn, M J Caplan, R D Blakely, A I Levey, G Rudnic. Cell-specific sorting of biogenic amine transporters expressed in epithelial cells. The Journal of biological chemistry. vol 271. issue 30. 1996-09-03. PMID:8663573. |
both madin-darby canine kidney (mdck) and llc-pk1 cells were stably transfected with cdnas encoding either the rat 5-ht transporter (sert), the human ne transporter (net), or the rat or human da transporter (dat). |
1996-09-03 |
2023-08-12 |
human |
| H H Gu, S Wall, G Rudnic. Ion coupling stoichiometry for the norepinephrine transporter in membrane vesicles from stably transfected cells. The Journal of biological chemistry. vol 271. issue 12. 1996-07-09. PMID:8636118. |
we prepared membrane vesicles from stable llc-pk1 cells expressing serotonin (5-ht) gamma-aminobutyric acid (gaba) and norepinephrine (ne) transporters (sert, gat-1, and net). |
1996-07-09 |
2023-08-12 |
Not clear |
| J Gelernter, A J Pakstis, K K Kid. Linkage mapping of serotonin transporter protein gene SLC6A4 on chromosome 17. Human genetics. vol 95. issue 6. 1995-07-26. PMID:7789954. |
serotonin transporter protein (sert) allows neurons to retrieve serotonin that has been released into a synapse. |
1995-07-26 |
2023-08-12 |
Not clear |
| Y Qian, H E Melikian, D B Rye, A I Levey, R D Blakel. Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 2. 1995-03-29. PMID:7869097. |
immunocytochemistry performed on rat brain sections with ct-2 antibody revealed sert expression associated with brainstem raphe nuclei in a pattern virtually identical to that obtained by labeling adjacent sections with 5ht antisera. |
1995-03-29 |
2023-08-12 |
human |
| E L Barker, H L Kimmel, R D Blakel. Chimeric human and rat serotonin transporters reveal domains involved in recognition of transporter ligands. Molecular pharmacology. vol 46. issue 5. 1994-12-29. PMID:7969065. |
the serotonin transporter (sert) is a target for many clinically significant drugs, such as cocaine, amphetamine, and antidepressants. |
1994-12-29 |
2023-08-12 |
human |
| E L Barker, H L Kimmel, R D Blakel. Chimeric human and rat serotonin transporters reveal domains involved in recognition of transporter ligands. Molecular pharmacology. vol 46. issue 5. 1994-12-29. PMID:7969065. |
serotonin uptake and radioligand binding assays revealed that rat and human serts show different sensitivities to some but not all transporter ligands; most tricyclic antidepressants were significantly more potent at the human sert, relative to rat sert, whereas d-amphetamine was a more potent inhibitor of rat sert. |
1994-12-29 |
2023-08-12 |
human |
| L L Demchyshyn, Z B Pristupa, K S Sugamori, E L Barker, R D Blakely, W J Wolfgang, M A Forte, H B Nizni. Cloning, expression, and localization of a chloride-facilitated, cocaine-sensitive serotonin transporter from Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 11. 1994-06-27. PMID:8197200. |
in marked contrast to the human sert (hsert), 5ht-mediated transport by dsert was not absolutely dependent on extracellular cl-, while the sodium-dependent uptake of 5ht was facilitated by increased extracellular cl- concentrations. |
1994-06-27 |
2023-08-12 |
human |