| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V M Pickel, J Cha. Ultrastructural localization of the serotonin transporter in limbic and motor compartments of the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 17. 1999-09-23. PMID:10460242. |
these findings also indicate that sert may play a minor substrate-dependent role in serotonin uptake or channel activity in selective nonserotonergic neurons and glia in the nac. |
1999-09-23 |
2023-08-12 |
rat |
| Z Szabo, U Scheffel, W B Mathews, H T Ravert, K Szabo, M Kraut, S Palmon, G A Ricaurte, R F Dannal. Kinetic analysis of [11C]McN5652: a serotonin transporter radioligand. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 19. issue 9. 1999-09-21. PMID:10478648. |
this study investigates the impulse response function of [11c](+)mcn5652, a radioligand used for positron emission tomography (pet) imaging of the serotonin transporter (sert) in the brain. |
1999-09-21 |
2023-08-12 |
human |
| A L Upton, N Salichon, C Lebrand, A Ravary, R Blakely, I Seif, P Gaspa. Excess of serotonin (5-HT) alters the segregation of ispilateral and contralateral retinal projections in monoamine oxidase A knock-out mice: possible role of 5-HT uptake in retinal ganglion cells during development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 16. 1999-09-01. PMID:10436056. |
in both maoa-ko and normal mice, high-affinity uptake of 5-ht and serotonin transporter (sert) immunoreactivity are observed in retinal axons from the optic cup to retinal terminal fields in the sc and dlgn. |
1999-09-01 |
2023-08-12 |
mouse |
| A L Upton, N Salichon, C Lebrand, A Ravary, R Blakely, I Seif, P Gaspa. Excess of serotonin (5-HT) alters the segregation of ispilateral and contralateral retinal projections in monoamine oxidase A knock-out mice: possible role of 5-HT uptake in retinal ganglion cells during development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 16. 1999-09-01. PMID:10436056. |
we show that, in addition to sert, developing rgcs also transiently express the vesicular monoamine transporter gene vmat2: thus, retinal axons could store 5-ht in synaptic vesicles and possibly use it as a borrowed neurotransmitter. |
1999-09-01 |
2023-08-12 |
mouse |
| A R Belous, S Ramamoothy, R D Blakely, M I Faktor, R Kh Lozier, A M Dupin, A G Bechiashvili, M A Morozova, O S Bruso. [Decrease in the platelet level of 43 kDa immunoreactive fraction of serotonin transporting protein correlates with depressive symptoms in patients with somatoform disorders]. Voprosy meditsinskoi khimii. vol 45. issue 3. 1999-08-26. PMID:10432563. |
to elucidate the role of serotonin transporter (sert) protein as a candidate target for somatoform disorders (sd), we have performed an association study of the sert immunoreactive (ir-sert) protein level by using site-specific antibodies directed at c-terminus epitope poorly conserved among other cotransporters. |
1999-08-26 |
2023-08-12 |
human |
| S Ramamoorthy, R D Blakel. Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants. Science (New York, N.Y.). vol 285. issue 5428. 1999-08-16. PMID:10427004. |
phosphorylation and sequestration of the serotonin transporter (sert) were substantially impacted by ligand occupancy. |
1999-08-16 |
2023-08-12 |
Not clear |
| S Ramamoorthy, R D Blakel. Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants. Science (New York, N.Y.). vol 285. issue 5428. 1999-08-16. PMID:10427004. |
ligands that can permeate the transporter, such as serotonin or the amphetamines, prevented pkc-dependent sert phosphorylation. |
1999-08-16 |
2023-08-12 |
Not clear |
| S Ramamoorthy, R D Blakel. Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants. Science (New York, N.Y.). vol 285. issue 5428. 1999-08-16. PMID:10427004. |
nontransported sert antagonists such as cocaine and antidepressants were permissive for sert phosphorylation but blocked serotonin effects. |
1999-08-16 |
2023-08-12 |
Not clear |
| S Ramamoorthy, R D Blakel. Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants. Science (New York, N.Y.). vol 285. issue 5428. 1999-08-16. PMID:10427004. |
pkc-dependent sert sequestration was also blocked by serotonin. |
1999-08-16 |
2023-08-12 |
Not clear |
| C I Petersen, L J DeFelic. Ionic interactions in the Drosophila serotonin transporter identify it as a serotonin channel. Nature neuroscience. vol 2. issue 7. 1999-08-02. PMID:10404179. |
to examine sert's response to high 5ht concentrations, we expressed drosophila sert (dsert) in xenopus oocytes and found that transport continued to increase with concentration up to 0.3 mm 5ht. |
1999-08-02 |
2023-08-12 |
xenopus_laevis |
| C I Petersen, L J DeFelic. Ionic interactions in the Drosophila serotonin transporter identify it as a serotonin channel. Nature neuroscience. vol 2. issue 7. 1999-08-02. PMID:10404179. |
as 5ht is a monovalent cation, its entry through an ion channel in sert might explain uptake at high concentrations. |
1999-08-02 |
2023-08-12 |
xenopus_laevis |
| C G Tate, E Whiteley, M J Betenbaug. Molecular chaperones stimulate the functional expression of the cocaine-sensitive serotonin transporter. The Journal of biological chemistry. vol 274. issue 25. 1999-07-15. PMID:10364189. |
the serotonin transporter (sert) is an n-glycosylated integral membrane protein that is predicted to contain 12 transmembrane regions. |
1999-07-15 |
2023-08-12 |
Not clear |
| S H Dresel, M P Kung, X Huang, K Plössl, C Hou, C Y Shiue, J Karp, H F Kun. In vivo imaging of serotonin transporters with [99mTc]TRODAT-1 in nonhuman primates. European journal of nuclear medicine. vol 26. issue 4. 1999-06-03. PMID:10199939. |
additionally, in vitro binding and autoradiographic experiments demonstrated that this tracer also binds to serotonin transporters (sert) in the midbrain/hypothalamus (mb) area. |
1999-06-03 |
2023-08-12 |
human |
| M Nishimura, K Sato, S Shimada, M Tohyam. Expression of norepinephrine and serotonin transporter mRNAs in the rat superior cervical ganglion. Brain research. Molecular brain research. vol 67. issue 1. 1999-05-21. PMID:10101235. |
we investigated the gene expression of three monoamine transporters (norepinephrine transporter, net; serotonin transporter, sert; and dopamine transporter, dat) in the rat superior cervical ganglion (scg). |
1999-05-21 |
2023-08-12 |
rat |
| R T Malison, L H Price, R Berman, C H van Dyck, G H Pelton, L Carpenter, G Sanacora, M J Owens, C B Nemeroff, N Rajeevan, R M Baldwin, J P Seibyl, R B Innis, D S Charne. Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography. Biological psychiatry. vol 44. issue 11. 1999-03-23. PMID:9836013. |
prior research has suggested reductions in the density of serotonin transporter (sert) binding sites in blood platelets and post-mortem brain tissue of depressed patients. |
1999-03-23 |
2023-08-12 |
Not clear |
| A Frazer, L C Daw. Serotonin transporter function in vivo: assessment by chronoamperometry. Annals of the New York Academy of Sciences. vol 861. 1999-02-25. PMID:9928259. |
from these data, it is inferred that both the sert and net contribute to the active clearance of exogenously applied 5-ht in the dentate gyrus. |
1999-02-25 |
2023-08-12 |
rat |
| M S Brownfield, J Yracheta, F Chu, D Lorenz, A Dia. Functional chemical neuroanatomy of serotonergic neurons and their targets: antibody production and immunohistochemistry (IHC) for 5-HT, its precursor (5-HTP) and metabolite (5-HIAA), biosynthetic enzyme (TPH), transporter (SERT), and three receptors (5-HT2A, 5-ht5a, 5-HT7). Annals of the New York Academy of Sciences. vol 861. 1999-02-25. PMID:9928261. |
functional chemical neuroanatomy of serotonergic neurons and their targets: antibody production and immunohistochemistry (ihc) for 5-ht, its precursor (5-htp) and metabolite (5-hiaa), biosynthetic enzyme (tph), transporter (sert), and three receptors (5-ht2a, 5-ht5a, 5-ht7). |
1999-02-25 |
2023-08-12 |
Not clear |
| J K McQueen, H Wilson, B E Sumner, G Fin. Serotonin transporter (SERT) mRNA and binding site densities in male rat brain affected by sex steroids. Brain research. Molecular brain research. vol 63. issue 2. 1999-02-19. PMID:9878762. |
serotonin transporter (sert) mrna and binding site densities in male rat brain affected by sex steroids. |
1999-02-19 |
2023-08-12 |
human |
| J K McQueen, H Wilson, B E Sumner, G Fin. Serotonin transporter (SERT) mRNA and binding site densities in male rat brain affected by sex steroids. Brain research. Molecular brain research. vol 63. issue 2. 1999-02-19. PMID:9878762. |
estrogen increases serotonin transporter (sert) mrna and binding sites in female rat brain. |
1999-02-19 |
2023-08-12 |
human |
| W Liu, N Gu, G Feng, J Zhang, S Li, S Bai, T Shen, D S Clair, L H. [Association of VNTR region of the human serotonin transporter gene with bipolar disorder among the Han Chinese]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 15. issue 6. 1999-01-28. PMID:9845763. |
the serotonin transporter gene (sert) plays an important role in the serotonin uptake into neurons. |
1999-01-28 |
2023-08-12 |
human |